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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Thioredoxin-interacting protein''' is a [[protein]] that in humans is encoded by the ''TXNIP'' [[gene]].<ref name="pmid8086474">{{cite journal | vauthors = Chen KS, DeLuca HF | title = Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3 | journal = Biochimica et Biophysica Acta | volume = 1219 | issue = 1 | pages = 26–32 | date = Sep 1994 | pmid = 8086474 | pmc =  | doi = 10.1016/0167-4781(94)90242-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TXNIP thioredoxin interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10628| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Thioredoxin interacting protein
| HGNCid = 16952
| Symbol = TXNIP
| AltSymbols =; EST01027; HHCPA78; THIF; VDUP1
| OMIM = 606599
| ECnumber = 
| Homologene = 38186
| MGIid = 1889549
| GeneAtlas_image1 = PBB_GE_TXNIP_201010_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TXNIP_201008_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TXNIP_201009_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004857 |text = enzyme inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006979 |text = response to oxidative stress}} {{GNF_GO|id=GO:0030216 |text = keratinocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10628
    | Hs_Ensembl = ENSG00000117289
    | Hs_RefseqProtein = NP_006463
    | Hs_RefseqmRNA = NM_006472
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 144149826
    | Hs_GenLoc_end = 144153992
    | Hs_Uniprot = Q9H3M7
    | Mm_EntrezGene = 56338
    | Mm_Ensembl = ENSMUSG00000038393
    | Mm_RefseqmRNA = NM_001009935
    | Mm_RefseqProtein = NP_001009935
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 96643362
    | Mm_GenLoc_end = 96655007
    | Mm_Uniprot = Q91X82
  }}
}}
'''Thioredoxin interacting protein''', also known as '''TXNIP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TXNIP thioredoxin interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10628| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
TXNIP has been shown to [[Protein-protein interaction|interact]] with [[Thioredoxin]]<ref name=pmid10419473>{{cite journal | vauthors = Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J | title = Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression | journal = The Journal of Biological Chemistry | volume = 274 | issue = 31 | pages = 21645–50 | date = Jul 1999 | pmid = 10419473 | doi = 10.1074/jbc.274.31.21645 }}</ref> and [[ZBTB32]].<ref name=pmid12821938>{{cite journal | vauthors = Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I | title = VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression | journal = Oncogene | volume = 22 | issue = 26 | pages = 4035–46 | date = Jun 2003 | pmid = 12821938 | doi = 10.1038/sj.onc.1206610 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
==Related gene problems==
{{reflist|2}}
*[[TAR syndrome]]
==Further reading==
*[[1q21.1 deletion syndrome]]
*[[1q21.1 duplication syndrome]]
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J | title = Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression | journal = The Journal of Biological Chemistry | volume = 274 | issue = 31 | pages = 21645–50 | date = Jul 1999 | pmid = 10419473 | doi = 10.1074/jbc.274.31.21645 }}
| citations =
* {{cite journal | vauthors = Ludwig DL, Kotanides H, Le T, Chavkin D, Bohlen P, Witte L | title = Cloning, genetic characterization, and chromosomal mapping of the mouse VDUP1 gene | journal = Gene | volume = 269 | issue = 1-2 | pages = 103–12 | date = May 2001 | pmid = 11376942 | doi = 10.1016/S0378-1119(01)00455-3 }}
*{{cite journal | author=Chen KS, DeLuca HF |title=Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3. |journal=Biochim. Biophys. Acta |volume=1219 |issue= 1 |pages= 26-32 |year= 1994 |pmid= 8086474 |doi=  }}
* {{cite journal | vauthors = Bodnar JS, Chatterjee A, Castellani LW, Ross DA, Ohmen J, Cavalcoli J, Wu C, Dains KM, Catanese J, Chu M, Sheth SS, Charugundla K, Demant P, West DB, de Jong P, Lusis AJ | title = Positional cloning of the combined hyperlipidemia gene Hyplip1 | journal = Nature Genetics | volume = 30 | issue = 1 | pages = 110–6 | date = Jan 2002 | pmid = 11753387 | pmc = 2846781 | doi = 10.1038/ng811 }}
