CNKSR1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Connector enhancer of kinase suppressor of ras 1''' is an [[enzyme]] that in humans is encoded by the ''CNKSR1'' [[gene]].<ref name="pmid9814705">{{cite journal | vauthors = Therrien M, Wong AM, Rubin GM | title = CNK, a RAF-binding multidomain protein required for RAS signaling | journal = Cell | volume = 95 | issue = 3 | pages = 343–53 | date = Dec 1998 | pmid = 9814705 | pmc =  | doi = 10.1016/S0092-8674(00)81766-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10256| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_CNKSR1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wwv.
| PDB = {{PDB2|1wwv}}
| Name = Connector enhancer of kinase suppressor of Ras 1
| HGNCid = 19700
| Symbol = CNKSR1
| AltSymbols =; CNK; KSR; CNK1
| OMIM = 603272
| ECnumber = 
| Homologene = 4604
| MGIid = 2670958
| GeneAtlas_image1 = PBB_GE_CNKSR1_204740_at_tn.png
| Function = {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005911 |text = intercellular junction}} {{GNF_GO|id=GO:0005938 |text = cell cortex}}
| Process = {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007266 |text = Rho protein signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10256
    | Hs_Ensembl = ENSG00000142675
    | Hs_RefseqProtein = NP_006305
    | Hs_RefseqmRNA = NM_006314
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 26376573
    | Hs_GenLoc_end = 26388964
    | Hs_Uniprot = Q969H4
    | Mm_EntrezGene = 194231
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_110525
    | Mm_RefseqProtein = XP_110525
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Connector enhancer of kinase suppressor of Ras 1''', also known as '''CNKSR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10256| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target.  It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target.  It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.<ref name="entrez">{{cite web | title = Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10256| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CNKSR1 has been shown to [[Protein-protein interaction|interact]] with [[RhoD]]<ref name=pmid14749388>{{cite journal | vauthors = Jaffe AB, Aspenström P, Hall A | title = Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways | journal = Mol. Cell. Biol. | volume = 24 | issue = 4 | pages = 1736–46 | date = Feb 2004 | pmid = 14749388 | pmc = 344169 | doi = 10.1128/MCB.24.4.1736-1746.2004 }}</ref> and [[RASSF1]].<ref name=pmid15075335>{{cite journal | vauthors = Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B | title = The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death | journal = J. Biol. Chem. | volume = 279 | issue = 28 | pages = 29247–54 | date = Jul 2004 | pmid = 15075335 | doi = 10.1074/jbc.M401699200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Therrien M, Wong AM, Kwan E, Rubin GM | title = Functional analysis of CNK in RAS signaling | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 23 | pages = 13259–63 | year = 1999 | pmid = 10557308 | pmc = 23935 | doi = 10.1073/pnas.96.23.13259 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Hartsough MT, Morrison DK, Salerno M, Palmieri D, Ouatas T, Mair M, Patrick J, Steeg PS | title = Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway | journal = J. Biol. Chem. | volume = 277 | issue = 35 | pages = 32389–99 | year = 2002 | pmid = 12105213 | doi = 10.1074/jbc.M203115200 }}
*{{cite journal  | author=Therrien M, Wong AM, Rubin GM |title=CNK, a RAF-binding multidomain protein required for RAS signaling. |journal=Cell |volume=95 |issue= 3 |pages= 343-53 |year= 1998 |pmid= 9814705 |doi=  }}
* {{cite journal | vauthors = Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA | title = Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP | journal = Nature | volume = 427 | issue = 6971 | pages = 256–60 | year = 2004 | pmid = 14724641 | doi = 10.1038/nature02237 }}
*{{cite journal | author=Therrien M, Wong AM, Kwan E, Rubin GM |title=Functional analysis of CNK in RAS signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 23 |pages= 13259-63 |year= 1999 |pmid= 10557308 |doi= }}
* {{cite journal | vauthors = Jaffe AB, Aspenström P, Hall A | title = Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways | journal = Mol. Cell. Biol. | volume = 24 | issue = 4 | pages = 1736–46 | year = 2004 | pmid = 14749388 | pmc = 344169 | doi = 10.1128/MCB.24.4.1736-1746.2004 }}
*{{cite journal | author=Hartsough MT, Morrison DK, Salerno M, ''et al.'' |title=Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 32389-99 |year= 2002 |pmid= 12105213 |doi= 10.1074/jbc.M203115200 }}
* {{cite journal | vauthors = Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B | title = The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death | journal = J. Biol. Chem. | volume = 279 | issue = 28 | pages = 29247–54 | year = 2004 | pmid = 15075335 | doi = 10.1074/jbc.M401699200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Jaffe AB, Hall A, Schmidt A | title = Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho | journal = Curr. Biol. | volume = 15 | issue = 5 | pages = 405–12 | year = 2005 | pmid = 15753034 | doi = 10.1016/j.cub.2004.12.082 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Ziogas A, Moelling K, Radziwill G | title = CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation | journal = J. Biol. Chem. | volume = 280 | issue = 25 | pages = 24205–11 | year = 2005 | pmid = 15845549 | doi = 10.1074/jbc.M413327200 }}
*{{cite journal  | author=Matheny SA, Chen C, Kortum RL, ''et al.'' |title=Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. |journal=Nature |volume=427 |issue= 6971 |pages= 256-60 |year= 2004 |pmid= 14724641 |doi= 10.1038/nature02237 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Jaffe AB, Aspenström P, Hall A |title=Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. |journal=Mol. Cell. Biol. |volume=24 |issue= 4 |pages= 1736-46 |year= 2004 |pmid= 14749388 |doi= }}
* {{cite journal | vauthors = Fritz RD, Radziwill G | title = The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor | journal = Biochem. Biophys. Res. Commun. | volume = 338 | issue = 4 | pages = 1906–12 | year = 2006 | pmid = 16289034 | doi = 10.1016/j.bbrc.2005.10.168 }}
*{{cite journal | author=Rabizadeh S, Xavier RJ, Ishiguro K, ''et al.'' |title=The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29247-54 |year= 2004 |pmid= 15075335 |doi= 10.1074/jbc.M401699200 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Jaffe AB, Hall A, Schmidt A |title=Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. |journal=Curr. Biol. |volume=15 |issue= 5 |pages= 405-12 |year= 2005 |pmid= 15753034 |doi= 10.1016/j.cub.2004.12.082 }}
*{{cite journal | author=Ziogas A, Moelling K, Radziwill G |title=CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation. |journal=J. Biol. Chem. |volume=280 |issue= 25 |pages= 24205-11 |year= 2005 |pmid= 15845549 |doi= 10.1074/jbc.M413327200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Fritz RD, Radziwill G |title=The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 4 |pages= 1906-12 |year= 2006 |pmid= 16289034 |doi= 10.1016/j.bbrc.2005.10.168 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|CNKSR1}}
* {{UCSC gene details|CNKSR1}}
 
