VAMP4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Vesicle-associated membrane protein 4''' is a [[protein]] that in humans is encoded by the ''VAMP4'' [[gene]].<ref name="pmid9553086">{{cite journal | vauthors = Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH | title = Seven novel mammalian SNARE proteins localize to distinct membrane compartments | journal = The Journal of Biological Chemistry | volume = 273 | issue = 17 | pages = 10317–24 | date = Apr 1998 | pmid = 9553086 | pmc = | doi = 10.1074/jbc.273.17.10317 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VAMP4 vesicle-associated membrane protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8674| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_VAMP4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2nps.
| PDB = {{PDB2|2nps}}
| Name = Vesicle-associated membrane protein 4
| HGNCid = 12645
| Symbol = VAMP4
| AltSymbols =; VAMP24
| OMIM = 606909
| ECnumber = 
| Homologene = 37847
| MGIid = 1858730
| GeneAtlas_image1 = PBB_GE_VAMP4_207350_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_VAMP4_213480_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8674
    | Hs_Ensembl = ENSG00000117533
    | Hs_RefseqProtein = NP_003753
    | Hs_RefseqmRNA = NM_003762
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 169935923
    | Hs_GenLoc_end = 169977837
    | Hs_Uniprot = O75379
    | Mm_EntrezGene = 53330
    | Mm_Ensembl = ENSMUSG00000026696
    | Mm_RefseqmRNA = NM_016796
    | Mm_RefseqProtein = NP_058076
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 164407398
    | Mm_GenLoc_end = 164435753
    | Mm_Uniprot = Q9D095
  }}
}}
'''Vesicle-associated membrane protein 4''', also known as '''VAMP4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VAMP4 vesicle-associated membrane protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8674| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport.<ref name="entrez">{{cite web | title = Entrez Gene: VAMP4 vesicle-associated membrane protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8674| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
VAMP4 has been shown to [[Protein-protein interaction|interact]] with [[AP1M1]],<ref name=pmid14608369>{{cite journal | vauthors = Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA | title = AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1 | journal = EMBO Reports | volume = 4 | issue = 12 | pages = 1182–9 | date = Dec 2003 | pmid = 14608369 | pmc = 1326413 | doi = 10.1038/sj.embor.7400018 }}</ref> [[STX6]]<ref name=pmid11839770>{{cite journal | vauthors = Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L | title = Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform | journal = The Journal of Cell Biology | volume = 156 | issue = 4 | pages = 653–64 | date = Feb 2002 | pmid = 11839770 | pmc = 2174079 | doi = 10.1083/jcb.200110081 }}</ref> and [[STX16]].<ref name=pmid11839770/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = Apr 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
| citations =
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = Apr 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Steegmaier M, Klumperman J, Foletti DL, Yoo JS, Scheller RH | title = Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking | journal = Molecular Biology of the Cell | volume = 10 | issue = 6 | pages = 1957–72 | date = Jun 1999 | pmid = 10359608 | pmc = 25394 | doi = 10.1091/mbc.10.6.1957 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
* {{cite journal | vauthors = Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH | title = SNAREs contribute to the specificity of membrane fusion | journal = Neuron | volume = 26 | issue = 2 | pages = 457–64 | date = May 2000 | pmid = 10839363 | doi = 10.1016/S0896-6273(00)81177-0 }}
*{{cite journal  | author=Advani RJ, Bae HR, Bock JB, ''et al.'' |title=Seven novel mammalian SNARE proteins localize to distinct membrane compartments. |journal=J. Biol. Chem. |volume=273 |issue= 17 |pages= 10317-24 |year= 1998 |pmid= 9553086 |doi=  }}
* {{cite journal | vauthors = Peden AA, Park GY, Scheller RH | title = The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding | journal = The Journal of Biological Chemistry | volume = 276 | issue = 52 | pages = 49183–7 | date = Dec 2001 | pmid = 11598115 | doi = 10.1074/jbc.M106646200 }}
*{{cite journal | author=Steegmaier M, Klumperman J, Foletti DL, ''et al.'' |title=Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking. |journal=Mol. Biol. Cell |volume=10 |issue= 6 |pages= 1957-72 |year= 1999 |pmid= 10359608 |doi= }}
* {{cite journal | vauthors = Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L | title = Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform | journal = The Journal of Cell Biology | volume = 156 | issue = 4 | pages = 653–64 | date = Feb 2002 | pmid = 11839770 | pmc = 2174079 | doi = 10.1083/jcb.200110081 }}
*{{cite journal | author=Scales SJ, Chen YA, Yoo BY, ''et al.'' |title=SNAREs contribute to the specificity of membrane fusion. |journal=Neuron |volume=26 |issue= 2 |pages= 457-64 |year= 2000 |pmid= 10839363 |doi= }}
* {{cite journal | vauthors = Zeng Q, Tran TT, Tan HX, Hong W | title = The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network | journal = The Journal of Biological Chemistry | volume = 278 | issue = 25 | pages = 23046–54 | date = Jun 2003 | pmid = 12682051 | doi = 10.1074/jbc.M303214200 }}
*{{cite journal | author=Peden AA, Park GY, Scheller RH |title=The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding. |journal=J. Biol. Chem. |volume=276 |issue= 52 |pages= 49183-7 |year= 2002 |pmid= 11598115 |doi= 10.1074/jbc.M106646200 }}
* {{cite journal | vauthors = Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA | title = AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1 | journal = EMBO Reports | volume = 4 | issue = 12 | pages = 1182–9 | date = Dec 2003 | pmid = 14608369 | pmc = 1326413 | doi = 10.1038/sj.embor.7400018 }}
*{{cite journal | author=Mallard F, Tang BL, Galli T, ''et al.'' |title=Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. |journal=J. Cell Biol. |volume=156 |issue= 4 |pages= 653-64 |year= 2002 |pmid= 11839770 |doi= 10.1083/jcb.200110081 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Zeng Q, Tran TT, Tan HX, Hong W |title=The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 23046-54 |year= 2003 |pmid= 12682051 |doi= 10.1074/jbc.M303214200 }}
*{{cite journal | author=Hinners I, Wendler F, Fei H, ''et al.'' |title=AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1. |journal=EMBO Rep. |volume=4 |issue= 12 |pages= 1182-9 |year= 2004 |pmid= 14608369 |doi= 10.1038/sj.embor.7400018 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=8674}}


{{protein-stub}}
{{gene-1-stub}}
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Latest revision as of 15:28, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Vesicle-associated membrane protein 4 is a protein that in humans is encoded by the VAMP4 gene.[1][2]

Function

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport.[2]

Interactions

VAMP4 has been shown to interact with AP1M1,[3] STX6[4] and STX16.[4]

References

  1. ↑ Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH (Apr 1998). "Seven novel mammalian SNARE proteins localize to distinct membrane compartments". The Journal of Biological Chemistry. 273 (17): 10317–24. doi:10.1074/jbc.273.17.10317. PMID 9553086.
  2. ↑ 2.0 2.1 "Entrez Gene: VAMP4 vesicle-associated membrane protein 4".
  3. ↑ Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Reports. 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. PMC 1326413. PMID 14608369.
  4. ↑ 4.0 4.1 Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.

Further reading

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