OVGP1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Oviduct-specific glycoprotein''' also known as '''oviductal glycoprotein''' (OGP) or '''estrogen-dependent oviduct protein''' (EGP) or '''mucin-9''' (MUC9) is a [[protein]] that in humans is encoded by the ''OVGP1'' [[gene]].<ref name="pmid7819450">{{cite journal |vauthors=Arias EB, Verhage HG, Jaffe RC | title = Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein | journal = Biol Reprod | volume = 51 | issue = 4 | pages = 685–94 |date=Feb 1995 | pmid = 7819450 | pmc =  | doi =10.1095/biolreprod51.4.685  }}</ref><ref name="pmid9341614">{{cite journal |vauthors=Lapensee L, Paquette Y, Bleau G | title = Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9) | journal = Fertil Steril | volume = 68 | issue = 4 | pages = 702–8 |date=Nov 1997 | pmid = 9341614 | pmc =  | doi =10.1016/S0015-0282(97)00317-8  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5016| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)
| HGNCid = 8524
| Symbol = OVGP1
| AltSymbols =; EGP; CHIT5; MUC9; OGP
| OMIM = 603578
| ECnumber = 
| Homologene = 74442
| MGIid = 106661
| GeneAtlas_image1 = PBB_GE_OVGP1_205432_at_tn.png
| Function = {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0004568 |text = chitinase activity}} {{GNF_GO|id=GO:0043169 |text = cation binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006032 |text = chitin catabolic process}} {{GNF_GO|id=GO:0007338 |text = single fertilization}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5016
    | Hs_Ensembl = ENSG00000085465
    | Hs_RefseqProtein = NP_002548
    | Hs_RefseqmRNA = NM_002557
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 111758459
    | Hs_GenLoc_end = 111771922
    | Hs_Uniprot = Q12889
    | Mm_EntrezGene = 12659
    | Mm_Ensembl = ENSMUSG00000074340
    | Mm_RefseqmRNA = NM_007696
    | Mm_RefseqProtein = NP_031722
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 106101858
    | Mm_GenLoc_end = 106115479
    | Mm_Uniprot = Q54AJ4
  }}
}}
'''Oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)''', also known as '''OVGP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5016| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Oviduct-specific glycoprotein is a large, carbohydrate-rich, [[epithelium|epithelial]] [[glycoprotein]] with numerous O-glycosylation sites located within [[threonine]], [[serine]], and [[proline]]-rich tandem repeats. The gene is similar to members of the [[mucin]] and the [[List of glycoside hydrolase families#Family 18|glycosyl hydrolase 18]] gene families. Regulation of expression may be [[estrogen]]-dependent. Gene expression and protein secretion occur during late [[ovarian follicle|follicular]] development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated [[oviduct]]al epithelial cells and associates with ovulated [[oocyte]]s, [[blastomere]]s, and spermatozoon [[acrosome|acrosomal]] regions.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions.<ref name="entrez">{{cite web | title = Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5016| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Verhage HG, Fazleabas AT, Donnelly K |title=The in vitro synthesis and release of proteins by the human oviduct |journal=Endocrinology |volume=122 |issue= 4 |pages= 1639–45 |year= 1988 |pmid= 3278893 |doi=10.1210/endo-122-4-1639 }}
| citations =
*{{cite journal  |vauthors=Iontcheva I, Oppenheim FG, Troxler RF |title=Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins |journal=J. Dent. Res. |volume=76 |issue= 3 |pages= 734–43 |year= 1997 |pmid= 9109822 |doi=10.1177/00220345970760030501 }}
*{{cite journal  | author=Verhage HG, Fazleabas AT, Donnelly K |title=The in vitro synthesis and release of proteins by the human oviduct. |journal=Endocrinology |volume=122 |issue= 4 |pages= 1639-45 |year= 1988 |pmid= 3278893 |doi= }}
*{{cite journal  |vauthors=Iontcheva I, Oppenheim FG, Offner GD, Troxler RF |title=Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system |journal=J. Dent. Res. |volume=79 |issue= 2 |pages= 732–9 |year= 2000 |pmid= 10728974 |doi=10.1177/00220345000790020601 }}
*{{cite journal  | author=Arias EB, Verhage HG, Jaffe RC |title=Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein. |journal=Biol. Reprod. |volume=51 |issue= 4 |pages= 685-94 |year= 1995 |pmid= 7819450 |doi= }}
*{{cite journal  |vauthors=Agarwal A, Yeung WS, Lee KF |title=Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter |journal=Mol. Hum. Reprod. |volume=8 |issue= 2 |pages= 167–75 |year= 2002 |pmid= 11818519 |doi=10.1093/molehr/8.2.167 }}
*{{cite journal  | author=Iontcheva I, Oppenheim FG, Troxler RF |title=Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins. |journal=J. Dent. Res. |volume=76 |issue= 3 |pages= 734-43 |year= 1997 |pmid= 9109822 |doi= }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Lapensée L, Paquette Y, Bleau G |title=Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9). |journal=Fertil. Steril. |volume=68 |issue= 4 |pages= 702-8 |year= 1997 |pmid= 9341614 |doi= }}
