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{{ | '''Alpha-amylase 1''' is an [[enzyme]] that in humans is encoded by the ''AMY1A'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AMY1A amylase, alpha 1A; salivary| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=276| accessdate = }}</ref> This gene is found in many organisms, see [[Alpha-Amylase]]. | ||
}} | |||
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| summary_text = Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: AMY1A amylase, alpha 1A; salivary| url = | | summary_text = Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: AMY1A amylase, alpha 1A; salivary| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=276| accessdate = }}</ref> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|AMY1A}} | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Bank RA, Hettema EH, Arwert F |title=Electrophoretic characterization of posttranslational modifications of human parotid salivary alpha-amylase. |journal=Electrophoresis |volume=12 |issue= 1 |pages= 74–9 |year= 1991 |pmid= 1710976 |doi= 10.1002/elps.1150120114 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Groot PC, Mager WH, Henriquez NV |title=Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers. |journal=Genomics |volume=8 |issue= 1 |pages= 97–105 |year= 1991 |pmid= 2081604 |doi=10.1016/0888-7543(90)90230-R |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Nishide T, Nakamura Y, Emi M |title=Primary structure of human salivary alpha-amylase gene. |journal=Gene |volume=41 |issue= 2–3 |pages= 299–304 |year= 1986 |pmid= 2423416 |doi=10.1016/0378-1119(86)90110-1 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Davis MM, Hodes ME, Munsick RA |title=Pancreatic amylase expression in human pancreatic development |journal=Hybridoma |volume=5 |issue= 2 |pages= 137–45 |year= 1986 |pmid= 2424823 |doi=10.1089/hyb.1986.5.137 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Handy DE, Larsen SH, Karn RC, Hodes ME |title=Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1 |journal=Mol. Biol. Med. |volume=4 |issue= 3 |pages= 145–55 |year= 1987 |pmid= 2442579 |doi= }} | ||
*{{cite journal | | *{{cite journal | vauthors=Horii A, Emi M, Tomita N |title=Primary structure of human pancreatic alpha-amylase gene: its comparison with human salivary alpha-amylase gene |journal=Gene |volume=60 |issue= 1 |pages= 57–64 |year= 1988 |pmid= 2450054 |doi=10.1016/0378-1119(87)90213-7 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Gumucio DL, Wiebauer K, Caldwell RM |title=Concerted evolution of human amylase genes |journal=Mol. Cell. Biol. |volume=8 |issue= 3 |pages= 1197–205 |year= 1988 |pmid= 2452973 |doi= | pmc=363264 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH |title=Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene |journal=Nucleic Acids Res. |volume=16 |issue= 17 |pages= 8261–76 |year= 1988 |pmid= 2458567 |doi=10.1093/nar/16.17.8261 | pmc=338557 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Groot PC, Bleeker MJ, Pronk JC |title=The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes |journal=Genomics |volume=5 |issue= 1 |pages= 29–42 |year= 1989 |pmid= 2788608 |doi=10.1016/0888-7543(89)90083-9 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Pronk JC, Frants RR, Jansen W |title=Evidence of duplication of the human salivary amylase gene |journal=Hum. Genet. |volume=60 |issue= 1 |pages= 32–5 |year= 1982 |pmid= 6176528 |doi=10.1007/BF00281260 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Zabel BU, Naylor SL, Sakaguchi AY |title=High-resolution chromosomal localization of human genes for amylase, proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=80 |issue= 22 |pages= 6932–6 |year= 1984 |pmid= 6196780 |doi=10.1073/pnas.80.22.6932 | pmc=390100 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Tricoli JV, Shows TB |title=Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1 |journal=Somat. Cell Mol. Genet. |volume=10 |issue= 2 |pages= 205–10 |year= 1984 |pmid= 6608795 |doi=10.1007/BF01534909 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Nishide T, Emi M, Nakamura Y, Matsubara K |title=Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases [corrected] |journal=Gene |volume=28 |issue= 2 |pages= 263–70 |year= 1984 |pmid= 6610603 |doi=10.1016/0378-1119(84)90265-8 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Seyama K, Nukiwa T, Takahashi K |title=Amylase mRNA transcripts in normal tissues and neoplasms: the implication of different expressions of amylase isogenes |journal=J. Cancer Res. Clin. Oncol. |volume=120 |issue= 4 |pages= 213–20 |year= 1994 |pmid= 7507116 |doi=10.1007/BF01372559 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Ragunath C, Sundar K, Ramasubbu N |title=Expression, characterization, and biochemical properties of recombinant human salivary amylase |journal=Protein Expr. Purif. |volume=24 |issue= 2 |pages= 202–11 |year= 2002 |pmid= 11858714 |doi= 10.1006/prep.2001.1559 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Hokari S, Miura K, Koyama I |title=A restriction endonuclease assay for expression of human alpha-amylase isozymes |journal=Clin. Chim. Acta |volume=322 |issue= 1–2 |pages= 113–6 |year= 2002 |pmid= 12104089 |doi=10.1016/S0009-8981(02)00161-4 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H |title=AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50885–92 |year= 2003 |pmid= 12414807 |doi= 10.1074/jbc.M206387200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Ramasubbu N, Ragunath C, Mishra PJ |title=Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase |journal=J. Mol. Biol. |volume=325 |issue= 5 |pages= 1061–76 |year= 2003 |pmid= 12527308 |doi=10.1016/S0022-2836(02)01326-8 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Kandra L, Gyémánt G, Remenyik J |title=Subsite mapping of human salivary alpha-amylase and the mutant Y151M |journal=FEBS Lett. |volume=544 |issue= 1–3 |pages= 194–8 |year= 2003 |pmid= 12782315 |doi=10.1016/S0014-5793(03)00495-2 |display-authors=etal}} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=276}} | |||
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Revision as of 18:00, 29 August 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Alpha-amylase 1 is an enzyme that in humans is encoded by the AMY1A gene.[1] This gene is found in many organisms, see Alpha-Amylase.
