PLSCR1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Phospholipid scramblase 1''' is an [[enzyme]] that in humans is encoded by the ''PLSCR1'' [[gene]].<ref name="pmid9218461">{{cite journal | vauthors = Zhou Q, Zhao J, Stout JG, Luhm RA, Wiedmer T, Sims PJ | title = Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids | journal = J Biol Chem | volume = 272 | issue = 29 | pages = 18240–4 | date = August 1997 | pmid = 9218461 | pmc =  | doi = 10.1074/jbc.272.29.18240 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLSCR1 phospholipid scramblase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5359| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Phospholipid scramblase 1
| HGNCid = 9092
| Symbol = PLSCR1
| AltSymbols =; MMTRA1B
| OMIM = 604170
| ECnumber = 
| Homologene = 41418
| MGIid = 893575
| GeneAtlas_image1 = PBB_GE_PLSCR1_202446_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PLSCR1_202430_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0017128 |text = phospholipid scramblase activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0017121 |text = phospholipid scrambling}} {{GNF_GO|id=GO:0030168 |text = platelet activation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5359
    | Hs_Ensembl = ENSG00000188313
    | Hs_RefseqProtein = NP_066928
    | Hs_RefseqmRNA = NM_021105
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 147715658
    | Hs_GenLoc_end = 147745186
    | Hs_Uniprot = O15162
    | Mm_EntrezGene = 22038
    | Mm_Ensembl = ENSMUSG00000032369
    | Mm_RefseqmRNA = NM_011636
    | Mm_RefseqProtein = NP_035766
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 92054019
    | Mm_GenLoc_end = 92076049
    | Mm_Uniprot = Q4FK16
  }}
}}
'''Phospholipid scramblase 1''', also known as '''PLSCR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLSCR1 phospholipid scramblase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5359| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
PLSCR1 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
{{div col|colwidth=20em}}
| section_title =  
* [[CPSF6]],<ref name = pmid16189514/>
| summary_text =  
* [[Epidermal growth factor receptor]],<ref name = pmid12009895/>
}}
* [[NEU4]],<ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
* [[SHC1]],<ref name = pmid12009895>{{cite journal | vauthors = Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ | title = Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor | journal = Biochemistry | volume = 41 | issue = 20 | pages = 6338–45 | date = May 2002 | pmid = 12009895 | doi = 10.1021/bi025610l}}</ref><ref name = pmid12871937>{{cite journal | vauthors = Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T | title = Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor | journal = J. Biol. Chem. | volume = 278 | issue = 39 | pages = 37413–8 | date = September 2003 | pmid = 12871937 | doi = 10.1074/jbc.M306182200 }}</ref>  
* [[SLPI]],<ref name = pmid10869562>{{cite journal | vauthors = Tseng CC, Tseng CP | title = Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement | journal = FEBS Lett. | volume = 475 | issue = 3 | pages = 232–6 | date = June 2000 | pmid = 10869562 | doi = 10.1016/s0014-5793(00)01700-2}}</ref>  and
* [[TFG (gene)|TFG]].<ref name = pmid16189514/>
{{Div col end}}


