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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein kinase tousled-like 1''' is an [[enzyme]] that in humans is encoded by the ''TLK1'' [[gene]].<ref name="pmid9427565">{{cite journal | vauthors = Yamakawa A, Kameoka Y, Hashimoto K, Yoshitake Y, Nishikawa K, Tanihara K, Date T | title = cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal | journal = Gene | volume = 202 | issue = 1-2 | pages = 193–201 | date = Nov 1997 | pmid = 9427565 | pmc =  | doi = 10.1016/S0378-1119(97)00495-2 }}</ref><ref name="pmid12660173">{{cite journal | vauthors = Groth A, Lukas J, Nigg EA, Silljé HH, Wernstedt C, Bartek J, Hansen K | title = Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint | journal = The EMBO Journal | volume = 22 | issue = 7 | pages = 1676–87 | date = Apr 2003 | pmid = 12660173 | pmc = 152895 | doi = 10.1093/emboj/cdg151 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TLK1 tousled-like kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9874| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tousled-like kinase 1
| HGNCid = 11841
| Symbol = TLK1
| AltSymbols =; KIAA0137; PKU-BETA
| OMIM = 608438
| ECnumber = 
| Homologene = 8185
| MGIid = 2441683
| GeneAtlas_image1 = PBB_GE_TLK1_202606_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TLK1_210379_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TLK1_211077_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001672 |text = regulation of chromatin assembly or disassembly}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006974 |text = response to DNA damage stimulus}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9874
    | Hs_Ensembl = ENSG00000198586
    | Hs_RefseqProtein = NP_036422
    | Hs_RefseqmRNA = NM_012290
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 171556816
    | Hs_GenLoc_end = 171725289
    | Hs_Uniprot = Q9UKI8
    | Mm_EntrezGene = 228012
    | Mm_Ensembl = ENSMUSG00000041997
    | Mm_RefseqmRNA = XM_001002185
    | Mm_RefseqProtein = XP_001002185
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 70513221
    | Mm_GenLoc_end = 70626319
    | Mm_Uniprot = A0PJK0
  }}
}}
'''Tousled-like kinase 1''', also known as '''TLK1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TLK1 tousled-like kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9874| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The Tousled-like kinases, first described in [[Arabidopsis|Arabadopsis]], are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM]<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: TLK1 tousled-like kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9874| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  | author=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821-30 |year= 1994 |pmid= 8274451 |doi=  }}
*{{cite journal  | author=Nagase T, Seki N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167-74, 199-210 |year= 1996 |pmid= 8590280 |doi=  }}
*{{cite journal  | author=Yamakawa A, Kameoka Y, Hashimoto K, ''et al.'' |title=cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal. |journal=Gene |volume=202 |issue= 1-2 |pages= 193-201 |year= 1998 |pmid= 9427565 |doi=  }}
*{{cite journal  | author=Silljé HH, Takahashi K, Tanaka K, ''et al.'' |title=Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. |journal=EMBO J. |volume=18 |issue= 20 |pages= 5691-702 |year= 1999 |pmid= 10523312 |doi= 10.1093/emboj/18.20.5691 }}
*{{cite journal  | author=Cabaniols JP, Ravichandran V, Roche PA |title=Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly. |journal=Mol. Biol. Cell |volume=10 |issue= 12 |pages= 4033-41 |year= 2000 |pmid= 10588641 |doi=  }}
*{{cite journal  | author=Li Y, DeFatta R, Anthony C, ''et al.'' |title=A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed. |journal=Oncogene |volume=20 |issue= 6 |pages= 726-38 |year= 2001 |pmid= 11314006 |doi= 10.1038/sj.onc.1204147 }}
*{{cite journal  | author=Silljé HH, Nigg EA |title=Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. |journal=Curr. Biol. |volume=11 |issue= 13 |pages= 1068-73 |year= 2001 |pmid= 11470414 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Groth A, Lukas J, Nigg EA, ''et al.'' |title=Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. |journal=EMBO J. |volume=22 |issue= 7 |pages= 1676-87 |year= 2003 |pmid= 12660173 |doi= 10.1093/emboj/cdg151 }}
*{{cite journal  | author=Krause DR, Jonnalagadda JC, Gatei MH, ''et al.'' |title=Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. |journal=Oncogene |volume=22 |issue= 38 |pages= 5927-37 |year= 2003 |pmid= 12955071 |doi= 10.1038/sj.onc.1206691 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Norton KS, McClusky D, Sen S, ''et al.'' |title=TLK1B is elevated with eIF4E overexpression in breast cancer. |journal=J. Surg. Res. |volume=116 |issue= 1 |pages= 98-103 |year= 2004 |pmid= 14732354 |doi=  }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Kodym R, Henöckl C, Fürweger C |title=Identification of the human DEAD-box protein p68 as a substrate of Tlk1. |journal=Biochem. Biophys. Res. Commun. |volume=333 |issue= 2 |pages= 411-7 |year= 2005 |pmid= 15950181 |doi= 10.1016/j.bbrc.2005.05.136 }}
*{{cite journal  | author=Sunavala-Dossabhoy G, Balakrishnan SK, Sen S, ''et al.'' |title=The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks. |journal=BMC Mol. Biol. |volume=6 |issue=  |pages= 19 |year= 2006 |pmid= 16156902 |doi= 10.1186/1471-2199-6-19 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Sen SP, De Benedetti A |title=TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1. |journal=BMC Mol. Biol. |volume=7 |issue=  |pages= 37 |year= 2006 |pmid= 17054786 |doi= 10.1186/1471-2199-7-37 }}
}}
{{refend}}