*{{cite journal  |vauthors=Lok IH, Briton-Jones CM, Yuen PM, Haines CJ |title=Variable expression of oviductin mRNA at different stages of human reproductive cycle |journal=J. Assist. Reprod. Genet. |volume=19 |issue= 12 |pages= 569–76 |year= 2003 |pmid= 12503889 |doi=10.1023/A:1021263132176 |pmc=3455833}}
*{{cite journal  | author=Iontcheva I, Oppenheim FG, Offner GD, Troxler RF |title=Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system. |journal=J. Dent. Res. |volume=79 |issue= 2 |pages= 732-9 |year= 2000 |pmid= 10728974 |doi=  }}
*{{cite journal  |vauthors=Chen Q, Zhang J, Sweet F |title=Homology of primate DNA fragments for estrous-associated oviductal glycoprotein |journal=Hereditas |volume=139 |issue= 1 |pages= 75–9 |year= 2004 |pmid= 14641477 |doi=10.1111/j.1601-5223.2003.01640.x }}
*{{cite journal  | author=Agarwal A, Yeung WS, Lee KF |title=Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter. |journal=Mol. Hum. Reprod. |volume=8 |issue= 2 |pages= 167-75 |year= 2002 |pmid= 11818519 |doi=  }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Woo MM |title=Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer |journal=Clin. Cancer Res. |volume=10 |issue= 23 |pages= 7958–64 |year= 2005 |pmid= 15585630 |doi= 10.1158/1078-0432.CCR-04-1261 |name-list-format=vanc| author2=Alkushi A  | author3=Verhage HG  | display-authors=3  | last4=Magliocco  | first4=AM  | last5=Leung  | first5=PC  | last6=Gilks  | first6=CB  | last7=Auersperg  | first7=N }}
*{{cite journal  | author=Lok IH, Briton-Jones CM, Yuen PM, Haines CJ |title=Variable expression of oviductin mRNA at different stages of human reproductive cycle. |journal=J. Assist. Reprod. Genet. |volume=19 |issue= 12 |pages= 569-76 |year= 2003 |pmid= 12503889 |doi= }}
*{{cite journal  | author=Ling L |title=Expression of human oviductin in an immortalized human oviductal cell line |journal=Fertil. Steril. |volume=84 Suppl 2 |issue=  |pages= 1095–103 |year= 2006 |pmid= 16209999 |doi= 10.1016/j.fertnstert.2005.06.006 |name-list-format=vanc| author2=Lee YL  | author3=Lee KF  | display-authors=3  | last4=Tsao  | first4=Sai-Wah  | last5=Yeung  | first5=William S.B.  | last6=Kan  | first6=Frederick W.K. }}
*{{cite journal  | author=Chen Q, Zhang J, Sweet F |title=Homology of primate DNA fragments for estrous-associated oviductal glycoprotein. |journal=Hereditas |volume=139 |issue= 1 |pages= 75-9 |year= 2004 |pmid= 14641477 |doi=  }}
*{{cite journal  |vauthors=Kadam KM, D'Souza SJ, Bandivdekar AH, Natraj U |title=Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9 |journal=Mol. Hum. Reprod. |volume=12 |issue= 4 |pages= 275–82 |year= 2006 |pmid= 16567366 |doi= 10.1093/molehr/gal028 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gregory SG |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |name-list-format=vanc| author2=Barlow KF  | author3=McLay KE  | display-authors=3  | last4=Kaul  | first4=R.  | last5=Swarbreck  | first5=D.  | last6=Dunham  | first6=A.  | last7=Scott  | first7=C. E.  | last8=Howe  | first8=K. L.  | last9=Woodfine  | first9=K. }}
*{{cite journal  | author=Woo MM, Alkushi A, Verhage HG, ''et al.'' |title=Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 23 |pages= 7958-64 |year= 2005 |pmid= 15585630 |doi= 10.1158/1078-0432.CCR-04-1261 }}
*{{cite journal  | author=Ling L, Lee YL, Lee KF, ''et al.'' |title=Expression of human oviductin in an immortalized human oviductal cell line. |journal=Fertil. Steril. |volume=84 Suppl 2 |issue=  |pages= 1095-103 |year= 2006 |pmid= 16209999 |doi= 10.1016/j.fertnstert.2005.06.006 }}
*{{cite journal  | author=Kadam KM, D'Souza SJ, Bandivdekar AH, Natraj U |title=Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9. |journal=Mol. Hum. Reprod. |volume=12 |issue= 4 |pages= 275-82 |year= 2006 |pmid= 16567366 |doi= 10.1093/molehr/gal028 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-1-stub}}

Revision as of 00:43, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Oviduct-specific glycoprotein also known as oviductal glycoprotein (OGP) or estrogen-dependent oviduct protein (EGP) or mucin-9 (MUC9) is a protein that in humans is encoded by the OVGP1 gene.[1][2][3]

Function

Oviduct-specific glycoprotein is a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoon acrosomal regions.[3]

References

  1. ↑ Arias EB, Verhage HG, Jaffe RC (Feb 1995). "Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein". Biol Reprod. 51 (4): 685–94. doi:10.1095/biolreprod51.4.685. PMID 7819450.
  2. ↑ Lapensee L, Paquette Y, Bleau G (Nov 1997). "Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9)". Fertil Steril. 68 (4): 702–8. doi:10.1016/S0015-0282(97)00317-8. PMID 9341614.
  3. ↑ 3.0 3.1 "Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)".

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=OVGP1&oldid=1411309"