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{{Infobox_gene}}
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'''Prolargin''' is a [[protein]] that in humans is encoded by the ''PRELP'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRELP proline/arginine-rich end leucine-rich repeat protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5549| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Proline/arginine-rich end leucine-rich repeat protein
| HGNCid = 9357
| Symbol = PRELP
| AltSymbols =; MGC45323; MST161; MSTP161; SLRR2A
| OMIM = 601914
| ECnumber = 
| Homologene = 2041
| MGIid = 2151110
| GeneAtlas_image1 = PBB_GE_PRELP_37022_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRELP_204223_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}}  
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5549
    | Hs_Ensembl = ENSG00000188783
    | Hs_RefseqProtein = NP_002716
    | Hs_RefseqmRNA = NM_002725
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 201711506
    | Hs_GenLoc_end = 201727098
    | Hs_Uniprot = P51888
    | Mm_EntrezGene = 116847
    | Mm_Ensembl = ENSMUSG00000041577
    | Mm_RefseqmRNA = NM_054077
    | Mm_RefseqProtein = NP_473418
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 135726689
    | Mm_GenLoc_end = 135737788
    | Mm_Uniprot = Q543S0
  }}
}}
'''Proline/arginine-rich end leucine-rich repeat protein''', also known as '''PRELP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRELP proline/arginine-rich end leucine-rich repeat protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5549| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.<ref name="entrez">{{cite web | title = Entrez Gene: PRELP proline/arginine-rich end leucine-rich repeat protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5549| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson–Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.<ref name="entrez">{{cite web | title = Entrez Gene: PRELP proline/arginine-rich end leucine-rich repeat protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5549| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Lewis M |title=PRELP, collagen, and a theory of Hutchinson-Gilford progeria. |journal=Ageing Res. Rev. |volume=2 |issue= 1 |pages= 95-105 |year= 2003 |pmid= 12437997 |doi=  }}
*{{cite journal  | author=Lewis M |title=PRELP, collagen, and a theory of Hutchinson–Gilford progeria. |journal=Ageing Res. Rev. |volume=2 |issue= 1 |pages= 95–105 |year= 2003 |pmid= 12437997 |doi=10.1016/S1568-1637(02)00044-2 }}
*{{cite journal  | author=Bengtsson E, Neame PJ, Heinegård D, Sommarin Y |title=The primary structure of a basic leucine-rich repeat protein, PRELP, found in connective tissues. |journal=J. Biol. Chem. |volume=270 |issue= 43 |pages= 25639-44 |year= 1995 |pmid= 7592739 |doi=  }}
*{{cite journal  | vauthors=Bengtsson E, Neame PJ, Heinegård D, Sommarin Y |title=The primary structure of a basic leucine-rich repeat protein, PRELP, found in connective tissues. |journal=J. Biol. Chem. |volume=270 |issue= 43 |pages= 25639–44 |year= 1995 |pmid= 7592739 |doi=10.1074/jbc.270.43.25639 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | author=Grover J, Chen XN, Korenberg JR, ''et al.'' |title=The gene organization, chromosome location, and expression of a 55-kDa matrix protein (PRELP) of human articular cartilage. |journal=Genomics |volume=38 |issue= 2 |pages= 109-17 |year= 1997 |pmid= 8954791 |doi= 10.1006/geno.1996.0605 }}
*{{cite journal   |vauthors=Grover J, Chen XN, Korenberg JR, etal |title=The gene organization, chromosome location, and expression of a 55-kDa matrix protein (PRELP) of human articular cartilage. |journal=Genomics |volume=38 |issue= 2 |pages= 109–17 |year= 1997 |pmid= 8954791 |doi= 10.1006/geno.1996.0605 }}
*{{cite journal  | author=Grover J, Roughley PJ |title=Characterization of the human proline/arginine-rich end leucine-rich repeat protein (PRELP) gene promoter and identification of a repressor element. |journal=Biochem. J. |volume=336 ( Pt 1) |issue=  |pages= 77-82 |year= 1999 |pmid= 9806887 |doi=  }}
*{{cite journal  | vauthors=Grover J, Roughley PJ |title=Characterization of the human proline/arginine-rich end leucine-rich repeat protein (PRELP) gene promoter and identification of a repressor element. |journal=Biochem. J. |volume=336 |issue=  1|pages= 77–82 |year= 1999 |pmid= 9806887 |doi= | pmc=1219844 }}
*{{cite journal | author=Bengtsson E, Mörgelin M, Sasaki T, ''et al.'' |title=The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 15061-8 |year= 2002 |pmid= 11847210 |doi= 10.1074/jbc.M108285200 }}
*{{cite journal   |vauthors=Bengtsson E, Mörgelin M, Sasaki T, etal |title=The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 15061–8 |year= 2002 |pmid= 11847210 |doi= 10.1074/jbc.M108285200 }}
*{{cite journal | author=Wistow G, Bernstein SL, Wyatt MK, ''et al.'' |title=Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue=  |pages= 205-20 |year= 2002 |pmid= 12107410 |doi=  }}
*{{cite journal   |vauthors=Wistow G, Bernstein SL, Wyatt MK, etal |title=Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue=  |pages= 205–20 |year= 2002 |pmid= 12107410 |doi=  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Johnson JM, Young TL, Rada JA |title=Small leucine rich repeat proteoglycans (SLRPs) in the human sclera: identification of abundant levels of PRELP. |journal=Mol. Vis. |volume=12 |issue=  |pages= 1057-66 |year= 2006 |pmid= 17093390 |doi=  }}
*{{cite journal  | vauthors=Johnson JM, Young TL, Rada JA |title=Small leucine rich repeat proteoglycans (SLRPs) in the human sclera: identification of abundant levels of PRELP. |journal=Mol. Vis. |volume=12 |issue=  |pages= 1057–66 |year= 2006 |pmid= 17093390 |doi=  }}
*{{cite journal | author=Grover J, Lee ER, Mounkes LC, ''et al.'' |title=The consequence of PRELP overexpression on skin. |journal=Matrix Biol. |volume=26 |issue= 2 |pages= 140-3 |year= 2007 |pmid= 17123807 |doi= 10.1016/j.matbio.2006.10.005 }}
*{{cite journal   |vauthors=Grover J, Lee ER, Mounkes LC, etal |title=The consequence of PRELP overexpression on skin. |journal=Matrix Biol. |volume=26 |issue= 2 |pages= 140–3 |year= 2007 |pmid= 17123807 |doi= 10.1016/j.matbio.2006.10.005 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:39, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Prolargin is a protein that in humans is encoded by the PRELP gene.[1]

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson–Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: PRELP proline/arginine-rich end leucine-rich repeat protein".

Further reading



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