VPS24: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Charged multivesicular body protein 3''' is a [[protein]] that in humans is encoded by the ''VPS24'' [[gene]].<ref name="pmid11549700">{{cite journal | vauthors = Wilson EM, Oh Y, Hwa V, Rosenfeld RG | title = Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells | journal = J Clin Endocrinol Metab | volume = 86 | issue = 9 | pages = 4504–11 | date = Sep 2001 | pmid = 11549700 | pmc =  | doi = 10.1210/jc.86.9.4504 }}</ref><ref name="pmid12878588">{{cite journal | vauthors = Whitley P, Reaves BJ, Hashimoto M, Riley AM, Potter BV, Holman GD | title = Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization | journal = J Biol Chem | volume = 278 | issue = 40 | pages = 38786–95 | date = Sep 2003 | pmid = 12878588 | pmc =  | doi = 10.1074/jbc.M306864200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51652| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_VPS24_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2gd5.
| PDB = {{PDB2|2gd5}}
| Name = Vacuolar protein sorting 24 homolog (S. cerevisiae)
| HGNCid = 29865
| Symbol = VPS24
| AltSymbols =; CGI-149; CHMP3; NEDF
| OMIM = 610052
| ECnumber = 
| Homologene = 6368
| MGIid = 1913950
| GeneAtlas_image1 = PBB_GE_VPS24_217837_s_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51652
    | Hs_Ensembl = ENSG00000115561
    | Hs_RefseqProtein = NP_001005753
    | Hs_RefseqmRNA = NM_001005753
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 86584064
    | Hs_GenLoc_end = 86644111
    | Hs_Uniprot = Q9Y3E7
    | Mm_EntrezGene = 66700
    | Mm_Ensembl = ENSMUSG00000053119
    | Mm_RefseqmRNA = XM_973747
    | Mm_RefseqProtein = XP_978841
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 71473426
    | Mm_GenLoc_end = 71512117
    | Mm_Uniprot = Q9CQ10
  }}
}}
'''Vacuolar protein sorting 24 homolog (S. cerevisiae)''', also known as '''VPS24''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51652| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51652| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
VPS24 has been shown to [[Protein-protein interaction|interact]] with [[IGFBP7]].<ref name=pmid11549700 />
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W | title = Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics | journal = Genome Res. | volume = 10 | issue = 5 | pages = 703–13 | year = 2000 | pmid = 10810093 | pmc = 310876 | doi = 10.1101/gr.10.5.703 }}
| citations =
* {{cite journal | vauthors = Babst M, Katzmann DJ, Estepa-Sabal EJ, Meerloo T, Emr SD | title = Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting | journal = Dev. Cell | volume = 3 | issue = 2 | pages = 271–82 | year = 2002 | pmid = 12194857 | doi = 10.1016/S1534-5807(02)00220-4 }}
*{{cite journal | author=Lai CH, Chou CY, Ch'ang LY, ''et al.'' |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703-13 |year= 2000 |pmid= 10810093 |doi=  }}
* {{cite journal | vauthors = Su ZZ, Kang DC, Chen Y, Pekarskaya O, Chao W, Volsky DJ, Fisher PB | title = Identification of gene products suppressed by human immunodeficiency virus type 1 infection or gp120 exposure of primary human astrocytes by rapid subtraction hybridization | journal = J. Neurovirol. | volume = 9 | issue = 3 | pages = 372–89 | year = 2003 | pmid = 12775420 | doi = 10.1080/13550280390201263 }}
*{{cite journal  | author=Wilson EM, Oh Y, Hwa V, Rosenfeld RG |title=Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 9 |pages= 4504-11 |year= 2001 |pmid= 11549700 |doi=  }}
* {{cite journal | vauthors = Strack B, Calistri A, Craig S, Popova E, Göttlinger HG | title = AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding | journal = Cell | volume = 114 | issue = 6 | pages = 689–99 | year = 2003 | pmid = 14505569 | doi = 10.1016/S0092-8674(03)00653-6 }}
*{{cite journal | author=Babst M, Katzmann DJ, Estepa-Sabal EJ, ''et al.'' |title=Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. |journal=Dev. Cell |volume=3 |issue= 2 |pages= 271-82 |year= 2002 |pmid= 12194857 |doi= }}
* {{cite journal | vauthors = von Schwedler UK, Stuchell M, Müller B, Ward DM, Chung HY, Morita E, Wang HE, Davis T, He GP, Cimbora DM, Scott A, Kräusslich HG, Kaplan J, Morham SG, Sundquist WI | title = The protein network of HIV budding | journal = Cell | volume = 114 | issue = 6 | pages = 701–13 | year = 2003 | pmid = 14505570 | doi = 10.1016/S0092-8674(03)00714-1 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Martin-Serrano J, Yarovoy A, Perez-Caballero D, Bieniasz PD, Yaravoy A | title = Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 21 | pages = 12414–9 | year = 2003 | pmid = 14519844 | pmc = 218772 | doi = 10.1073/pnas.2133846100 }}
*{{cite journal | author=Su ZZ, Kang DC, Chen Y, ''et al.'' |title=Identification of gene products suppressed by human immunodeficiency virus type 1 infection or gp120 exposure of primary human astrocytes by rapid subtraction hybridization. |journal=J. Neurovirol. |volume=9 |issue= 3 |pages= 372-89 |year= 2003 |pmid= 12775420 |doi=  }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional Proteomics Mapping of a Human Signaling Pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal  | author=Whitley P, Reaves BJ, Hashimoto M, ''et al.'' |title=Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38786-95 |year= 2003 |pmid= 12878588 |doi= 10.1074/jbc.M306864200 }}
