Natriuretic peptide precursor C: Difference between revisions

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{{Infobox_gene}}
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'''Natriuretic peptide precursor C''', also known as '''NPPC''', is a [[protein]] that in humans is encoded by the ''NPPC'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NPPC natriuretic peptide precursor C| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4880| accessdate = }}</ref><ref name="pmid8330189">{{cite journal |vauthors=Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O | title = C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid | journal = Brain Res. | volume = 612 | issue = 1–2 | pages = 104–9 |date=May 1993 | pmid = 8330189 | doi = 10.1016/0006-8993(93)91649-D| url =  }}</ref><ref name="pmid7698765">{{cite journal |vauthors=Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K | title = Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC) | journal = Genomics | volume = 24 | issue = 2 | pages = 383–7 |date=November 1994 | pmid = 7698765 | doi = 10.1006/geno.1994.1633 | url = }}</ref> The precursor NPPC protein is cleaved to the 22 [[amino acid]] [[peptide]] '''C-type natriuretic peptide''' (''CNP'').
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[[Natriuretic peptide]]s comprise a family of 3 structurally related molecules: atrial natriuretic peptide ([[atrial natriuretic peptide|ANP]]), brain natriuretic peptide ([[brain natriuretic peptide|BNP]]), and C-type natriuretic peptide (CNP), encoded by a gene symbolized ''NPPC''. These peptides possess potent [[Natriuresis|natriuretic]], [[diuretic]], and [[vasodilation|vasodilating]] activities and are implicated in body fluid homeostasis and blood pressure control.<ref name="entrez" />
{{GNF_Protein_box
Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective [[agonist]] for the B-type natriuretic receptor ([[atrial natriuretic peptide receptor|NPRB]]) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA).<ref name="pmid8959763">{{cite journal |vauthors=Barr CS, Rhodes P, Struthers AD | title = C-type natriuretic peptide | journal = Peptides | volume = 17 | issue = 7 | pages = 1243–51 | year = 1996 | pmid = 8959763 | doi = 10.1016/S0196-9781(96)00110-6 | url =   }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Natriuretic peptide precursor C
| HGNCid = 7941
| Symbol = NPPC
| AltSymbols =; CNP
| OMIM = 600296
| ECnumber = 
| Homologene = 7867
| MGIid = 97369
| GeneAtlas_image1 = PBB_GE_NPPC_221348_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006182 |text = cGMP biosynthetic process}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0019229 |text = regulation of vasoconstriction}} {{GNF_GO|id=GO:0050880 |text = regulation of blood vessel size}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4880
    | Hs_Ensembl = ENSG00000163273
    | Hs_RefseqProtein = NP_077720
    | Hs_RefseqmRNA = NM_024409
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 232498379
    | Hs_GenLoc_end = 232499203
    | Hs_Uniprot = P23582
    | Mm_EntrezGene = 18159
    | Mm_Ensembl = ENSMUSG00000026241
    | Mm_RefseqmRNA = NM_010933
    | Mm_RefseqProtein = NP_035063
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 88497462
    | Mm_GenLoc_end = 88501743
    | Mm_Uniprot = Q544K5
  }}
}}
'''Natriuretic peptide precursor C''', also known as '''NPPC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NPPC natriuretic peptide precursor C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4880| accessdate = }}</ref>


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[[File:C-type natriuretic peptide.png|thumb|250px|Structure of C-type natriuretic peptide (human)]]
{{PBB_Summary
| section_title =
| summary_text = Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP; MIM 108780), brain natriuretic peptide (BNP; MIM 600295), and C-type natriuretic peptide, CNP, encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: NPPC natriuretic peptide precursor C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4880| accessdate = }}</ref>
}}


