RAB3B: Difference between revisions

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{{Infobox_gene}}
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'''Ras-related protein Rab-3B''' is a [[protein]] that in humans is encoded by the ''RAB3B'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB3B RAB3B, member RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5865| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = RAB3B, member RAS oncogene family
| HGNCid = 9778
| Symbol = RAB3B
| AltSymbols =;
| OMIM = 179510
| ECnumber = 
| Homologene = 2149
| MGIid = 1917158
| GeneAtlas_image1 = PBB_GE_RAB3B_205924_at_tn.png
| GeneAtlas_image2 = PBB_GE_RAB3B_205925_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0031045 |text = dense core granule}}
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0017157 |text = regulation of exocytosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5865
    | Hs_Ensembl = ENSG00000169213
    | Hs_RefseqProtein = NP_002858
    | Hs_RefseqmRNA = NM_002867
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 52146216
    | Hs_GenLoc_end = 52229024
    | Hs_Uniprot = P20337
    | Mm_EntrezGene = 69908
    | Mm_Ensembl = ENSMUSG00000003411
    | Mm_RefseqmRNA = NM_023537
    | Mm_RefseqProtein = NP_076026
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 108388240
    | Mm_GenLoc_end = 108438745
    | Mm_Uniprot = Q0PD62
  }}
}}
'''RAB3B, member RAS oncogene family''', also known as '''RAB3B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB3B RAB3B, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5865| accessdate = }}</ref>
 
