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{{Infobox_gene}}
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'''Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A''' is an [[enzyme]] that in humans is encoded by the ''PDE11A'' [[gene]].<ref name="pmid10725373">{{cite journal | vauthors = Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC | title = Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A | journal = Proc Natl Acad Sci U S A | volume = 97 | issue = 7 | pages = 3702–7 |date=Apr 2000 | pmid = 10725373 | pmc = 16303 | doi = 10.1073/pnas.050585197 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDE11A phosphodiesterase 11A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50940| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Phosphodiesterase 11A
| HGNCid = 8773
| Symbol = PDE11A
| AltSymbols =; FLJ23693; MGC133355; MGC133356
| OMIM = 604961
| ECnumber = 
| Homologene = 56763
| MGIid = 3036251
| GeneAtlas_image1 = PBB_GE_PDE11A_221110_x_at_tn.png
| Function = {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0047555 |text = 3',5'-cyclic-GMP phosphodiesterase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 50940
    | Hs_Ensembl = ENSG00000128655
    | Hs_RefseqProtein = NP_001070664
    | Hs_RefseqmRNA = NM_001077196
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 178201060
    | Hs_GenLoc_end = 178681312
    | Hs_Uniprot = Q9HCR9
    | Mm_EntrezGene = 241489
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_001002911
    | Mm_RefseqProtein = XP_001002911
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Phosphodiesterase 11A''', also known as '''PDE11A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PDE11A phosphodiesterase 11A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50940| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: PDE11A phosphodiesterase 11A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50940| accessdate = }}</ref>
| summary_text = The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez"/>
}}
}}
==Inhibitors==
* BC11-38 <ref name="pmid22284362">{{cite journal |vauthors=Ceyhan O, Birsoy K, Hoffman CS |title=Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen |journal=Chem. Biol. |volume=19 |issue=1 |pages=155–63 |year=2012 |pmid=22284362 |doi=10.1016/j.chembiol.2011.12.010 |url=}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Beavo JA, Conti M, Heaslip RJ |title=Multiple cyclic nucleotide phosphodiesterases. |journal=Mol. Pharmacol. |volume=46 |issue= 3 |pages= 399-405 |year= 1994 |pmid= 7935318 |doi=  }}
*{{cite journal  | vauthors=Beavo JA, Conti M, Heaslip RJ |title=Multiple cyclic nucleotide phosphodiesterases. |journal=Mol. Pharmacol. |volume=46 |issue= 3 |pages= 399–405 |year= 1994 |pmid= 7935318 |doi=  }}
*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
*{{cite journal  |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097}}
*{{cite journal | author=Fawcett L, Baxendale R, Stacey P, ''et al.'' |title=Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3702-7 |year= 2000 |pmid= 10725373 |doi= 10.1073/pnas.050585197 }}
*{{cite journal   |vauthors=Yuasa K, Kotera J, Fujishige K, etal |title=Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31469–79 |year= 2000 |pmid= 10906126 |doi= 10.1074/jbc.M003041200 }}
*{{cite journal | author=Yuasa K, Kotera J, Fujishige K, ''et al.'' |title=Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31469-79 |year= 2000 |pmid= 10906126 |doi= 10.1074/jbc.M003041200 }}
*{{cite journal   |vauthors=Hetman JM, Robas N, Baxendale R, etal |title=Cloning and characterization of two splice variants of human phosphodiesterase 11A. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 23 |pages= 12891–5 |year= 2001 |pmid= 11050148 |doi= 10.1073/pnas.200355397  | pmc=18860 }}
*{{cite journal  | author=Hetman JM, Robas N, Baxendale R, ''et al.'' |title=Cloning and characterization of two splice variants of human phosphodiesterase 11A. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 23 |pages= 12891-5 |year= 2001 |pmid= 11050148 |doi= 10.1073/pnas.200355397 }}
*{{cite journal  | vauthors=Yuasa K, Kanoh Y, Okumura K, Omori K |title=Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains. |journal=Eur. J. Biochem. |volume=268 |issue= 1 |pages= 168–78 |year= 2001 |pmid= 11121118 |doi=10.1046/j.1432-1327.2001.01866.x  }}
*{{cite journal | author=Yuasa K, Kanoh Y, Okumura K, Omori K |title=Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains. |journal=Eur. J. Biochem. |volume=268 |issue= 1 |pages= 168-78 |year= 2001 |pmid= 11121118 |doi= }}
*{{cite journal   |vauthors=Zauli G, Milani D, Mirandola P, etal |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483–91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com }}
*{{cite journal  | author=Zauli G, Milani D, Mirandola P, ''et al.'' |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483-91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com }}
*{{cite journal  | vauthors=Yuasa K, Ohgaru T, Asahina M, Omori K |title=Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants. |journal=Eur. J. Biochem. |volume=268 |issue= 16 |pages= 4440–8 |year= 2001 |pmid= 11502204 |doi=10.1046/j.1432-1327.2001.02366.x  }}
