CACYBP: Difference between revisions

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Revision as of 09:09, 30 August 2017

Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene.^[1]^[2]^[3]

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[3]

Interactions

CACYBP has been shown to interact with SKP1A^[4] and SIAH1.^[1]

References

↑ ^1.0 ^1.1 Matsuzawa SI, Reed JC (Jun 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Mol Cell. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. PMID 11389839.
↑ Matsuzawa S, Li C, Ni CZ, Takayama S, Reed JC, Ely KR (Jan 2003). "Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP)". J Biol Chem. 278 (3): 1837–40. doi:10.1074/jbc.M210263200. PMID 12421809.
↑ ^3.0 ^3.1 "Entrez Gene: CACYBP calcyclin binding protein".
↑ Matsuzawa, S I; Reed J C (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Mol. Cell. United States. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. ISSN 1097-2765. PMID 11389839.

External links

Human CACYBP genome location and CACYBP gene details page in the UCSC Genome Browser.

Filipek A, Jastrzebska B, Nowotny M, et al. (2002). "Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells". J. Biol. Chem. 277 (23): 21103–9. doi:10.1074/jbc.M111010200. PMID 11927578.
Liu WX, Wu J, Zhao Z, et al. (2003). "[Cloning and expression of human calcyclin binding protein (hCacyBP) gene]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (2): 181–6. PMID 12006993.
Filipek A, Jastrzebska B, Nowotny M, Kuznicki J (2002). "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family". J. Biol. Chem. 277 (32): 28848–52. doi:10.1074/jbc.M203602200. PMID 12042313.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wu J, Tan X, Peng X, et al. (2004). "Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells". J. Biochem. Mol. Biol. 36 (4): 354–8. doi:10.5483/bmbrep.2003.36.4.354. PMID 12895292.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Santelli E, Leone M, Li C, et al. (2005). "Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex". J. Biol. Chem. 280 (40): 34278–87. doi:10.1074/jbc.M506707200. PMID 16085652.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Sun S, Ning X, Liu J, et al. (2007). "Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma". Biochem. Biophys. Res. Commun. 356 (4): 864–71. doi:10.1016/j.bbrc.2007.03.080. PMID 17400182.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid11389839-1] 1.0 ^1.1 Matsuzawa SI, Reed JC (Jun 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Mol Cell. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. PMID 11389839.

[pmid12421809-2] Matsuzawa S, Li C, Ni CZ, Takayama S, Reed JC, Ely KR (Jan 2003). "Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP)". J Biol Chem. 278 (3): 1837–40. doi:10.1074/jbc.M210263200. PMID 12421809.

[entrez-3] 3.0 ^3.1 "Entrez Gene: CACYBP calcyclin binding protein".

