POLR1B: Difference between revisions

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{{Infobox_gene}}
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'''DNA-directed RNA polymerase I subunit RPA2''' is an [[enzyme]] that in [[human]]s is encoded by the ''POLR1B'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: POLR1B polymerase (RNA) I polypeptide B, 128kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84172| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Polymerase (RNA) I polypeptide B, 128kDa
| HGNCid = 20454
| Symbol = POLR1B
| AltSymbols =; FLJ10816; FLJ21921; MGC131780; RPA135; Rpo1-2
| OMIM = 602000
| ECnumber = 
| Homologene = 7133
| MGIid = 108014
| GeneAtlas_image1 = PBB_GE_POLR1B_220113_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003899 |text = DNA-directed RNA polymerase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84172
    | Hs_Ensembl = ENSG00000125630
    | Hs_RefseqProtein = NP_061887
    | Hs_RefseqmRNA = NM_019014
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 113016084
    | Hs_GenLoc_end = 113051879
    | Hs_Uniprot = Q9H9Y6
    | Mm_EntrezGene = 20017
    | Mm_Ensembl = ENSMUSG00000027395
    | Mm_RefseqmRNA = NM_009086
    | Mm_RefseqProtein = NP_033112
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 128792436
    | Mm_GenLoc_end = 128818035
    | Mm_Uniprot = Q3UMX7
  }}
}}
'''Polymerase (RNA) I polypeptide B, 128kDa''', also known as '''POLR1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: POLR1B polymerase (RNA) I polypeptide B, 128kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84172| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Seither P, Zatsepina O, Hoffmann M, Grummt I |title=Constitutive and strong association of PAF53 with RNA polymerase I. |journal=Chromosoma |volume=106 |issue= 4 |pages= 216-25 |year= 1997 |pmid= 9254723 |doi=  }}
*{{cite journal  | vauthors=Seither P, Zatsepina O, Hoffmann M, Grummt I |title=Constitutive and strong association of PAF53 with RNA polymerase I. |journal=Chromosoma |volume=106 |issue= 4 |pages= 216–25 |year= 1997 |pmid= 9254723 |doi=10.1007/s004120050242 }}
*{{cite journal  | author=Miller G, Panov KI, Friedrich JK, ''et al.'' |title=hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters. |journal=EMBO J. |volume=20 |issue= 6 |pages= 1373-82 |year= 2001 |pmid= 11250903 |doi= 10.1093/emboj/20.6.1373 }}
*{{cite journal  | vauthors=Miller G, Panov KI, Friedrich JK |title=hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters |journal=EMBO J. |volume=20 |issue= 6 |pages= 1373–82 |year= 2001 |pmid= 11250903 |doi= 10.1093/emboj/20.6.1373 | pmc=145519 }}
*{{cite journal  | author=Seither P, Iben S, Thiry M, Grummt I |title=PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I. |journal=Biol. Chem. |volume=382 |issue= 8 |pages= 1163-70 |year= 2002 |pmid= 11592397 |doi=  }}
*{{cite journal  | vauthors=Seither P, Iben S, Thiry M, Grummt I |title=PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I |journal=Biol. Chem. |volume=382 |issue= 8 |pages= 1163–70 |year= 2002 |pmid= 11592397 |doi=10.1515/BC.2001.146 }}
*{{cite journal  | author=Shiau AK, Barstad D, Radek JT, ''et al.'' |title=Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism. |journal=Nat. Struct. Biol. |volume=9 |issue= 5 |pages= 359-64 |year= 2002 |pmid= 11953755 |doi= 10.1038/nsb787 }}
*{{cite journal  | vauthors=Shiau AK, Barstad D, Radek JT |title=Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism |journal=Nat. Struct. Biol. |volume=9 |issue= 5 |pages= 359–64 |year= 2002 |pmid= 11953755 |doi= 10.1038/nsb787 }}
*{{cite journal  | author=Egea PF, Mitschler A, Moras D |title=Molecular recognition of agonist ligands by RXRs. |journal=Mol. Endocrinol. |volume=16 |issue= 5 |pages= 987-97 |year= 2002 |pmid= 11981034 |doi=  }}
