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{{ | '''Fc receptor-like protein 3''' is a [[protein]] that in humans is encoded by the ''FCRL3'' [[gene]].<ref name="pmid11493702">{{cite journal | vauthors = Davis RS, Wang YH, Kubagawa H, Cooper MD | title = Identification of a family of Fc receptor homologs with preferential B cell expression | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 17 | pages = 9772–7 |date=Aug 2001 | pmid = 11493702 | pmc = 55528 | doi = 10.1073/pnas.171308498 }}</ref><ref name="pmid12014205">{{cite journal | vauthors = Davis RS, ((Dennis G Jr)), Kubagawa H, Cooper MD | title = Fc receptor homologs (FcRH1-5) extend the Fc receptor family | journal = Curr Top Microbiol Immunol | volume = 266 | issue = | pages = 85–112 |date=May 2002 | pmid = 12014205 | pmc = | doi = 10.1007/978-3-662-04700-2_7}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FCRL3 Fc receptor-like 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115352| accessdate = }}</ref> | ||
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| summary_text = This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.<ref name="entrez" | | summary_text = This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.<ref name="entrez" /> | ||
}} | }} | ||
==Interactions== | |||
FCRL3 has been shown to [[Protein-protein interaction|interact]] with [[PTPN6]].<ref name=pmid12051764>{{cite journal |last=Xu |first=Ming-jiang |author2=Zhao Runxiang |author3=Cao Hongxi |author4=Zhao Zhizhuang Joe |date=May 2002 |title=SPAP2, an Ig family receptor containing both ITIMs and ITAMs |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue=3 |pages=1037–46 |publisher= |location = United States| issn = 0006-291X| pmid = 12051764 |doi = 10.1016/S0006-291X(02)00332-7 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | author= | *{{cite journal | author=Miller I |title=IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells |journal=Blood |volume=99 |issue= 8 |pages= 2662–9 |year= 2002 |pmid= 11929751 |doi=10.1182/blood.V99.8.2662 |name-list-format=vanc| author2=Hatzivassiliou G | author3=Cattoretti G | display-authors=3 | last4=Mendelsohn | first4=C | last5=Dalla-Favera | first5=R }} | ||
*{{cite journal | vauthors=Xu MJ, Zhao R, Cao H, Zhao ZJ |title=SPAP2, an Ig family receptor containing both ITIMs and ITAMs |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 3 |pages= 1037–46 |year= 2002 |pmid= 12051764 |doi= 10.1016/S0006-291X(02)00332-7 }} | |||
*{{cite journal | | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | ||
*{{cite journal | author= | *{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }} | ||
*{{cite journal | author=Kochi Y |title=A functional variant in FcRH3, encoding Fc Receptor Homolog 3, is associated with rheumatoid arthritis and several autoimmunities |journal=Nat. Genet. |volume=37 |issue= 5 |pages= 478–85 |year= 2005 |pmid= 15838509 |doi= 10.1038/ng1540 | pmc=1362949 |name-list-format=vanc| author2=Yamada R | author3=Suzuki A | display-authors=3 | last4=Harley | first4=John B | last5=Shirasawa | first5=Senji | last6=Sawada | first6=Tetsuji | last7=Bae | first7=Sang-Cheol | last8=Tokuhiro | first8=Shinya | last9=Chang | first9=Xiaotian }} | |||
*{{cite journal | author=Ota T, | *{{cite journal | author=Simmonds MJ |title=Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue= 3 |pages= 1056–61 |year= 2006 |pmid= 16384851 |doi= 10.1210/jc.2005-1634 |name-list-format=vanc| author2=Heward JM | author3=Carr-Smith J | display-authors=3 | last4=Foxall | first4=H | last5=Franklyn | first5=JA | last6=Gough | first6=SC }} | ||
*{{cite journal | author=Eyre S |title=Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity? |journal=[[Arthritis Research & Therapy]] |volume=8 |issue= 4 |pages= R117 |year= 2007 |pmid= 16859508 |doi= 10.1186/ar2006 | pmc=1779391 |name-list-format=vanc| author2=Bowes J | author3=Potter C | display-authors=3 | last4=Worthington | first4=Jane | last5=Barton | first5=Anne }} | |||