{{protein-stub}}
TLK1 has been shown to [[Protein-protein interaction|interact]] with [[ASF1B]],<ref name=pmid11470414>{{cite journal | vauthors = Silljé HH, Nigg EA | title = Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases | journal = Current Biology | volume = 11 | issue = 13 | pages = 1068–73 | date = Jul 2001 | pmid = 11470414 | doi = 10.1016/S0960-9822(01)00298-6 }}</ref><ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref> [[ASF1A]]<ref name=pmid11470414/><ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref> and [[TLK2]].<ref name=pmid10523312>{{cite journal | vauthors = Silljé HH, Takahashi K, Tanaka K, Van Houwe G, Nigg EA | title = Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication | journal = The EMBO Journal | volume = 18 | issue = 20 | pages = 5691–702 | date = Oct 1999 | pmid = 10523312 | pmc = 1171636 | doi = 10.1093/emboj/18.20.5691 }}</ref>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = Jun 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
* {{cite journal | vauthors = Schultz SJ, Nigg EA | title = Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans | journal = Cell Growth & Differentiation | volume = 4 | issue = 10 | pages = 821–30 | date = Oct 1993 | pmid = 8274451 | doi =  }}
* {{cite journal | vauthors = Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N | title = Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 2 | issue = 4 | pages = 167–74, 199–210 | date = Aug 1995 | pmid = 8590280 | doi = 10.1093/dnares/2.4.167 }}
* {{cite journal | vauthors = Silljé HH, Takahashi K, Tanaka K, Van Houwe G, Nigg EA | title = Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication | journal = The EMBO Journal | volume = 18 | issue = 20 | pages = 5691–702 | date = Oct 1999 | pmid = 10523312 | pmc = 1171636 | doi = 10.1093/emboj/18.20.5691 }}
* {{cite journal | vauthors = Cabaniols JP, Ravichandran V, Roche PA | title = Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly | journal = Molecular Biology of the Cell | volume = 10 | issue = 12 | pages = 4033–41 | date = Dec 1999 | pmid = 10588641 | pmc = 25741 | doi = 10.1091/mbc.10.12.4033 }}
* {{cite journal | vauthors = Li Y, DeFatta R, Anthony C, Sunavala G, De Benedetti A | title = A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed | journal = Oncogene | volume = 20 | issue = 6 | pages = 726–38 | date = Feb 2001 | pmid = 11314006 | doi = 10.1038/sj.onc.1204147 }}
* {{cite journal | vauthors = Silljé HH, Nigg EA | title = Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases | journal = Current Biology | volume = 11 | issue = 13 | pages = 1068–73 | date = Jul 2001 | pmid = 11470414 | doi = 10.1016/S0960-9822(01)00298-6 }}
* {{cite journal | vauthors = Krause DR, Jonnalagadda JC, Gatei MH, Sillje HH, Zhou BB, Nigg EA, Khanna K | title = Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1 | journal = Oncogene | volume = 22 | issue = 38 | pages = 5927–37 | date = Sep 2003 | pmid = 12955071 | doi = 10.1038/sj.onc.1206691 }}
* {{cite journal | vauthors = Norton KS, McClusky D, Sen S, Yu H, Meschonat C, Debenedetti A, Li BD | title = TLK1B is elevated with eIF4E overexpression in breast cancer | journal = The Journal of Surgical Research | volume = 116 | issue = 1 | pages = 98–103 | date = Jan 2004 | pmid = 14732354 | doi = 10.1016/j.jss.2003.08.001 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Kodym R, Henöckl C, Fürweger C | title = Identification of the human DEAD-box protein p68 as a substrate of Tlk1 | journal = Biochemical and Biophysical Research Communications | volume = 333 | issue = 2 | pages = 411–7 | date = Jul 2005 | pmid = 15950181 | doi = 10.1016/j.bbrc.2005.05.136 }}
* {{cite journal | vauthors = Sunavala-Dossabhoy G, Balakrishnan SK, Sen S, Nuthalapaty S, De Benedetti A | title = The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks | journal = BMC Molecular Biology | volume = 6 | pages = 19 | year = 2006 | pmid = 16156902 | pmc = 1242231 | doi = 10.1186/1471-2199-6-19 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Sen SP, De Benedetti A | title = TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1 | journal = BMC Molecular Biology | volume = 7 | pages = 37 | year = 2006 | pmid = 17054786 | pmc = 1626478 | doi = 10.1186/1471-2199-7-37 }}
{{Refend}}
 
