REG1A: Difference between revisions

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Latest revision as of 09:04, 10 September 2017

Lithostathine-1-alpha also known as islet cells regeneration factor (ICRF) or islet of Langerhans regenerating protein (REG) is a protein that in humans is encoded by the REG1A gene.^[1]^[2]^[3]

Function

This protein is a type I subclass member of the Regenerating protein family. The Reg protein family is a multi protein family grouped into four subclasses, types I, II, III and IV based on the primary structures of the proteins. This protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandomly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.^[3]

References

↑ Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H (Jun 1990). "Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The gene encode protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene". J Biol Chem. 265 (13): 7432–9. PMID 2332435.
↑ Gharib B, Fox MF, Bartoli C, Giorgi D, Sansonetti A, Swallow DM, Dagorn JC, Berge-lefranc JL (Aug 1993). "regeneration". Ann Hum Genet. 57 (Pt 1): 9–16. doi:10.1111/j.1469-1809.1993.tb00882.x. PMID 8333731.
↑ ^3.0 ^3.1 "Entrez Gene: REG1A regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)".

De Reggi M, Gharib B (2002). "Protein-X, Pancreatic Stone-, Pancreatic thread-, reg-protein, P19, lithostathine, and now what? Characterization, structural analysis and putative function(s) of the major non-enzymatic protein of pancreatic secretions". Curr. Protein Pept. Sci. 2 (1): 19–42. doi:10.2174/1389203013381233. PMID 12369899.
Itoh T, Tsuzuki H, Katoh T, Teraoka H, Matsumoto K, Yoshida N, Terazono K, Watanabe T, Yonekura H, Yamamoto H (1990). "Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae". FEBS Lett. 272 (1–2): 85–8. doi:10.1016/0014-5793(90)80454-Q. PMID 2226837.
de la Monte SM, Ozturk M, Wands JR (1990). "Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain". J. Clin. Invest. 86 (3): 1004–13. doi:10.1172/JCI114762. PMC 296822. PMID 2394826.
De Caro AM, Adrich Z, Fournet B, Capon C, Bonicel JJ, De Caro JD, Rovery M (1989). "N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue". Biochim. Biophys. Acta. 994 (3): 281–4. doi:10.1016/0167-4838(89)90305-1. PMID 2493268.
Giorgi D, Bernard JP, Rouquier S, Iovanna J, Sarles H, Dagorn JC (1989). "Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis". J. Clin. Invest. 84 (1): 100–6. doi:10.1172/JCI114128. PMC 303958. PMID 2525567.
Stewart TA (1989). "The human reg gene encodes pancreatic stone protein". Biochem. J. 260 (2): 622–3. PMC 1138718. PMID 2764894.
Terazono K, Yamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y, Okamoto H (1988). "A novel gene activated in regenerating islets". J. Biol. Chem. 263 (5): 2111–4. PMID 2963000.
Rouimi P, Bonicel J, Rovery M, De Caro A (1987). "Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein". FEBS Lett. 216 (2): 195–9. doi:10.1016/0014-5793(87)80688-9. PMID 3108036.
Rouimi P, de Caro J, Bonicel J, Rovery M, de Caro A (1988). "The disulfide bridges of the immunoreactive forms of human pancreatic stone protein isolated from pancreatic juice". FEBS Lett. 229 (1): 171–4. doi:10.1016/0014-5793(88)80820-2. PMID 3345835.
Montalto G, Bonicel J, Multigner L, Rovery M, Sarles H, De Caro A (1987). "Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein". Biochem. J. 238 (1): 227–32. PMC 1147119. PMID 3541906.
De Caro AM, Bonicel JJ, Rouimi P, De Caro JD, Sarles H, Rovery M (1987). "Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice". Eur. J. Biochem. 168 (1): 201–7. doi:10.1111/j.1432-1033.1987.tb13405.x. PMID 3665916.
Gross J, Carlson RI, Brauer AW, Margolies MN, Warshaw AL, Wands JR (1986). "Isolation, characterization, and distribution of an unusual pancreatic human secretory protein". J. Clin. Invest. 76 (6): 2115–26. doi:10.1172/JCI112216. PMC 424321. PMID 3908481.
Perfetti R, Hawkins AL, Griffin CA, Egan JM, Zenilman ME, Shuldiner AR (1994). "Assignment of the human pancreatic regenerating (REG) gene to chromosome 2p12". Genomics. 20 (2): 305–7. doi:10.1006/geno.1994.1173. PMID 8020983.
Otonkoski T, Mally MI, Hayek A (1994). "Opposite effects of beta-cell differentiation and growth on reg expression in human fetal pancreatic cells". Diabetes. 43 (9): 1164–6. doi:10.2337/diabetes.43.9.1164. PMID 8070617.
Moriizumi S, Watanabe T, Unno M, Nakagawara K, Suzuki Y, Miyashita H, Yonekura H, Okamoto H (1994). "Isolation, structural determination and expression of a novel reg gene, human regI beta". Biochim. Biophys. Acta. 1217 (2): 199–202. doi:10.1016/0167-4781(94)90035-3. PMID 8110835.
Bartoli C, Gharib B, Giorgi D, Sansonetti A, Dagorn JC, Bergé-Lefranc JL (1993). "A gene homologous to the reg gene is expressed in the human pancreas". FEBS Lett. 327 (3): 289–93. doi:10.1016/0014-5793(93)81006-L. PMID 8348956.
Bertrand JA, Pignol D, Bernard JP, Verdier JM, Dagorn JC, Fontecilla-Camps JC (1996). "Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation". EMBO J. 15 (11): 2678–84. PMC 450203. PMID 8654365.
Patard L, Stoven V, Gharib B, Bontems F, Lallemand JY, De Reggi M (1997). "What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy". Protein Eng. 9 (11): 949–57. doi:10.1093/protein/9.11.949. PMID 8961348.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[pmid2332435-1] Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H (Jun 1990). "Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The gene encode protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene". J Biol Chem. 265 (13): 7432–9. PMID 2332435.

