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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''Cysteine and glycine-rich protein 1''' is a [[protein]] that in humans is encoded by the ''CSRP1'' [[gene]].<ref name="pmid2115670">{{cite journal | vauthors = Liebhaber SA, Emery JG, Urbanek M, Wang XK, Cooke NE | title = Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif | journal = Nucleic Acids Res | volume = 18 | issue = 13 | pages = 3871–9 |date=Aug 1990 | pmid = 2115670 | pmc = 331088 | doi =10.1093/nar/18.13.3871 }}</ref><ref name="pmid9925910">{{cite journal | vauthors = Erdel M, Weiskirchen R | title = Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization | journal = Cytogenet Cell Genet | volume = 83 | issue = 1–2 | pages = 10–1 |date=Mar 1999 | pmid = 9925910 | pmc =  | doi =10.1159/000015152 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CSRP1 cysteine and glycine-rich protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1465| accessdate = }}</ref>
| image = PBB_Protein_CSRP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ctl.
| PDB = {{PDB2|1ctl}}
| Name = Cysteine and glycine-rich protein 1
| HGNCid = 2469
| Symbol = CSRP1
| AltSymbols =; CRP1; CRP; CSRP; CYRP; D1S181E; DKFZp686M148
| OMIM = 123876
| ECnumber =
| Homologene = 37874
| MGIid = 88549
| GeneAtlas_image1 = PBB_GE_CSRP1_200621_at_tn.png
  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1465
    | Hs_Ensembl = ENSG00000159176
    | Hs_RefseqProtein = NP_004069
    | Hs_RefseqmRNA = NM_004078
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 199719281
    | Hs_GenLoc_end = 199745207
    | Hs_Uniprot = P21291
    | Mm_EntrezGene = 13007
    | Mm_Ensembl = ENSMUSG00000026421
    | Mm_RefseqmRNA = NM_007791
    | Mm_RefseqProtein = NP_031817
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 137536472
    | Mm_GenLoc_end = 137568640
    | Mm_Uniprot = Q4FJX4
  }}
}}
'''Cysteine and glycine-rich protein 1''', also known as '''CSRP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CSRP1 cysteine and glycine-rich protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1465| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = CSRP1 is a member of the CSRP family of genes encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation.  The LIM/double zinc-finger motif found in CRP1 is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation  Other genes in the family include CSRP2 and CSRP3.<ref name="entrez">{{cite web | title = Entrez Gene: CSRP1 cysteine and glycine-rich protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1465| accessdate = }}</ref>
| summary_text = CSRP1 is a member of the CSRP family of genes encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation.  The LIM/double zinc-finger motif found in CRP1 is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation  Other genes in the family include CSRP2 and CSRP3.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CRP}}
* {{UCSC gene info|CSRP1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Weiskirchen R, Günther K |title=The CRP/MLP/TLP family of LIM domain proteins: acting by connecting. |journal=Bioessays |volume=25 |issue= 2 |pages= 152-62 |year= 2003 |pmid= 12539241 |doi= 10.1002/bies.10226 }}
*{{cite journal  | vauthors=Weiskirchen R, Günther K |title=The CRP/MLP/TLP family of LIM domain proteins: acting by connecting |journal=BioEssays |volume=25 |issue= 2 |pages= 152–62 |year= 2003 |pmid= 12539241 |doi= 10.1002/bies.10226 }}
*{{cite journal  | author=Wang X, Lee G, Liebhaber SA, Cooke NE |title=Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc. |journal=J. Biol. Chem. |volume=267 |issue= 13 |pages= 9176-84 |year= 1992 |pmid= 1374386 |doi=  }}
*{{cite journal  | vauthors=Wang X, Lee G, Liebhaber SA, Cooke NE |title=Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc |journal=J. Biol. Chem. |volume=267 |issue= 13 |pages= 9176–84 |year= 1992 |pmid= 1374386 |doi=  }}
*{{cite journal  | author=Wang X, Ray K, Szpirer J, ''et al.'' |title=Analysis of the human cysteine-rich protein gene (CSRP), assignment to chromosome 1q24-1q32, and identification of an associated MspI polymorphism. |journal=Genomics |volume=14 |issue= 2 |pages= 391-7 |year= 1992 |pmid= 1385304 |doi= }}
*{{cite journal  | vauthors=Wang X, Ray K, Szpirer J |title=Analysis of the human cysteine-rich protein gene (CSRP), assignment to chromosome 1q24-1q32, and identification of an associated MspI polymorphism |journal=Genomics |volume=14 |issue= 2 |pages= 391–7 |year= 1992 |pmid= 1385304 |doi=10.1016/S0888-7543(05)80231-|display-authors=etal}}
