PDE1A: Difference between revisions

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{{Infobox_gene}}
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'''Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A''' is an [[enzyme]] that in humans is encoded by the ''PDE1A'' [[gene]].<ref name="pmid8557689">{{cite journal | vauthors = Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K | title = Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases | journal = J Biol Chem | volume = 271 | issue = 2 | pages = 796–806 |date=Feb 1996 | pmid = 8557689 | pmc =  | doi =10.1074/jbc.271.2.796 }}</ref><ref name="pmid11342109">{{cite journal | vauthors = Michibata H, Yanaka N, Kanoh Y, Okumura K, Omori K | title = Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization | journal = Biochim Biophys Acta | volume = 1517 | issue = 2 | pages = 278–87 |date=May 2001 | pmid = 11342109 | pmc =  | doi =  10.1016/s0167-4781(00)00293-1}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDE1A phosphodiesterase 1A, calmodulin-dependent| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5136| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Phosphodiesterase 1A, calmodulin-dependent
| HGNCid = 8774
| Symbol = PDE1A
| AltSymbols =; HCAM1; HSPDE1A; MGC26303
| OMIM = 171890
| ECnumber =
| Homologene = 21043
| MGIid = 1201792
  | GeneAtlas_image1 = PBB_GE_PDE1A_208396_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004117 |text = calmodulin-dependent cyclic-nucleotide phosphodiesterase activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5136
    | Hs_Ensembl = ENSG00000115252
    | Hs_RefseqProtein = NP_001003683
    | Hs_RefseqmRNA = NM_001003683
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 182720051
    | Hs_GenLoc_end = 183095348
    | Hs_Uniprot = P54750
    | Mm_EntrezGene = 18573
    | Mm_Ensembl = ENSMUSG00000059173
    | Mm_RefseqmRNA = NM_001009978
    | Mm_RefseqProtein = NP_001009978
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 79635292
    | Mm_GenLoc_end = 79930314
    | Mm_Uniprot = Q8BRR9
  }}
}}
'''Phosphodiesterase 1A, calmodulin-dependent''', also known as '''PDE1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PDE1A phosphodiesterase 1A, calmodulin-dependent| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5136| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Loughney K, Martins TJ, Harris EA, ''et al.'' |title=Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases. |journal=J. Biol. Chem. |volume=271 |issue= 2 |pages= 796-806 |year= 1996 |pmid= 8557689 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Snyder PB, Florio VA, Ferguson K, Loughney K |title=Isolation, expression and analysis of splice variants of a human Ca2+/calmodulin-stimulated phosphodiesterase (PDE1A). |journal=Cell. Signal. |volume=11 |issue= 7 |pages= 535–44 |year= 1999 |pmid= 10405764 |doi=10.1016/S0898-6568(99)00027-3 }}
*{{cite journal  | author=Snyder PB, Florio VA, Ferguson K, Loughney K |title=Isolation, expression and analysis of splice variants of a human Ca2+/calmodulin-stimulated phosphodiesterase (PDE1A). |journal=Cell. Signal. |volume=11 |issue= 7 |pages= 535-44 |year= 1999 |pmid= 10405764 |doi=  }}
*{{cite journal   |vauthors=Zauli G, Milani D, Mirandola P, etal |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483–91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com }}
*{{cite journal | author=Zauli G, Milani D, Mirandola P, ''et al.'' |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483-91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com }}
*{{cite journal   |vauthors=Harrington JJ, Sherf B, Rundlett S, etal |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 }}
*{{cite journal | author=Harrington JJ, Sherf B, Rundlett S, ''et al.'' |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440-5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 }}
