LRRFIP1: Difference between revisions

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Orthologs
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Latest revision as of 18:09, 2 September 2017

Leucine-rich repeat flightless-interacting protein 1 is a protein that in humans is encoded by the LRRFIP1 gene.^[1]^[2]^[3]^[4]

Interactions

LRRFIP1 has been shown to interact with FLII.^[2]^[5]

References

↑ Reed AL, Yamazaki H, Kaufman JD, Rubinstein Y, Murphy B, Johnson AC (Sep 1998). "Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor". J Biol Chem. 273 (34): 21594–602. doi:10.1074/jbc.273.34.21594. PMID 9705290.
↑ ^2.0 ^2.1 Liu YT, Yin HL (May 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J Biol Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. PMID 9525888.
↑ Suriano AR, Sanford AN, Kim N, Oh M, Kennedy S, Henderson MJ, Dietzmann K, Sullivan KE (Oct 2005). "GCF2/LRRFIP1 represses tumor necrosis factor alpha expression". Mol Cell Biol. 25 (20): 9073–81. doi:10.1128/MCB.25.20.9073-9081.2005. PMC 1265793. PMID 16199883.
↑ "Entrez Gene: LRRFIP1 leucine rich repeat (in FLII) interacting protein 1".
↑ Fong KS, de Couet HG (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.

Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.
Khachigian LM, Santiago FS, Rafty LA, Chan OL, Delbridge GJ, Bobik A, Collins T, Johnson AC (1999). "GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury". Circ. Res. 84 (11): 1258–67. doi:10.1161/01.res.84.11.1258. PMID 10364563.
Fong KS, de Couet HG (1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.
Rikiyama T, Curtis J, Oikawa M, Zimonjic DB, Popescu N, Murphy BA, Wilson MA, Johnson AC (2003). "GCF2: expression and molecular analysis of repression". Biochim. Biophys. Acta. 1629 (1–3): 15–25. doi:10.1016/s0167-4781(03)00156-8. PMID 14522076.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[pmid9705290-1] Reed AL, Yamazaki H, Kaufman JD, Rubinstein Y, Murphy B, Johnson AC (Sep 1998). "Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor". J Biol Chem. 273 (34): 21594–602. doi:10.1074/jbc.273.34.21594. PMID 9705290.

[pmid9525888-2] 2.0 ^2.1 Liu YT, Yin HL (May 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J Biol Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. PMID 9525888.

[pmid16199883-3] Suriano AR, Sanford AN, Kim N, Oh M, Kennedy S, Henderson MJ, Dietzmann K, Sullivan KE (Oct 2005). "GCF2/LRRFIP1 represses tumor necrosis factor alpha expression". Mol Cell Biol. 25 (20): 9073–81. doi:10.1128/MCB.25.20.9073-9081.2005. PMC 1265793. PMID 16199883.

[entrez-4] "Entrez Gene: LRRFIP1 leucine rich repeat (in FLII) interacting protein 1".

[pmid10366446-5] Fong KS, de Couet HG (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.

