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{{Infobox_gene}}
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'''Synaptic vesicle glycoprotein 2A''' is a ubiquitous synaptic vesicle [[protein]] that in humans is encoded by the ''SV2A'' [[gene]].<ref name="pmid7681585">{{cite journal | vauthors = Bajjalieh SM, Peterson K, Linial M, Scheller RH | title = Brain contains two forms of synaptic vesicle protein 2 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 6 | pages = 2150–4 | date = Mar 1993 | pmid = 7681585 | pmc = 46043 | doi = 10.1073/pnas.90.6.2150 }}</ref><ref name="pmid10611374">{{cite journal | vauthors = Crowder KM, Gunther JM, Jones TA, Hale BD, Zhang HZ, Peterson MR, Scheller RH, Chavkin C, Bajjalieh SM | title = Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A) | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 26 | pages = 15268–73 | date = Dec 1999 | pmid = 10611374 | pmc = 24809 | doi = 10.1073/pnas.96.26.15268 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SV2A synaptic vesicle glycoprotein 2A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9900| accessdate = }}</ref> The protein is targeted by the anti-epileptic drugs ([[anticonvulsant]]s) [[levetiracetam]] and [[brivaracetam]].<ref name="pmid19777068">{{cite journal | vauthors = Ulloa CM, Towfigh A, Safdieh J | title = Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures | journal = Neuropsychiatric Disease and Treatment | volume = 5 | issue =  | pages = 467–76 | year = 2009 | pmid = 19777068 | pmc = 2747386 | doi = 10.2147/ndt.s4844 }}</ref> but not the chemically similar drug [[etiracetam]]
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==See also==
{{GNF_Protein_box
* [[SV2B]]
| image =
| image_source =
| PDB =
| Name = Synaptic vesicle glycoprotein 2A
| HGNCid = 20566
| Symbol = SV2A
| AltSymbols =; KIAA0736; SV2
| OMIM = 185860
| ECnumber = 
| Homologene = 32237
| MGIid = 1927139
| GeneAtlas_image1 = PBB_GE_SV2A_203069_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006836 |text = neurotransmitter transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9900
    | Hs_Ensembl = ENSG00000159164
    | Hs_RefseqProtein = NP_055664
    | Hs_RefseqmRNA = NM_014849
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 148141494
    | Hs_GenLoc_end = 148156058
    | Hs_Uniprot = Q7L0J3
    | Mm_EntrezGene = 64051
    | Mm_Ensembl = ENSMUSG00000038486
    | Mm_RefseqmRNA = NM_022030
    | Mm_RefseqProtein = NP_071313
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 96266591
    | Mm_GenLoc_end = 96280604
    | Mm_Uniprot = Q9JIS5
  }}
}}
'''Synaptic vesicle glycoprotein 2A''', also known as '''SV2A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SV2A synaptic vesicle glycoprotein 2A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9900| accessdate = }}</ref>


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== References ==
{{PBB_Summary
{{reflist}}
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| summary_text =
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==References==
== Further reading ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bajjalieh SM, Peterson K, Shinghal R, Scheller RH | title = SV2, a brain synaptic vesicle protein homologous to bacterial transporters | journal = Science | volume = 257 | issue = 5074 | pages = 1271–3 | date = Aug 1992 | pmid = 1519064 | doi = 10.1126/science.1519064 }}
| citations =
* {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 5 | pages = 277–86 | date = Oct 1998 | pmid = 9872452 | doi = 10.1093/dnares/5.5.277 }}
*{{cite journal | author=Bajjalieh SM, Peterson K, Shinghal R, Scheller RH |title=SV2, a brain synaptic vesicle protein homologous to bacterial transporters. |journal=Science |volume=257 |issue= 5074 |pages= 1271-3 |year= 1992 |pmid= 1519064 |doi= }}
* {{cite journal | vauthors = Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS | title = The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface | journal = The Journal of Biological Chemistry | volume = 275 | issue = 1 | pages = 451–60 | date = Jan 2000 | pmid = 10617638 | doi = 10.1074/jbc.275.1.451 }}
*{{cite journal  | author=Bajjalieh SM, Peterson K, Linial M, Scheller RH |title=Brain contains two forms of synaptic vesicle protein 2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 6 |pages= 2150-4 |year= 1993 |pmid= 7681585 |doi=  }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277-86 |year= 1999 |pmid= 9872452 |doi= }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal  | author=Crowder KM, Gunther JM, Jones TA, ''et al.'' |title=Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 26 |pages= 15268-73 |year= 2000 |pmid= 10611374 |doi=  }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
*{{cite journal | author=Son YJ, Scranton TW, Sunderland WJ, ''et al.'' |title=The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 451-60 |year= 2000 |pmid= 10617638 |doi= }}
* {{cite journal | vauthors = Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B | title = The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 26 | pages = 9861–6 | date = Jun 2004 | pmid = 15210974 | pmc = 470764 | doi = 10.1073/pnas.0308208101 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG, Leite JP, Pant HC, Dosemeci A | title = Phosphoproteomic analysis of synaptosomes from human cerebral cortex | journal = Journal of Proteome Research | volume = 4 | issue = 2 | pages = 306–15 | year = 2005 | pmid = 15822905 | doi = 10.1021/pr0498436 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T | title = Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries | journal = DNA Research | volume = 12 | issue = 2 | pages = 117–26 | year = 2007 | pmid = 16303743 | doi = 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415–8 | date = Jan 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal  | author=Lynch BA, Lambeng N, Nocka K, ''et al.'' |title=The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 26 |pages= 9861-6 |year= 2004 |pmid= 15210974 |doi= 10.1073/pnas.0308208101 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=DeGiorgis JA, Jaffe H, Moreira JE, ''et al.'' |title=Phosphoproteomic analysis of synaptosomes from human cerebral cortex. |journal=J. Proteome Res. |volume=4 |issue= 2 |pages= 306-15 |year= 2005 |pmid= 15822905 |doi= 10.1021/pr0498436 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 20:00, 30 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Synaptic vesicle glycoprotein 2A is a ubiquitous synaptic vesicle protein that in humans is encoded by the SV2A gene.[1][2][3] The protein is targeted by the anti-epileptic drugs (anticonvulsants) levetiracetam and brivaracetam.[4] but not the chemically similar drug etiracetam

See also

References

  1. ↑ Bajjalieh SM, Peterson K, Linial M, Scheller RH (Mar 1993). "Brain contains two forms of synaptic vesicle protein 2". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2150–4. doi:10.1073/pnas.90.6.2150. PMC 46043. PMID 7681585.
  2. ↑ Crowder KM, Gunther JM, Jones TA, Hale BD, Zhang HZ, Peterson MR, Scheller RH, Chavkin C, Bajjalieh SM (Dec 1999). "Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 15268–73. doi:10.1073/pnas.96.26.15268. PMC 24809. PMID 10611374.
  3. ↑ "Entrez Gene: SV2A synaptic vesicle glycoprotein 2A".
  4. ↑ Ulloa CM, Towfigh A, Safdieh J (2009). "Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures". Neuropsychiatric Disease and Treatment. 5: 467–76. doi:10.2147/ndt.s4844. PMC 2747386. PMID 19777068.

Further reading


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