SLAMF7: Difference between revisions

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Revision as of 06:25, 11 September 2017

SLAM family member 7 is a protein that in humans is encoded by the SLAMF7 gene.^[1]^[2]^[3]

The surface antigen CD319 (SLAMF7) is a robust marker of normal plasma cells and malignant plasma cells in multiple myeloma. In contrast to CD138 (the traditional plasma cell marker), CD319/SLAMF7 is much more stable and allows robust isolation of malignant plasma cells from delayed or even cryopreserved samples.^[4]

Elotuzumab is an antibody that targets this protein.

References

↑ Murphy JJ, Hobby P, Vilarino-Varela J, Bishop B, Iordanidou P, Sutton BJ, Norton JD (Feb 2002). "A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion". The Biochemical Journal. 361 (Pt 3): 431–6. doi:10.1042/0264-6021:3610431. PMC 1222324. PMID 11802771.
↑ Boles KS, Mathew PA (Feb 2001). "Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily". Immunogenetics. 52 (3–4): 302–7. doi:10.1007/s002510000274. PMID 11220635.
↑ "Entrez Gene: SLAMF7 SLAM family member 7".
↑ Frigyesi I, Adolfsson J, Ali M, Christophersen MK, Johnsson E, Turesson I, Gullberg U, Hansson M, Nilsson B (Feb 2014). "Robust isolation of malignant plasma cells in multiple myeloma". Blood. 123 (9): 1336–40. doi:10.1182/blood-2013-09-529800. PMID 24385542.

Claus M, Meinke S, Bhat R, Watzl C (2007). "Regulation of NK cell activity by 2B4, NTB-A and CRACC". Frontiers in Bioscience. 13 (13): 956–65. doi:10.2741/2735. PMID 17981603.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Bouchon A, Cella M, Grierson HL, Cohen JI, Colonna M (Nov 2001). "Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family". Journal of Immunology. 167 (10): 5517–21. doi:10.4049/jimmunol.167.10.5517. PMID 11698418.
Tovar V, del Valle J, Zapater N, Martin M, Romero X, Pizcueta P, Bosch J, Terhorst C, Engel P (Sep 2002). "Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors". Immunogenetics. 54 (6): 394–402. doi:10.1007/s00251-002-0483-3. PMID 12242590.
Del Valle JM, Engel P, Martín M (May 2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)". The Journal of Biological Chemistry. 278 (19): 17430–7. doi:10.1074/jbc.M301569200. PMID 12621057.
Zhang Z, Henzel WJ (Oct 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Lee JK, Boles KS, Mathew PA (Oct 2004). "Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs". European Journal of Immunology. 34 (10): 2791–9. doi:10.1002/eji.200424917. PMID 15368295.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Stark S, Watzl C (Feb 2006). "2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells". International Immunology. 18 (2): 241–7. doi:10.1093/intimm/dxh358. PMID 16410313.
Lee JK, Mathew SO, Vaidya SV, Kumaresan PR, Mathew PA (Oct 2007). "CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes". Journal of Immunology. 179 (7): 4672–8. doi:10.4049/jimmunol.179.7.4672. PMID 17878365.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid11802771-1] Murphy JJ, Hobby P, Vilarino-Varela J, Bishop B, Iordanidou P, Sutton BJ, Norton JD (Feb 2002). "A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion". The Biochemical Journal. 361 (Pt 3): 431–6. doi:10.1042/0264-6021:3610431. PMC 1222324. PMID 11802771.

[pmid11220635-2] Boles KS, Mathew PA (Feb 2001). "Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily". Immunogenetics. 52 (3–4): 302–7. doi:10.1007/s002510000274. PMID 11220635.

[entrez-3] "Entrez Gene: SLAMF7 SLAM family member 7".

[pmid24385542-4] Frigyesi I, Adolfsson J, Ali M, Christophersen MK, Johnsson E, Turesson I, Gullberg U, Hansson M, Nilsson B (Feb 2014). "Robust isolation of malignant plasma cells in multiple myeloma". Blood. 123 (9): 1336–40. doi:10.1182/blood-2013-09-529800. PMID 24385542.

