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{{Underlinked|date=March 2014}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''Phenylalanyl-tRNA synthetase beta chain''' is an [[enzyme]] that in humans is encoded by the ''FARSB'' [[gene]].<ref name="pmid10049785">{{cite journal | vauthors = Rodova M, Ankilova V, Safro MG | title = Human [[phenylalanyl]]-tRNA synthetase: cloning, characterization of the deduced [[amino acid]] sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells | journal = Biochem Biophys Res Commun | volume = 255 | issue = 3 | pages = 765–73 |date=Apr 1999 | pmid = 10049785 | pmc =  | doi = 10.1006/bbrc.1999.0141 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FARSB phenylalanyl-tRNA synthetase, beta subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10056| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Phenylalanyl-tRNA synthetase, beta subunit
| HGNCid = 17800
| Symbol = FARSB
| AltSymbols =; FARSLB; FRSB; HSPC173; PheHB; PheRS
| OMIM = 609690
| ECnumber = 
| Homologene = 4160
| MGIid = 1346035
| GeneAtlas_image1 = PBB_GE_FARSB_gnf1h00075_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004826 |text = phenylalanine-tRNA ligase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
  | Process = {{GNF_GO|id=GO:0006412 |text = translation}} {{GNF_GO|id=GO:0006432 |text = phenylalanyl-tRNA aminoacylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10056
    | Hs_Ensembl = ENSG00000116120
    | Hs_RefseqProtein = NP_005678
    | Hs_RefseqmRNA = NM_005687
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 223143506
    | Hs_GenLoc_end = 223229049
    | Hs_Uniprot = Q9NSD9
    | Mm_EntrezGene = 23874
    | Mm_Ensembl = ENSMUSG00000026245
    | Mm_RefseqmRNA = NM_011811
    | Mm_RefseqProtein = NP_035941
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 78301105
    | Mm_GenLoc_end = 78372006
    | Mm_Uniprot = Q3TG12
  }}
}}
'''Phenylalanyl-tRNA synthetase, beta subunit''', also known as '''FARSB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FARSB phenylalanyl-tRNA synthetase, beta subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10056| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified.<ref name="entrez">{{cite web | title = Entrez Gene: FARSB phenylalanyl-tRNA synthetase, beta subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10056| accessdate = }}</ref>
| summary_text = This gene encodes a highly conserved enzyme that belongs to the [[aminoacyl-tRNA]] synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching [[L-phenylalanine]] to the terminal [[adenosine]] of the appropriate tRNA. A [[pseudogene]] located on [[chromosome 10]] has been identified.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Archambault de Vencay J, Thomes JC, Julien R |title=Phenylalanyl-tRNA synthetase of the human placenta. Evidence for different enzymatic forms in equilibrium. |journal=FEBS Lett. |volume=89 |issue= 1 |pages= 98-102 |year= 1978 |pmid= 658405 |doi=  }}
*{{cite journal  | vauthors=Archambault de Vencay J, Thomes JC, Julien R |title=Phenylalanyl-tRNA synthetase of the human placenta. Evidence for different enzymatic forms in equilibrium |journal=FEBS Lett. |volume=89 |issue= 1 |pages= 98–102 |year= 1978 |pmid= 658405 |doi=10.1016/0014-5793(78)80531-6 }}
*{{cite journal  | author=Nazarenko IA, Peterson ET, Zakharova OD, ''et al.'' |title=Recognition nucleotides for human phenylalanyl-tRNA synthetase. |journal=Nucleic Acids Res. |volume=20 |issue= 3 |pages= 475-8 |year= 1992 |pmid= 1741281 |doi=  }}
*{{cite journal  | vauthors=Nazarenko IA, Peterson ET, Zakharova OD |title=Recognition nucleotides for human phenylalanyl-tRNA synthetase |journal=Nucleic Acids Res. |volume=20 |issue= 3 |pages= 475–8 |year= 1992 |pmid= 1741281 |doi=10.1093/nar/20.3.475  | pmc=310410 |display-authors=etal}}
*{{cite journal  | author=Sen S, Zhou H, Ripmaster T, ''et al.'' |title=Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6164-9 |year= 1997 |pmid= 9177188 |doi= }}
*{{cite journal  | vauthors=Sen S, Zhou H, Ripmaster T |title=Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6164–9 |year= 1997 |pmid= 9177188 |doi=10.1073/pnas.94.12.6164  | pmc=21020  |display-authors=etal}}