*{{cite journal  | vauthors=Egea PF, Mitschler A, Moras D |title=Molecular recognition of agonist ligands by RXRs |journal=Mol. Endocrinol. |volume=16 |issue= 5 |pages= 987–97 |year= 2002 |pmid= 11981034 |doi=10.1210/me.16.5.987 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal  | vauthors=Bouwmeester T, Bauch A, Ruffner H |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal  | author=Yamamoto K, Yamamoto M, Hanada K, ''et al.'' |title=Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. |journal=Mol. Cell. Biol. |volume=24 |issue= 14 |pages= 6338-49 |year= 2004 |pmid= 15226435 |doi= 10.1128/MCB.24.14.6338-6349.2004 }}
*{{cite journal  | vauthors=Yamamoto K, Yamamoto M, Hanada K |title=Multiple Protein-Protein Interactions by RNA Polymerase I-Associated Factor PAF49 and Role of PAF49 in rRNA Transcription |journal=Mol. Cell. Biol. |volume=24 |issue= 14 |pages= 6338–49 |year= 2004 |pmid= 15226435 |doi= 10.1128/MCB.24.14.6338-6349.2004 | pmc=434256 }}
*{{cite journal  | author=Philimonenko VV, Zhao J, Iben S, ''et al.'' |title=Nuclear actin and myosin I are required for RNA polymerase I transcription. |journal=Nat. Cell Biol. |volume=6 |issue= 12 |pages= 1165-72 |year= 2005 |pmid= 15558034 |doi= 10.1038/ncb1190 }}
*{{cite journal  | vauthors=Philimonenko VV, Zhao J, Iben S |title=Nuclear actin and myosin I are required for RNA polymerase I transcription |journal=Nat. Cell Biol. |volume=6 |issue= 12 |pages= 1165–72 |year= 2005 |pmid= 15558034 |doi= 10.1038/ncb1190 }}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | author=Zhang C, Comai L, Johnson DL |title=PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex. |journal=Mol. Cell. Biol. |volume=25 |issue= 16 |pages= 6899-911 |year= 2005 |pmid= 16055704 |doi= 10.1128/MCB.25.16.6899-6911.2005 }}
*{{cite journal  | vauthors=Zhang C, Comai L, Johnson DL |title=PTEN Represses RNA Polymerase I Transcription by Disrupting the SL1 Complex |journal=Mol. Cell. Biol. |volume=25 |issue= 16 |pages= 6899–911 |year= 2005 |pmid= 16055704 |doi= 10.1128/MCB.25.16.6899-6911.2005 | pmc=1190253 }}
*{{cite journal  | author=Percipalle P, Fomproix N, Cavellán E, ''et al.'' |title=The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription. |journal=EMBO Rep. |volume=7 |issue= 5 |pages= 525-30 |year=  |pmid= 16514417 |doi= 10.1038/sj.embor.7400657 }}
*{{cite journal  | vauthors=Percipalle P, Fomproix N, Cavellán E |title=The chromatin remodelling complex WSTF–SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription |journal=EMBO Rep. |volume=7 |issue= 5 |pages= 525–30 |year=  2006|pmid= 16514417 |doi= 10.1038/sj.embor.7400657 | pmc=1479564 }}
*{{cite journal  | author=Panova TB, Panov KI, Russell J, Zomerdijk JC |title=Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription. |journal=Mol. Cell. Biol. |volume=26 |issue= 16 |pages= 5957-68 |year= 2006 |pmid= 16880508 |doi= 10.1128/MCB.00673-06 }}
*{{cite journal  | vauthors=Panova TB, Panov KI, Russell J, Zomerdijk JC |title=Casein Kinase 2 Associates with Initiation-Competent RNA Polymerase I and Has Multiple Roles in Ribosomal DNA Transcription |journal=Mol. Cell. Biol. |volume=26 |issue= 16 |pages= 5957–68 |year= 2006 |pmid= 16880508 |doi= 10.1128/MCB.00673-06 | pmc=1592790 }}
*{{cite journal  | author=Johnson SS, Zhang C, Fromm J, ''et al.'' |title=Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases. |journal=Mol. Cell |volume=26 |issue= 3 |pages= 367-79 |year= 2007 |pmid= 17499043 |doi= 10.1016/j.molcel.2007.03.021 }}
*{{cite journal  | vauthors=Johnson SS, Zhang C, Fromm J |title=Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases |journal=Mol. Cell |volume=26 |issue= 3 |pages= 367–79 |year= 2007 |pmid= 17499043 |doi= 10.1016/j.molcel.2007.03.021 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:25, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA-directed RNA polymerase I subunit RPA2 is an enzyme that in humans is encoded by the POLR1B gene.[1]


References

  1. ↑ "Entrez Gene: POLR1B polymerase (RNA) I polypeptide B, 128kDa".

Further reading



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