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[5]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Leucine-rich repeat flightless-interacting protein 1''' is a [[protein]] that in humans is encoded by the ''LRRFIP1'' [[gene]].<ref name="pmid9705290">{{cite journal | vauthors = Reed AL, Yamazaki H, Kaufman JD, Rubinstein Y, Murphy B, Johnson AC | title = Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor | journal = J Biol Chem | volume = 273 | issue = 34 | pages = 21594–602 | date = Sep 1998 | pmid = 9705290 | pmc =  | doi = 10.1074/jbc.273.34.21594 }}</ref><ref name="pmid9525888">{{cite journal | vauthors = Liu YT, Yin HL | title = Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies | journal = J Biol Chem | volume = 273 | issue = 14 | pages = 7920–7 | date = May 1998 | pmid = 9525888 | pmc =  | doi = 10.1074/jbc.273.14.7920 }}</ref><ref name="pmid16199883">{{cite journal | vauthors = Suriano AR, Sanford AN, Kim N, Oh M, Kennedy S, Henderson MJ, Dietzmann K, Sullivan KE | title = GCF2/LRRFIP1 represses tumor necrosis factor alpha expression | journal = Mol Cell Biol | volume = 25 | issue = 20 | pages = 9073–81 | date = Oct 2005 | pmid = 16199883 | pmc = 1265793 | doi = 10.1128/MCB.25.20.9073-9081.2005 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LRRFIP1 leucine rich repeat (in FLII) interacting protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9208| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Interactions ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Leucine rich repeat (in FLII) interacting protein 1
- | HGNCid = 6702
- | Symbol = LRRFIP1
- | AltSymbols =; GCF2; FLAP-1; FLIIAP1; GCF-2; HUFI-1; MGC10947; MGC119738; MGC119739; TRIP
- | OMIM = 603256
- | ECnumber =
- | Homologene = 81730
- | MGIid =
- | GeneAtlas_image1 = PBB_GE_LRRFIP1_201862_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_LRRFIP1_201861_s_at_tn.png
- | GeneAtlas_image3 = PBB_GE_LRRFIP1_211452_x_at_tn.png
- | Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003725 |text = double-stranded RNA binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}}
- | Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 9208
-    | Hs_Ensembl = ENSG00000124831
-    | Hs_RefseqProtein = NP_004726
-    | Hs_RefseqmRNA = NM_004735
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 2
-    | Hs_GenLoc_start = 238265661
-    | Hs_GenLoc_end = 238352869
-    | Hs_Uniprot =
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Leucine rich repeat (in FLII) interacting protein 1''', also known as '''LRRFIP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LRRFIP1 leucine rich repeat (in FLII) interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9208| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+LRRFIP1 has been shown to [[Protein-protein interaction|interact]] with [[FLII]].<ref name=pmid9525888 /><ref name=pmid10366446>{{cite journal | vauthors = Fong KS, de Couet HG | title = Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system | journal = Genomics | volume = 58 | issue = 2 | pages = 146–57 | date = Jun 1999 | pmid = 10366446 | doi = 10.1006/geno.1999.5817 }}</ref>
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Wilson SA, Brown EC, Kingsman AJ, Kingsman SM | title = TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I | journal = Nucleic Acids Res. | volume = 26 | issue = 15 | pages = 3460–7 | year = 1998 | pmid = 9671805 | pmc = 147727 | doi = 10.1093/nar/26.15.3460 }}
-| citations =
+* {{cite journal | vauthors = Khachigian LM, Santiago FS, Rafty LA, Chan OL, Delbridge GJ, Bobik A, Collins T, Johnson AC | title = GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury | journal = Circ. Res. | volume = 84 | issue = 11 | pages = 1258–67 | year = 1999 | pmid = 10364563 | doi = 10.1161/01.res.84.11.1258 }}
-*{{cite journal  | author=Liu YT, Yin HL |title=Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. |journal=J. Biol. Chem. |volume=273 |issue= 14 |pages= 7920-7 |year= 1998 |pmid= 9525888 |doi=  }}
+* {{cite journal | vauthors = Fong KS, de Couet HG | title = Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system | journal = Genomics | volume = 58 | issue = 2 | pages = 146–57 | year = 1999 | pmid = 10366446 | doi = 10.1006/geno.1999.5817 }}
-*{{cite journal  | author=Wilson SA, Brown EC, Kingsman AJ, Kingsman SM |title=TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I. |journal=Nucleic Acids Res. |volume=26 |issue= 15 |pages= 3460-7 |year= 1998 |pmid= 9671805 |doi=  }}
+* {{cite journal | vauthors = Rikiyama T, Curtis J, Oikawa M, Zimonjic DB, Popescu N, Murphy BA, Wilson MA, Johnson AC | title = GCF2: expression and molecular analysis of repression | journal = Biochim. Biophys. Acta | volume = 1629 | issue = 1–3 | pages = 15–25 | year = 2003 | pmid = 14522076 | doi = 10.1016/s0167-4781(03)00156-8 }}
-*{{cite journal  | author=Reed AL, Yamazaki H, Kaufman JD, ''et al.'' |title=Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21594-602 |year= 1998 |pmid= 9705290 |doi=  }}
+* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
-*{{cite journal  | author=Khachigian LM, Santiago FS, Rafty LA, ''et al.'' |title=GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury. |journal=Circ. Res. |volume=84 |issue= 11 |pages= 1258-67 |year= 1999 |pmid= 10364563 |doi=  }}
+* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
-*{{cite journal  | author=Fong KS, de Couet HG |title=Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system. |journal=Genomics |volume=58 |issue= 2 |pages= 146-57 |year= 1999 |pmid= 10366446 |doi= 10.1006/geno.1999.5817 }}
+* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Rikiyama T, Curtis J, Oikawa M, ''et al.'' |title=GCF2: expression and molecular analysis of repression. |journal=Biochim. Biophys. Acta |volume=1629 |issue= 1-3 |pages= 15-25 |year= 2003 |pmid= 14522076 |doi=  }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
-*{{cite journal  | author=Suriano AR, Sanford AN, Kim N, ''et al.'' |title=GCF2/LRRFIP1 represses tumor necrosis factor alpha expression. |journal=Mol. Cell. Biol. |volume=25 |issue= 20 |pages= 9073-81 |year= 2005 |pmid= 16199883 |doi= 10.1128/MCB.25.20.9073-9081.2005 }}
-*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
-*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
-}}
 {{refend}}
-{{protein-stub}}
-{{WikiDoc Sources}}
+{{gene-2-stub}}

LRRFIP1: Difference between revisions

Latest revision as of 18:09, 2 September 2017

Interactions

References

Further reading

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