TAF5L: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L''' is an [[enzyme]] that in humans is encoded by the ''TAF5L'' [[gene]].<ref name="pmid9674425">{{cite journal | vauthors = Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y | title = Histone-like TAFs within the PCAF histone acetylase complex | journal = Cell | volume = 94 | issue = 1 | pages = 35–44  | date = Aug 1998 | pmid = 9674425 | pmc =  | doi = 10.1016/S0092-8674(00)81219-2 }}</ref><ref name="pmid11124703">{{cite journal | vauthors = Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G | title = Characterization of 16 novel human genes showing high similarity to yeast sequences | journal = Yeast | volume = 18 | issue = 1 | pages = 69–80  | date = Jan 2001 | pmid = 11124703 | pmc = | doi = 10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27097| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
| HGNCid = 17304
| Symbol = TAF5L
| AltSymbols =; PAF65B
| OMIM = 
| ECnumber = 
| Homologene = 8676
| MGIid = 1919039
| GeneAtlas_image1 = PBB_GE_TAF5L_213654_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27097
    | Hs_Ensembl = ENSG00000135801
    | Hs_RefseqProtein = NP_001020418
    | Hs_RefseqmRNA = NM_001025247
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 227795481
    | Hs_GenLoc_end = 227828417
    | Hs_Uniprot = O75529
    | Mm_EntrezGene = 102162
    | Mm_Ensembl = ENSMUSG00000038697
    | Mm_RefseqmRNA = NM_133966
    | Mm_RefseqProtein = NP_598727
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 126882400
    | Mm_GenLoc_end = 126907399
    | Mm_Uniprot = Q3U3C7
  }}
}}
'''TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa''', also known as '''TAF5L''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27097| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27097| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
TAF5L has been shown to [[Protein-protein interaction|interact]] with [[TAF9]]<ref name=pmid11564863>{{cite journal | vauthors = Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG | title = Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo | journal = Mol. Cell. Biol. | volume = 21 | issue = 20 | pages = 6782–95  | date = Oct 2001 | pmid = 11564863 | pmc = 99856 | doi = 10.1128/MCB.21.20.6782-6795.2001 }}</ref> and [[Transcription initiation protein SPT3 homolog]].<ref name=pmid11564863/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Struhl K, Moqtaderi Z | title = The TAFs in the HAT | journal = Cell | volume = 94 | issue = 1 | pages = 1–4 | year = 1998 | pmid = 9674419 | doi = 10.1016/S0092-8674(00)81213-1 }}
| citations =
* {{cite journal | vauthors = Brand M, Yamamoto K, Staub A, Tora L | title = Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction | journal = J. Biol. Chem. | volume = 274 | issue = 26 | pages = 18285–9 | year = 1999 | pmid = 10373431 | doi = 10.1074/jbc.274.26.18285 }}
*{{cite journal | author=Struhl K, Moqtaderi Z |title=The TAFs in the HAT. |journal=Cell |volume=94 |issue= 1 |pages= 1-4 |year= 1998 |pmid= 9674419 |doi= }}
* {{cite journal | vauthors = Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L | title = UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation | journal = EMBO J. | volume = 20 | issue = 12 | pages = 3187–96 | year = 2001 | pmid = 11406595 | pmc = 150203 | doi = 10.1093/emboj/20.12.3187 }}
*{{cite journal  | author=Ogryzko VV, Kotani T, Zhang X, ''et al.'' |title=Histone-like TAFs within the PCAF histone acetylase complex. |journal=Cell |volume=94 |issue= 1 |pages= 35-44 |year= 1998 |pmid= 9674425 |doi=  }}
* {{cite journal | vauthors = Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG | title = Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo | journal = Mol. Cell. Biol. | volume = 21 | issue = 20 | pages = 6782–95 | year = 2001 | pmid = 11564863 | pmc = 99856 | doi = 10.1128/MCB.21.20.6782-6795.2001 }}
*{{cite journal | author=Brand M, Yamamoto K, Staub A, Tora L |title=Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18285-9 |year= 1999 |pmid= 10373431 |doi=  }}
* {{cite journal | vauthors = Cavusoglu N, Brand M, Tora L, Van Dorsselaer A | title = Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis | journal = Proteomics | volume = 3 | issue = 2 | pages = 217–23 | year = 2003 | pmid = 12601814 | doi = 10.1002/pmic.200390030 }}
*{{cite journal  | author=Stanchi F, Bertocco E, Toppo S, ''et al.'' |title=Characterization of 16 novel human genes showing high similarity to yeast sequences. |journal=Yeast |volume=18 |issue= 1 |pages= 69-80 |year= 2001 |pmid= 11124703 |doi= 10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H }}