==References==
==References==
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==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Schulz S |title=C-type natriuretic peptide and guanylyl cyclase B receptor. |journal=Peptides |volume=26 |issue= 6 |pages= 1024-34 |year= 2005 |pmid= 15911070 |doi= 10.1016/j.peptides.2004.08.027 }}
*{{cite journal  | author=Schulz S |title=C-type natriuretic peptide and guanylyl cyclase B receptor |journal=Peptides |volume=26 |issue= 6 |pages= 1024–34 |year= 2005 |pmid= 15911070 |doi= 10.1016/j.peptides.2004.08.027 }}
*{{cite journal | author=Suga S, Nakao K, Hosoda K, ''et al.'' |title=Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. |journal=Endocrinology |volume=130 |issue= 1 |pages= 229-39 |year= 1992 |pmid= 1309330 |doi=  }}
*{{cite journal   |vauthors=Suga S, Nakao K, Hosoda K, etal |title=Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide |journal=Endocrinology |volume=130 |issue= 1 |pages= 229–39 |year= 1992 |pmid= 1309330 |doi=10.1210/en.130.1.229 }}
*{{cite journal | author=Ogawa Y, Nakao K, Nakagawa O, ''et al.'' |title=Human C-type natriuretic peptide. Characterization of the gene and peptide. |journal=Hypertension |volume=19 |issue= 6 Pt 2 |pages= 809-13 |year= 1992 |pmid= 1339402 |doi=  }}
*{{cite journal   |vauthors=Ogawa Y, Nakao K, Nakagawa O, etal |title=Human C-type natriuretic peptide. Characterization of the gene and peptide |journal=Hypertension |volume=19 |issue= 6 Pt 2 |pages= 809–13 |year= 1992 |pmid= 1339402 |doi=  10.1161/01.hyp.19.6.809}}
*{{cite journal | author=Ishizaka Y, Kangawa K, Minamino N, ''et al.'' |title=Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1. |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 2 |pages= 697-704 |year= 1993 |pmid= 1472040 |doi=  }}
*{{cite journal   |vauthors=Ishizaka Y, Kangawa K, Minamino N, etal |title=Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1 |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 2 |pages= 697–704 |year= 1993 |pmid= 1472040 |doi=10.1016/0006-291X(92)92257-X }}
*{{cite journal | author=Komatsu Y, Nakao K, Suga S, ''et al.'' |title=C-type natriuretic peptide (CNP) in rats and humans. |journal=Endocrinology |volume=129 |issue= 2 |pages= 1104-6 |year= 1991 |pmid= 1855454 |doi=  }}
*{{cite journal   |vauthors=Komatsu Y, Nakao K, Suga S, etal |title=C-type natriuretic peptide (CNP) in rats and humans |journal=Endocrinology |volume=129 |issue= 2 |pages= 1104–6 |year= 1991 |pmid= 1855454 |doi=10.1210/endo-129-2-1104 }}
*{{cite journal | author=Tawaragi Y, Fuchimura K, Tanaka S, ''et al.'' |title=Gene and precursor structures of human C-type natriuretic peptide. |journal=Biochem. Biophys. Res. Commun. |volume=175 |issue= 2 |pages= 645-51 |year= 1991 |pmid= 2018508 |doi=  }}
*{{cite journal   |vauthors=Tawaragi Y, Fuchimura K, Tanaka S, etal |title=Gene and precursor structures of human C-type natriuretic peptide |journal=Biochem. Biophys. Res. Commun. |volume=175 |issue= 2 |pages= 645–51 |year= 1991 |pmid= 2018508 |doi=10.1016/0006-291X(91)91614-I }}
*{{cite journal | author=Ogawa Y, Itoh H, Yoshitake Y, ''et al.'' |title=Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC). |journal=Genomics |volume=24 |issue= 2 |pages= 383-7 |year= 1995 |pmid= 7698765 |doi= 10.1006/geno.1994.1633 }}
*{{cite journal   |vauthors=Ogawa Y, Itoh H, Yoshitake Y, etal |title=Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC) |journal=Genomics |volume=24 |issue= 2 |pages= 383–7 |year= 1995 |pmid= 7698765 |doi= 10.1006/geno.1994.1633 }}
*{{cite journal | author=Kaneko T, Shirakami G, Nakao K, ''et al.'' |title=C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid. |journal=Brain Res. |volume=612 |issue= 1-2 |pages= 104-9 |year= 1993 |pmid= 8330189 |doi=  }}