==See also==
== See also ==
*[[Scramblase]]
*[[Scramblase]]
==References==
 
{{reflist|2}}
== References ==
==Further reading==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bassé F, Stout JG, Sims PJ, Wiedmer T | title = Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid. | journal = J. Biol. Chem. | volume = 271 | issue = 29 | pages = 17205–10 | year = 1996 | pmid = 8663431 | doi = 10.1074/jbc.271.29.17205 }}
| citations =
* {{cite journal | vauthors = Zhou Q, Sims PJ, Wiedmer T | title = Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids. | journal = Biochemistry | volume = 37 | issue = 8 | pages = 2356–60 | year = 1998 | pmid = 9485382 | doi = 10.1021/bi972625o }}
*{{cite journal | author=Bassé F, Stout JG, Sims PJ, Wiedmer T |title=Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid. |journal=J. Biol. Chem. |volume=271 |issue= 29 |pages= 17205-10 |year= 1996 |pmid= 8663431 |doi= }}
* {{cite journal | vauthors = Zhao J, Zhou Q, Wiedmer T, Sims PJ | title = Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids. | journal = Biochemistry | volume = 37 | issue = 18 | pages = 6361–6 | year = 1998 | pmid = 9572851 | doi = 10.1021/bi980218m }}
*{{cite journal | author=Zhou Q, Zhao J, Stout JG, ''et al.'' |title=Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids. |journal=J. Biol. Chem. |volume=272 |issue= 29 |pages= 18240-4 |year= 1997 |pmid= 9218461 |doi= }}
* {{cite journal | vauthors = Kasukabe T, Kobayashi H, Kaneko Y, Okabe-Kado J, Honma Y | title = Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene | journal = Biochem. Biophys. Res. Commun. | volume = 249 | issue = 2 | pages = 449–55 | year = 1998 | pmid = 9712717 | doi = 10.1006/bbrc.1998.9190 }}
*{{cite journal | author=Zhou Q, Sims PJ, Wiedmer T |title=Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids. |journal=Biochemistry |volume=37 |issue= 8 |pages= 2356-60 |year= 1998 |pmid= 9485382 |doi= 10.1021/bi972625o }}
* {{cite journal | vauthors = Zhou Q, Zhao J, Al-Zoghaibi F, Zhou A, Wiedmer T, Silverman RH, Sims PJ | title = Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha | journal = Blood | volume = 95 | issue = 8 | pages = 2593–9 | year = 2000 | pmid = 10753839 | doi = }}
*{{cite journal | author=Zhao J, Zhou Q, Wiedmer T, Sims PJ |title=Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids. |journal=Biochemistry |volume=37 |issue= 18 |pages= 6361-6 |year= 1998 |pmid= 9572851 |doi= 10.1021/bi980218m }}
* {{cite journal | vauthors = Frasch SC, Henson PM, Kailey JM, Richter DA, Janes MS, Fadok VA, Bratton DL | title = Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta | journal = J. Biol. Chem. | volume = 275 | issue = 30 | pages = 23065–73 | year = 2000 | pmid = 10770950 | doi = 10.1074/jbc.M003116200 }}
*{{cite journal | author=Kasukabe T, Kobayashi H, Kaneko Y, ''et al.'' |title=Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene. |journal=Biochem. Biophys. Res. Commun. |volume=249 |issue= 2 |pages= 449-55 |year= 1998 |pmid= 9712717 |doi= 10.1006/bbrc.1998.9190 }}
* {{cite journal | vauthors = Tseng CC, Tseng CP | title = Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement | journal = FEBS Lett. | volume = 475 | issue = 3 | pages = 232–6 | year = 2000 | pmid = 10869562 | doi = 10.1016/S0014-5793(00)01700-2 }}
