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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Regulator of G-protein signaling 18''' is a [[protein]] that in humans is encoded by the ''RGS18'' [[gene]].<ref name="pmid11042171">{{cite journal | vauthors = Park IK, Klug CA, Li K, Jerabek L, Li L, Nanamori M, Neubig RR, Hood L, Weissman IL, Clarke MF | title = Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 2 | pages = 915-23 | date = Jan 2001 | pmid = 11042171 | pmc =  | doi = 10.1074/jbc.M005947200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RGS18 regulator of G-protein signalling 18| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64407| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_RGS18_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dlv.
| PDB = {{PDB2|2dlv}}, {{PDB2|2jm5}}, {{PDB2|2owi}}
| Name = Regulator of G-protein signalling 18
| HGNCid = 14261
| Symbol = RGS18
| AltSymbols =; RGS13
| OMIM = 607192
| ECnumber = 
| Homologene = 11281
| MGIid = 1927498
| GeneAtlas_image1 = PBB_GE_RGS18_gnf1h08828_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0016299 |text = regulator of G-protein signaling activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0008277 |text = regulation of G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0009968 |text = negative regulation of signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 64407
    | Hs_Ensembl = ENSG00000150681
    | Hs_RefseqProtein = NP_570138
    | Hs_RefseqmRNA = NM_130782
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 190394210
    | Hs_GenLoc_end = 190421568
    | Hs_Uniprot = Q9NS28
    | Mm_EntrezGene = 64214
    | Mm_Ensembl = ENSMUSG00000026357
    | Mm_RefseqmRNA = NM_022881
    | Mm_RefseqProtein = NP_075019
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 146515059
    | Mm_GenLoc_end = 146537645
    | Mm_Uniprot = Q544K2
  }}
}}
'''Regulator of G-protein signalling 18''', also known as '''RGS18''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RGS18 regulator of G-protein signalling 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64407| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.<ref name="entrez">{{cite web | title = Entrez Gene: RGS18 regulator of G-protein signalling 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64407| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Park IK, Klug CA, Li K, ''et al.'' |title=Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. |journal=J. Biol. Chem. |volume=276 |issue= 2 |pages= 915-23 |year= 2001 |pmid= 11042171 |doi= 10.1074/jbc.M005947200 }}
*{{cite journal  | author=Nagata Y, Oda M, Nakata H, ''et al.'' |title=A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. |journal=Blood |volume=97 |issue= 10 |pages= 3051-60 |year= 2001 |pmid= 11342430 |doi=  }}
*{{cite journal  | author=Yowe D, Weich N, Prabhudas M, ''et al.'' |title=RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes. |journal=Biochem. J. |volume=359 |issue= Pt 1 |pages= 109-18 |year= 2003 |pmid= 11563974 |doi=  }}
*{{cite journal  | author=Sierra DA, Gilbert DJ, Householder D, ''et al.'' |title=Evolution of the regulators of G-protein signaling multigene family in mouse and human. |journal=Genomics |volume=79 |issue= 2 |pages= 177-85 |year= 2002 |pmid= 11829488 |doi= 10.1006/geno.2002.6693 }}
*{{cite journal  | author=Gagnon AW, Murray DL, Leadley RJ |title=Cloning and characterization of a novel regulator of G protein signalling in human platelets. |journal=Cell. Signal. |volume=14 |issue= 7 |pages= 595-606 |year= 2002 |pmid= 11955952 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Larminie C, Murdock P, Walhin JP, ''et al.'' |title=Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system. |journal=Brain Res. Mol. Brain Res. |volume=122 |issue= 1 |pages= 24-34 |year= 2004 |pmid= 14992813 |doi= 10.1016/j.molbrainres.2003.11.014 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Aldenhoven J, Chen Y, Moran C |title=Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels. |journal=Cytogenet. Genome Res. |volume=112 |issue= 3-4 |pages= 341F |year= 2006 |pmid= 16484797 |doi= 10.1159/000089896 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}


