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{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein kinase 16''' is an [[enzyme]] that in humans is encoded by the ''STK16'' [[gene]].<ref name="pmid9712705">{{cite journal | vauthors = Ligos JM, Gerwin N, Fernández P, Gutierrez-Ramos JC, Bernad A | title = Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases | journal = Biochemical and Biophysical Research Communications | volume = 249 | issue = 2 | pages = 380–4 | date = August 1998 | pmid = 9712705 | pmc =  | doi = 10.1006/bbrc.1998.9163 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STK16 serine/threonine kinase 16| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8576| accessdate = }}</ref>
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_STK16_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2buj.
| PDB = {{PDB2|2buj}}
| Name = Serine/threonine kinase 16
| HGNCid = 11394
| Symbol = STK16
| AltSymbols =; FLJ39635; KRCT; MPSK; PKL12; TSF1
| OMIM = 604719
| ECnumber = 
| Homologene = 2739
| MGIid = 1313271
| GeneAtlas_image1 = PBB_GE_STK16_209622_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8576
    | Hs_Ensembl = ENSG00000115661
    | Hs_RefseqProtein = NP_001008910
    | Hs_RefseqmRNA = NM_001008910
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 219818436
    | Hs_GenLoc_end = 219821870
    | Hs_Uniprot = O75716
    | Mm_EntrezGene = 20872
    | Mm_Ensembl = ENSMUSG00000026201
    | Mm_RefseqmRNA = NM_011494
    | Mm_RefseqProtein = NP_035624
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 75094003
    | Mm_GenLoc_end = 75098754
    | Mm_Uniprot = Q3UEG5
  }}
}}
'''Serine/threonine kinase 16''', also known as '''STK16''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STK16 serine/threonine kinase 16| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8576| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
STK16 has been shown to [[Protein-protein interaction|interact]] with [[N-acetyl-D-glucosamine kinase|NAGK]].<ref name=pmid11741987>{{cite journal | vauthors = Ligos JM, de Lera TL, Hinderlich S, Guinea B, Sánchez L, Roca R, Valencia A, Bernad A | title = Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling | journal = The Journal of Biological Chemistry | volume = 277 | issue = 8 | pages = 6333–43 | date = February 2002 | pmid = 11741987 | doi = 10.1074/jbc.M105766200 }}</ref>
{{reflist|2}}
 