[pmid8333731-2] Gharib B, Fox MF, Bartoli C, Giorgi D, Sansonetti A, Swallow DM, Dagorn JC, Berge-lefranc JL (Aug 1993). "regeneration". Ann Hum Genet. 57 (Pt 1): 9–16. doi:10.1111/j.1469-1809.1993.tb00882.x. PMID 8333731.

[entrez-3] 3.0 ^3.1 "Entrez Gene: REG1A regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Lithostathine-1-alpha''' also known as '''islet cells regeneration factor''' (ICRF) or '''islet of Langerhans regenerating protein''' (REG) is a [[protein]] that in humans is encoded by the ''REG1A'' [[gene]].<ref name="pmid2332435">{{cite journal | vauthors = Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H | title = Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The gene encode protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene | journal = J Biol Chem | volume = 265 | issue = 13 | pages = 7432–9 | date = Jun 1990 | pmid = 2332435 | pmc =  | doi =  }}</ref><ref name="pmid8333731">{{cite journal | vauthors = Gharib B, Fox MF, Bartoli C, Giorgi D, Sansonetti A, Swallow DM, Dagorn JC, Berge-lefranc JL | title = Human [[Regeneration (biology)|regeneration]] protein/lithostathine genes map to chromosome 2p12 | journal = Ann Hum Genet | volume = 57 | issue = Pt 1 | pages = 9–16 | date = Aug 1993 | pmid = 8333731 | pmc =  | doi = 10.1111/j.1469-1809.1993.tb00882.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: REG1A regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5967| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image = PBB_Protein_REG1A_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lit.
- | PDB = {{PDB2|1lit}}, {{PDB2|1qdd}}
- | Name = Regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)
- | HGNCid = 9951
- | Symbol = REG1A
- | AltSymbols =; REG; PSP; ICRF; MGC12447; P19; PSPS; PSPS1; PTP
- | OMIM = 167770
- | ECnumber =
- | Homologene = 68282
- | MGIid = 97895
- | GeneAtlas_image1 = PBB_GE_REG1A_209752_at_tn.png
- | Function = {{GNF_GO|id=GO:0005529 |text = sugar binding}}
- | Component =
- | Process = {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5967
-    | Hs_Ensembl = ENSG00000115386
-    | Hs_RefseqProtein = NP_002900
-    | Hs_RefseqmRNA = NM_002909
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 2
-    | Hs_GenLoc_start = 79201092
-    | Hs_GenLoc_end = 79204053
-    | Hs_Uniprot = P05451
-    | Mm_EntrezGene = 19692
-    | Mm_Ensembl = ENSMUSG00000059654
-    | Mm_RefseqmRNA = NM_009042
-    | Mm_RefseqProtein = NP_033068
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 6
-    | Mm_GenLoc_start = 78355492
-    | Mm_GenLoc_end = 78358175
-    | Mm_Uniprot = Q3TV26
-  }}
-}}
-'''Regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)''', also known as '''REG1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: REG1A regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5967| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+This protein is a type I subclass member of the [[Regenerating protein family]]. The Reg protein family is a multi protein family grouped into four subclasses, types I, II, III and IV based on the primary structures of the proteins. This protein that is secreted by the [[exocrine pancreas]]. It is associated with [[islet cell]] [[Regeneration (biology)|regeneration]] and [[diabetes mellitus|diabetogenesis]] and may be involved in pancreatic [[calculus (medicine)|lithogenesis]]. Reg family members [[REG1B]], [[REG1P|REGL]], [[REG3A|PAP]] and this gene are tandomly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandomly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.<ref name="entrez">{{cite web | title = Entrez Gene: REG1A regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5967| accessdate = }}</ref>