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==Interactions==
RAB3B has been shown to [[Protein-protein interaction|interact]] with [[RPH3A]].<ref name=pmid12578829>{{cite journal |last=Fukuda |first=Mitsunori |date=Apr 2003 |title=Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2 |journal=J. Biol. Chem. |volume=278 |issue=17 |pages=15373–80 |publisher= |location = United States| issn = 0021-9258| pmid = 12578829 |doi = 10.1074/jbc.M212341200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid8636125>{{cite journal |last=Weber |first=E |authorlink= |author2=Jilling T |author3=Kirk K L  |date=Mar 1996 |title=Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells |journal=J. Biol. Chem. |volume=271 |issue=12 |pages=6963–71 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8636125 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.271.12.6963 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Rousseau-Merck MF, Zahraoui A, Touchot N, ''et al.'' |title=Chromosome assignment of four RAS-related RAB genes. |journal=Hum. Genet. |volume=86 |issue= 4 |pages= 350-4 |year= 1991 |pmid= 1999336 |doi=  }}
*{{cite journal   |vauthors=Rousseau-Merck MF, Zahraoui A, Touchot N, etal |title=Chromosome assignment of four RAS-related RAB genes. |journal=Hum. Genet. |volume=86 |issue= 4 |pages= 350–4 |year= 1991 |pmid= 1999336 |doi=10.1007/BF00201831 }}
*{{cite journal  | author=Zahraoui A, Touchot N, Chardin P, Tavitian A |title=The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. |journal=J. Biol. Chem. |volume=264 |issue= 21 |pages= 12394-401 |year= 1989 |pmid= 2501306 |doi=  }}
*{{cite journal  |vauthors=Zahraoui A, Touchot N, Chardin P, Tavitian A |title=The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. |journal=J. Biol. Chem. |volume=264 |issue= 21 |pages= 12394–401 |year= 1989 |pmid= 2501306 |doi=  }}
*{{cite journal | author=Weber E, Berta G, Tousson A, ''et al.'' |title=Expression and polarized targeting of a rab3 isoform in epithelial cells. |journal=J. Cell Biol. |volume=125 |issue= 3 |pages= 583-94 |year= 1994 |pmid= 8175882 |doi=  }}
*{{cite journal   |vauthors=Weber E, Berta G, Tousson A, etal |title=Expression and polarized targeting of a rab3 isoform in epithelial cells. |journal=J. Cell Biol. |volume=125 |issue= 3 |pages= 583–94 |year= 1994 |pmid= 8175882 |doi=10.1083/jcb.125.3.583  | pmc=2119989 }}
*{{cite journal  | author=Weber E, Jilling T, Kirk KL |title=Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 6963-71 |year= 1996 |pmid= 8636125 |doi=  }}
*{{cite journal  |vauthors=Weber E, Jilling T, Kirk KL |title=Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 6963–71 |year= 1996 |pmid= 8636125 |doi=10.1074/jbc.271.12.6963 }}
*{{cite journal | author=Regazzi R, Ravazzola M, Iezzi M, ''et al.'' |title=Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells. |journal=J. Cell. Sci. |volume=109 ( Pt 9) |issue=  |pages= 2265-73 |year= 1997 |pmid= 8886977 |doi=  }}
*{{cite journal   |vauthors=Regazzi R, Ravazzola M, Iezzi M, etal |title=Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells. |journal=J. Cell Sci. |volume=109 |issue=  9|pages= 2265–73 |year= 1997 |pmid= 8886977 |doi=  }}
*{{cite journal  | author=Sidhu RS, Bhullar RP |title=Rab3B in human platelet is membrane bound and interacts with Ca(2+)/calmodulin. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 5 |pages= 1039-43 |year= 2002 |pmid= 11741295 |doi= 10.1006/bbrc.2001.6113 }}
*{{cite journal  |vauthors=Sidhu RS, Bhullar RP |title=Rab3B in human platelet is membrane bound and interacts with Ca(2+)/calmodulin. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 5 |pages= 1039–43 |year= 2002 |pmid= 11741295 |doi= 10.1006/bbrc.2001.6113 }}
*{{cite journal | author=van IJzendoorn SC, Tuvim MJ, Weimbs T, ''et al.'' |title=Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells. |journal=Dev. Cell |volume=2 |issue= 2 |pages= 219-28 |year= 2002 |pmid= 11832247 |doi=  }}
*{{cite journal   |vauthors=van IJzendoorn SC, Tuvim MJ, Weimbs T, etal |title=Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells. |journal=Dev. Cell |volume=2 |issue= 2 |pages= 219–28 |year= 2002 |pmid= 11832247 |doi=10.1016/S1534-5807(02)00115-6 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Fukuda M |title=Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15373-80 |year= 2003 |pmid= 12578829 |doi= 10.1074/jbc.M212341200 }}
*{{cite journal  | author=Fukuda M |title=Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15373–80 |year= 2003 |pmid= 12578829 |doi= 10.1074/jbc.M212341200 }}
*{{cite journal | author=Yamamoto Y, Nishimura N, Morimoto S, ''et al.'' |title=Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 2 |pages= 270-5 |year= 2003 |pmid= 12901864 |doi=  }}
*{{cite journal   |vauthors=Yamamoto Y, Nishimura N, Morimoto S, etal |title=Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 2 |pages= 270–5 |year= 2003 |pmid= 12901864 |doi=10.1016/S0006-291X(03)01358-5 }}
*{{cite journal | author=Matsumoto M, Miki T, Shibasaki T, ''et al.'' |title=Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 22 |pages= 8313-8 |year= 2004 |pmid= 15159548 |doi= 10.1073/pnas.0306709101 }}
*{{cite journal   |vauthors=Matsumoto M, Miki T, Shibasaki T, etal |title=Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 22 |pages= 8313–8 |year= 2004 |pmid= 15159548 |doi= 10.1073/pnas.0306709101 | pmc=420391 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal   |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 20:42, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras-related protein Rab-3B is a protein that in humans is encoded by the RAB3B gene.[1]


Interactions

RAB3B has been shown to interact with RPH3A.[2][3]

References

  1. ↑ "Entrez Gene: RAB3B RAB3B, member RAS oncogene family".
  2. ↑ Fukuda, Mitsunori (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. United States. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. ISSN 0021-9258. PMID 12578829.
  3. ↑ Weber, E; Jilling T; Kirk K L (Mar 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". J. Biol. Chem. UNITED STATES. 271 (12): 6963–71. doi:10.1074/jbc.271.12.6963. ISSN 0021-9258. PMID 8636125.

Further reading



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