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein.[1]
References
External links
- Human AMY1A genome location and AMY1A gene details page in the UCSC Genome Browser.
Further reading
- Bank RA, Hettema EH, Arwert F, et al. (1991). "Electrophoretic characterization of posttranslational modifications of human parotid salivary alpha-amylase". Electrophoresis. 12 (1): 74–9. doi:10.1002/elps.1150120114. PMID 1710976.
- Groot PC, Mager WH, Henriquez NV, et al. (1991). "Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers". Genomics. 8 (1): 97–105. doi:10.1016/0888-7543(90)90230-R. PMID 2081604.
- Nishide T, Nakamura Y, Emi M, et al. (1986). "Primary structure of human salivary alpha-amylase gene". Gene. 41 (2–3): 299–304. doi:10.1016/0378-1119(86)90110-1. PMID 2423416.
- Davis MM, Hodes ME, Munsick RA, et al. (1986). "Pancreatic amylase expression in human pancreatic development". Hybridoma. 5 (2): 137–45. doi:10.1089/hyb.1986.5.137. PMID 2424823.
- Handy DE, Larsen SH, Karn RC, Hodes ME (1987). "Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1". Mol. Biol. Med. 4 (3): 145–55. PMID 2442579.
- Horii A, Emi M, Tomita N, et al. (1988). "Primary structure of human pancreatic alpha-amylase gene: its comparison with human salivary alpha-amylase gene". Gene. 60 (1): 57–64. doi:10.1016/0378-1119(87)90213-7. PMID 2450054.
- Gumucio DL, Wiebauer K, Caldwell RM, et al. (1988). "Concerted evolution of human amylase genes". Mol. Cell. Biol. 8 (3): 1197–205. PMC 363264. PMID 2452973.
- Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH (1988). "Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene". Nucleic Acids Res. 16 (17): 8261–76. doi:10.1093/nar/16.17.8261. PMC 338557. PMID 2458567.
- Groot PC, Bleeker MJ, Pronk JC, et al. (1989). "The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes". Genomics. 5 (1): 29–42. doi:10.1016/0888-7543(89)90083-9. PMID 2788608.
- Pronk JC, Frants RR, Jansen W, et al. (1982). "Evidence of duplication of the human salivary amylase gene". Hum. Genet. 60 (1): 32–5. doi:10.1007/BF00281260. PMID 6176528.
- Zabel BU, Naylor SL, Sakaguchi AY, et al. (1984). "High-resolution chromosomal localization of human genes for amylase, proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization". Proc. Natl. Acad. Sci. U.S.A. 80 (22): 6932–6. doi:10.1073/pnas.80.22.6932. PMC 390100. PMID 6196780.
- Tricoli JV, Shows TB (1984). "Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1". Somat. Cell Mol. Genet. 10 (2): 205–10. doi:10.1007/BF01534909. PMID 6608795.
- Nishide T, Emi M, Nakamura Y, Matsubara K (1984). "Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases [corrected]". Gene. 28 (2): 263–70. doi:10.1016/0378-1119(84)90265-8. PMID 6610603.
- Seyama K, Nukiwa T, Takahashi K, et al. (1994). "Amylase mRNA transcripts in normal tissues and neoplasms: the implication of different expressions of amylase isogenes". J. Cancer Res. Clin. Oncol. 120 (4): 213–20. doi:10.1007/BF01372559. PMID 7507116.
- Ragunath C, Sundar K, Ramasubbu N (2002). "Expression, characterization, and biochemical properties of recombinant human salivary amylase". Protein Expr. Purif. 24 (2): 202–11. doi:10.1006/prep.2001.1559. PMID 11858714.
- Hokari S, Miura K, Koyama I, et al. (2002). "A restriction endonuclease assay for expression of human alpha-amylase isozymes". Clin. Chim. Acta. 322 (1–2): 113–6. doi:10.1016/S0009-8981(02)00161-4. PMID 12104089.
- Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (2003). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem. 277 (52): 50885–92. doi:10.1074/jbc.M206387200. PMID 12414807.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ramasubbu N, Ragunath C, Mishra PJ (2003). "Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase". J. Mol. Biol. 325 (5): 1061–76. doi:10.1016/S0022-2836(02)01326-8. PMID 12527308.
- Kandra L, Gyémánt G, Remenyik J, et al. (2003). "Subsite mapping of human salivary alpha-amylase and the mutant Y151M". FEBS Lett. 544 (1–3): 194–8. doi:10.1016/S0014-5793(03)00495-2. PMID 12782315.
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