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{{Infobox_gene}}
{{PBB_Controls
'''AT-rich interactive domain-containing protein 4B''' is a [[protein]] that in humans is encoded by the ''ARID4B'' [[gene]].<ref name="pmid11481388">{{cite journal | vauthors = Cao J, Gao T, Stanbridge EJ, Irie R | title = RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis | journal = J Natl Cancer Inst | volume = 93 | issue = 15 | pages = 1159–65 | date = Aug 2001 | pmid = 11481388 | pmc =  | doi = 10.1093/jnci/93.15.1159 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51742| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = AT rich interactive domain 4B (RBP1-like)
| HGNCid = 15550
| Symbol = ARID4B
| AltSymbols =; BCAA; BRCAA1; DKFZp313M2420; MGC163290; RBBP1L1; RBP1L1; SAP180
| OMIM = 609696
| ECnumber = 
| Homologene = 12847
| MGIid = 2137512
| GeneAtlas_image1 = PBB_GE_ARID4B_221230_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006333 |text = chromatin assembly or disassembly}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51742
    | Hs_Ensembl = ENSG00000054267
    | Hs_RefseqProtein = NP_057458
    | Hs_RefseqmRNA = NM_016374
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 233396835
    | Hs_GenLoc_end = 233558155
    | Hs_Uniprot = 
    | Mm_EntrezGene = 94246
    | Mm_Ensembl = ENSMUSG00000039219
    | Mm_RefseqmRNA = NM_194262
    | Mm_RefseqProtein = NP_919238
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 13912267
    | Mm_GenLoc_end = 13989859
    | Mm_Uniprot = 
  }}
}}
'''AT rich interactive domain 4B (RBP1-like)''', also known as '''ARID4B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51742| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein with sequence similarity to [[retinoblastoma]]-binding protein-1. The encoded protein is a subunit of the [[histone deacetylase]]-dependent [[SIN3A]] transcriptional [[corepressor]] complex, which functions in diverse cellular processes including [[cell proliferation|proliferation]], [[Cellular differentiation|differentiation]], [[apoptosis]], [[oncogenesis]], and [[cell fate determination]]. The gene product is recognized by [[IgG]] [[antibody]] isolated from a [[breast cancer]] patient and appears to be a [[molecular marker]] associated with a broad range of human malignancies. Alternate transcriptional [[Alternative splicing|splice]] variants encoding different [[isoform]]s have been characterized.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51742| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ARID4B}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus. | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
| citations =
*{{cite journal | vauthors = Bommel H, Xie G, Rossoll W, Wiese S, Jablonka S, Boehm T, Sendtner M | title = Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease. | journal = J. Cell Biol. | volume = 159 | issue = 4 | pages = 563–9 | year = 2003 | pmid = 12446740 | pmc = 2173089 | doi = 10.1083/jcb.200208001 }}
*{{cite journal  | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
*{{cite journal | vauthors = Fleischer TC, Yun UJ, Ayer DE | title = Identification and characterization of three new components of the mSin3A corepressor complex. | journal = Mol. Cell. Biol. | volume = 23 | issue = 10 | pages = 3456–67 | year = 2003 | pmid = 12724404 | pmc = 164750 | doi = 10.1128/MCB.23.10.3456-3467.2003 }}
*{{cite journal  | author=Cao J, Gao T, Stanbridge EJ, Irie R |title=RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis. |journal=J. Natl. Cancer Inst. |volume=93 |issue= 15 |pages= 1159-65 |year= 2001 |pmid= 11481388 |doi=  }}
*{{cite journal | vauthors = Cui D, Jin G, Gao T, Sun T, Tian F, Estrada GG, Gao H, Sarai A | title = Characterization of BRCAA1 and its novel antigen epitope identification. | journal = Cancer Epidemiol. Biomarkers Prev. | volume = 13 | issue = 7 | pages = 1136–45 | year = 2004 | pmid = 15247124 | doi =  }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi= }}
*{{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Bommel H, Xie G, Rossoll W, ''et al.'' |title=Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease. |journal=J. Cell Biol. |volume=159 |issue= 4 |pages= 563-9 |year= 2003 |pmid= 12446740 |doi= 10.1083/jcb.200208001 }}
*{{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Fleischer TC, Yun UJ, Ayer DE |title=Identification and characterization of three new components of the mSin3A corepressor complex. |journal=Mol. Cell. Biol. |volume=23 |issue= 10 |pages= 3456-67 |year= 2003 |pmid= 12724404 |doi= }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Cui D, Jin G, Gao T, ''et al.'' |title=Characterization of BRCAA1 and its novel antigen epitope identification. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=13 |issue= 7 |pages= 1136-45 |year= 2004 |pmid= 15247124 |doi=  }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 03:18, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene.[1][2]

Function

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.[2]

References

  1. ↑ Cao J, Gao T, Stanbridge EJ, Irie R (Aug 2001). "RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis". J Natl Cancer Inst. 93 (15): 1159–65. doi:10.1093/jnci/93.15.1159. PMID 11481388.
  2. ↑ 2.0 2.1 "Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like)".

External links

Further reading


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