* {{cite journal | vauthors = Zhang K, Faiola F, Martinez E | title = Six lysine residues on c-Myc are direct substrates for acetylation by p300 | journal = Biochem. Biophys. Res. Commun. | volume = 336 | issue = 1 | pages = 274–80 | year = 2005 | pmid = 16126174 | doi = 10.1016/j.bbrc.2005.08.075 }}
*{{cite journal | author=Brand M, Moggs JG, Oulad-Abdelghani M, ''et al.'' |title=UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. |journal=EMBO J. |volume=20 |issue= 12 |pages= 3187-96 |year= 2001 |pmid= 11406595 |doi= 10.1093/emboj/20.12.3187 }}
* {{cite journal | vauthors = Chistiakov DA, Chernisheva A, Savost'anov KV, Turakulov RI, Kuraeva TL, Dedov II, Nosikov VV | title = The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients | journal = Autoimmunity | volume = 38 | issue = 4 | pages = 283–93 | year = 2005 | pmid = 16206511 | doi = 10.1080/08916930500128594 }}
*{{cite journal | author=Martinez E, Palhan VB, Tjernberg A, ''et al.'' |title=Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6782-95 |year= 2001 |pmid= 11564863 |doi= 10.1128/MCB.21.20.6782-6795.2001 }}
* {{cite journal | vauthors = Kuninger D, Wright A, Rotwein P | title = Muscle cell survival mediated by the transcriptional coactivators p300 and PCAF displays different requirements for acetyltransferase activity | journal = Am. J. Physiol., Cell Physiol. | volume = 291 | issue = 4 | pages = C699-709 | year = 2006 | pmid = 16672693 | doi = 10.1152/ajpcell.00056.2006 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Okumura K, Mendoza M, Bachoo RM, DePinho RA, Cavenee WK, Furnari FB | title = PCAF modulates PTEN activity | journal = J. Biol. Chem. | volume = 281 | issue = 36 | pages = 26562–8 | year = 2006 | pmid = 16829519 | doi = 10.1074/jbc.M605391200 }}
*{{cite journal  | author=Cavusoglu N, Brand M, Tora L, Van Dorsselaer A |title=Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis. |journal=Proteomics |volume=3 |issue= 2 |pages= 217-23 |year= 2003 |pmid= 12601814 |doi= 10.1002/pmic.200390030 }}
* {{cite journal | vauthors = Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR, Montminy M | title = Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression | journal = EMBO J. | volume = 26 | issue = 12 | pages = 2880–9 | year = 2007 | pmid = 17476304 | pmc = 1894761 | doi = 10.1038/sj.emboj.7601715 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Zhang K, Faiola F, Martinez E |title=Six lysine residues on c-Myc are direct substrates for acetylation by p300. |journal=Biochem. Biophys. Res. Commun. |volume=336 |issue= 1 |pages= 274-80 |year= 2005 |pmid= 16126174 |doi= 10.1016/j.bbrc.2005.08.075 }}
*{{cite journal | author=Chistiakov DA, Chernisheva A, Savost'anov KV, ''et al.'' |title=The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients. |journal=Autoimmunity |volume=38 |issue= 4 |pages= 283-93 |year= 2005 |pmid= 16206511 |doi= }}
*{{cite journal | author=Kuninger D, Wright A, Rotwein P |title=Muscle cell survival mediated by the transcriptional coactivators p300 and PCAF displays different requirements for acetyltransferase activity. |journal=Am. J. Physiol., Cell Physiol. |volume=291 |issue= 4 |pages= C699-709 |year= 2006 |pmid= 16672693 |doi= 10.1152/ajpcell.00056.2006 }}
*{{cite journal | author=Okumura K, Mendoza M, Bachoo RM, ''et al.'' |title=PCAF modulates PTEN activity. |journal=J. Biol. Chem. |volume=281 |issue= 36 |pages= 26562-8 |year= 2006 |pmid= 16829519 |doi= 10.1074/jbc.M605391200 }}
*{{cite journal | author=Ravnskjaer K, Kester H, Liu Y, ''et al.'' |title=Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. |journal=EMBO J. |volume=26 |issue= 12 |pages= 2880-9 |year= 2007 |pmid= 17476304 |doi= 10.1038/sj.emboj.7601715 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
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Latest revision as of 02:35, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L is an enzyme that in humans is encoded by the TAF5L gene.[1][2][3]

Function

The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[3]

Interactions

TAF5L has been shown to interact with TAF9[4] and Transcription initiation protein SPT3 homolog.[4]

References

  1. ↑ Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (Aug 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425.
  2. ↑ Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (Jan 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.
  3. ↑ 3.0 3.1 "Entrez Gene: TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa".
  4. ↑ 4.0 4.1 Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.

Further reading


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