*{{cite journal  | author=Rodova M, Ankilova V, Safro MG |title=Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells. |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 3 |pages= 765-73 |year= 1999 |pmid= 10049785 |doi= 10.1006/bbrc.1999.0141 }}
*{{cite journal  | vauthors=Zhou X, Richon VM, Ngo L |title=Cloning of the cDNA encoding phenylalanyl tRNA synthetase regulatory alpha-subunit-like protein whose expression is down-regulated during differentiation |journal=Gene |volume=233 |issue= 1–2 |pages= 13–9 |year= 1999 |pmid= 10375616 |doi=10.1016/S0378-1119(99)00170-5 |display-authors=etal}}
*{{cite journal  | author=Zhou X, Richon VM, Ngo L, ''et al.'' |title=Cloning of the cDNA encoding phenylalanyl tRNA synthetase regulatory alpha-subunit-like protein whose expression is down-regulated during differentiation. |journal=Gene |volume=233 |issue= 1-2 |pages= 13-9 |year= 1999 |pmid= 10375616 |doi=  }}
*{{cite journal  | vauthors=Zhang QH, Ye M, Wu XY |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934 |display-authors=etal}}
*{{cite journal  | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi=  }}
*{{cite journal  | vauthors=Moor N, Linshiz G, Safro M |title=Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes |journal=Protein Expr. Purif. |volume=24 |issue= 2 |pages= 260–7 |year= 2002 |pmid= 11858721 |doi= 10.1006/prep.2001.1560 }}
*{{cite journal  | author=Moor N, Linshiz G, Safro M |title=Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes. |journal=Protein Expr. Purif. |volume=24 |issue= 2 |pages= 260-7 |year= 2002 |pmid= 11858721 |doi= 10.1006/prep.2001.1560 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Moor N, Lavrik O, Favre A, Safro M |title=Prokaryotic and eukaryotic tetrameric phenylalanyl-tRNA synthetases display conservation of the binding mode of the tRNA(Phe) CCA end |journal=Biochemistry |volume=42 |issue= 36 |pages= 10697–708 |year= 2003 |pmid= 12962494 |doi= 10.1021/bi034732q }}
*{{cite journal  | author=Moor N, Lavrik O, Favre A, Safro M |title=Prokaryotic and eukaryotic tetrameric phenylalanyl-tRNA synthetases display conservation of the binding mode of the tRNA(Phe) CCA end. |journal=Biochemistry |volume=42 |issue= 36 |pages= 10697-708 |year= 2003 |pmid= 12962494 |doi= 10.1021/bi034732q }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Yu XY, Finn J, Hill JM |title=A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases |journal=Bioorg. Med. Chem. Lett. |volume=14 |issue= 5 |pages= 1339–42 |year= 2004 |pmid= 14980694 |doi= 10.1016/j.bmcl.2003.11.081 |display-authors=etal}}
*{{cite journal  | author=Yu XY, Finn J, Hill JM, ''et al.'' |title=A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases. |journal=Bioorg. Med. Chem. Lett. |volume=14 |issue= 5 |pages= 1339-42 |year= 2004 |pmid= 14980694 |doi= 10.1016/j.bmcl.2003.11.081 }}
*{{cite journal  | vauthors=Vasil'eva IA, Bogachev VS, Favre A |title=Role of low-molecular-weight substrates in functional binding of the tRNAPhe acceptor end by phenylalanyl-tRNA synthetase |journal=Biochemistry Mosc. |volume=69 |issue= 2 |pages= 143–53 |year= 2005 |pmid= 15000680 |doi=10.1023/B:BIRY.0000018944.53390.44 |display-authors=etal}}
*{{cite journal  | author=Vasil'eva IA, Bogachev VS, Favre A, ''et al.'' |title=Role of low-molecular-weight substrates in functional binding of the tRNAPhe acceptor end by phenylalanyl-tRNA synthetase. |journal=Biochemistry Mosc. |volume=69 |issue= 2 |pages= 143-53 |year= 2005 |pmid= 15000680 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}
*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|FARSB}}
* {{UCSC gene details|FARSB}}
 
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Latest revision as of 04:39, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Phenylalanyl-tRNA synthetase beta chain is an enzyme that in humans is encoded by the FARSB gene.[1][2]

This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified.[2]

References

  1. ↑ Rodova M, Ankilova V, Safro MG (Apr 1999). "Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells". Biochem Biophys Res Commun. 255 (3): 765–73. doi:10.1006/bbrc.1999.0141. PMID 10049785.
  2. ↑ 2.0 2.1 "Entrez Gene: FARSB phenylalanyl-tRNA synthetase, beta subunit".

Further reading

External links



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