{{protein-stub}}
RGS18 has been shown to [[Protein-protein interaction|interact]] with [[GNAI3]].<ref name=pmid11563974>{{cite journal | vauthors = Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR | title = RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes | journal = The Biochemical Journal | volume = 359 | issue = Pt 1 | pages = 109-18 | date = Oct 2001 | pmid = 11563974 | pmc = 1222126 | doi = 10.1042/bj3590109 }}</ref><ref name=pmid11955952>{{cite journal | vauthors = Gagnon AW, Murray DL, Leadley RJ | title = Cloning and characterization of a novel regulator of G protein signalling in human platelets | journal = Cellular Signalling | volume = 14 | issue = 7 | pages = 595-606 | date = Jul 2002 | pmid = 11955952 | doi = 10.1016/S0898-6568(02)00012-8 }}</ref>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Nagata Y, Oda M, Nakata H, Shozaki Y, Kozasa T, Todokoro K | title = A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes | journal = Blood | volume = 97 | issue = 10 | pages = 3051-60 | date = May 2001 | pmid = 11342430 | doi = 10.1182/blood.V97.10.3051 }}
* {{cite journal | vauthors = Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR | title = RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes | journal = The Biochemical Journal | volume = 359 | issue = Pt 1 | pages = 109-18 | date = Oct 2001 | pmid = 11563974 | pmc = 1222126 | doi = 10.1042/bj3590109 }}
* {{cite journal | vauthors = Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM | title = Evolution of the regulators of G-protein signaling multigene family in mouse and human | journal = Genomics | volume = 79 | issue = 2 | pages = 177-85 | date = Feb 2002 | pmid = 11829488 | doi = 10.1006/geno.2002.6693 }}
* {{cite journal | vauthors = Gagnon AW, Murray DL, Leadley RJ | title = Cloning and characterization of a novel regulator of G protein signalling in human platelets | journal = Cellular Signalling | volume = 14 | issue = 7 | pages = 595-606 | date = Jul 2002 | pmid = 11955952 | doi = 10.1016/S0898-6568(02)00012-8 }}
* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nature Biotechnology | volume = 21 | issue = 5 | pages = 566-9 | date = May 2003 | pmid = 12665801 | doi = 10.1038/nbt810 }}
* {{cite journal | vauthors = Larminie C, Murdock P, Walhin JP, Duckworth M, Blumer KJ, Scheideler MA, Garnier M | title = Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system | journal = Brain Research. Molecular Brain Research | volume = 122 | issue = 1 | pages = 24-34 | date = Mar 2004 | pmid = 14992813 | doi = 10.1016/j.molbrainres.2003.11.014 }}
* {{cite journal | vauthors = Aldenhoven J, Chen Y, Moran C | title = Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels | journal = Cytogenetic and Genome Research | volume = 112 | issue = 3-4 | pages = 341F | year = 2006 | pmid = 16484797 | doi = 10.1159/000089896 }}
{{Refend}}
 
{{PDB Gallery|geneid=64407}}
 
{{Gene-1-stub}}

Latest revision as of 09:10, 10 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.[1][2]

Function

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[2]

Interactions

RGS18 has been shown to interact with GNAI3.[3][4]

References

  1. ↑ Park IK, Klug CA, Li K, Jerabek L, Li L, Nanamori M, Neubig RR, Hood L, Weissman IL, Clarke MF (Jan 2001). "Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells". The Journal of Biological Chemistry. 276 (2): 915–23. doi:10.1074/jbc.M005947200. PMID 11042171.
  2. ↑ 2.0 2.1 "Entrez Gene: RGS18 regulator of G-protein signalling 18".
  3. ↑ Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR (Oct 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal. 359 (Pt 1): 109–18. doi:10.1042/bj3590109. PMC 1222126. PMID 11563974.
  4. ↑ Gagnon AW, Murray DL, Leadley RJ (Jul 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling. 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. PMID 11955952.

Further reading

  • Nagata Y, Oda M, Nakata H, Shozaki Y, Kozasa T, Todokoro K (May 2001). "A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes". Blood. 97 (10): 3051–60. doi:10.1182/blood.V97.10.3051. PMID 11342430.
  • Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR (Oct 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal. 359 (Pt 1): 109–18. doi:10.1042/bj3590109. PMC 1222126. PMID 11563974.
  • Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM (Feb 2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
  • Gagnon AW, Murray DL, Leadley RJ (Jul 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling. 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. PMID 11955952.
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
  • Larminie C, Murdock P, Walhin JP, Duckworth M, Blumer KJ, Scheideler MA, Garnier M (Mar 2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system". Brain Research. Molecular Brain Research. 122 (1): 24–34. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813.
  • Aldenhoven J, Chen Y, Moran C (2006). "Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels". Cytogenetic and Genome Research. 112 (3–4): 341F. doi:10.1159/000089896. PMID 16484797.
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