{{Gene-2-stub}}

Revision as of 11:55, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase tousled-like 1 is an enzyme that in humans is encoded by the TLK1 gene.[1][2][3]

Function

The Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM][3]

Interactions

TLK1 has been shown to interact with ASF1B,[4][5] ASF1A[4][6] and TLK2.[7]

References

  1. ↑ Yamakawa A, Kameoka Y, Hashimoto K, Yoshitake Y, Nishikawa K, Tanihara K, Date T (Nov 1997). "cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal". Gene. 202 (1–2): 193–201. doi:10.1016/S0378-1119(97)00495-2. PMID 9427565.
  2. ↑ Groth A, Lukas J, Nigg EA, Silljé HH, Wernstedt C, Bartek J, Hansen K (Apr 2003). "Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint". The EMBO Journal. 22 (7): 1676–87. doi:10.1093/emboj/cdg151. PMC 152895. PMID 12660173.
  3. ↑ 3.0 3.1 "Entrez Gene: TLK1 tousled-like kinase 1".
  4. ↑ 4.0 4.1 Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology. 11 (13): 1068–73. doi:10.1016/S0960-9822(01)00298-6. PMID 11470414.
  5. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  6. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  7. ↑ Silljé HH, Takahashi K, Tanaka K, Van Houwe G, Nigg EA (Oct 1999). "Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication". The EMBO Journal. 18 (20): 5691–702. doi:10.1093/emboj/18.20.5691. PMC 1171636. PMID 10523312.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=TLK1&oldid=1412737"