*{{cite journal  | author=Nishiyama A, Matsui M, Iwata S, ''et al.'' |title=Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression. |journal=J. Biol. Chem. |volume=274 |issue= 31 |pages= 21645-50 |year= 1999 |pmid= 10419473 |doi= }}
* {{cite journal | vauthors = Joguchi A, Otsuka I, Minagawa S, Suzuki T, Fujii M, Ayusawa D | title = Overexpression of VDUP1 mRNA sensitizes HeLa cells to paraquat | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 1 | pages = 293–7 | date = Apr 2002 | pmid = 12054598 | doi = 10.1016/S0006-291X(02)00208-5 }}
*{{cite journal | author=Ludwig DL, Kotanides H, Le T, ''et al.'' |title=Cloning, genetic characterization, and chromosomal mapping of the mouse VDUP1 gene. |journal=Gene |volume=269 |issue= 1-2 |pages= 103-12 |year= 2001 |pmid= 11376942 |doi= }}
* {{cite journal | vauthors = Butler LM, Zhou X, Xu WS, Scher HI, Rifkind RA, Marks PA, Richon VM | title = The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 18 | pages = 11700–5 | date = Sep 2002 | pmid = 12189205 | pmc = 129332 | doi = 10.1073/pnas.182372299 }}
*{{cite journal | author=Bodnar JS, Chatterjee A, Castellani LW, ''et al.'' |title=Positional cloning of the combined hyperlipidemia gene Hyplip1. |journal=Nat. Genet. |volume=30 |issue= 1 |pages= 110-6 |year= 2002 |pmid= 11753387 |doi= 10.1038/ng811 }}
* {{cite journal | vauthors = Schulze PC, De Keulenaer GW, Yoshioka J, Kassik KA, Lee RT | title = Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin | journal = Circulation Research | volume = 91 | issue = 8 | pages = 689–95 | date = Oct 2002 | pmid = 12386145 | doi = 10.1161/01.RES.0000037982.55074.F6 }}
*{{cite journal | author=Joguchi A, Otsuka I, Minagawa S, ''et al.'' |title=Overexpression of VDUP1 mRNA sensitizes HeLa cells to paraquat. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 1 |pages= 293-7 |year= 2002 |pmid= 12054598 |doi= 10.1016/S0006-291X(02)00208-5 }}
* {{cite journal | vauthors = Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I | title = VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression | journal = Oncogene | volume = 22 | issue = 26 | pages = 4035–46 | date = Jun 2003 | pmid = 12821938 | doi = 10.1038/sj.onc.1206610 }}
*{{cite journal | author=Butler LM, Zhou X, Xu WS, ''et al.'' |title=The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 18 |pages= 11700-5 |year= 2002 |pmid= 12189205 |doi= 10.1073/pnas.182372299 }}
* {{cite journal | vauthors = Champliaud MF, Viel A, Baden HP | title = The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes | journal = The Journal of Investigative Dermatology | volume = 121 | issue = 4 | pages = 781–5 | date = Oct 2003 | pmid = 14632196 | doi = 10.1046/j.1523-1747.2003.12539.x }}
*{{cite journal | author=Schulze PC, De Keulenaer GW, Yoshioka J, ''et al.'' |title=Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin. |journal=Circ. Res. |volume=91 |issue= 8 |pages= 689-95 |year= 2002 |pmid= 12386145 |doi= }}
* {{cite journal | vauthors = Kim KY, Shin SM, Kim JK, Paik SG, Yang Y, Choi I | title = Heat shock factor regulates VDUP1 gene expression | journal = Biochemical and Biophysical Research Communications | volume = 315 | issue = 2 | pages = 369–75 | date = Mar 2004 | pmid = 14766217 | doi = 10.1016/j.bbrc.2004.01.047 }}
*{{cite journal | author=Han SH, Jeon JH, Ju HR, ''et al.'' |title=VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. |journal=Oncogene |volume=22 |issue= 26 |pages= 4035-46 |year= 2003 |pmid= 12821938 |doi= 10.1038/sj.onc.1206610 }}
* {{cite journal | vauthors = Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT | title = Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein | journal = The Journal of Biological Chemistry | volume = 279 | issue = 29 | pages = 30369–74 | date = Jul 2004 | pmid = 15128745 | doi = 10.1074/jbc.M400549200 }}
*{{cite journal | author=Champliaud MF, Viel A, Baden HP |title=The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes. |journal=J. Invest. Dermatol. |volume=121 |issue= 4 |pages= 781-5 |year= 2003 |pmid= 14632196 |doi= 10.1046/j.1523-1747.2003.12539.x }}