*{{cite journal | author=Yuasa K, Ohgaru T, Asahina M, Omori K |title=Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants. |journal=Eur. J. Biochem. |volume=268 |issue= 16 |pages= 4440-8 |year= 2001 |pmid= 11502204 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Weeks JL, Zoraghi R, Beasley A, etal |title=High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients. |journal=Int. J. Impot. Res. |volume=17 |issue= 1 |pages= 5–9 |year= 2005 |pmid= 15538396 |doi= 10.1038/sj.ijir.3901283 }}
*{{cite journal  | author=Weeks JL, Zoraghi R, Beasley A, ''et al.'' |title=High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients. |journal=Int. J. Impot. Res. |volume=17 |issue= 1 |pages= 5-9 |year= 2005 |pmid= 15538396 |doi= 10.1038/sj.ijir.3901283 }}
*{{cite journal  | vauthors=Loughney K, Taylor J, Florio VA |title=3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues. |journal=Int. J. Impot. Res. |volume=17 |issue= 4 |pages= 320–5 |year= 2005 |pmid= 15800651 |doi= 10.1038/sj.ijir.3901317 }}
*{{cite journal | author=Loughney K, Taylor J, Florio VA |title=3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues. |journal=Int. J. Impot. Res. |volume=17 |issue= 4 |pages= 320-5 |year= 2005 |pmid= 15800651 |doi= 10.1038/sj.ijir.3901317 }}
*{{cite journal   |vauthors=Wayman C, Phillips S, Lunny C, etal |title=Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology. |journal=Int. J. Impot. Res. |volume=17 |issue= 3 |pages= 216–23 |year= 2005 |pmid= 15800654 |doi= 10.1038/sj.ijir.3901307 }}
*{{cite journal | author=Wayman C, Phillips S, Lunny C, ''et al.'' |title=Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology. |journal=Int. J. Impot. Res. |volume=17 |issue= 3 |pages= 216-23 |year= 2005 |pmid= 15800654 |doi= 10.1038/sj.ijir.3901307 }}
*{{cite journal   |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal   |vauthors=D'Andrea MR, Qiu Y, Haynes-Johnson D, etal |title=Expression of PDE11A in normal and malignant human tissues. |journal=J. Histochem. Cytochem. |volume=53 |issue= 7 |pages= 895–903 |year= 2005 |pmid= 15995148 |doi= 10.1369/jhc.5A6625.2005 }}
*{{cite journal  | author=D'Andrea MR, Qiu Y, Haynes-Johnson D, ''et al.'' |title=Expression of PDE11A in normal and malignant human tissues. |journal=J. Histochem. Cytochem. |volume=53 |issue= 7 |pages= 895-903 |year= 2005 |pmid= 15995148 |doi= 10.1369/jhc.5A6625.2005 }}
*{{cite journal  | author=Francis SH |title=Phosphodiesterase 11 (PDE11): is it a player in human testicular function? |journal=Int. J. Impot. Res. |volume=17 |issue= 5 |pages= 467–8 |year= 2005 |pmid= 16079899 |doi= 10.1038/sj.ijir.3901377 }}
*{{cite journal | author=Francis SH |title=Phosphodiesterase 11 (PDE11): is it a player in human testicular function? |journal=Int. J. Impot. Res. |volume=17 |issue= 5 |pages= 467-8 |year= 2005 |pmid= 16079899 |doi= 10.1038/sj.ijir.3901377 }}
*{{cite journal   |vauthors=Gross-Langenhoff M, Hofbauer K, Weber J, etal |title=cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11. |journal=J. Biol. Chem. |volume=281 |issue= 5 |pages= 2841–6 |year= 2006 |pmid= 16330539 |doi= 10.1074/jbc.M511468200 }}
*{{cite journal | author=Gross-Langenhoff M, Hofbauer K, Weber J, ''et al.'' |title=cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11. |journal=J. Biol. Chem. |volume=281 |issue= 5 |pages= 2841-6 |year= 2006 |pmid= 16330539 |doi= 10.1074/jbc.M511468200 }}
*{{cite journal   |vauthors=Horvath A, Boikos S, Giatzakis C, etal |title=A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia. |journal=Nat. Genet. |volume=38 |issue= 7 |pages= 794–800 |year= 2006 |pmid= 16767104 |doi= 10.1038/ng1809 }}
*{{cite journal | author=Horvath A, Boikos S, Giatzakis C, ''et al.'' |title=A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia. |journal=Nat. Genet. |volume=38 |issue= 7 |pages= 794-800 |year= 2006 |pmid= 16767104 |doi= 10.1038/ng1809 }}
*{{cite journal   |vauthors=Wong ML, Whelan F, Deloukas P, etal |title=Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 41 |pages= 15124–9 |year= 2006 |pmid= 17008408 |doi= 10.1073/pnas.0602795103 | pmc=1581426 }}
*{{cite journal | author=Wong ML, Whelan F, Deloukas P, ''et al.'' |title=Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 41 |pages= 15124-9 |year= 2006 |pmid= 17008408 |doi= 10.1073/pnas.0602795103 }}
}}
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Latest revision as of 17:48, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.[1][2]

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.[2]

Inhibitors

References

  1. ↑ Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC (Apr 2000). "Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A". Proc Natl Acad Sci U S A. 97 (7): 3702–7. doi:10.1073/pnas.050585197. PMC 16303. PMID 10725373.
  2. ↑ 2.0 2.1 "Entrez Gene: PDE11A phosphodiesterase 11A".
  3. ↑ Ceyhan O, Birsoy K, Hoffman CS (2012). "Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen". Chem. Biol. 19 (1): 155–63. doi:10.1016/j.chembiol.2011.12.010. PMID 22284362.

Further reading



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