-}}
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
-{{refbegin | 2}}
+== Further reading==
-{{PBB_Further_reading
+{{refbegin|2}}
-| citations =
+*{{cite journal | vauthors = De Reggi M, Gharib B | title = Protein-X, Pancreatic Stone-, Pancreatic thread-, reg-protein, P19, lithostathine, and now what? Characterization, structural analysis and putative function(s) of the major non-enzymatic protein of pancreatic secretions | journal = Curr. Protein Pept. Sci. | volume = 2 | issue =1 | pages = 19–42 | year = 2002 | pmid = 12369899 | doi = 10.2174/1389203013381233 }}
-*{{cite journal  | author=De Reggi M, Gharib B |title=Protein-X, Pancreatic Stone-, Pancreatic thread-, reg-protein, P19, lithostathine, and now what? Characterization, structural analysis and putative function(s) of the major non-enzymatic protein of pancreatic secretions. |journal=Curr. Protein Pept. Sci. |volume=2 |issue= 1 |pages= 19-42 |year= 2002 |pmid= 12369899 |doi=  }}
+*{{cite journal | vauthors = Itoh T, Tsuzuki H, Katoh T, Teraoka H, Matsumoto K, Yoshida N, Terazono K, Watanabe T, Yonekura H, Yamamoto H | title = Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae | journal = FEBS Lett. | volume = 272 | issue = 1–2 | pages = 85–8 | year = 1990 | pmid = 2226837 | doi = 10.1016/0014-5793(90)80454-Q }}
-*{{cite journal  | author=Itoh T, Tsuzuki H, Katoh T, ''et al.'' |title=Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae. |journal=FEBS Lett. |volume=272 |issue= 1-2 |pages= 85-8 |year= 1990 |pmid= 2226837 |doi=  }}
+*{{cite journal | vauthors = de la Monte SM, Ozturk M, Wands JR | title = Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain | journal = J. Clin. Invest. | volume = 86 | issue = 3 | pages = 1004–13 | year = 1990 | pmid = 2394826 | pmc = 296822 | doi = 10.1172/JCI114762 }}
-*{{cite journal  | author=Watanabe T, Yonekura H, Terazono K, ''et al.'' |title=Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. |journal=J. Biol. Chem. |volume=265 |issue= 13 |pages= 7432-9 |year= 1990 |pmid= 2332435 |doi=  }}
+*{{cite journal | vauthors = De Caro AM, Adrich Z, Fournet B, Capon C, Bonicel JJ, De Caro JD, Rovery M | title = N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue | journal = Biochim. Biophys. Acta | volume = 994 | issue = 3 | pages = 281–4 | year = 1989 | pmid = 2493268 | doi = 10.1016/0167-4838(89)90305-1 }}
-*{{cite journal  | author=de la Monte SM, Ozturk M, Wands JR |title=Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain. |journal=J. Clin. Invest. |volume=86 |issue= 3 |pages= 1004-13 |year= 1990 |pmid= 2394826 |doi=  }}
+*{{cite journal | vauthors = Giorgi D, Bernard JP, Rouquier S, Iovanna J, Sarles H, Dagorn JC | title = Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis | journal = J. Clin. Invest. | volume = 84 | issue = 1 | pages = 100–6 | year = 1989 | pmid = 2525567 | pmc = 303958 | doi = 10.1172/JCI114128 }}
-*{{cite journal  | author=De Caro AM, Adrich Z, Fournet B, ''et al.'' |title=N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue. |journal=Biochim. Biophys. Acta |volume=994 |issue= 3 |pages= 281-4 |year= 1989 |pmid= 2493268 |doi=  }}
+*{{cite journal | author = Stewart TA | title = The human reg gene encodes pancreatic stone protein | journal = Biochem. J. | volume = 260 | issue = 2 | pages = 622–3 | year = 1989 | pmid = 2764894 | pmc = 1138718 | doi =  }}
-*{{cite journal  | author=Giorgi D, Bernard JP, Rouquier S, ''et al.'' |title=Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis. |journal=J. Clin. Invest. |volume=84 |issue= 1 |pages= 100-6 |year= 1989 |pmid= 2525567 |doi=  }}
