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{{ | '''UDP-glucuronosyltransferase 1-10''' is an [[enzyme]] that in humans is encoded by the ''UGT1A10'' [[gene]].<ref name="pmid9295054">{{cite journal |vauthors=Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW | title = The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence | journal = Pharmacogenetics | volume = 7 | issue = 4 | pages = 255–69 |date=Oct 1997 | pmid = 9295054 | pmc = | doi =10.1097/00008571-199708000-00001 }}</ref><ref name="pmid9325166">{{cite journal |vauthors=Mojarrabi B, Mackenzie PI | title = The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid | journal = Biochem Biophys Res Commun | volume = 238 | issue = 3 | pages = 775–8 |date=Oct 1997 | pmid = 9325166 | pmc = | doi = 10.1006/bbrc.1997.7388 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54575| accessdate = }}</ref> | ||
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| summary_text = This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.<ref name="entrez" | | summary_text = This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on [[mycophenolic acid]], [[coumarins]], and [[quinolines]].<ref name="entrez" /> | ||
}} | }} | ||
==Interactive pathway map== | |||
{{IrinotecanPathway_WP229|highlight=UGT1A10}} | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Tukey RH, Strassburg CP |title=Human UDP-glucuronosyltransferases: metabolism, expression, and disease |journal=Annu. Rev. Pharmacol. Toxicol. |volume=40 |issue= |pages= 581–616 |year= 2000 |pmid= 10836148 |doi= 10.1146/annurev.pharmtox.40.1.581 }} | ||
*{{cite journal |vauthors=Tukey RH, Strassburg CP |title=Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract |journal=Mol. Pharmacol. |volume=59 |issue= 3 |pages= 405–14 |year= 2001 |pmid= 11179432 |doi= }} | |||
*{{cite journal | | *{{cite journal |vauthors=King CD, Rios GR, Green MD, Tephly TR |title=UDP-glucuronosyltransferases |journal=Curr. Drug Metab. |volume=1 |issue= 2 |pages= 143–61 |year= 2001 |pmid= 11465080 |doi=10.2174/1389200003339171 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Harding D, Jeremiah SJ, Povey S, Burchell B |title=Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1 |journal=Ann. Hum. Genet. |volume=54 |issue= Pt 1 |pages= 17–21 |year= 1990 |pmid= 2108603 |doi=10.1111/j.1469-1809.1990.tb00356.x }} | ||
*{{cite journal | | *{{cite journal | author=van Es HH |title=Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37 |journal=Cytogenet. Cell Genet. |volume=63 |issue= 2 |pages= 114–6 |year= 1993 |pmid= 8467709 |doi=10.1159/000133513 |name-list-format=vanc| author2=Bout A | author3=Liu J | display-authors=3 | last4=Anderson | first4=L. | last5=Duncan | first5=A.M.V. | last6=Bosma | first6=P. | last7=Elferink | first7=Oude | last8=Jansen | first8=P.L.M. | last9=Chowdhury | first9=Roy }} | ||
*{{cite journal | author=van Es HH | *{{cite journal |vauthors=Strassburg CP, Oldhafer K, Manns MP, Tukey RH |title=Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue |journal=Mol. Pharmacol. |volume=52 |issue= 2 |pages= 212–20 |year= 1997 |pmid= 9271343 |doi= }} | ||
*{{cite journal | | *{{cite journal |vauthors=Mojarrabi B, Mackenzie PI |title=Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 3 |pages= 704–9 |year= 1998 |pmid= 9647757 |doi= 10.1006/bbrc.1998.8843 }} | ||
*{{cite journal | | *{{cite journal | author=Strassburg CP |title=Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus |journal=Biochem. J. |volume=338 |issue= 2|pages= 489–98 |year= 1999 |pmid= 10024527 |doi=10.1042/0264-6021:3380489 | pmc=1220077 |name-list-format=vanc| author2=Strassburg A | author3=Nguyen N | display-authors=3 | last4=Li | first4=Qing | last5=Manns | first5=Michael P. | last6=Tukey | first6=Robert H. }} | ||
*{{cite journal |vauthors=Cheng Z, Radominska-Pandya A, Tephly TR |title=Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10 |journal=Drug Metab. Dispos. |volume=27 |issue= 10 |pages= 1165–70 |year= 1999 |pmid= 10497143 |doi= }} | |||
*{{cite journal | author=Strassburg CP | *{{cite journal | author=Strassburg CP |title=Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 36164–71 |year= 2000 |pmid= 10748067 |doi= 10.1074/jbc.M002180200 |name-list-format=vanc| author2=Kneip S | author3=Topp J | display-authors=3 | last4=Obermayer-Straub | first4=P | last5=Barut | first5=A | last6=Tukey | first6=RH | last7=Manns | first7=MP }} | ||