*{{cite journal | author= | *{{cite journal | author=Umemura T |title=Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis |journal=Clin. Immunol. |volume=122 |issue= 3 |pages= 338–42 |year= 2007 |pmid= 17020818 |doi= 10.1016/j.clim.2006.08.012 |name-list-format=vanc| author2=Ota M | author3=Yoshizawa K | display-authors=3 | last4=Katsuyama | first4=Yoshihiko | last5=Ichijo | first5=Tetsuya | last6=Tanaka | first6=Eiji | last7=Kawa | first7=Shigeyuki | last8=Kiyosawa | first8=Kendo }} | ||
*{{cite journal | author=Schäfer N |title=Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata |journal=Int. J. Immunogenet. |volume=33 |issue= 6 |pages= 393–5 |year= 2007 |pmid= 17117947 |doi= 10.1111/j.1744-313X.2006.00633.x |name-list-format=vanc| author2=Blaumeiser B | author3=Becker T | display-authors=3 | last4=Freudenberg-Hua | first4=Y. | last5=Hanneken | first5=S. | last6=Eigelshoven | first6=S. | last7=Schmael | first7=C. | last8=Lambert | first8=J. | last9=De Weert | first9=J. }} | |||
*{{cite journal | author= | *{{cite journal | author=Newman WG |title=Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population |journal=Arthritis Rheum. |volume=54 |issue= 12 |pages= 3820–7 |year= 2007 |pmid= 17133579 |doi= 10.1002/art.22270 |name-list-format=vanc| author2=Zhang Q | author3=Liu X | display-authors=3 | last4=Walker | first4=Erin | last5=Ternan | first5=Heather | last6=Owen | first6=Julie | last7=Johnson | first7=Ben | last8=Greer | first8=Wenda | last9=Mosher | first9=Dianne P. }} | ||
*{{cite journal | author=Choi CB |title=The -169C/T polymorphism in FCRL3 is not associated with susceptibility to rheumatoid arthritis or systemic lupus erythematosus in a case-control study of Koreans |journal=Arthritis Rheum. |volume=54 |issue= 12 |pages= 3838–41 |year= 2007 |pmid= 17133581 |doi= 10.1002/art.22248 |name-list-format=vanc| author2=Kang CP | author3=Seong SS | display-authors=3 | last4=Bae | first4=Sang-Cheol | last5=Kang | first5=Changwon }} | |||
*{{cite journal | author=Owen CJ |title=Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association |journal=J. Clin. Endocrinol. Metab. |volume=92 |issue= 3 |pages= 1106–11 |year= 2007 |pmid= 17200162 |doi= 10.1210/jc.2006-2183 |name-list-format=vanc| author2=Kelly H | author3=Eden JA | display-authors=3 | last4=Merriman | first4=M. E. | last5=Pearce | first5=S. H. S. | last6=Merriman | first6=T. R. }} | |||
*{{cite journal | vauthors=Taylor AI, Gould HJ, Sutton BJ, Calvert RA |title=The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL |journal=Immunogenetics |volume=59 |issue= 4 |pages= 323–8 |year= 2007 |pmid= 17273841 |doi= 10.1007/s00251-007-0195-9 }} | |||
*{{cite journal | author=Martínez A |title=Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD |journal=Tissue Antigens |volume=69 |issue= 4 |pages= 313–7 |year= 2007 |pmid= 17389014 |doi= 10.1111/j.1399-0039.2007.00816.x |name-list-format=vanc| author2=Núñez C | author3=Martín MC | display-authors=3 | last4=Mendoza | first4=J. L. | last5=Taxonera | first5=C. | last6=Díaz-Rubio | first6=M. | last7=De La Concha | first7=E. G. | last8=Urcelay | first8=E. }} | |||
*{{cite journal | author=Martínez A |title=FcRL3 and multiple sclerosis pathogenesis: role in autoimmunity? |journal=J. Neuroimmunol. |volume=189 |issue= 1–2 |pages= 132–6 |year= 2007 |pmid= 17617473 |doi= 10.1016/j.jneuroim.2007.06.018 |name-list-format=vanc| author2=Mas A | author3=de Las Heras V | display-authors=3 | last4=Bartolome | first4=M | last5=Arroyo | first5=R | last6=Fernandezarquero | first6=M | last7=Delaconcha | first7=E | last8=Urcelay | first8=E }} | |||
*{{cite journal | author= | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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[[Category:Fc receptors]] | |||
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Revision as of 04:44, 31 August 2017
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Ensembl |
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RefSeq (mRNA) |
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Location (UCSC) | n/a | n/a | |||||
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Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.[1][2][3]
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.[3]
Interactions
FCRL3 has been shown to interact with PTPN6.[4]
References
- ↑ Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.