==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Berson AE, Young C, Morrison SL, Fujii GH, Sheung J, Wu B, Bolen JB, Burkhardt AL | title = Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase | journal = Biochemical and Biophysical Research Communications | volume = 259 | issue = 3 | pages = 533–8 | date = June 1999 | pmid = 10364453 | doi = 10.1006/bbrc.1999.0811 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Ohta S, Takeuchi M, Deguchi M, Tsuji T, Gahara Y, Nagata K | title = A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway | journal = The Biochemical Journal | volume = 350 Pt 2 | issue =  | pages = 395–404 | date = September 2000 | pmid = 10947953 | pmc = 1221266 | doi = 10.1042/0264-6021:3500395 }}
*{{cite journal  | author=Ligos JM, Gerwin N, Fernández P, ''et al.'' |title=Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases. |journal=Biochem. Biophys. Res. Commun. |volume=249 |issue= 2 |pages= 380-4 |year= 1998 |pmid= 9712705 |doi= 10.1006/bbrc.1998.9163 }}
* {{cite journal | vauthors = Ligos JM, de Lera TL, Hinderlich S, Guinea B, Sánchez L, Roca R, Valencia A, Bernad A | title = Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling | journal = The Journal of Biological Chemistry | volume = 277 | issue = 8 | pages = 6333–43 | date = February 2002 | pmid = 11741987 | doi = 10.1074/jbc.M105766200 }}
*{{cite journal | author=Berson AE, Young C, Morrison SL, ''et al.'' |title=Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase. |journal=Biochem. Biophys. Res. Commun. |volume=259 |issue= 3 |pages= 533-8 |year= 1999 |pmid= 10364453 |doi= 10.1006/bbrc.1999.0811 }}
* {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = June 2004 | pmid = 15146197 | doi = 10.1038/nbt971 }}
*{{cite journal | author=Ohta S, Takeuchi M, Deguchi M, ''et al.'' |title=A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway. |journal=Biochem. J. |volume=350 Pt 2 |issue=  |pages= 395-404 |year= 2001 |pmid= 10947953 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Ligos JM, de Lera TL, Hinderlich S, ''et al.'' |title=Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6333-43 |year= 2002 |pmid= 11741987 |doi= 10.1074/jbc.M105766200 }}
* {{cite journal | vauthors = Guinea B, Ligos JM, Laín de Lera T, Martín-Caballero J, Flores J, Gonzalez de la Peña M, García-Castro J, Bernad A | title = Nucleocytoplasmic shuttling of STK16 (PKL12), a Golgi-resident serine/threonine kinase involved in VEGF expression regulation | journal = Experimental Cell Research | volume = 312 | issue = 2 | pages = 135–44 | date = January 2006 | pmid = 16310770 | doi = 10.1016/j.yexcr.2005.10.010 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Guinea B, Ligos JM, Laín de Lera T, ''et al.'' |title=Nucleocytoplasmic shuttling of STK16 (PKL12), a Golgi-resident serine/threonine kinase involved in VEGF expression regulation. |journal=Exp. Cell Res. |volume=312 |issue= 2 |pages= 135-44 |year= 2006 |pmid= 16310770 |doi= 10.1016/j.yexcr.2005.10.010 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=8576}}
{{WikiDoc Sources}}
 
{{gene-2-stub}}

Latest revision as of 07:12, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase 16 is an enzyme that in humans is encoded by the STK16 gene.[1][2]


Interactions

STK16 has been shown to interact with NAGK.[3]

References

  1. ↑ Ligos JM, Gerwin N, Fernández P, Gutierrez-Ramos JC, Bernad A (August 1998). "Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases". Biochemical and Biophysical Research Communications. 249 (2): 380–4. doi:10.1006/bbrc.1998.9163. PMID 9712705.
  2. ↑ "Entrez Gene: STK16 serine/threonine kinase 16".
  3. ↑ Ligos JM, de Lera TL, Hinderlich S, Guinea B, Sánchez L, Roca R, Valencia A, Bernad A (February 2002). "Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling". The Journal of Biological Chemistry. 277 (8): 6333–43. doi:10.1074/jbc.M105766200. PMID 11741987.

Further reading

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Berson AE, Young C, Morrison SL, Fujii GH, Sheung J, Wu B, Bolen JB, Burkhardt AL (June 1999). "Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase". Biochemical and Biophysical Research Communications. 259 (3): 533–8. doi:10.1006/bbrc.1999.0811. PMID 10364453.
  • Ohta S, Takeuchi M, Deguchi M, Tsuji T, Gahara Y, Nagata K (September 2000). "A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway". The Biochemical Journal. 350 Pt 2: 395–404. doi:10.1042/0264-6021:3500395. PMC 1221266. PMID 10947953.
  • Ligos JM, de Lera TL, Hinderlich S, Guinea B, Sánchez L, Roca R, Valencia A, Bernad A (February 2002). "Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling". The Journal of Biological Chemistry. 277 (8): 6333–43. doi:10.1074/jbc.M105766200. PMID 11741987.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Guinea B, Ligos JM, Laín de Lera T, Martín-Caballero J, Flores J, Gonzalez de la Peña M, García-Castro J, Bernad A (January 2006). "Nucleocytoplasmic shuttling of STK16 (PKL12), a Golgi-resident serine/threonine kinase involved in VEGF expression regulation". Experimental Cell Research. 312 (2): 135–44. doi:10.1016/j.yexcr.2005.10.010. PMID 16310770.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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