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{{Underlinked|date=March 2014}}
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{{Infobox_gene}}
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'''TFIIA-alpha and beta-like factor''' is a [[protein]] that in humans is encoded by the ''GTF2A1L'' [[gene]].<ref name="pmid10364255">{{cite journal |vauthors=Upadhyaya AB, Lee SH, DeJong J | title = Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis | journal = J Biol Chem | volume = 274 | issue = 25 | pages = 18040–8 |date=Jul 1999 | pmid = 10364255 | pmc =  | doi =10.1074/jbc.274.25.18040  }}</ref><ref name="pmid11889132">{{cite journal |vauthors=Xie W, Han S, Khan M, DeJong J | title = Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation | journal = J Biol Chem | volume = 277 | issue = 20 | pages = 17765–74 |date=May 2002 | pmid = 11889132 | pmc =  | doi = 10.1074/jbc.M200954200 }}</ref><ref name="pmid16525715">{{cite journal |vauthors=Huang M, Wang H, Li J, Zhou Z, Du Y, Lin M, Sha J | title = Involvement of ALF in human spermatogenesis and male infertility | journal = Int J Mol Med | volume = 17 | issue = 4 | pages = 599–604 |date=Mar 2006 | pmid = 16525715 | pmc =  | doi =  10.3892/ijmm.17.4.599}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ALF TFIIA-alpha/beta-like factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11036| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = TFIIA-alpha/beta-like factor
| HGNCid =
| Symbol = ALF
| AltSymbols =; MGC26254
| OMIM = 605358
| ECnumber =
| Homologene = 86732
| MGIid = 1919078
  | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016986 |text = transcription initiation factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
  | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11036
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_006863
    | Hs_RefseqmRNA = NM_006872
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr =   
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 71828
    | Mm_Ensembl = ENSMUSG00000024154
    | Mm_RefseqmRNA = NM_023630
    | Mm_RefseqProtein = NP_076119
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 88577003
    | Mm_GenLoc_end = 88623475
    | Mm_Uniprot = Q8R4I4
  }}
}}
'''TFIIA-alpha/beta-like factor''', also known as '''ALF''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ALF TFIIA-alpha/beta-like factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11036| accessdate = }}</ref>