*{{cite journal   |vauthors=Kaneko T, Shirakami G, Nakao K, etal |title=C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid |journal=Brain Res. |volume=612 |issue= 1–2 |pages= 104–9 |year= 1993 |pmid= 8330189 |doi=10.1016/0006-8993(93)91649-D }}
*{{cite journal | author=Wei CM, Heublein DM, Perrella MA, ''et al.'' |title=Natriuretic peptide system in human heart failure. |journal=Circulation |volume=88 |issue= 3 |pages= 1004-9 |year= 1993 |pmid= 8353861 |doi=  }}
*{{cite journal   |vauthors=Wei CM, Heublein DM, Perrella MA, etal |title=Natriuretic peptide system in human heart failure |journal=Circulation |volume=88 |issue= 3 |pages= 1004–9 |year= 1993 |pmid= 8353861 |doi=  10.1161/01.cir.88.3.1004}}
*{{cite journal | author=Igaki T, Itoh H, Suga S, ''et al.'' |title=Insulin suppresses endothelial secretion of C-type natriuretic peptide, a novel endothelium-derived relaxing peptide. |journal=Diabetes |volume=45 Suppl 3 |issue=  |pages= S62-4 |year= 1996 |pmid= 8674895 |doi=  }}
*{{cite journal   |vauthors=Igaki T, Itoh H, Suga S, etal |title=Insulin suppresses endothelial secretion of C-type natriuretic peptide, a novel endothelium-derived relaxing peptide |journal=Diabetes |volume=45 Suppl 3 |issue=  |pages= S62–4 |year= 1996 |pmid= 8674895 |doi=  10.2337/diab.45.3.s62}}
*{{cite journal | author=Igaki T, Itoh H, Suga S, ''et al.'' |title=C-type natriuretic peptide in chronic renal failure and its action in humans. |journal=Kidney Int. Suppl. |volume=55 |issue=  |pages= S144-7 |year= 1996 |pmid= 8743538 |doi=  }}
*{{cite journal   |vauthors=Igaki T, Itoh H, Suga S, etal |title=C-type natriuretic peptide in chronic renal failure and its action in humans |journal=Kidney Int. Suppl. |volume=55 |issue=  |pages= S144–7 |year= 1996 |pmid= 8743538 |doi=  }}
*{{cite journal  | author=Vollmar AM, Paumgartner G, Gerbes AL |title=Differential gene expression of the three natriuretic peptides and natriuretic peptide receptor subtypes in human liver. |journal=Gut |volume=40 |issue= 1 |pages= 145-50 |year= 1997 |pmid= 9155593 |doi=  }}
*{{cite journal  |vauthors=Vollmar AM, Paumgartner G, Gerbes AL |title=Differential gene expression of the three natriuretic peptides and natriuretic peptide receptor subtypes in human liver |journal=Gut |volume=40 |issue= 1 |pages= 145–50 |year= 1997 |pmid= 9155593 |doi= 10.1136/gut.40.1.145 | pmc=1027025 }}
*{{cite journal  | author=Watanabe Y, Nakajima K, Shimamori Y, Fujimoto Y |title=Comparison of the hydrolysis of the three types of natriuretic peptides by human kidney neutral endopeptidase 24.11. |journal=Biochem. Mol. Med. |volume=61 |issue= 1 |pages= 47-51 |year= 1997 |pmid= 9232196 |doi=  }}
*{{cite journal  |vauthors=Watanabe Y, Nakajima K, Shimamori Y, Fujimoto Y |title=Comparison of the hydrolysis of the three types of natriuretic peptides by human kidney neutral endopeptidase 24.11 |journal=Biochem. Mol. Med. |volume=61 |issue= 1 |pages= 47–51 |year= 1997 |pmid= 9232196 |doi=10.1006/bmme.1997.2584 }}
*{{cite journal  | author=He Xl , Chow Dc , Martick MM, Garcia KC |title=Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone. |journal=Science |volume=293 |issue= 5535 |pages= 1657-62 |year= 2001 |pmid= 11533490 |doi= 10.1126/science.1062246 }}
*{{cite journal  |author1=He Xl |author2=Chow Dc |author3=Martick MM |author4=Garcia KC |title=Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone |journal=Science |volume=293 |issue= 5535 |pages= 1657–62 |year= 2001 |pmid= 11533490 |doi= 10.1126/science.1062246 }}
*{{cite journal | author=Cataliotti A, Giordano M, De Pascale E, ''et al.'' |title=CNP production in the kidney and effects of protein intake restriction in nephrotic syndrome. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 3 |pages= F464-72 |year= 2002 |pmid= 12167597 |doi= 10.1152/ajprenal.00372.2001 }}
