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{{Infobox_gene}}
{{PBB_Controls
'''Vacuolar protein sorting-associated protein 45''' is a [[protein]] that in humans is encoded by the ''VPS45'' [[gene]].<ref name="pmid8996080">{{cite journal | vauthors = Pevsner J, Hsu SC, Hyde PS, Scheller RH | title = Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking | journal = Gene | volume = 183 | issue = 1-2 | pages = 7–14 |date=Feb 1997 | pmid = 8996080 | pmc =  | doi =10.1016/S0378-1119(96)00367-8  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11311| accessdate = }}</ref>
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Vacuolar protein sorting 45 homolog (S. cerevisiae)
| HGNCid = 14579
| Symbol = VPS45
| AltSymbols =; H1; H1VPS45; VPS45A; VPS45B; VPS54A; VSP45; VSP45A
| OMIM = 610035
| ECnumber = 
| Homologene = 5250
| MGIid = 891965
| GeneAtlas_image1 = PBB_GE_VPS45_209268_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005798 |text = Golgi-associated vesicle}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006904 |text = vesicle docking during exocytosis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11311
    | Hs_Ensembl = ENSG00000136631
    | Hs_RefseqProtein = NP_009190
    | Hs_RefseqmRNA = NM_007259
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 148305993
    | Hs_GenLoc_end = 148384129
    | Hs_Uniprot = Q9NRW7
    | Mm_EntrezGene = 22365
    | Mm_Ensembl = ENSMUSG00000015747
    | Mm_RefseqmRNA = NM_013841
    | Mm_RefseqProtein = NP_038869
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 96085265
    | Mm_GenLoc_end = 96143871
    | Mm_Uniprot = Q3THX4
  }}
}}
'''Vacuolar protein sorting 45 homolog (S. cerevisiae)''', also known as '''VPS45''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11311| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Vesicle (biology and chemistry)|Vesicle]] mediated [[protein targeting|protein sorting]] plays an important role in segregation of intracellular molecules into distinct [[organelle]]s. Genetic studies in yeast have identified more than 40 [[vacuolar protein sorting]] (VPS) genes involved in [[vesicle transport]] to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including [[inflammation#Cell derived mediators|inflammatory mediators]].<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators.<ref name="entrez">{{cite web | title = Entrez Gene: VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11311| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
| citations =
*{{cite journal  | vauthors=Tellam JT, James DE, Stevens TH, Piper RC |title=Identification of a mammalian Golgi Sec1p-like protein, mVps45. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6187–93 |year= 1997 |pmid= 9045632 |doi=10.1074/jbc.272.10.6187 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Pevsner J, Hsu SC, Hyde PS, Scheller RH |title=Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking. |journal=Gene |volume=183 |issue= 1-2 |pages= 7-14 |year= 1997 |pmid= 8996080 |doi= }}
*{{cite journal   |vauthors=Rajasekariah P, Eyre HJ, Stanley KK, etal |title=Molecular cloning and characterization of a cDNA encoding the human leucocyte vacuolar protein sorting (h1Vps45). |journal=Int. J. Biochem. Cell Biol. |volume=31 |issue= 6 |pages= 683–94 |year= 1999 |pmid= 10404641 |doi=10.1016/S1357-2725(99)00017-5 }}
*{{cite journal  | author=Tellam JT, James DE, Stevens TH, Piper RC |title=Identification of a mammalian Golgi Sec1p-like protein, mVps45. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6187-93 |year= 1997 |pmid= 9045632 |doi=  }}
*{{cite journal   |vauthors=Nielsen E, Christoforidis S, Uttenweiler-Joseph S, etal |title=Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. |journal=J. Cell Biol. |volume=151 |issue= 3 |pages= 601–12 |year= 2000 |pmid= 11062261 |doi=10.1083/jcb.151.3.601  | pmc=2185588 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=de Renzis S, Sönnichsen B, Zerial M |title=Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. |journal=Nat. Cell Biol. |volume=4 |issue= 2 |pages= 124–33 |year= 2002 |pmid= 11788822 |doi= 10.1038/ncb744 }}
*{{cite journal | author=Rajasekariah P, Eyre HJ, Stanley KK, ''et al.'' |title=Molecular cloning and characterization of a cDNA encoding the human leucocyte vacuolar protein sorting (h1Vps45). |journal=Int. J. Biochem. Cell Biol. |volume=31 |issue= 6 |pages= 683-94 |year= 1999 |pmid= 10404641 |doi=  }}
*{{cite journal   |vauthors=Dulubova I, Yamaguchi T, Gao Y, etal |title=How Tlg2p/syntaxin 16 'snares' Vps45. |journal=EMBO J. |volume=21 |issue= 14 |pages= 3620–31 |year= 2002 |pmid= 12110575 |doi= 10.1093/emboj/cdf381 | pmc=126126 }}
*{{cite journal | author=Nielsen E, Christoforidis S, Uttenweiler-Joseph S, ''et al.'' |title=Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. |journal=J. Cell Biol. |volume=151 |issue= 3 |pages= 601-12 |year= 2000 |pmid= 11062261 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=de Renzis S, Sönnichsen B, Zerial M |title=Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. |journal=Nat. Cell Biol. |volume=4 |issue= 2 |pages= 124-33 |year= 2002 |pmid= 11788822 |doi= 10.1038/ncb744 }}
*{{cite journal   |vauthors=Kim BY, Ueda M, Kominami E, etal |title=Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex. |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 3 |pages= 577–82 |year= 2004 |pmid= 14623309 |doi=10.1016/j.bbrc.2003.10.030 }}
*{{cite journal | author=Dulubova I, Yamaguchi T, Gao Y, ''et al.'' |title=How Tlg2p/syntaxin 16 'snares' Vps45. |journal=EMBO J. |volume=21 |issue= 14 |pages= 3620-31 |year= 2002 |pmid= 12110575 |doi= 10.1093/emboj/cdf381 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Kim BY, Ueda M, Kominami E, ''et al.'' |title=Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex. |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 3 |pages= 577-82 |year= 2004 |pmid= 14623309 |doi=  }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 15:39, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Vacuolar protein sorting-associated protein 45 is a protein that in humans is encoded by the VPS45 gene.[1][2]

Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators.[2]

References

  1. ↑ Pevsner J, Hsu SC, Hyde PS, Scheller RH (Feb 1997). "Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking". Gene. 183 (1–2): 7–14. doi:10.1016/S0378-1119(96)00367-8. PMID 8996080.
  2. ↑ 2.0 2.1 "Entrez Gene: VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)".

Further reading


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