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→‎Further reading: 10.1093/oxfordjournals.humrep.a136893
 
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{{about|the human gene|the communication standard|Standard Marine Communication Phrases|the video game|Sonic Mega Collection#Sonic Mega Collection Plus}}
{{PBB_Controls
{{Infobox_gene}}
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'''Sperm mitochondrial-associated cysteine-rich protein''' is a [[protein]] that in humans is encoded by the ''SMCP'' [[gene]].<ref name="pmid8833144">{{cite journal | vauthors = Aho H, Schwemmer M, Tessman D, Murphy D, Mattei G, Engel W, Adham IM | title = Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP) | journal = Genomics | volume = 32 | issue = 2 | pages = 184–90 | date = Mar 1996 | pmid = 8833144 | pmc = | doi = 10.1006/geno.1996.0104 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SMCP sperm mitochondria-associated cysteine-rich protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4184| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Sperm mitochondria-associated cysteine-rich protein
| HGNCid = 6962
| Symbol = SMCP
| AltSymbols =; MCSP; MCS; HSMCSGEN1; MGC26305; MGC26519
| OMIM = 601148
| ECnumber = 
| Homologene = 
| MGIid = 
| GeneAtlas_image1 = PBB_GE_SMCP_206406_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0007341 |text = penetration of zona pellucida}} {{GNF_GO|id=GO:0030317 |text = sperm motility}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4184
    | Hs_Ensembl = ENSG00000163206
    | Hs_RefseqProtein = NP_109588
    | Hs_RefseqmRNA = NM_030663
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 151117417
    | Hs_GenLoc_end = 151124147
    | Hs_Uniprot = P49901
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Sperm mitochondria-associated cysteine-rich protein''', also known as '''SMCP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SMCP sperm mitochondria-associated cysteine-rich protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4184| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Sperm [[mitochondria]] differ in morphology and subcellular localization from those of [[somatic cell]]s. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm [[flagellum]]. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath.<ref name="entrez">{{cite web | title = Entrez Gene: SMCP sperm mitochondria-associated cysteine-rich protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4184| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
{{refbegin | 2}}
== Further reading ==
{{PBB_Further_reading
{{refbegin|33em}}
| citations =
* {{cite journal | vauthors = Behne D, Kyriakopoulos A | title = Mammalian selenium-containing proteins | journal = Annual Review of Nutrition | volume = 21 | issue =  | pages = 453–73 | year = 2001 | pmid = 11375445 | doi = 10.1146/annurev.nutr.21.1.453 }}
*{{cite journal | author=Behne D, Kyriakopoulos A |title=Mammalian selenium-containing proteins. |journal=Annu. Rev. Nutr. |volume=21 |issue=  |pages= 453-73 |year= 2001 |pmid= 11375445 |doi= 10.1146/annurev.nutr.21.1.453 }}
* {{cite journal | vauthors = Karimpour I, Cutler M, Shih D, Smith J, Kleene KC | title = Sequence of the gene encoding the mitochondrial capsule selenoprotein of mouse sperm: identification of three in-phase TGA selenocysteine codons | journal = DNA and Cell Biology | volume = 11 | issue = 9 | pages = 693–9 | date = Nov 1992 | pmid = 1418626 | doi = 10.1089/dna.1992.11.693 }}
*{{cite journal | author=Karimpour I, Cutler M, Shih D, ''et al.'' |title=Sequence of the gene encoding the mitochondrial capsule selenoprotein of mouse sperm: identification of three in-phase TGA selenocysteine codons. |journal=DNA Cell Biol. |volume=11 |issue= 9 |pages= 693-9 |year= 1992 |pmid= 1418626 |doi= }}
* {{cite journal | vauthors = Saaranen M, Suistomaa U, Vanha-Perttula T | title = Semen selenium content and sperm mitochondrial volume in human and some animal species | journal = Human Reproduction | volume = 4 | issue = 3 | pages = 304–8 | date = Apr 1989 | pmid = 2715306 | doi = 10.1093/oxfordjournals.humrep.a136893 }}
*{{cite journal | author=Saaranen M, Suistomaa U, Vanha-Perttula T |title=Semen selenium content and sperm mitochondrial volume in human and some animal species. |journal=Hum. Reprod. |volume=4 |issue= 3 |pages= 304-8 |year= 1989 |pmid= 2715306 |doi= }}
