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{{Infobox_gene}}
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'''Protein SMG5''' is a [[protein]] that in humans is encoded by the ''SMG5'' [[gene]].<ref name="pmid12676087">{{cite journal | vauthors = Reichenbach P, Hoss M, Azzalin CM, Nabholz M, Bucher P, Lingner J | title = A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed | journal = Curr Biol | volume = 13 | issue = 7 | pages = 568–74 |date=Apr 2003 | pmid = 12676087 | pmc =  | doi =10.1016/S0960-9822(03)00173-8 }}</ref><ref name="pmid12699629">{{cite journal | vauthors = Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L | title = Functional conservation of the telomerase protein Est1p in humans | journal = Curr Biol | volume = 13 | issue = 8 | pages = 698–704 |date=Apr 2003 | pmid = 12699629 | pmc =  | doi =10.1016/S0960-9822(03)00210-0  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SMG5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23381| accessdate = }}</ref> This protein contains a [[PIN domain]] that appears to have mutated the residues in the active site.<ref name="pmid17053788">{{cite journal |vauthors=Glavan F, Behm-Ansmant I, Izaurralde E, Conti E |title=Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex |journal=EMBO J. |volume=25 |issue=21 |pages=5117–25 |date=November 2006 |pmid=17053788 |pmc=1630413 |doi=10.1038/sj.emboj.7601377 |url=}}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_SMG5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2hwy.
| PDB = {{PDB2|2hwy}}
| Name = Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
| HGNCid = 24644
| Symbol = SMG5
| AltSymbols =; EST1B; FLJ34864; KIAA1089; LPTS-RP1; LPTSRP1; RP11-54H19.7; SMG-5
| OMIM =
| ECnumber =
| Homologene = 9095
| MGIid = 2447364
  | GeneAtlas_image1 = PBB_GE_SMG5_212147_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMG5_34868_at_tn.png
  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0051721 |text = protein phosphatase 2A binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000184 |text = mRNA catabolic process, nonsense-mediated decay}} {{GNF_GO|id=GO:0006406 |text = mRNA export from nucleus}} {{GNF_GO|id=GO:0035303 |text = regulation of dephosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23381
    | Hs_Ensembl = ENSG00000198952
    | Hs_RefseqProtein = NP_056142
    | Hs_RefseqmRNA = NM_015327
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 154485639
    | Hs_GenLoc_end = 154519240
    | Hs_Uniprot = Q9UPR3
    | Mm_EntrezGene = 229512
    | Mm_Ensembl = ENSMUSG00000001415
    | Mm_RefseqmRNA = XM_130930
    | Mm_RefseqProtein = XP_130930
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 88422208
    | Mm_GenLoc_end = 88448264
    | Mm_Uniprot = Q3UZS1
  }}
}}
'''Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)''', also known as '''SMG5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SMG5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23381| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal   |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 }}
*{{cite journal | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi=  }}
*{{cite journal   |vauthors=Kikuno R, Nagase T, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=10.1093/dnares/6.3.197 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Reichenbach P, Höss M, Azzalin CM, ''et al.'' |title=A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed. |journal=Curr. Biol. |volume=13 |issue= 7 |pages= 568-74 |year= 2003 |pmid= 12676087 |doi=  }}
*{{cite journal   |vauthors=Ohnishi T, Yamashita A, Kashima I, etal |title=Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1187–200 |year= 2004 |pmid= 14636577 |doi=10.1016/S1097-2765(03)00443-X }}
*{{cite journal | author=Snow BE, Erdmann N, Cruickshank J, ''et al.'' |title=Functional conservation of the telomerase protein Est1p in humans. |journal=Curr. Biol. |volume=13 |issue= 8 |pages= 698-704 |year= 2004 |pmid= 12699629 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ohnishi T, Yamashita A, Kashima I, ''et al.'' |title=Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1187-200 |year= 2004 |pmid= 14636577 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Unterholzner L, Izaurralde E |title=SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. |journal=Mol. Cell |volume=16 |issue= 4 |pages= 587–96 |year= 2005 |pmid= 15546618 |doi= 10.1016/j.molcel.2004.10.013 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Fukuhara N, Ebert J, Unterholzner L, etal |title=SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. |journal=Mol. Cell |volume=17 |issue= 4 |pages= 537–47 |year= 2005 |pmid= 15721257 |doi= 10.1016/j.molcel.2005.01.010 }}
*{{cite journal  | author=Unterholzner L, Izaurralde E |title=SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. |journal=Mol. Cell |volume=16 |issue= 4 |pages= 587-96 |year= 2005 |pmid= 15546618 |doi= 10.1016/j.molcel.2004.10.013 }}
*{{cite journal  | vauthors=Azzalin CM, Lingner J |title=The human RNA surveillance factor UPF1 is required for S phase progression and genome stability. |journal=Curr. Biol. |volume=16 |issue= 4 |pages= 433–9 |year= 2006 |pmid= 16488880 |doi= 10.1016/j.cub.2006.01.018 }}
*{{cite journal | author=Fukuhara N, Ebert J, Unterholzner L, ''et al.'' |title=SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. |journal=Mol. Cell |volume=17 |issue= 4 |pages= 537-47 |year= 2005 |pmid= 15721257 |doi= 10.1016/j.molcel.2005.01.010 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Azzalin CM, Lingner J |title=The human RNA surveillance factor UPF1 is required for S phase progression and genome stability. |journal=Curr. Biol. |volume=16 |issue= 4 |pages= 433-9 |year= 2006 |pmid= 16488880 |doi= 10.1016/j.cub.2006.01.018 }}
*{{cite journal   |vauthors=Lee H, Sengupta N, Villagra A, etal |title=Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation. |journal=Mol. Cell. Biol. |volume=26 |issue= 14 |pages= 5259–69 |year= 2006 |pmid= 16809764 |doi= 10.1128/MCB.01971-05  | pmc=1592721 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Lee H, Sengupta N, Villagra A, ''et al.'' |title=Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation. |journal=Mol. Cell. Biol. |volume=26 |issue= 14 |pages= 5259-69 |year= 2006 |pmid= 16809764 |doi= 10.1128/MCB.01971-05 }}
*{{cite journal | author=Glavan F, Behm-Ansmant I, Izaurralde E, Conti E |title=Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. |journal=EMBO J. |volume=25 |issue= 21 |pages= 5117-25 |year= 2007 |pmid= 17053788 |doi= 10.1038/sj.emboj.7601377 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=23381}}
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{{protein-stub}}
{{gene-1-stub}}
{{WikiDoc Sources}}

Latest revision as of 06:41, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein SMG5 is a protein that in humans is encoded by the SMG5 gene.[1][2][3] This protein contains a PIN domain that appears to have mutated the residues in the active site.[4]


References

  1. ↑ Reichenbach P, Hoss M, Azzalin CM, Nabholz M, Bucher P, Lingner J (Apr 2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed". Curr Biol. 13 (7): 568–74. doi:10.1016/S0960-9822(03)00173-8. PMID 12676087.
  2. ↑ Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (Apr 2003). "Functional conservation of the telomerase protein Est1p in humans". Curr Biol. 13 (8): 698–704. doi:10.1016/S0960-9822(03)00210-0. PMID 12699629.
  3. ↑ "Entrez Gene: SMG5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)".
  4. ↑ Glavan F, Behm-Ansmant I, Izaurralde E, Conti E (November 2006). "Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex". EMBO J. 25 (21): 5117–25. doi:10.1038/sj.emboj.7601377. PMC 1630413. PMID 17053788.

Further reading



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