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<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.<ref name="entrez">{{cite web | title = Entrez Gene: ALF TFIIA-alpha/beta-like factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11036| accessdate = }}</ref>
| summary_text = The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a [[eukaryotic]] core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct [[isoforms]], have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Loveys DA, Streiff MB, Kato GJ |title=E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein. |journal=Nucleic Acids Res. |volume=24 |issue= 14 |pages= 2813-20 |year= 1996 |pmid= 8759016 |doi=  }}
*{{cite journal  |vauthors=Loveys DA, Streiff MB, Kato GJ |title=E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein |journal=Nucleic Acids Res. |volume=24 |issue= 14 |pages= 2813–20 |year= 1996 |pmid= 8759016 |doi=10.1093/nar/24.14.2813  | pmc=145994 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Malik S, Guermah M, Roeder RG |title=A dynamic model for PC4 coactivator function in RNA polymerase II transcription. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 5 |pages= 2192-7 |year= 1998 |pmid= 9482861 |doi= }}
*{{cite journal  |vauthors=Malik S, Guermah M, Roeder RG |title=A dynamic model for PC4 coactivator function in RNA polymerase II transcription |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 5 |pages= 2192–7 |year= 1998 |pmid= 9482861 |doi=10.1073/pnas.95.5.2192  | pmc=19292 }}
*{{cite journal  | author=Upadhyaya AB, Lee SH, DeJong J |title=Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 18040-8 |year= 1999 |pmid= 10364255 |doi=  }}
*{{cite journal   |vauthors=Han SY, Zhou L, Upadhyaya A, etal |title=TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors during spermatogenesis in the mouse |journal=Biol. Reprod. |volume=64 |issue= 2 |pages= 507–17 |year= 2001 |pmid= 11159353 |doi=10.1095/biolreprod64.2.507 }}
*{{cite journal | author=Han SY, Zhou L, Upadhyaya A, ''et al.'' |title=TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors during spermatogenesis in the mouse. |journal=Biol. Reprod. |volume=64 |issue= 2 |pages= 507-17 |year= 2001 |pmid= 11159353 |doi=  }}
*{{cite journal   |vauthors=Yoshida S, Ohbo K, Takakura A, etal |title=Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice |journal=Dev. Biol. |volume=240 |issue= 2 |pages= 517–30 |year= 2002 |pmid= 11784080 |doi= 10.1006/dbio.2001.0473 }}
*{{cite journal | author=Yoshida S, Ohbo K, Takakura A, ''et al.'' |title=Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice. |journal=Dev. Biol. |volume=240 |issue= 2 |pages= 517-30 |year= 2002 |pmid= 11784080 |doi= 10.1006/dbio.2001.0473 }}
*{{cite journal   |vauthors=Upadhyaya AB, Khan M, Mou TC, etal |title=The germ cell-specific transcription factor ALF. Structural properties and stabilization of the TATA-binding protein (TBP)-DNA complex |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34208–16 |year= 2002 |pmid= 12107178 |doi= 10.1074/jbc.M204808200 }}
*{{cite journal | author=Xie W, Han S, Khan M, DeJong J |title=Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17765-74 |year= 2002 |pmid= 11889132 |doi= 10.1074/jbc.M200954200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Upadhyaya AB, Khan M, Mou TC, ''et al.'' |title=The germ cell-specific transcription factor ALF. Structural properties and stabilization of the TATA-binding protein (TBP)-DNA complex. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34208-16 |year= 2002 |pmid= 12107178 |doi= 10.1074/jbc.M204808200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Howe ML, Mehmud ZF, Saha S, etal |title=Transcription Factor IIA tau is associated with undifferentiated cells and its gene expression is repressed in primary neurons at the chromatin level in vivo |journal=Stem Cells Dev. |volume=15 |issue= 2 |pages= 175–90 |year= 2006 |pmid= 16646664 |doi= 10.1089/scd.2006.15.175 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Kim M, Li D, Cui Y, etal |title=Regulatory factor interactions and somatic silencing of the germ cell-specific ALF gene |journal=J. Biol. Chem. |volume=281 |issue= 45 |pages= 34288–98 |year= 2006 |pmid= 16966320 |doi= 10.1074/jbc.M607168200 }}
*{{cite journal | author=Huang M, Wang H, Li J, ''et al.'' |title=Involvement of ALF in human spermatogenesis and male infertility. |journal=Int. J. Mol. Med. |volume=17 |issue= 4 |pages= 599-604 |year= 2006 |pmid= 16525715 |doi=  }}
*{{cite journal  | author=Howe ML, Mehmud ZF, Saha S, ''et al.'' |title=Transcription Factor IIA tau is associated with undifferentiated cells and its gene expression is repressed in primary neurons at the chromatin level in vivo. |journal=Stem Cells Dev. |volume=15 |issue= 2 |pages= 175-90 |year= 2006 |pmid= 16646664 |doi= 10.1089/scd.2006.15.175 }}
*{{cite journal | author=Kim M, Li D, Cui Y, ''et al.'' |title=Regulatory factor interactions and somatic silencing of the germ cell-specific ALF gene. |journal=J. Biol. Chem. |volume=281 |issue= 45 |pages= 34288-98 |year= 2006 |pmid= 16966320 |doi= 10.1074/jbc.M607168200 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 09:08, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

TFIIA-alpha and beta-like factor is a protein that in humans is encoded by the GTF2A1L gene.[1][2][3][4]

The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.[4]

References

  1. ↑ Upadhyaya AB, Lee SH, DeJong J (Jul 1999). "Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis". J Biol Chem. 274 (25): 18040–8. doi:10.1074/jbc.274.25.18040. PMID 10364255.
  2. ↑ Xie W, Han S, Khan M, DeJong J (May 2002). "Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation". J Biol Chem. 277 (20): 17765–74. doi:10.1074/jbc.M200954200. PMID 11889132.
  3. ↑ Huang M, Wang H, Li J, Zhou Z, Du Y, Lin M, Sha J (Mar 2006). "Involvement of ALF in human spermatogenesis and male infertility". Int J Mol Med. 17 (4): 599–604. doi:10.3892/ijmm.17.4.599. PMID 16525715.
  4. ↑ 4.0 4.1 "Entrez Gene: ALF TFIIA-alpha/beta-like factor".

Further reading



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