*{{cite journal | author=Zhou Q, Zhao J, Al-Zoghaibi F, ''et al.'' |title=Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha. |journal=Blood |volume=95 |issue= 8 |pages= 2593-9 |year= 2000 |pmid= 10753839 |doi= }}
* {{cite journal | vauthors = Wiedmer T, Zhou Q, Kwoh DY, Sims PJ | title = Identification of three new members of the phospholipid scramblase gene family | journal = Biochim. Biophys. Acta | volume = 1467 | issue = 1 | pages = 244–53 | year = 2000 | pmid = 10930526 | doi = 10.1016/S0005-2736(00)00236-4 }}
*{{cite journal | author=Frasch SC, Henson PM, Kailey JM, ''et al.'' |title=Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23065-73 |year= 2000 |pmid= 10770950 |doi= 10.1074/jbc.M003116200 }}
* {{cite journal | vauthors = Sun J, Zhao J, Schwartz MA, Wang JY, Wiedmer T, Sims PJ | title = c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1 | journal = J. Biol. Chem. | volume = 276 | issue = 31 | pages = 28984–90 | year = 2001 | pmid = 11390389 | doi = 10.1074/jbc.M102505200 }}
*{{cite journal | author=Tseng CC, Tseng CP |title=Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement. |journal=FEBS Lett. |volume=475 |issue= 3 |pages= 232-6 |year= 2000 |pmid= 10869562 |doi= }}
* {{cite journal | vauthors = Silverman RH, Halloum A, Zhou A, Dong B, Al-Zoghaibi F, Kushner D, Zhou Q, Zhao J, Wiedmer T, Sims PJ | title = Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1 | journal = Cancer Res. | volume = 62 | issue = 2 | pages = 397–402 | year = 2002 | pmid = 11809687 | doi = }}
*{{cite journal | author=Wiedmer T, Zhou Q, Kwoh DY, Sims PJ |title=Identification of three new members of the phospholipid scramblase gene family. |journal=Biochim. Biophys. Acta |volume=1467 |issue= 1 |pages= 244-53 |year= 2000 |pmid= 10930526 |doi= }}
* {{cite journal | vauthors = Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ | title = Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor | journal = Biochemistry | volume = 41 | issue = 20 | pages = 6338–45 | year = 2002 | pmid = 12009895 | doi = 10.1021/bi025610l }}
*{{cite journal | author=Sun J, Zhao J, Schwartz MA, ''et al.'' |title=c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28984-90 |year= 2001 |pmid= 11390389 |doi= 10.1074/jbc.M102505200 }}
* {{cite journal | vauthors = Zhou Q, Zhao J, Wiedmer T, Sims PJ | title = Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1 | journal = Blood | volume = 99 | issue = 11 | pages = 4030–8 | year = 2002 | pmid = 12010804 | doi = 10.1182/blood-2001-12-0271 }}
*{{cite journal | author=Silverman RH, Halloum A, Zhou A, ''et al.'' |title=Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1. |journal=Cancer Res. |volume=62 |issue= 2 |pages= 397-402 |year= 2002 |pmid= 11809687 |doi= }}
* {{cite journal | vauthors = Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS | title = Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase | journal = J. Biol. Chem. | volume = 277 | issue = 31 | pages = 28051–7 | year = 2002 | pmid = 12023963 | doi = 10.1074/jbc.M202665200 }}
*{{cite journal | author=Sun J, Nanjundan M, Pike LJ, ''et al.'' |title=Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor. |journal=Biochemistry |volume=41 |issue= 20 |pages= 6338-45 |year= 2002 |pmid= 12009895 |doi= }}
