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{{Infobox_gene}}
{{PBB_Controls
'''Inter-alpha-trypsin inhibitor heavy chain H3''' is a [[protein]] that in humans is encoded by the ''ITIH3'' [[gene]].<ref name="pmid2465147">{{cite journal |vauthors=Diarra-Mehrpour M, Bourguignon J, Sesboue R, Mattei MG, Passage E, Salier JP, Martin JP | title = Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes | journal = Eur J Biochem | volume = 179 | issue = 1 | pages = 147–54 |date=Apr 1989 | pmid = 2465147 | pmc =  | doi =10.1111/j.1432-1033.1989.tb14532.x  }}</ref><ref name="pmid10100603">{{cite journal |vauthors=Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP | title = The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair? | journal = FEBS Lett | volume = 446 | issue = 1 | pages = 6–8 |date=May 1999 | pmid = 10100603 | pmc =  | doi =10.1016/S0014-5793(99)00173-8  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ITIH3 inter-alpha (globulin) inhibitor H3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3699| accessdate = }}</ref>
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{GNF_Protein_box
* [[Inter-alpha-trypsin inhibitor]]
| image =
* [[ITIH1]]
| image_source =
* [[ITIH2]]
| PDB =
* [[ITIH4]]
| Name = Inter-alpha (globulin) inhibitor H3
| HGNCid = 6168
| Symbol = ITIH3
| AltSymbols =; H3P
| OMIM = 146650
| ECnumber = 
| Homologene = 1669
| MGIid = 96620
| GeneAtlas_image1 = PBB_GE_ITIH3_205755_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0030212 |text = hyaluronan metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3699
    | Hs_Ensembl = ENSG00000162267
    | Hs_RefseqProtein = NP_002208
    | Hs_RefseqmRNA = NM_002217
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 52803852
    | Hs_GenLoc_end = 52817852
    | Hs_Uniprot = Q06033
    | Mm_EntrezGene = 16426
    | Mm_Ensembl = ENSMUSG00000006522
    | Mm_RefseqmRNA = NM_008407
    | Mm_RefseqProtein = NP_032433
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 29737582
    | Mm_GenLoc_end = 29752553
    | Mm_Uniprot = Q91WG9
  }}
}}
'''Inter-alpha (globulin) inhibitor H3''', also known as '''ITIH3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ITIH3 inter-alpha (globulin) inhibitor H3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3699| accessdate = }}</ref>