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''SLAM family member 7''' is a [[protein]] that in humans is encoded by the ''SLAMF7'' [[gene]].<ref name="pmid11802771">{{cite journal | vauthors = Murphy JJ, Hobby P, Vilarino-Varela J, Bishop B, Iordanidou P, Sutton BJ, Norton JD | title = A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion | journal = The Biochemical Journal | volume = 361 | issue = Pt 3 | pages = 431–6 | date = Feb 2002 | pmid = 11802771 | pmc = 1222324 | doi = 10.1042/0264-6021:3610431 }}</ref><ref name="pmid11220635">{{cite journal | vauthors = Boles KS, Mathew PA | title = Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily | journal = Immunogenetics | volume = 52 | issue = 3-4 | pages = 302–7 | date = Feb 2001 | pmid = 11220635 | pmc =  | doi = 10.1007/s002510000274 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLAMF7 SLAM family member 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57823| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+The surface antigen [[CD319]] (SLAMF7) is a robust marker of normal [[plasma cell]]s and malignant plasma cells in [[multiple myeloma]]. In contrast to CD138 (the traditional plasma cell marker), CD319/SLAMF7 is much more stable and allows robust isolation of malignant plasma cells from delayed or even cryopreserved samples.<ref name="pmid24385542">{{cite journal | vauthors = Frigyesi I, Adolfsson J, Ali M, Christophersen MK, Johnsson E, Turesson I, Gullberg U, Hansson M, Nilsson B | title = Robust isolation of malignant plasma cells in multiple myeloma | journal = Blood | volume = 123 | issue = 9 | pages = 1336–40 | date = Feb 2014 | pmid = 24385542 | doi = 10.1182/blood-2013-09-529800 }}</ref>
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = SLAM family member 7
- | HGNCid = 21394
- | Symbol = SLAMF7
- | AltSymbols =; CS1; 19A; CD319; CRACC
- | OMIM = 606625
- | ECnumber =
- | Homologene = 49660
- | MGIid = 1922595
- | GeneAtlas_image1 = PBB_GE_SLAMF7_219159_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0030101 |text = natural killer cell activation}} {{GNF_GO|id=GO:0042267 |text = natural killer cell mediated cytotoxicity}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 57823
-    | Hs_Ensembl = ENSG00000026751
-    | Hs_RefseqProtein = NP_067004
-    | Hs_RefseqmRNA = NM_021181
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 158975679
-    | Hs_GenLoc_end = 158991235
-    | Hs_Uniprot = Q9NQ25
-    | Mm_EntrezGene = 75345
-    | Mm_Ensembl = ENSMUSG00000038179
-    | Mm_RefseqmRNA = NM_144539
-    | Mm_RefseqProtein = NP_653122
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 1
-    | Mm_GenLoc_start = 173469078
-    | Mm_GenLoc_end = 173485678
-    | Mm_Uniprot = Q18PI2
-  }}
-}}
-'''SLAM family member 7''', also known as '''SLAMF7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLAMF7 SLAM family member 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57823| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+[[Elotuzumab]] is an antibody that targets this protein.
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Claus M, Meinke S, Bhat R, Watzl C | title = Regulation of NK cell activity by 2B4, NTB-A and CRACC | journal = Frontiers in Bioscience | volume = 13 | issue = 13 | pages = 956–65 | year = 2007 | pmid = 17981603 | doi = 10.2741/2735 }}
-| citations =
+* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
-*{{cite journal  | author=Claus M, Meinke S, Bhat R, Watzl C |title=Regulation of NK cell activity by 2B4, NTB-A and CRACC. |journal=Front. Biosci. |volume=13 |issue=  |pages= 956-65 |year= 2007 |pmid= 17981603 |doi=  }}
+* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
-*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
+* {{cite journal | vauthors = Bouchon A, Cella M, Grierson HL, Cohen JI, Colonna M | title = Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family | journal = Journal of Immunology | volume = 167 | issue = 10 | pages = 5517–21 | date = Nov 2001 | pmid = 11698418 | doi = 10.4049/jimmunol.167.10.5517 }}
-*{{cite journal  | author=Boles KS, Mathew PA |title=Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily. |journal=Immunogenetics |volume=52 |issue= 3-4 |pages= 302-7 |year= 2001 |pmid= 11220635 |doi=  }}
