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{{Infobox_gene}}
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'''Anthrax toxin receptor 1''' (ANTXR1 or also known asTEM8) is a [[protein]] that in humans is encoded by the ''ANTXR1'' [[gene]].<ref name="pmid10947988">{{cite journal |vauthors=St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW | title = Genes expressed in human tumor endothelium | journal = Science | volume = 289 | issue = 5482 | pages = 1197–202 |date=Aug 2000 | pmid = 10947988 | pmc =  | doi =10.1126/science.289.5482.1197 }}</ref><ref name="pmid11559528">{{cite journal |vauthors=Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B | title = Cell surface tumor endothelial markers are conserved in mice and humans | journal = Cancer Res | volume = 61 | issue = 18 | pages = 6649–55 |date=Sep 2001 | pmid = 11559528 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ANTXR1 anthrax toxin receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84168| accessdate = }}</ref> Its molecular weight is predicted as about 63kDa.
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Anthrax toxin receptor 1
| HGNCid = 21014
| Symbol = ANTXR1
| AltSymbols =; ATR; FLJ10601; FLJ11298; FLJ21776; TEM8
| OMIM = 606410
| ECnumber =
  | Homologene = 12976
| MGIid = 1916788
| GeneAtlas_image1 = PBB_GE_ANTXR1_220092_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
  | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84168
    | Hs_Ensembl = ENSG00000169604
    | Hs_RefseqProtein = NP_060623
    | Hs_RefseqmRNA = NM_018153
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 69093993
    | Hs_GenLoc_end = 69329804
    | Hs_Uniprot = Q9H6X2
    | Mm_EntrezGene = 69538
    | Mm_Ensembl = ENSMUSG00000033420
    | Mm_RefseqmRNA = NM_054041
    | Mm_RefseqProtein = NP_473382
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 87099487
    | Mm_GenLoc_end = 87301349
    | Mm_Uniprot = Q505H2
  }}
}}
'''Anthrax toxin receptor 1''', also known as '''ANTXR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ANTXR1 anthrax toxin receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84168| accessdate = }}</ref>