[autogenerated1-4] Matsuzawa, S I; Reed J C (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Mol. Cell. United States. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. ISSN 1097-2765. PMID 11389839.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Calcyclin-binding protein''' is a [[protein]] that in humans is encoded by the ''CACYBP'' [[gene]].<ref name="pmid11389839">{{cite journal | vauthors = Matsuzawa SI, Reed JC | title = Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses | journal = Mol Cell | volume = 7 | issue = 5 | pages = 915–26 |date=Jun 2001 | pmid = 11389839 | pmc =  | doi =10.1016/S1097-2765(01)00242-8  }}</ref><ref name="pmid12421809">{{cite journal | vauthors = Matsuzawa S, Li C, Ni CZ, Takayama S, Reed JC, Ely KR | title = Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP) | journal = J Biol Chem | volume = 278 | issue = 3 | pages = 1837–40 |date=Jan 2003 | pmid = 12421809 | pmc =  | doi = 10.1074/jbc.M210263200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CACYBP calcyclin binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27101| accessdate = }}</ref>
-| update_page = yes
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_CACYBP_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x5m.
- | PDB = {{PDB2|1x5m}}, {{PDB2|2a26}}
- | Name = Calcyclin binding protein
- | HGNCid = 30423
- | Symbol = CACYBP
- | AltSymbols =; SIP; GIG5; MGC87971; PNAS-107; RP1-102G20.6; S100A6BP
- | OMIM = 606186
- | ECnumber =
- | Homologene = 7649
- | MGIid = 1270839
- | GeneAtlas_image1 = PBB_GE_CACYBP_210691_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_CACYBP_201381_x_at_tn.png
- | GeneAtlas_image3 = PBB_GE_CACYBP_201382_at_tn.png
- | Function =
-  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
-  | Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 27101
-    | Hs_Ensembl = ENSG00000116161
-    | Hs_RefseqProtein = NP_001007215
-    | Hs_RefseqmRNA = NM_001007214
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 173235194
-    | Hs_GenLoc_end = 173247786
-    | Hs_Uniprot = Q9HB71
-    | Mm_EntrezGene = 12301
-    | Mm_Ensembl = ENSMUSG00000014226
-    | Mm_RefseqmRNA = NM_009786
-    | Mm_RefseqProtein = NP_033916
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 1
-    | Mm_GenLoc_start = 162039046
-    | Mm_GenLoc_end = 162049422
-    | Mm_Uniprot = Q9CXW3
-  }}
-}}
-'''Calcyclin binding protein''', also known as '''CACYBP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CACYBP calcyclin binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27101| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: CACYBP calcyclin binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27101| accessdate = }}</ref>
+| summary_text = The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref name="entrez"/>
 }}
+==Interactions==
+CACYBP has been shown to [[Protein-protein interaction|interact]] with [[SKP1A]]<ref name=autogenerated1>{{cite journal |last=Matsuzawa |first=S I |author2=Reed J C |date=May 2001 |title=Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses |journal=Mol. Cell |volume=7 |issue=5 |pages=915–26 |publisher= |location = United States| issn = 1097-2765| pmid = 11389839 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1097-2765(01)00242-8 }}</ref> and [[SIAH1]].<ref name=pmid11389839/>
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|CACYBP}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Matsuzawa SI, Reed JC |title=Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. |journal=Mol. Cell |volume=7 |issue= 5 |pages= 915-26 |year= 2001 |pmid= 11389839 |doi=  }}
+*{{cite journal  | vauthors=Filipek A, Jastrzebska B, Nowotny M |title=Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 21103–9 |year= 2002 |pmid= 11927578 |doi= 10.1074/jbc.M111010200 |display-authors=etal}}
-*{{cite journal  | author=Filipek A, Jastrzebska B, Nowotny M, ''et al.'' |title=Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 21103-9 |year= 2002 |pmid= 11927578 |doi= 10.1074/jbc.M111010200 }}
+*{{cite journal  | vauthors=Liu WX, Wu J, Zhao Z |title=[Cloning and expression of human calcyclin binding protein (hCacyBP) gene] |journal=Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao |volume=34 |issue= 2 |pages= 181–6 |year= 2003 |pmid= 12006993 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Liu WX, Wu J, Zhao Z, ''et al.'' |title=[Cloning and expression of human calcyclin binding protein (hCacyBP) gene] |journal=Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao |volume=34 |issue= 2 |pages= 181-6 |year= 2003 |pmid= 12006993 |doi=  }}
+*{{cite journal  | vauthors=Filipek A, Jastrzebska B, Nowotny M, Kuznicki J |title=CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28848–52 |year= 2002 |pmid= 12042313 |doi= 10.1074/jbc.M203602200 }}
-*{{cite journal  | author=Filipek A, Jastrzebska B, Nowotny M, Kuznicki J |title=CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28848-52 |year= 2002 |pmid= 12042313 |doi= 10.1074/jbc.M203602200 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Matsuzawa S, Li C, Ni CZ, ''et al.'' |title=Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP). |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1837-40 |year= 2003 |pmid= 12421809 |doi= 10.1074/jbc.M210263200 }}
+*{{cite journal  | vauthors=Wu J, Tan X, Peng X |title=Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells. |journal=J. Biochem. Mol. Biol. |volume=36 |issue= 4 |pages= 354–8 |year= 2004 |pmid= 12895292 |doi=  10.5483/bmbrep.2003.36.4.354|display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
-*{{cite journal  | author=Wu J, Tan X, Peng X, ''et al.'' |title=Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells. |journal=J. Biochem. Mol. Biol. |volume=36 |issue= 4 |pages= 354-8 |year= 2004 |pmid= 12895292 |doi=  }}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | vauthors=Santelli E, Leone M, Li C |title=Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. |journal=J. Biol. Chem. |volume=280 |issue= 40 |pages= 34278–87 |year= 2005 |pmid= 16085652 |doi= 10.1074/jbc.M506707200 |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
-*{{cite journal  | author=Santelli E, Leone M, Li C, ''et al.'' |title=Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. |journal=J. Biol. Chem. |volume=280 |issue= 40 |pages= 34278-87 |year= 2005 |pmid= 16085652 |doi= 10.1074/jbc.M506707200 }}
+*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 |display-authors=etal}}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal  | vauthors=Sun S, Ning X, Liu J |title=Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma. |journal=Biochem. Biophys. Res. Commun. |volume=356 |issue= 4 |pages= 864–71 |year= 2007 |pmid= 17400182 |doi= 10.1016/j.bbrc.2007.03.080 |display-authors=etal}}
-*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
-*{{cite journal  | author=Sun S, Ning X, Liu J, ''et al.'' |title=Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma. |journal=Biochem. Biophys. Res. Commun. |volume=356 |issue= 4 |pages= 864-71 |year= 2007 |pmid= 17400182 |doi= 10.1016/j.bbrc.2007.03.080 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=27101}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
-{{protein-stub}}
+{{gene-1-stub}}
-{{WikiDoc Sources}}

CACYBP: Difference between revisions

Revision as of 09:09, 30 August 2017

Contents

Interactions

References

External links

Further reading

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