+* {{cite journal | vauthors = Tovar V, del Valle J, Zapater N, Martin M, Romero X, Pizcueta P, Bosch J, Terhorst C, Engel P | title = Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors | journal = Immunogenetics | volume = 54 | issue = 6 | pages = 394–402 | date = Sep 2002 | pmid = 12242590 | doi = 10.1007/s00251-002-0483-3 }}
-*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
+* {{cite journal | vauthors = Del Valle JM, Engel P, Martín M | title = The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2) | journal = The Journal of Biological Chemistry | volume = 278 | issue = 19 | pages = 17430–7 | date = May 2003 | pmid = 12621057 | doi = 10.1074/jbc.M301569200 }}
-*{{cite journal  | author=Bouchon A, Cella M, Grierson HL, ''et al.'' |title=Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family. |journal=J. Immunol. |volume=167 |issue= 10 |pages= 5517-21 |year= 2001 |pmid= 11698418 |doi=  }}
+* {{cite journal | vauthors = Zhang Z, Henzel WJ | title = Signal peptide prediction based on analysis of experimentally verified cleavage sites | journal = Protein Science | volume = 13 | issue = 10 | pages = 2819–24 | date = Oct 2004 | pmid = 15340161 | pmc = 2286551 | doi = 10.1110/ps.04682504 }}
-*{{cite journal  | author=Murphy JJ, Hobby P, Vilarino-Varela J, ''et al.'' |title=A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion. |journal=Biochem. J. |volume=361 |issue= Pt 3 |pages= 431-6 |year= 2002 |pmid= 11802771 |doi=  }}
+* {{cite journal | vauthors = Lee JK, Boles KS, Mathew PA | title = Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs | journal = European Journal of Immunology | volume = 34 | issue = 10 | pages = 2791–9 | date = Oct 2004 | pmid = 15368295 | doi = 10.1002/eji.200424917 }}
-*{{cite journal  | author=Tovar V, del Valle J, Zapater N, ''et al.'' |title=Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors. |journal=Immunogenetics |volume=54 |issue= 6 |pages= 394-402 |year= 2002 |pmid= 12242590 |doi= 10.1007/s00251-002-0483-3 }}
+* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = Jan 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
-*{{cite journal  | author=Del Valle JM, Engel P, Martín M |title=The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2). |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 17430-7 |year= 2003 |pmid= 12621057 |doi= 10.1074/jbc.M301569200 }}
+* {{cite journal | vauthors = Stark S, Watzl C | title = 2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells | journal = International Immunology | volume = 18 | issue = 2 | pages = 241–7 | date = Feb 2006 | pmid = 16410313 | doi = 10.1093/intimm/dxh358 }}
-*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
+* {{cite journal | vauthors = Lee JK, Mathew SO, Vaidya SV, Kumaresan PR, Mathew PA | title = CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes | journal = Journal of Immunology | volume = 179 | issue = 7 | pages = 4672–8 | date = Oct 2007 | pmid = 17878365 | doi = 10.4049/jimmunol.179.7.4672 }}
-*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
-*{{cite journal  | author=Lee JK, Boles KS, Mathew PA |title=Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. |journal=Eur. J. Immunol. |volume=34 |issue= 10 |pages= 2791-9 |year= 2004 |pmid= 15368295 |doi= 10.1002/eji.200424917 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
-*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
-*{{cite journal  | author=Stark S, Watzl C |title=2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells. |journal=Int. Immunol. |volume=18 |issue= 2 |pages= 241-7 |year= 2006 |pmid= 16410313 |doi= 10.1093/intimm/dxh358 }}
-*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
-*{{cite journal  | author=Lee JK, Mathew SO, Vaidya SV, ''et al.'' |title=CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. |journal=J. Immunol. |volume=179 |issue= 7 |pages= 4672-8 |year= 2007 |pmid= 17878365 |doi=  }}
-}}
 {{refend}}
-{{protein-stub}}
+{{gene-1-stub}}
-{{WikiDoc Sources}}

SLAMF7: Difference between revisions

Revision as of 06:25, 11 September 2017

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