* {{cite journal | vauthors = Lin Y, Kimpler LA, Naismith TV, Lauer JM, Hanson PI | title = Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1 | journal = J. Biol. Chem. | volume = 280 | issue = 13 | pages = 12799–809 | year = 2005 | pmid = 15632132 | doi = 10.1074/jbc.M413968200 }}
*{{cite journal | author=Strack B, Calistri A, Craig S, ''et al.'' |title=AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. |journal=Cell |volume=114 |issue= 6 |pages= 689-99 |year= 2003 |pmid= 14505569 |doi= }}
* {{cite journal | vauthors = Yan Q, Hunt PR, Frelin L, Vida TA, Pevsner J, Bean AJ | title = mVps24p functions in EGF receptor sorting/trafficking from the early endosome | journal = Exp. Cell Res. | volume = 304 | issue = 1 | pages = 265–73 | year = 2005 | pmid = 15707591 | doi = 10.1016/j.yexcr.2004.11.003 }}
*{{cite journal | author=von Schwedler UK, Stuchell M, Müller B, ''et al.'' |title=The protein network of HIV budding. |journal=Cell |volume=114 |issue= 6 |pages= 701-13 |year= 2003 |pmid= 14505570 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Martin-Serrano J, Yarovoy A, Perez-Caballero D, ''et al.'' |title=Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 21 |pages= 12414-9 |year= 2003 |pmid= 14519844 |doi= 10.1073/pnas.2133846100 }}
* {{cite journal | vauthors = Walker GE, Antoniono RJ, Ross HJ, Paisley TE, Oh Y | title = Neuroendocrine-like differentiation of non-small cell lung carcinoma cells: regulation by cAMP and the interaction of mac25/IGFBP-rP1 and 25.1 | journal = Oncogene | volume = 25 | issue = 13 | pages = 1943–54 | year = 2006 | pmid = 16302002 | doi = 10.1038/sj.onc.1209213 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
* {{cite journal | vauthors = Bache KG, Stuffers S, Malerød L, Slagsvold T, Raiborg C, Lechardeur D, Wälchli S, Lukacs GL, Brech A, Stenmark H | title = The ESCRT-III Subunit hVps24 Is Required for Degradation but Not Silencing of the Epidermal Growth Factor Receptor | journal = Mol. Biol. Cell | volume = 17 | issue = 6 | pages = 2513–23 | year = 2006 | pmid = 16554368 | pmc = 1474783 | doi = 10.1091/mbc.E05-10-0915 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM | title = A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex | journal = Genomics | volume = 88 | issue = 3 | pages = 333–46 | year = 2006 | pmid = 16730941 | doi = 10.1016/j.ygeno.2006.04.003 }}
*{{cite journal | author=Lin Y, Kimpler LA, Naismith TV, ''et al.'' |title=Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12799-809 |year= 2005 |pmid= 15632132 |doi= 10.1074/jbc.M413968200 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Yan Q, Hunt PR, Frelin L, ''et al.'' |title=mVps24p functions in EGF receptor sorting/trafficking from the early endosome. |journal=Exp. Cell Res. |volume=304 |issue= 1 |pages= 265-73 |year= 2005 |pmid= 15707591 |doi= 10.1016/j.yexcr.2004.11.003 }}
* {{cite journal | vauthors = Zamborlini A, Usami Y, Radoshitzky SR, Popova E, Palu G, Göttlinger H | title = Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 50 | pages = 19140–5 | year = 2007 | pmid = 17146056 | pmc = 1748189 | doi = 10.1073/pnas.0603788103 }}
*{{cite journal | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Walker GE, Antoniono RJ, Ross HJ, ''et al.'' |title=Neuroendocrine-like differentiation of non-small cell lung carcinoma cells: regulation by cAMP and the interaction of mac25/IGFBP-rP1 and 25.1. |journal=Oncogene |volume=25 |issue= 13 |pages= 1943-54 |year= 2006 |pmid= 16302002 |doi= 10.1038/sj.onc.1209213 }}
*{{cite journal | author=Bache KG, Stuffers S, Malerød L, ''et al.'' |title=The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. |journal=Mol. Biol. Cell |volume=17 |issue= 6 |pages= 2513-23 |year= 2006 |pmid= 16554368 |doi= 10.1091/mbc.E05-10-0915 }}
*{{cite journal | author=Tsang HT, Connell JW, Brown SE, ''et al.'' |title=A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. |journal=Genomics |volume=88 |issue= 3 |pages= 333-46 |year= 2006 |pmid= 16730941 |doi= 10.1016/j.ygeno.2006.04.003 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Zamborlini A, Usami Y, Radoshitzky SR, ''et al.'' |title=Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 50 |pages= 19140-5 |year= 2007 |pmid= 17146056 |doi= 10.1073/pnas.0603788103 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=51652}}
{{WikiDoc Sources}}
 
 
{{gene-2-stub}}

Latest revision as of 02:06, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.[1][2][3]

Function

This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]

Interactions

VPS24 has been shown to interact with IGFBP7.[1]

References

  1. ↑ 1.0 1.1 Wilson EM, Oh Y, Hwa V, Rosenfeld RG (Sep 2001). "Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells". J Clin Endocrinol Metab. 86 (9): 4504–11. doi:10.1210/jc.86.9.4504. PMID 11549700.
  2. ↑ Whitley P, Reaves BJ, Hashimoto M, Riley AM, Potter BV, Holman GD (Sep 2003). "Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization". J Biol Chem. 278 (40): 38786–95. doi:10.1074/jbc.M306864200. PMID 12878588.
  3. ↑ 3.0 3.1 "Entrez Gene: VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae)".

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=VPS24&oldid=1412181"