+*{{cite journal | vauthors = Terazono K, Yamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y, Okamoto H | title = A novel gene activated in regenerating islets | journal = J. Biol. Chem. | volume = 263 | issue = 5 | pages = 2111–4 | year = 1988 | pmid = 2963000 | doi =  }}
-*{{cite journal  | author=Stewart TA |title=The human reg gene encodes pancreatic stone protein. |journal=Biochem. J. |volume=260 |issue= 2 |pages= 622-3 |year= 1989 |pmid= 2764894 |doi=  }}
+*{{cite journal | vauthors = Rouimi P, Bonicel J, Rovery M, De Caro A | title = Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein | journal = FEBS Lett. | volume = 216 | issue = 2 | pages = 195–9 | year = 1987 | pmid = 3108036 | doi = 10.1016/0014-5793(87)80688-9 }}
-*{{cite journal  | author=Terazono K, Yamamoto H, Takasawa S, ''et al.'' |title=A novel gene activated in regenerating islets. |journal=J. Biol. Chem. |volume=263 |issue= 5 |pages= 2111-4 |year= 1988 |pmid= 2963000 |doi=  }}
+*{{cite journal | vauthors = Rouimi P, de Caro J, Bonicel J, Rovery M, de Caro A | title = The disulfide bridges of the immunoreactive forms of human pancreatic stone protein isolated from pancreatic juice | journal = FEBS Lett. | volume = 229 | issue = 1 | pages = 171–4 | year = 1988 | pmid = 3345835 | doi = 10.1016/0014-5793(88)80820-2 }}
-*{{cite journal  | author=Rouimi P, Bonicel J, Rovery M, De Caro A |title=Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein. |journal=FEBS Lett. |volume=216 |issue= 2 |pages= 195-9 |year= 1987 |pmid= 3108036 |doi=  }}
+*{{cite journal | vauthors = Montalto G, Bonicel J, Multigner L, Rovery M, Sarles H, De Caro A | title = Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein | journal = Biochem. J. | volume = 238 | issue = 1 | pages = 227–32 | year = 1987 | pmid = 3541906 | pmc = 1147119 | doi =  }}
-*{{cite journal  | author=Rouimi P, de Caro J, Bonicel J, ''et al.'' |title=The disulfide bridges of the immunoreactive forms of human pancreatic stone protein isolated from pancreatic juice. |journal=FEBS Lett. |volume=229 |issue= 1 |pages= 171-4 |year= 1988 |pmid= 3345835 |doi=  }}
+*{{cite journal | vauthors = De Caro AM, Bonicel JJ, Rouimi P, De Caro JD, Sarles H, Rovery M | title = Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice | journal = Eur. J. Biochem. | volume = 168 | issue = 1 | pages = 201–7 | year = 1987 | pmid = 3665916 | doi = 10.1111/j.1432-1033.1987.tb13405.x }}
-*{{cite journal  | author=Montalto G, Bonicel J, Multigner L, ''et al.'' |title=Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein. |journal=Biochem. J. |volume=238 |issue= 1 |pages= 227-32 |year= 1987 |pmid= 3541906 |doi=  }}
+*{{cite journal | vauthors = Gross J, Carlson RI, Brauer AW, Margolies MN, Warshaw AL, Wands JR | title = Isolation, characterization, and distribution of an unusual pancreatic human secretory protein | journal = J. Clin. Invest. | volume = 76 | issue = 6 | pages = 2115–26 | year = 1986 | pmid = 3908481 | pmc = 424321 | doi = 10.1172/JCI112216 }}
-*{{cite journal  | author=De Caro AM, Bonicel JJ, Rouimi P, ''et al.'' |title=Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice. |journal=Eur. J. Biochem. |volume=168 |issue= 1 |pages= 201-7 |year= 1987 |pmid= 3665916 |doi=  }}
+*{{cite journal | vauthors = Perfetti R, Hawkins AL, Griffin CA, Egan JM, Zenilman ME, Shuldiner AR | title = Assignment of the human pancreatic regenerating (REG) gene to chromosome 2p12 | journal = Genomics | volume = 20 | issue = 2 | pages = 305–7 | year = 1994 | pmid = 8020983 | doi = 10.1006/geno.1994.1173 }}
-*{{cite journal  | author=Gross J, Carlson RI, Brauer AW, ''et al.'' |title=Isolation, characterization, and distribution of an unusual pancreatic human secretory protein. |journal=J. Clin. Invest. |volume=76 |issue= 6 |pages= 2115-26 |year= 1986 |pmid= 3908481 |doi=  }}