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==References==
{{PBB_Summary
{{reflist}}
| section_title =
| summary_text =
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Salier JP, Simon D, Rouet P, etal |title=Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. |journal=Genomics |volume=14 |issue= 1 |pages= 83–8 |year= 1992 |pmid= 1385302 |doi=10.1016/S0888-7543(05)80287-3 }}
| citations =
*{{cite journal   |vauthors=Enghild JJ, Salvesen G, Hefta SA, etal |title=Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor. |journal=J. Biol. Chem. |volume=266 |issue= 2 |pages= 747–51 |year= 1991 |pmid= 1898736 |doi=  }}
*{{cite journal | author=Jean L, Risler JL, Nagase T, ''et al.'' |title=The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair? |journal=FEBS Lett. |volume=446 |issue= 1 |pages= 6-8 |year= 1999 |pmid= 10100603 |doi=  }}
*{{cite journal   |vauthors=Salier JP, Diarra-Mehrpour M, Sesboue R, etal |title=Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 23 |pages= 8272–6 |year= 1988 |pmid= 2446322 |doi=10.1073/pnas.84.23.8272  | pmc=299524  }}
*{{cite journal | author=Salier JP, Simon D, Rouet P, ''et al.'' |title=Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. |journal=Genomics |volume=14 |issue= 1 |pages= 83-8 |year= 1992 |pmid= 1385302 |doi=  }}
*{{cite journal  |vauthors=Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G |title=Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. |journal=J. Biol. Chem. |volume=264 |issue= 27 |pages= 15975–81 |year= 1989 |pmid= 2476436 |doi=  }}
*{{cite journal | author=Enghild JJ, Salvesen G, Hefta SA, ''et al.'' |title=Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor. |journal=J. Biol. Chem. |volume=266 |issue= 2 |pages= 747-51 |year= 1991 |pmid= 1898736 |doi= }}
*{{cite journal   |vauthors=Diarra-Mehrpour M, Bourguignon J, Sarafan N, etal |title=Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes. |journal=Biochim. Biophys. Acta |volume=1219 |issue= 2 |pages= 551–4 |year= 1994 |pmid= 7522574 |doi=  10.1016/0167-4781(94)90087-6}}
*{{cite journal  | author=Salier JP, Diarra-Mehrpour M, Sesboue R, ''et al.'' |title=Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 23 |pages= 8272-6 |year= 1988 |pmid= 2446322 |doi=  }}
*{{cite journal   |vauthors=Bourguignon J, Diarra-Mehrpour M, Thiberville L, etal |title=Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence. |journal=Eur. J. Biochem. |volume=212 |issue= 3 |pages= 771–6 |year= 1993 |pmid= 7681778 |doi=10.1111/j.1432-1033.1993.tb17717.x  }}
*{{cite journal | author=Diarra-Mehrpour M, Bourguignon J, Sesboüé R, ''et al.'' |title=Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes. |journal=Eur. J. Biochem. |volume=179 |issue= 1 |pages= 147-54 |year= 1989 |pmid= 2465147 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G |title=Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. |journal=J. Biol. Chem. |volume=264 |issue= 27 |pages= 15975-81 |year= 1989 |pmid= 2476436 |doi= }}
*{{cite journal  |vauthors=Blom AM, Thuveson M, Fries E |title=Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells |journal=Biochem. J. |volume=328 |issue= 1|pages= 185–91 |year= 1998 |pmid= 9359851 |doi= | pmc=1218904 }}
*{{cite journal  | author=Diarra-Mehrpour M, Bourguignon J, Sarafan N, ''et al.'' |title=Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes. |journal=Biochim. Biophys. Acta |volume=1219 |issue= 2 |pages= 551-4 |year= 1994 |pmid= 7522574 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Bourguignon J, Diarra-Mehrpour M, Thiberville L, ''et al.'' |title=Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence. |journal=Eur. J. Biochem. |volume=212 |issue= 3 |pages= 771-6 |year= 1993 |pmid= 7681778 |doi=  }}
*{{cite journal   |vauthors=Diarra-Mehrpour M, Sarafan N, Bourguignon J, etal |title=Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26809–19 |year= 1998 |pmid= 9756925 |doi=10.1074/jbc.273.41.26809 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Thuveson M, Fries E |title=Intracellular proteolytic processing of the heavy chain of rat pre-alpha-inhibitor. The COOH-terminal propeptide is required for coupling to bikunin |journal=J. Biol. Chem. |volume=274 |issue= 10 |pages= 6741–6 |year= 1999 |pmid= 10037773 |doi=10.1074/jbc.274.10.6741  }}
*{{cite journal | author=Blom AM, Thuveson M, Fries E |title=Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells. |journal=Biochem. J. |volume=328 ( Pt 1) |issue= |pages= 185-91 |year= 1998 |pmid= 9359851 |doi=  }}
*{{cite journal   |vauthors=Bourguignon J, Borghi H, Sesboüé R, etal |title=Immunohistochemical distribution of inter-alpha-trypsin inhibitor chains in normal and malignant human lung tissue |journal=J. Histochem. Cytochem. |volume=47 |issue= 12 |pages= 1625–32 |year= 1999 |pmid= 10567446 |doi=  10.1177/002215549904701214}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  |vauthors=Thuveson M, Fries E |title=The low pH in trans-Golgi triggers autocatalytic cleavage of pre-alpha -inhibitor heavy chain precursor |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 30996–1000 |year= 2000 |pmid= 10893227 |doi= 10.1074/jbc.M002399200 }}
*{{cite journal | author=Diarra-Mehrpour M, Sarafan N, Bourguignon J, ''et al.'' |title=Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage. |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26809-19 |year= 1998 |pmid= 9756925 |doi=  }}
*{{cite journal   |vauthors=Kato M, Seki N, Sugano S, etal |title=Identification of sonic hedgehog-responsive genes using cDNA microarray |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 2 |pages= 472–8 |year= 2002 |pmid= 11716497 |doi= 10.1006/bbrc.2001.5976 }}
*{{cite journal  | author=Thuveson M, Fries E |title=Intracellular proteolytic processing of the heavy chain of rat pre-alpha-inhibitor. The COOH-terminal propeptide is required for coupling to bikunin. |journal=J. Biol. Chem. |volume=274 |issue= 10 |pages= 6741-6 |year= 1999 |pmid= 10037773 |doi= }}
*{{cite journal   |vauthors=Paris S, Sesboüé R, Delpech B, etal |title=Inhibition of tumor growth and metastatic spreading by overexpression of inter-alpha-trypsin inhibitor family chains |journal=Int. J. Cancer |volume=97 |issue= 5 |pages= 615–20 |year= 2002 |pmid= 11807786 |doi=10.1002/ijc.10120  }}
*{{cite journal | author=Bourguignon J, Borghi H, Sesboüé R, ''et al.'' |title=Immunohistochemical distribution of inter-alpha-trypsin inhibitor chains in normal and malignant human lung tissue. |journal=J. Histochem. Cytochem. |volume=47 |issue= 12 |pages= 1625-32 |year= 1999 |pmid= 10567446 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Thuveson M, Fries E |title=The low pH in trans-Golgi triggers autocatalytic cleavage of pre-alpha -inhibitor heavy chain precursor. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 30996-1000 |year= 2000 |pmid= 10893227 |doi= 10.1074/jbc.M002399200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Kato M, Seki N, Sugano S, ''et al.'' |title=Identification of sonic hedgehog-responsive genes using cDNA microarray. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 2 |pages= 472-8 |year= 2002 |pmid= 11716497 |doi= 10.1006/bbrc.2001.5976 }}
 
*{{cite journal | author=Paris S, Sesboüé R, Delpech B, ''et al.'' |title=Inhibition of tumor growth and metastatic spreading by overexpression of inter-alpha-trypsin inhibitor family chains. |journal=Int. J. Cancer |volume=97 |issue= 5 |pages= 615-20 |year= 2002 |pmid= 11807786 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
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{{refend}}


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Latest revision as of 00:12, 1 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Inter-alpha-trypsin inhibitor heavy chain H3 is a protein that in humans is encoded by the ITIH3 gene.[1][2][3]

See also

References

  1. ↑ Diarra-Mehrpour M, Bourguignon J, Sesboue R, Mattei MG, Passage E, Salier JP, Martin JP (Apr 1989). "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes". Eur J Biochem. 179 (1): 147–54. doi:10.1111/j.1432-1033.1989.tb14532.x. PMID 2465147.
  2. ↑ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603.
  3. ↑ "Entrez Gene: ITIH3 inter-alpha (globulin) inhibitor H3".

Further reading


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