* {{cite journal | vauthors = Nakamaki T, Okabe-Kado J, Yamamoto-Yamaguchi Y, ((Hino Ki)), Tomoyasu S, Honma Y, Kasukabe T | title = Role of MmTRA1b/phospholipid scramblase1 gene expression in the induction of differentiation of human myeloid leukemia cells into granulocytes | journal = Exp. Hematol. | volume = 30 | issue = 5 | pages = 421–9 | year = 2002 | pmid = 12031648 | doi = 10.1016/S0301-472X(02)00779-8 }}
*{{cite journal | author=Zhou Q, Zhao J, Wiedmer T, Sims PJ |title=Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1. |journal=Blood |volume=99 |issue= 11 |pages= 4030-8 |year= 2002 |pmid= 12010804 |doi= 10.1182/blood-2001-12-0271 }}
* {{cite journal | vauthors = Wiedmer T, Zhao J, Nanjundan M, Sims PJ | title = Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane | journal = Biochemistry | volume = 42 | issue = 5 | pages = 1227–33 | year = 2003 | pmid = 12564925 | doi = 10.1021/bi026679w }}
*{{cite journal | author=Xu YC, Wu RF, Gu Y, ''et al.'' |title=Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28051-7 |year= 2002 |pmid= 12023963 |doi= 10.1074/jbc.M202665200 }}
* {{cite journal | vauthors = Kametaka S, Shibata M, Moroe K, Kanamori S, Ohsawa Y, Waguri S, Sims PJ, Emoto K, Umeda M, Uchiyama Y | title = Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE)) | journal = J. Biol. Chem. | volume = 278 | issue = 17 | pages = 15239–45 | year = 2003 | pmid = 12586838 | doi = 10.1074/jbc.M208611200 }}
*{{cite journal | author=Nakamaki T, Okabe-Kado J, Yamamoto-Yamaguchi Y, ''et al.'' |title=Role of MmTRA1b/phospholipid scramblase1 gene expression in the induction of differentiation of human myeloid leukemia cells into granulocytes. |journal=Exp. Hematol. |volume=30 |issue= 5 |pages= 421-9 |year= 2002 |pmid= 12031648 |doi= }}
* {{cite journal | vauthors = Rami A, Sims J, Botez G, Winckler J | title = Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia | journal = Neurochem. Int. | volume = 43 | issue = 1 | pages = 79–87 | year = 2003 | pmid = 12605885 | doi = 10.1016/S0197-0186(02)00194-8 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T | title = Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor | journal = J. Biol. Chem. | volume = 278 | issue = 39 | pages = 37413–8 | year = 2003 | pmid = 12871937 | doi = 10.1074/jbc.M306182200 }}
*{{cite journal | author=Wiedmer T, Zhao J, Nanjundan M, Sims PJ |title=Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane. |journal=Biochemistry |volume=42 |issue= 5 |pages= 1227-33 |year= 2003 |pmid= 12564925 |doi= 10.1021/bi026679w }}
*{{cite journal | author=Kametaka S, Shibata M, Moroe K, ''et al.'' |title=Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE)). |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15239-45 |year= 2003 |pmid= 12586838 |doi= 10.1074/jbc.M208611200 }}
*{{cite journal  | author=Rami A, Sims J, Botez G, Winckler J |title=Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia. |journal=Neurochem. Int. |volume=43 |issue= 1 |pages= 79-87 |year= 2003 |pmid= 12605885 |doi=  }}
*{{cite journal  | author=Nanjundan M, Sun J, Zhao J, ''et al.'' |title=Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor. |journal=J. Biol. Chem. |volume=278 |issue= 39 |pages= 37413-8 |year= 2003 |pmid= 12871937 |doi= 10.1074/jbc.M306182200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-3-stub}}