- ↑ Davis RS, Dennis G Jr, Kubagawa H, Cooper MD (May 2002). "Fc receptor homologs (FcRH1-5) extend the Fc receptor family". Curr Top Microbiol Immunol. 266: 85–112. doi:10.1007/978-3-662-04700-2_7. PMID 12014205.
- ↑ 3.0 3.1 "Entrez Gene: FCRL3 Fc receptor-like 3".
- ↑ Xu, Ming-jiang; Zhao Runxiang; Cao Hongxi; Zhao Zhizhuang Joe (May 2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. United States. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. ISSN 0006-291X. PMID 12051764.
Further reading
- Miller I, Hatzivassiliou G, Cattoretti G, et al. (2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells". Blood. 99 (8): 2662–9. doi:10.1182/blood.V99.8.2662. PMID 11929751.
- Xu MJ, Zhao R, Cao H, Zhao ZJ (2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. PMID 12051764.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Kochi Y, Yamada R, Suzuki A, et al. (2005). "A functional variant in FcRH3, encoding Fc Receptor Homolog 3, is associated with rheumatoid arthritis and several autoimmunities". Nat. Genet. 37 (5): 478–85. doi:10.1038/ng1540. PMC 1362949. PMID 15838509.
- Simmonds MJ, Heward JM, Carr-Smith J, et al. (2006). "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease". J. Clin. Endocrinol. Metab. 91 (3): 1056–61. doi:10.1210/jc.2005-1634. PMID 16384851.
- Eyre S, Bowes J, Potter C, et al. (2007). "Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?". Arthritis Research & Therapy. 8 (4): R117. doi:10.1186/ar2006. PMC 1779391. PMID 16859508.
- Umemura T, Ota M, Yoshizawa K, et al. (2007). "Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis". Clin. Immunol. 122 (3): 338–42. doi:10.1016/j.clim.2006.08.012. PMID 17020818.
- Schäfer N, Blaumeiser B, Becker T, et al. (2007). "Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata". Int. J. Immunogenet. 33 (6): 393–5. doi:10.1111/j.1744-313X.2006.00633.x. PMID 17117947.
- Newman WG, Zhang Q, Liu X, et al. (2007). "Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population". Arthritis Rheum. 54 (12): 3820–7. doi:10.1002/art.22270. PMID 17133579.
- Choi CB, Kang CP, Seong SS, et al. (2007). "The -169C/T polymorphism in FCRL3 is not associated with susceptibility to rheumatoid arthritis or systemic lupus erythematosus in a case-control study of Koreans". Arthritis Rheum. 54 (12): 3838–41. doi:10.1002/art.22248. PMID 17133581.
- Owen CJ, Kelly H, Eden JA, et al. (2007). "Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association". J. Clin. Endocrinol. Metab. 92 (3): 1106–11. doi:10.1210/jc.2006-2183. PMID 17200162.
- Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics. 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841.
- Martínez A, Núñez C, Martín MC, et al. (2007). "Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD". Tissue Antigens. 69 (4): 313–7. doi:10.1111/j.1399-0039.2007.00816.x. PMID 17389014.
- Martínez A, Mas A, de Las Heras V, et al. (2007). "FcRL3 and multiple sclerosis pathogenesis: role in autoimmunity?". J. Neuroimmunol. 189 (1–2): 132–6. doi:10.1016/j.jneuroim.2007.06.018. PMID 17617473.
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