{{PDB Gallery|geneid=10256}}
 
 
{{gene-1-stub}}

Latest revision as of 02:17, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the CNKSR1 gene.[1][2]

Function

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.[2]

Interactions

CNKSR1 has been shown to interact with RhoD[3] and RASSF1.[4]

References

  1. ↑ Therrien M, Wong AM, Rubin GM (Dec 1998). "CNK, a RAF-binding multidomain protein required for RAS signaling". Cell. 95 (3): 343–53. doi:10.1016/S0092-8674(00)81766-3. PMID 9814705.
  2. ↑ 2.0 2.1 "Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1".
  3. ↑ Jaffe AB, Aspenström P, Hall A (Feb 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. PMC 344169. PMID 14749388.
  4. ↑ Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B (Jul 2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. doi:10.1074/jbc.M401699200. PMID 15075335.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Therrien M, Wong AM, Kwan E, Rubin GM (1999). "Functional analysis of CNK in RAS signaling". Proc. Natl. Acad. Sci. U.S.A. 96 (23): 13259–63. doi:10.1073/pnas.96.23.13259. PMC 23935. PMID 10557308.
  • Hartsough MT, Morrison DK, Salerno M, Palmieri D, Ouatas T, Mair M, Patrick J, Steeg PS (2002). "Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway". J. Biol. Chem. 277 (35): 32389–99. doi:10.1074/jbc.M203115200. PMID 12105213.
  • Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA (2004). "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP". Nature. 427 (6971): 256–60. doi:10.1038/nature02237. PMID 14724641.
  • Jaffe AB, Aspenström P, Hall A (2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. PMC 344169. PMID 14749388.
  • Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B (2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. doi:10.1074/jbc.M401699200. PMID 15075335.
  • Jaffe AB, Hall A, Schmidt A (2005). "Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho". Curr. Biol. 15 (5): 405–12. doi:10.1016/j.cub.2004.12.082. PMID 15753034.
  • Ziogas A, Moelling K, Radziwill G (2005). "CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation". J. Biol. Chem. 280 (25): 24205–11. doi:10.1074/jbc.M413327200. PMID 15845549.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Fritz RD, Radziwill G (2006). "The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor". Biochem. Biophys. Res. Commun. 338 (4): 1906–12. doi:10.1016/j.bbrc.2005.10.168. PMID 16289034.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.

External links


Retrieved from "https://www.wikidoc.org/index.php?title=CNKSR1&oldid=1411229"