Latest revision as of 00:49, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Phospholipid scramblase 1 is an enzyme that in humans is encoded by the PLSCR1 gene.[1][2]

Interactions

PLSCR1 has been shown to interact with:

See also

References

  1. ↑ Zhou Q, Zhao J, Stout JG, Luhm RA, Wiedmer T, Sims PJ (August 1997). "Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids". J Biol Chem. 272 (29): 18240–4. doi:10.1074/jbc.272.29.18240. PMID 9218461.
  2. ↑ "Entrez Gene: PLSCR1 phospholipid scramblase 1".
  3. ↑ 3.0 3.1 3.2 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  4. ↑ 4.0 4.1 Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ (May 2002). "Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor". Biochemistry. 41 (20): 6338–45. doi:10.1021/bi025610l. PMID 12009895.
  5. ↑ Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T (September 2003). "Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor". J. Biol. Chem. 278 (39): 37413–8. doi:10.1074/jbc.M306182200. PMID 12871937.
  6. ↑ Tseng CC, Tseng CP (June 2000). "Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement". FEBS Lett. 475 (3): 232–6. doi:10.1016/s0014-5793(00)01700-2. PMID 10869562.

Further reading

  • Bassé F, Stout JG, Sims PJ, Wiedmer T (1996). "Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid". J. Biol. Chem. 271 (29): 17205–10. doi:10.1074/jbc.271.29.17205. PMID 8663431.
  • Zhou Q, Sims PJ, Wiedmer T (1998). "Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids". Biochemistry. 37 (8): 2356–60. doi:10.1021/bi972625o. PMID 9485382.
  • Zhao J, Zhou Q, Wiedmer T, Sims PJ (1998). "Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids". Biochemistry. 37 (18): 6361–6. doi:10.1021/bi980218m. PMID 9572851.
  • Kasukabe T, Kobayashi H, Kaneko Y, Okabe-Kado J, Honma Y (1998). "Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene". Biochem. Biophys. Res. Commun. 249 (2): 449–55. doi:10.1006/bbrc.1998.9190. PMID 9712717.
  • Zhou Q, Zhao J, Al-Zoghaibi F, Zhou A, Wiedmer T, Silverman RH, Sims PJ (2000). "Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha". Blood. 95 (8): 2593–9. PMID 10753839.
  • Frasch SC, Henson PM, Kailey JM, Richter DA, Janes MS, Fadok VA, Bratton DL (2000). "Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta". J. Biol. Chem. 275 (30): 23065–73. doi:10.1074/jbc.M003116200. PMID 10770950.
  • Tseng CC, Tseng CP (2000). "Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement". FEBS Lett. 475 (3): 232–6. doi:10.1016/S0014-5793(00)01700-2. PMID 10869562.
  • Wiedmer T, Zhou Q, Kwoh DY, Sims PJ (2000). "Identification of three new members of the phospholipid scramblase gene family". Biochim. Biophys. Acta. 1467 (1): 244–53. doi:10.1016/S0005-2736(00)00236-4. PMID 10930526.
  • Sun J, Zhao J, Schwartz MA, Wang JY, Wiedmer T, Sims PJ (2001). "c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1". J. Biol. Chem. 276 (31): 28984–90. doi:10.1074/jbc.M102505200. PMID 11390389.
  • Silverman RH, Halloum A, Zhou A, Dong B, Al-Zoghaibi F, Kushner D, Zhou Q, Zhao J, Wiedmer T, Sims PJ (2002). "Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1". Cancer Res. 62 (2): 397–402. PMID 11809687.
  • Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ (2002). "Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor". Biochemistry. 41 (20): 6338–45. doi:10.1021/bi025610l. PMID 12009895.
  • Zhou Q, Zhao J, Wiedmer T, Sims PJ (2002). "Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1". Blood. 99 (11): 4030–8. doi:10.1182/blood-2001-12-0271. PMID 12010804.
  • Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase". J. Biol. Chem. 277 (31): 28051–7. doi:10.1074/jbc.M202665200. PMID 12023963.
  • Nakamaki T, Okabe-Kado J, Yamamoto-Yamaguchi Y, Hino Ki, Tomoyasu S, Honma Y, Kasukabe T (2002). "Role of MmTRA1b/phospholipid scramblase1 gene expression in the induction of differentiation of human myeloid leukemia cells into granulocytes". Exp. Hematol. 30 (5): 421–9. doi:10.1016/S0301-472X(02)00779-8. PMID 12031648.
  • Wiedmer T, Zhao J, Nanjundan M, Sims PJ (2003). "Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane". Biochemistry. 42 (5): 1227–33. doi:10.1021/bi026679w. PMID 12564925.
  • Kametaka S, Shibata M, Moroe K, Kanamori S, Ohsawa Y, Waguri S, Sims PJ, Emoto K, Umeda M, Uchiyama Y (2003). "Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))". J. Biol. Chem. 278 (17): 15239–45. doi:10.1074/jbc.M208611200. PMID 12586838.
  • Rami A, Sims J, Botez G, Winckler J (2003). "Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia". Neurochem. Int. 43 (1): 79–87. doi:10.1016/S0197-0186(02)00194-8. PMID 12605885.
  • Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T (2003). "Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor". J. Biol. Chem. 278 (39): 37413–8. doi:10.1074/jbc.M306182200. PMID 12871937.


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