* {{cite journal | vauthors = Coon H, Singh N, Dunn D, Eckfeldt JH, Province MA, Hopkins PN, Weiss R, Hunt SC, Leppert MF | title = TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study | journal = Atherosclerosis | volume = 174 | issue = 2 | pages = 357–62 | date = Jun 2004 | pmid = 15136067 | doi = 10.1016/j.atherosclerosis.2004.02.004 }}
*{{cite journal | author=Kim KY, Shin SM, Kim JK, ''et al.'' |title=Heat shock factor regulates VDUP1 gene expression. |journal=Biochem. Biophys. Res. Commun. |volume=315 |issue= 2 |pages= 369-75 |year= 2004 |pmid= 14766217 |doi= 10.1016/j.bbrc.2004.01.047 }}
* {{cite journal | vauthors = Nishinaka Y, Masutani H, Oka S, Matsuo Y, Yamaguchi Y, Nishio K, Ishii Y, Yodoi J | title = Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 36 | pages = 37559–65 | date = Sep 2004 | pmid = 15234975 | doi = 10.1074/jbc.M405473200 }}
*{{cite journal | author=Schulze PC, Yoshioka J, Takahashi T, ''et al.'' |title=Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. |journal=J. Biol. Chem. |volume=279 |issue= 29 |pages= 30369-74 |year= 2004 |pmid= 15128745 |doi= 10.1074/jbc.M400549200 }}
* {{cite journal | vauthors = Aitken CJ, Hodge JM, Nishinaka Y, Vaughan T, Yodoi J, Day CJ, Morrison NA, Nicholson GC | title = Regulation of human osteoclast differentiation by thioredoxin binding protein-2 and redox-sensitive signaling | journal = Journal of Bone and Mineral Research | volume = 19 | issue = 12 | pages = 2057–64 | date = Dec 2004 | pmid = 15537450 | doi = 10.1359/JBMR.040913 }}
*{{cite journal | author=Coon H, Singh N, Dunn D, ''et al.'' |title=TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study. |journal=Atherosclerosis |volume=174 |issue= 2 |pages= 357-62 |year= 2004 |pmid= 15136067 |doi= 10.1016/j.atherosclerosis.2004.02.004 }}
* {{cite journal | vauthors = Yamawaki H, Pan S, Lee RT, Berk BC | title = Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells | journal = The Journal of Clinical Investigation | volume = 115 | issue = 3 | pages = 733–8 | date = Mar 2005 | pmid = 15696199 | pmc = 546457 | doi = 10.1172/JCI23001 }}
*{{cite journal | author=Nishinaka Y, Masutani H, Oka S, ''et al.'' |title=Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1. |journal=J. Biol. Chem. |volume=279 |issue= 36 |pages= 37559-65 |year= 2004 |pmid= 15234975 |doi= 10.1074/jbc.M405473200 }}
* {{cite journal | vauthors = Minn AH, Hafele C, Shalev A | title = Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis | journal = Endocrinology | volume = 146 | issue = 5 | pages = 2397–405 | date = May 2005 | pmid = 15705778 | doi = 10.1210/en.2004-1378 }}
*{{cite journal | author=Aitken CJ, Hodge JM, Nishinaka Y, ''et al.'' |title=Regulation of human osteoclast differentiation by thioredoxin binding protein-2 and redox-sensitive signaling. |journal=J. Bone Miner. Res. |volume=19 |issue= 12 |pages= 2057-64 |year= 2005 |pmid= 15537450 |doi= 10.1359/JBMR.040913 }}
*{{cite journal | author=Yamawaki H, Pan S, Lee RT, Berk BC |title=Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells. |journal=J. Clin. Invest. |volume=115 |issue= 3 |pages= 733-8 |year= 2005 |pmid= 15696199 |doi= 10.1172/JCI200523001 }}
*{{cite journal | author=Minn AH, Hafele C, Shalev A |title=Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis. |journal=Endocrinology |volume=146 |issue= 5 |pages= 2397-405 |year= 2005 |pmid= 15705778 |doi= 10.1210/en.2004-1378 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
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Latest revision as of 12:32, 15 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.[1][2]

Interactions

TXNIP has been shown to interact with Thioredoxin[3] and ZBTB32.[4]

Related gene problems

References

  1. ↑ Chen KS, DeLuca HF (Sep 1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochimica et Biophysica Acta. 1219 (1): 26–32. doi:10.1016/0167-4781(94)90242-9. PMID 8086474.
  2. ↑ "Entrez Gene: TXNIP thioredoxin interacting protein".
  3. ↑ Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". The Journal of Biological Chemistry. 274 (31): 21645–50. doi:10.1074/jbc.274.31.21645. PMID 10419473.
  4. ↑ Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (Jun 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene. 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=TXNIP&oldid=1411866"