*{{cite journal  | author=Liebhaber SA, Emery JG, Urbanek M, ''et al.'' |title=Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif. |journal=Nucleic Acids Res. |volume=18 |issue= 13 |pages= 3871-9 |year= 1990 |pmid= 2115670 |doi=  }}
*{{cite journal  | vauthors=Feuerstein R, Wang X, Song D |title=The LIM/double zinc-finger motif functions as a protein dimerization domain |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 22 |pages= 10655–9 |year= 1994 |pmid= 7938009 |doi=10.1073/pnas.91.22.10655 | pmc=45080  |display-authors=etal}}
*{{cite journal  | author=Feuerstein R, Wang X, Song D, ''et al.'' |title=The LIM/double zinc-finger motif functions as a protein dimerization domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 22 |pages= 10655-9 |year= 1994 |pmid= 7938009 |doi=  }}
*{{cite journal  | vauthors=Dubé JY, Chapdelaine P, Trahan PL |title=Abundant cysteine-rich protein-1 is localized in the stromal compartment of the human prostate |journal=Arch. Androl. |volume=40 |issue= 2 |pages= 109–15 |year= 1998 |pmid= 9507743 |doi=10.3109/01485019808987933 |display-authors=etal}}
*{{cite journal  | author=Dubé JY, Chapdelaine P, Trahan PL, ''et al.'' |title=Abundant cysteine-rich protein-1 is localized in the stromal compartment of the human prostate. |journal=Arch. Androl. |volume=40 |issue= 2 |pages= 109-15 |year= 1998 |pmid= 9507743 |doi=  }}
*{{cite journal  | vauthors=Harper BD, Beckerle MC, Pomiès P |title=Fine mapping of the alpha-actinin binding site within cysteine-rich protein |journal=Biochem. J. |volume=350 Pt 1 |issue=  Pt 1|pages= 269–74 |year= 2001 |pmid= 10926853 |doi= 10.1042/0264-6021:3500269| pmc=1221251 }}
*{{cite journal  | author=Erdel M, Weiskirchen R |title=Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 1-2 |pages= 10-1 |year= 1999 |pmid= 9925910 |doi=  }}
*{{cite journal  | vauthors=Andersen JS, Lyon CE, Fox AH |title=Directed proteomic analysis of the human nucleolus |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 |display-authors=etal}}
*{{cite journal  | author=Harper BD, Beckerle MC, Pomiès P |title=Fine mapping of the alpha-actinin binding site within cysteine-rich protein. |journal=Biochem. J. |volume=350 Pt 1 |issue=  |pages= 269-74 |year= 2001 |pmid= 10926853 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  | vauthors=Hirasawa Y, Arai M, Imazeki F |title=Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma |journal=Oncology |volume=71 |issue= 1–2 |pages= 77–85 |year= 2007 |pmid= 17341888 |doi= 10.1159/000100475 |display-authors=etal}}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | vauthors=Wang Q, Williamson M, Bott S |title=Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer |journal=Oncogene |volume=26 |issue= 45 |pages= 6560–5 |year= 2007 |pmid= 17486081 |doi= 10.1038/sj.onc.1210472 |display-authors=etal}}
*{{cite journal  | author=Hirasawa Y, Arai M, Imazeki F, ''et al.'' |title=Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma. |journal=Oncology |volume=71 |issue= 1-2 |pages= 77-85 |year= 2007 |pmid= 17341888 |doi= 10.1159/000100475 }}
*{{cite journal  | author=Wang Q, Williamson M, Bott S, ''et al.'' |title=Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer. |journal=Oncogene |volume=26 |issue= 45 |pages= 6560-5 |year= 2007 |pmid= 17486081 |doi= 10.1038/sj.onc.1210472 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1465}}
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Revision as of 10:07, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cysteine and glycine-rich protein 1 is a protein that in humans is encoded by the CSRP1 gene.[1][2][3]

CSRP1 is a member of the CSRP family of genes encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in CRP1 is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation Other genes in the family include CSRP2 and CSRP3.[3]

References

  1. Liebhaber SA, Emery JG, Urbanek M, Wang XK, Cooke NE (Aug 1990). "Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif". Nucleic Acids Res. 18 (13): 3871–9. doi:10.1093/nar/18.13.3871. PMC 331088. PMID 2115670.
  2. Erdel M, Weiskirchen R (Mar 1999). "Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 10–1. doi:10.1159/000015152. PMID 9925910.
  3. 3.0 3.1 "Entrez Gene: CSRP1 cysteine and glycine-rich protein 1".

External links

Further reading