*{{cite journal   |vauthors=Cataliotti A, Giordano M, De Pascale E, etal |title=CNP production in the kidney and effects of protein intake restriction in nephrotic syndrome |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 3 |pages= F464–72 |year= 2002 |pmid= 12167597 |doi= 10.1152/ajprenal.00372.2001 }}
*{{cite journal | author=Evans JJ, Youssef AH, Yandle TG, ''et al.'' |title=Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells. |journal=J. Endocrinol. |volume=175 |issue= 1 |pages= 225-32 |year= 2002 |pmid= 12379507 |doi=  }}
*{{cite journal   |vauthors=Evans JJ, Youssef AH, Yandle TG, etal |title=Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells |journal=J. Endocrinol. |volume=175 |issue= 1 |pages= 225–32 |year= 2002 |pmid= 12379507 |doi=10.1677/joe.0.1750225 }}
*{{cite journal | author=Ono K, Mannami T, Baba S, ''et al.'' |title=A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension. |journal=Hypertens. Res. |volume=25 |issue= 5 |pages= 727-30 |year= 2003 |pmid= 12452325 |doi=  }}
*{{cite journal   |vauthors=Ono K, Mannami T, Baba S, etal |title=A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension |journal=Hypertens. Res. |volume=25 |issue= 5 |pages= 727–30 |year= 2003 |pmid= 12452325 |doi=10.1291/hypres.25.727 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Hirsch JR, Skutta N, Schlatter E |title=Signaling and distribution of NPR-Bi, the human splice form of the natriuretic peptide receptor type B. |journal=Am. J. Physiol. Renal Physiol. |volume=285 |issue= 2 |pages= F370-4 |year= 2003 |pmid= 12709393 |doi= 10.1152/ajprenal.00049.2003 }}
*{{cite journal  |vauthors=Hirsch JR, Skutta N, Schlatter E |title=Signaling and distribution of NPR-Bi, the human splice form of the natriuretic peptide receptor type B |journal=Am. J. Physiol. Renal Physiol. |volume=285 |issue= 2 |pages= F370–4 |year= 2003 |pmid= 12709393 |doi= 10.1152/ajprenal.00049.2003 }}
*{{cite journal | author=Wu C, Wu F, Pan J, ''et al.'' |title=Furin-mediated processing of Pro-C-type natriuretic peptide. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25847-52 |year= 2003 |pmid= 12736257 |doi= 10.1074/jbc.M301223200 }}
*{{cite journal   |vauthors=Wu C, Wu F, Pan J, etal |title=Furin-mediated processing of Pro-C-type natriuretic peptide |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25847–52 |year= 2003 |pmid= 12736257 |doi= 10.1074/jbc.M301223200 }}
}}
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==External links==
{{WikiDoc Sources}}
* {{MeshName|C-Type+Natriuretic+Peptide}}
 
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Revision as of 18:11, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene.[1][2][3] The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP).

Function

Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.[1] Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA).[4]

File:C-type natriuretic peptide.png
Structure of C-type natriuretic peptide (human)

References

  1. ↑ 1.0 1.1 "Entrez Gene: NPPC natriuretic peptide precursor C".
  2. ↑ Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (May 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Res. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189.
  3. ↑ Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (November 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.
  4. ↑ Barr CS, Rhodes P, Struthers AD (1996). "C-type natriuretic peptide". Peptides. 17 (7): 1243–51. doi:10.1016/S0196-9781(96)00110-6. PMID 8959763.

Further reading

External links



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