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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''T-complex protein 1 subunit eta''' is a [[protein]] that in humans is encoded by the ''CCT7'' [[gene]].<ref name="pmid9819444">{{cite journal | vauthors = Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI | title = Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT | journal = Molecular and Cellular Biology | volume = 18 | issue = 12 | pages = 7584–9 | date = Dec 1998 | pmid = 9819444 | pmc = 109339 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CCT7 chaperonin containing TCP1, subunit 7 (eta)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10574| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chaperonin containing TCP1, subunit 7 (eta)
| HGNCid = 1622
| Symbol = CCT7
| AltSymbols =; CCT-ETA; Ccth; MGC110985; Nip7-1; TCP-1-eta
| OMIM = 605140
| ECnumber = 
| Homologene = 4694
| MGIid = 107184
| GeneAtlas_image1 = PBB_GE_CCT7_200812_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005832 |text = chaperonin-containing T-complex}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006457 |text = protein folding}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10574
    | Hs_Ensembl = ENSG00000135624
    | Hs_RefseqProtein = NP_001009570
    | Hs_RefseqmRNA = NM_001009570
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 73314913
    | Hs_GenLoc_end = 73333655
    | Hs_Uniprot = Q99832
    | Mm_EntrezGene = 12468
    | Mm_Ensembl = ENSMUSG00000030007
    | Mm_RefseqmRNA = NM_007638
    | Mm_RefseqProtein = NP_031664
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 85417731
    | Mm_GenLoc_end = 85434130
    | Mm_Uniprot = Q3TET0
  }}
}}
'''Chaperonin containing TCP1, subunit 7 (eta)''', also known as '''CCT7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCT7 chaperonin containing TCP1, subunit 7 (eta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10574| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.<ref name="entrez">{{cite web | title = Entrez Gene: CCT7 chaperonin containing TCP1, subunit 7 (eta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10574| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CCT7 has been shown to [[Protein-protein interaction|interact]] with [[PPP4C]].<ref name=pmid18715871>{{cite journal | vauthors = Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC | title = PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 | journal = The Journal of Biological Chemistry | volume = 283 | issue = 43 | pages = 29273–84 | date = Oct 2008 | pmid = 18715871 | pmc = 2662017 | doi = 10.1074/jbc.M803443200 }}</ref><ref name=pmid16085932>{{cite journal | vauthors = Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R | title = A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity | journal = Molecular & Cellular Proteomics | volume = 4 | issue = 11 | pages = 1725–40 | date = Nov 2005 | pmid = 16085932 | doi = 10.1074/mcp.M500231-MCP200 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
==External links==
* {{UCSC gene info|CCT7}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kubota H, Hynes G, Carne A, Ashworth A, Willison K | title = Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin | journal = Current Biology | volume = 4 | issue = 2 | pages = 89–99  | date = Feb 1994 | pmid = 7953530 | doi = 10.1016/S0960-9822(94)00024-2 }}
| citations =
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4  | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Kubota H, Hynes G, Carne A, ''et al.'' |title=Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. |journal=Curr. Biol. |volume=4 |issue= 2 |pages= 89-99 |year= 1994 |pmid= 7953530 |doi= }}
* {{cite journal | vauthors = Hynes G, Celis JE, Lewis VA, Carne A, U S, Lauridsen JB, Willison KR | title = Analysis of chaperonin-containing TCP-1 subunits in the human keratinocyte two-dimensional protein database: further characterisation of antibodies to individual subunits | journal = Electrophoresis | volume = 17 | issue = 11 | pages = 1720–7 | year = 1997 | date = Nov 1996 | pmid = 8982604 | doi = 10.1002/elps.1150171109 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Liou AK, Willison KR | title = Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes | journal = The EMBO Journal | volume = 16 | issue = 14 | pages = 4311–6  | date = Jul 1997 | pmid = 9250675 | pmc = 1170057 | doi = 10.1093/emboj/16.14.4311 }}
*{{cite journal | author=Hynes G, Celis JE, Lewis VA, ''et al.'' |title=Analysis of chaperonin-containing TCP-1 subunits in the human keratinocyte two-dimensional protein database: further characterisation of antibodies to individual subunits. |journal=Electrophoresis |volume=17 |issue= 11 |pages= 1720-7 |year= 1997 |pmid= 8982604 |doi= 10.1002/elps.1150171109 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56  | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Liou AK, Willison KR |title=Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes. |journal=EMBO J. |volume=16 |issue= 14 |pages= 4311-6 |year= 1997 |pmid= 9250675 |doi= }}
* {{cite journal | vauthors = Yokota S, Yanagi H, Yura T, Kubota H | title = Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle | journal = European Journal of Biochemistry / FEBS | volume = 268 | issue = 17 | pages = 4664–73  | date = Sep 2001 | pmid = 11532003 | doi = 10.1046/j.1432-1327.2001.02393.x }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | title = Protein-protein interaction panel using mouse full-length cDNAs | journal = Genome Research | volume = 11 | issue = 10 | pages = 1758–65  | date = Oct 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 }}
*{{cite journal  | author=Won KA, Schumacher RJ, Farr GW, ''et al.'' |title=Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 7584-9 |year= 1998 |pmid= 9819444 |doi=  }}
* {{cite journal | vauthors = Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R | title = A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death | journal = The Journal of Biological Chemistry | volume = 278 | issue = 51 | pages = 51901–10 | year = 2004 | date = Dec 2003 | pmid = 14532270 | doi = 10.1074/jbc.M309655200 }}
*{{cite journal | author=Yokota S, Yanagi H, Yura T, Kubota H |title=Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle. |journal=Eur. J. Biochem. |volume=268 |issue= 17 |pages= 4664-73 |year= 2001 |pmid= 11532003 |doi= }}
* {{cite journal | vauthors = Hanafy KA, Martin E, Murad F | title = CCTeta, a novel soluble guanylyl cyclase-interacting protein | journal = The Journal of Biological Chemistry | volume = 279 | issue = 45 | pages = 46946–53  | date = Nov 2004 | pmid = 15347653 | doi = 10.1074/jbc.M404134200 }}
*{{cite journal | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758-65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68  | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY | title = Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress | journal = Biochemical and Biophysical Research Communications | volume = 337 | issue = 4 | pages = 1308–18  | date = Dec 2005 | pmid = 16236267 | doi = 10.1016/j.bbrc.2005.09.191 }}
*{{cite journal  | author=Imai Y, Soda M, Murakami T, ''et al.'' |title=A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51901-10 |year= 2004 |pmid= 14532270 |doi= 10.1074/jbc.M309655200 }}
*{{cite journal | author=Hanafy KA, Martin E, Murad F |title=CCTeta, a novel soluble guanylyl cyclase-interacting protein. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46946-53 |year= 2004 |pmid= 15347653 |doi= 10.1074/jbc.M404134200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Guo D, Han J, Adam BL, ''et al.'' |title=Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 4 |pages= 1308-18 |year= 2005 |pmid= 16236267 |doi= 10.1016/j.bbrc.2005.09.191 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-2-stub}}