*{{cite journal  | vauthors=Yan C, Zhao AZ, Sonnenburg WK, Beavo JA |title=Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis. |journal=Biol. Reprod. |volume=64 |issue= 6 |pages= 1746–54 |year= 2001 |pmid= 11369604 |doi=10.1095/biolreprod64.6.1746 }}
*{{cite journal  | author=Michibata H, Yanaka N, Kanoh Y, ''et al.'' |title=Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization. |journal=Biochim. Biophys. Acta |volume=1517 |issue= 2 |pages= 278-87 |year= 2001 |pmid= 11342109 |doi=  }}
*{{cite journal  | vauthors=Fidock M, Miller M, Lanfear J |title=Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants. |journal=Cell. Signal. |volume=14 |issue= 1 |pages= 53–60 |year= 2002 |pmid= 11747989 |doi=10.1016/S0898-6568(01)00207-8 }}
*{{cite journal  | author=Yan C, Zhao AZ, Sonnenburg WK, Beavo JA |title=Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis. |journal=Biol. Reprod. |volume=64 |issue= 6 |pages= 1746-54 |year= 2001 |pmid= 11369604 |doi=  }}
*{{cite journal   |vauthors=Ritter M, Buechler C, Boettcher A, etal |title=Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. |journal=Genomics |volume=79 |issue= 5 |pages= 693–702 |year= 2002 |pmid= 11991719 |doi= 10.1006/geno.2002.6761 }}
*{{cite journal  | author=Fidock M, Miller M, Lanfear J |title=Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants. |journal=Cell. Signal. |volume=14 |issue= 1 |pages= 53-60 |year= 2002 |pmid= 11747989 |doi=  }}
*{{cite journal  | vauthors=Lefièvre L, de Lamirande E, Gagnon C |title=Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa. |journal=Biol. Reprod. |volume=67 |issue= 2 |pages= 423–30 |year= 2003 |pmid= 12135876 |doi=10.1095/biolreprod67.2.423 }}
*{{cite journal | author=Ritter M, Buechler C, Boettcher A, ''et al.'' |title=Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. |journal=Genomics |volume=79 |issue= 5 |pages= 693-702 |year= 2002 |pmid= 11991719 |doi= 10.1006/geno.2002.6761 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Lefièvre L, de Lamirande E, Gagnon C |title=Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa. |journal=Biol. Reprod. |volume=67 |issue= 2 |pages= 423-30 |year= 2003 |pmid= 12135876 |doi=  }}
*{{cite journal  | vauthors=Goraya TA, Masada N, Ciruela A, Cooper DM |title=Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A |journal=J. Biol. Chem. |volume=279 |issue= 39 |pages= 40494–504 |year= 2004 |pmid= 15272012 |doi= 10.1074/jbc.M313441200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Goraya TA, Masada N, Ciruela A, Cooper DM |title=Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A. |journal=J. Biol. Chem. |volume=279 |issue= 39 |pages= 40494-504 |year= 2004 |pmid= 15272012 |doi= 10.1074/jbc.M313441200 }}
*{{cite journal   |vauthors=Nagel DJ, Aizawa T, Jeon KI, etal |title=Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival |journal=Circ. Res. |volume=98 |issue= 6 |pages= 777–84 |year= 2006 |pmid= 16514069 |doi= 10.1161/01.RES.0000215576.27615.fd }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Nagel DJ, Aizawa T, Jeon KI, ''et al.'' |title=Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival. |journal=Circ. Res. |volume=98 |issue= 6 |pages= 777-84 |year= 2006 |pmid= 16514069 |doi= 10.1161/01.RES.0000215576.27615.fd }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 17:49, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A is an enzyme that in humans is encoded by the PDE1A gene.[1][2][3]


References

  1. ↑ Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K (Feb 1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases". J Biol Chem. 271 (2): 796–806. doi:10.1074/jbc.271.2.796. PMID 8557689.
  2. ↑ Michibata H, Yanaka N, Kanoh Y, Okumura K, Omori K (May 2001). "Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization". Biochim Biophys Acta. 1517 (2): 278–87. doi:10.1016/s0167-4781(00)00293-1. PMID 11342109.
  3. ↑ "Entrez Gene: PDE1A phosphodiesterase 1A, calmodulin-dependent".

Further reading



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