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| section_title =  
| summary_text = The protein encoded by this gene is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.<ref name="entrez">{{cite web | title = Entrez Gene: ANTXR1 anthrax toxin receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84168| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.<ref name="entrez" />
}}
}}
==See also==
* [[Anthrax toxin]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ANTXR1}}
* {{UCSC gene info|ATR}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Schmidt DR, Schreiber SL |title=Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. |journal=Biochemistry |volume=38 |issue= 44 |pages= 14711-7 |year= 1999 |pmid= 10545197 |doi=  }}
*{{cite journal  |vauthors=Schmidt DR, Schreiber SL |title=Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4 |journal=Biochemistry |volume=38 |issue= 44 |pages= 14711–7 |year= 1999 |pmid= 10545197 |doi=10.1021/bi991614n }}
*{{cite journal  | author=St Croix B, Rago C, Velculescu V, ''et al.'' |title=Genes expressed in human tumor endothelium. |journal=Science |volume=289 |issue= 5482 |pages= 1197-202 |year= 2000 |pmid= 10947988 |doi= }}
*{{cite journal  |vauthors=Liu XH, Collier RJ, Youle RJ |title=Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 46326–32 |year= 2002 |pmid= 11574549 |doi= 10.1074/jbc.M108930200 }}
*{{cite journal  | author=Carson-Walter EB, Watkins DN, Nanda A, ''et al.'' |title=Cell surface tumor endothelial markers are conserved in mice and humans. |journal=Cancer Res. |volume=61 |issue= 18 |pages= 6649-55 |year= 2001 |pmid= 11559528 |doi= }}
*{{cite journal  |vauthors=Bradley KA, Mogridge J, Mourez M |title=Identification of the cellular receptor for anthrax toxin |journal=Nature |volume=414 |issue= 6860 |pages= 225–9 |year= 2001 |pmid= 11700562 |doi= 10.1038/n35101999 |display-authors=etal}}
*{{cite journal  | author=Liu XH, Collier RJ, Youle RJ |title=Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 46326-32 |year= 2002 |pmid= 11574549 |doi= 10.1074/jbc.M108930200 }}
*{{cite journal  |vauthors=Latonen L, Taya Y, Laiho M |title=UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts |journal=Oncogene |volume=20 |issue= 46 |pages= 6784–93 |year= 2001 |pmid= 11709713 |doi= 10.1038/sj.onc.1204883 }}
*{{cite journal  | author=Bradley KA, Mogridge J, Mourez M, ''et al.'' |title=Identification of the cellular receptor for anthrax toxin. |journal=Nature |volume=414 |issue= 6860 |pages= 225-9 |year= 2001 |pmid= 11700562 |doi= 10.1038/n35101999 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Latonen L, Taya Y, Laiho M |title=UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts. |journal=Oncogene |volume=20 |issue= 46 |pages= 6784-93 |year= 2001 |pmid= 11709713 |doi= 10.1038/sj.onc.1204883 }}
*{{cite journal  |vauthors=Scobie HM, Rainey GJ, Bradley KA, Young JA |title=Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 9 |pages= 5170–4 |year= 2003 |pmid= 12700348 |doi= 10.1073/pnas.0431098100  | pmc=154317 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Bradley KA, Mogridge J, Jonah G |title=Binding of anthrax toxin to its receptor is similar to alpha integrin-ligand interactions |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49342–7 |year= 2004 |pmid= 14507921 |doi= 10.1074/jbc.M307900200 |display-authors=etal}}
*{{cite journal  | author=Scobie HM, Rainey GJ, Bradley KA, Young JA |title=Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 9 |pages= 5170-4 |year= 2003 |pmid= 12700348 |doi= 10.1073/pnas.0431098100 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Bradley KA, Mogridge J, Jonah G, ''et al.'' |title=Binding of anthrax toxin to its receptor is similar to alpha integrin-ligand interactions. |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49342-7 |year= 2004 |pmid= 14507921 |doi= 10.1074/jbc.M307900200 }}
*{{cite journal  |vauthors=Jones GG, Reaper PM, Pettitt AR, Sherrington PD |title=The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes |journal=Oncogene |volume=23 |issue= 10 |pages= 1911–21 |year= 2004 |pmid= 14755251 |doi= 10.1038/sj.onc.1207318 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8  | pmc=395752 }}
*{{cite journal  | author=Jones GG, Reaper PM, Pettitt AR, Sherrington PD |title=The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes. |journal=Oncogene |volume=23 |issue= 10 |pages= 1911-21 |year= 2004 |pmid= 14755251 |doi= 10.1038/sj.onc.1207318 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 }}
*{{cite journal  |vauthors=Bonuccelli G, Sotgia F, Frank PG |title=ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection |journal=Am. J. Physiol., Cell Physiol. |volume=288 |issue= 6 |pages= C1402–10 |year= 2005 |pmid= 15689409 |doi= 10.1152/ajpcell.00582.2004 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Hotchkiss KA, Basile CM, Spring SC |title=TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen |journal=Exp. Cell Res. |volume=305 |issue= 1 |pages= 133–44 |year= 2005 |pmid= 15777794 |doi= 10.1016/j.yexcr.2004.12.025 |display-authors=etal}}
*{{cite journal  | author=Bonuccelli G, Sotgia F, Frank PG, ''et al.'' |title=ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection. |journal=Am. J. Physiol., Cell Physiol. |volume=288 |issue= 6 |pages= C1402-10 |year= 2005 |pmid= 15689409 |doi= 10.1152/ajpcell.00582.2004 }}
*{{cite journal  |vauthors=Rmali KA, Puntis MC, Jiang WG |title=TEM-8 and tubule formation in endothelial cells, its potential role of its vW/TM domains |journal=Biochem. Biophys. Res. Commun. |volume=334 |issue= 1 |pages= 231–8 |year= 2005 |pmid= 15993844 |doi= 10.1016/j.bbrc.2005.06.085 }}
*{{cite journal  | author=Hotchkiss KA, Basile CM, Spring SC, ''et al.'' |title=TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen. |journal=Exp. Cell Res. |volume=305 |issue= 1 |pages= 133-44 |year= 2005 |pmid= 15777794 |doi= 10.1016/j.yexcr.2004.12.025 }}
*{{cite journal  |vauthors=Rainey GJ, Wigelsworth DJ, Ryan PL |title=Receptor-specific requirements for anthrax toxin delivery into cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 37 |pages= 13278–83 |year= 2005 |pmid= 16141341 |doi= 10.1073/pnas.0505865102  | pmc=1201603 |display-authors=etal}}
*{{cite journal  | author=Rmali KA, Puntis MC, Jiang WG |title=TEM-8 and tubule formation in endothelial cells, its potential role of its vW/TM domains. |journal=Biochem. Biophys. Res. Commun. |volume=334 |issue= 1 |pages= 231-8 |year= 2005 |pmid= 15993844 |doi= 10.1016/j.bbrc.2005.06.085 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rainey GJ, Wigelsworth DJ, Ryan PL, ''et al.'' |title=Receptor-specific requirements for anthrax toxin delivery into cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 37 |pages= 13278-83 |year= 2005 |pmid= 16141341 |doi= 10.1073/pnas.0505865102 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 08:38, 11 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Anthrax toxin receptor 1 (ANTXR1 or also known asTEM8) is a protein that in humans is encoded by the ANTXR1 gene.[1][2][3] Its molecular weight is predicted as about 63kDa.

The protein encoded by this gene is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.[3]

See also

References

  1. ↑ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science. 289 (5482): 1197–202. doi:10.1126/science.289.5482.1197. PMID 10947988.
  2. ↑ Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (Sep 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Res. 61 (18): 6649–55. PMID 11559528.
  3. ↑ 3.0 3.1 "Entrez Gene: ANTXR1 anthrax toxin receptor 1".

External links

Further reading


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