+*{{cite journal | vauthors = Otonkoski T, Mally MI, Hayek A | title = Opposite effects of beta-cell differentiation and growth on reg expression in human fetal pancreatic cells | journal = Diabetes | volume = 43 | issue = 9 | pages = 1164–6 | year = 1994 | pmid = 8070617 | doi = 10.2337/diabetes.43.9.1164 }}
-*{{cite journal  | author=Perfetti R, Hawkins AL, Griffin CA, ''et al.'' |title=Assignment of the human pancreatic regenerating (REG) gene to chromosome 2p12. |journal=Genomics |volume=20 |issue= 2 |pages= 305-7 |year= 1994 |pmid= 8020983 |doi= 10.1006/geno.1994.1173 }}
+*{{cite journal | vauthors = Moriizumi S, Watanabe T, Unno M, Nakagawara K, Suzuki Y, Miyashita H, Yonekura H, Okamoto H | title = Isolation, structural determination and expression of a novel reg gene, human regI beta | journal = Biochim. Biophys. Acta | volume = 1217 | issue = 2 | pages = 199–202 | year = 1994 | pmid = 8110835 | doi = 10.1016/0167-4781(94)90035-3 }}
-*{{cite journal  | author=Otonkoski T, Mally MI, Hayek A |title=Opposite effects of beta-cell differentiation and growth on reg expression in human fetal pancreatic cells. |journal=Diabetes |volume=43 |issue= 9 |pages= 1164-6 |year= 1994 |pmid= 8070617 |doi=  }}
+*{{cite journal | vauthors = Bartoli C, Gharib B, Giorgi D, Sansonetti A, Dagorn JC, Bergé-Lefranc JL | title = A gene homologous to the reg gene is expressed in the human pancreas | journal = FEBS Lett. | volume = 327 | issue = 3 | pages = 289–93 | year = 1993 | pmid = 8348956 | doi = 10.1016/0014-5793(93)81006-L }}
-*{{cite journal  | author=Moriizumi S, Watanabe T, Unno M, ''et al.'' |title=Isolation, structural determination and expression of a novel reg gene, human regI beta. |journal=Biochim. Biophys. Acta |volume=1217 |issue= 2 |pages= 199-202 |year= 1994 |pmid= 8110835 |doi=  }}
+*{{cite journal | vauthors = Bertrand JA, Pignol D, Bernard JP, Verdier JM, Dagorn JC, Fontecilla-Camps JC | title = Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation | journal = EMBO J. | volume = 15 | issue = 11 | pages = 2678–84 | year = 1996 | pmid = 8654365 | pmc = 450203 | doi =  }}
-*{{cite journal  | author=Gharib B, Fox MF, Bartoli C, ''et al.'' |title=Human regeneration protein/lithostathine genes map to chromosome 2p12. |journal=Ann. Hum. Genet. |volume=57 |issue= Pt 1 |pages= 9-16 |year= 1993 |pmid= 8333731 |doi=  }}
+*{{cite journal | vauthors = Patard L, Stoven V, Gharib B, Bontems F, Lallemand JY, De Reggi M | title = What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy | journal = Protein Eng. | volume = 9 | issue = 11 | pages = 949–57 | year = 1997 | pmid = 8961348 | doi = 10.1093/protein/9.11.949 }}
-*{{cite journal  | author=Bartoli C, Gharib B, Giorgi D, ''et al.'' |title=A gene homologous to the reg gene is expressed in the human pancreas. |journal=FEBS Lett. |volume=327 |issue= 3 |pages= 289-93 |year= 1993 |pmid= 8348956 |doi=  }}
-*{{cite journal  | author=Bertrand JA, Pignol D, Bernard JP, ''et al.'' |title=Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation. |journal=EMBO J. |volume=15 |issue= 11 |pages= 2678-84 |year= 1996 |pmid= 8654365 |doi=  }}
-*{{cite journal  | author=Patard L, Stoven V, Gharib B, ''et al.'' |title=What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy. |journal=Protein Eng. |volume=9 |issue= 11 |pages= 949-57 |year= 1997 |pmid= 8961348 |doi=  }}
-}}
 {{refend}}
+{{PDB Gallery|geneid=5967}}
-{{protein-stub}}
+{{gene-2-stub}}
-{{WikiDoc Sources}}

REG1A: Difference between revisions

Latest revision as of 09:04, 10 September 2017

Function

References

Further reading

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