* {{cite journal | vauthors = Cataldo L, Baig K, Oko R, Mastrangelo MA, Kleene KC | title = Developmental expression, intracellular localization, and selenium content of the cysteine-rich protein associated with the mitochondrial capsules of mouse sperm | journal = Molecular Reproduction and Development | volume = 45 | issue = 3 | pages = 320–31 | date = Nov 1996 | pmid = 8916043 | doi = 10.1002/(SICI)1098-2795(199611)45:3<320::AID-MRD9>3.0.CO;2-U }}
*{{cite journal  | author=Aho H, Schwemmer M, Tessman D, ''et al.'' |title=Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP). |journal=Genomics |volume=32 |issue= 2 |pages= 184-90 |year= 1997 |pmid= 8833144 |doi=  }}
* {{cite journal | vauthors = Herr JC, Thomas D, Bush LA, Coonrod S, Khole V, Howards SS, Flickinger CJ | title = Sperm mitochondria-associated cysteine-rich protein (SMCP) is an autoantigen in Lewis rats | journal = Biology of Reproduction | volume = 61 | issue = 2 | pages = 428–35 | date = Aug 1999 | pmid = 10411523 | doi = 10.1095/biolreprod61.2.428 }}
*{{cite journal | author=Cataldo L, Baig K, Oko R, ''et al.'' |title=Developmental expression, intracellular localization, and selenium content of the cysteine-rich protein associated with the mitochondrial capsules of mouse sperm. |journal=Mol. Reprod. Dev. |volume=45 |issue= 3 |pages= 320-31 |year= 1997 |pmid= 8916043 |doi= 10.1002/(SICI)1098-2795(199611)45:3<320::AID-MRD9>3.0.CO;2-U }}
* {{cite journal | vauthors = Nayernia K, Adham IM, Burkhardt-Göttges E, Neesen J, Rieche M, Wolf S, Sancken U, Kleene K, Engel W | title = Asthenozoospermia in mice with targeted deletion of the sperm mitochondrion-associated cysteine-rich protein (Smcp) gene | journal = Molecular and Cellular Biology | volume = 22 | issue = 9 | pages = 3046–52 | date = May 2002 | pmid = 11940662 | pmc = 133774 | doi = 10.1128/MCB.22.9.3046-3052.2002 }}
*{{cite journal | author=Herr JC, Thomas D, Bush LA, ''et al.'' |title=Sperm mitochondria-associated cysteine-rich protein (SMCP) is an autoantigen in Lewis rats. |journal=Biol. Reprod. |volume=61 |issue= 2 |pages= 428-35 |year= 1999 |pmid= 10411523 |doi= }}
* {{cite journal | vauthors = Hawthorne SK, Goodarzi G, Bagarova J, Gallant KE, Busanelli RR, Olend WJ, Kleene KC | title = Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene | journal = Genomics | volume = 87 | issue = 3 | pages = 382–91 | date = Mar 2006 | pmid = 16325371 | doi = 10.1016/j.ygeno.2005.09.010 }}
*{{cite journal | author=Nayernia K, Adham IM, Burkhardt-Göttges E, ''et al.'' |title=Asthenozoospermia in mice with targeted deletion of the sperm mitochondrion-associated cysteine-rich protein (Smcp) gene. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 3046-52 |year= 2002 |pmid= 11940662 |doi=  }}
* {{cite journal | vauthors = Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM | title = Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization | journal = Human Molecular Genetics | volume = 15 | issue = 23 | pages = 3411–9 | date = Dec 2006 | pmid = 17047026 | doi = 10.1093/hmg/ddl417 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Hawthorne SK, Goodarzi G, Bagarova J, ''et al.'' |title=Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene. |journal=Genomics |volume=87 |issue= 3 |pages= 382-91 |year= 2006 |pmid= 16325371 |doi= 10.1016/j.ygeno.2005.09.010 }}
*{{cite journal | author=Yatsenko AN, Roy A, Chen R, ''et al.'' |title=Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. |journal=Hum. Mol. Genet. |volume=15 |issue= 23 |pages= 3411-9 |year= 2007 |pmid= 17047026 |doi= 10.1093/hmg/ddl417 }}
}}
{{refend}}
{{refend}}


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[[Category:Selenoproteins]]

Latest revision as of 15:38, 23 November 2017

This article is about the human gene. For the communication standard, see Standard Marine Communication Phrases. For the video game, see Sonic Mega Collection § Sonic Mega Collection Plus.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sperm mitochondrial-associated cysteine-rich protein is a protein that in humans is encoded by the SMCP gene.[1][2]

Function

Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath.[2]

References

  1. ↑ Aho H, Schwemmer M, Tessman D, Murphy D, Mattei G, Engel W, Adham IM (Mar 1996). "Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP)". Genomics. 32 (2): 184–90. doi:10.1006/geno.1996.0104. PMID 8833144.
  2. ↑ 2.0 2.1 "Entrez Gene: SMCP sperm mitochondria-associated cysteine-rich protein".

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=SMCP&oldid=1411240"