*{{cite journal | | *{{cite journal | author=Gong QH |title=Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus |journal=Pharmacogenetics |volume=11 |issue= 4 |pages= 357–68 |year= 2001 |pmid= 11434514 |doi=10.1097/00008571-200106000-00011 |name-list-format=vanc| author2=Cho JW | author3=Huang T | display-authors=3 | last4=Potter | first4=Christine | last5=Gholami | first5=Nahid | last6=Basu | first6=Nikhil K. | last7=Kubota | first7=Shigeki | last8=Carvalho | first8=Sheryl | last9=Pennington | first9=Matthew W. }} | ||
*{{cite journal | author=Strassburg CP | *{{cite journal |vauthors=Zheng Z, Fang JL, Lazarus P |title=Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues |journal=Drug Metab. Dispos. |volume=30 |issue= 4 |pages= 397–403 |year= 2002 |pmid= 11901093 |doi=10.1124/dmd.30.4.397 }} | ||
*{{cite journal | author=Gong QH | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | ||
*{{cite journal | | *{{cite journal | author=Jinno H |title=Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10 |journal=Drug Metab. Dispos. |volume=31 |issue= 5 |pages= 528–32 |year= 2003 |pmid= 12695339 |doi=10.1124/dmd.31.5.528 |name-list-format=vanc| author2=Saeki M | author3=Tanaka-Kagawa T | display-authors=3 | last4=Hanioka | first4=N | last5=Saito | first5=Y | last6=Ozawa | first6=S | last7=Ando | first7=M | last8=Shirao | first8=K | last9=Minami | first9=H }} | ||
*{{cite journal | author=Strausberg RL | |||
*{{cite journal | author=Jinno H | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{Glycosyltransferases}} | |||
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Revision as of 09:43, 17 September 2017
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| Location (UCSC) | n/a | n/a | |||||
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UDP-glucuronosyltransferase 1-10 is an enzyme that in humans is encoded by the UGT1A10 gene.[1][2][3]
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.[3]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
Irinotecan Pathway edit
- ↑ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP46359".
References
- ↑ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (Oct 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.
- ↑ Mojarrabi B, Mackenzie PI (Oct 1997). "The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid". Biochem Biophys Res Commun. 238 (3): 775–8. doi:10.1006/bbrc.1997.7388. PMID 9325166.
- ↑ 3.0 3.1 "Entrez Gene: UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10".
Further reading
- Tukey RH, Strassburg CP (2000). "Human UDP-glucuronosyltransferases: metabolism, expression, and disease". Annu. Rev. Pharmacol. Toxicol. 40: 581–616. doi:10.1146/annurev.pharmtox.40.1.581. PMID 10836148.
- Tukey RH, Strassburg CP (2001). "Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract". Mol. Pharmacol. 59 (3): 405–14. PMID 11179432.
- King CD, Rios GR, Green MD, Tephly TR (2001). "UDP-glucuronosyltransferases". Curr. Drug Metab. 1 (2): 143–61. doi:10.2174/1389200003339171. PMID 11465080.
- Harding D, Jeremiah SJ, Povey S, Burchell B (1990). "Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1". Ann. Hum. Genet. 54 (Pt 1): 17–21. doi:10.1111/j.1469-1809.1990.tb00356.x. PMID 2108603.
- van Es HH, Bout A, Liu J, et al. (1993). "Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37". Cytogenet. Cell Genet. 63 (2): 114–6. doi:10.1159/000133513. PMID 8467709.
- Strassburg CP, Oldhafer K, Manns MP, Tukey RH (1997). "Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue". Mol. Pharmacol. 52 (2): 212–20. PMID 9271343.
- Mojarrabi B, Mackenzie PI (1998). "Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon". Biochem. Biophys. Res. Commun. 247 (3): 704–9. doi:10.1006/bbrc.1998.8843. PMID 9647757.
- Strassburg CP, Strassburg A, Nguyen N, et al. (1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus". Biochem. J. 338 (2): 489–98. doi:10.1042/0264-6021:3380489. PMC 1220077. PMID 10024527.
- Cheng Z, Radominska-Pandya A, Tephly TR (1999). "Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10". Drug Metab. Dispos. 27 (10): 1165–70. PMID 10497143.
- Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine". J. Biol. Chem. 275 (46): 36164–71. doi:10.1074/jbc.M002180200. PMID 10748067.
- Gong QH, Cho JW, Huang T, et al. (2001). "Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus". Pharmacogenetics. 11 (4): 357–68. doi:10.1097/00008571-200106000-00011. PMID 11434514.
- Zheng Z, Fang JL, Lazarus P (2002). "Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues". Drug Metab. Dispos. 30 (4): 397–403. doi:10.1124/dmd.30.4.397. PMID 11901093.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Jinno H, Saeki M, Tanaka-Kagawa T, et al. (2003). "Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10". Drug Metab. Dispos. 31 (5): 528–32. doi:10.1124/dmd.31.5.528. PMID 12695339.
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