Latest revision as of 09:20, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

T-complex protein 1 subunit eta is a protein that in humans is encoded by the CCT7 gene.[1][2]

Function

This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.[2]

Interactions

CCT7 has been shown to interact with PPP4C.[3][4]

References

  1. ↑ Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998). "Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT". Molecular and Cellular Biology. 18 (12): 7584–9. PMC 109339. PMID 9819444.
  2. ↑ 2.0 2.1 "Entrez Gene: CCT7 chaperonin containing TCP1, subunit 7 (eta)".
  3. ↑ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
  4. ↑ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

External links

Further reading

  • Kubota H, Hynes G, Carne A, Ashworth A, Willison K (Feb 1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Current Biology. 4 (2): 89–99. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Hynes G, Celis JE, Lewis VA, Carne A, U S, Lauridsen JB, Willison KR (Nov 1996). "Analysis of chaperonin-containing TCP-1 subunits in the human keratinocyte two-dimensional protein database: further characterisation of antibodies to individual subunits". Electrophoresis. 17 (11): 1720–7. doi:10.1002/elps.1150171109. PMID 8982604. Check date values in: |year= / |date= mismatch (help)
  • Liou AK, Willison KR (Jul 1997). "Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes". The EMBO Journal. 16 (14): 4311–6. doi:10.1093/emboj/16.14.4311. PMC 1170057. PMID 9250675.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Yokota S, Yanagi H, Yura T, Kubota H (Sep 2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". European Journal of Biochemistry / FEBS. 268 (17): 4664–73. doi:10.1046/j.1432-1327.2001.02393.x. PMID 11532003.
  • Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
  • Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (Dec 2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". The Journal of Biological Chemistry. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270. Check date values in: |year= / |date= mismatch (help)
  • Hanafy KA, Martin E, Murad F (Nov 2004). "CCTeta, a novel soluble guanylyl cyclase-interacting protein". The Journal of Biological Chemistry. 279 (45): 46946–53. doi:10.1074/jbc.M404134200. PMID 15347653.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  • Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (Dec 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical Research Communications. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.


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