ADCY5: Difference between revisions

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Adenylyl cyclase type 5 is an enzyme that in humans is encoded by the ADCY5 gene.^[1]^[2]

Interactions

ADCY5 has been shown to interact with RGS2.^[3]

References

↑ Raimundo S, Giray J, Volff JN, Schwab M, Altenbuchner J, Ratge D, Wisser H (October 1999). "Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues". Clin Chim Acta. 285 (1–2): 155–61. doi:10.1016/S0009-8981(99)00067-4. PMID 10481931.
↑ "Entrez Gene: ADCY5 adenylate cyclase 5".
↑ Salim S, Sinnarajah S, Kehrl JH, Dessauer CW (May 2003). "Identification of RGS2 and type V adenylyl cyclase interaction sites". J. Biol. Chem. 278 (18): 15842–9. doi:10.1074/jbc.M210663200. PMID 12604604.

External links

Human ADCY5 genome location and ADCY5 gene details page in the UCSC Genome Browser.

Yoshimura M, Cooper DM (1992). "Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells". Proc. Natl. Acad. Sci. U.S.A. 89 (15): 6716–20. doi:10.1073/pnas.89.15.6716. PMC 49574. PMID 1379717.
Iwami G, Kawabe J, Ebina T, Cannon PJ, Homcy CJ, Ishikawa Y (1995). "Regulation of adenylyl cyclase by protein kinase A". J. Biol. Chem. 270 (21): 12481–4. doi:10.1074/jbc.270.21.12481. PMID 7759492.
Haber N, Stengel D, Defer N, Roeckel N, Mattei MG, Hanoune J (1994). "Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI". Hum. Genet. 94 (1): 69–73. doi:10.1007/BF02272844. PMID 8034296.
Kawabe J, Iwami G, Ebina T, Ohno S, Katada T, Ueda Y, Homcy CJ, Ishikawa Y (1994). "Differential activation of adenylyl cyclase by protein kinase C isoenzymes". J. Biol. Chem. 269 (24): 16554–8. PMID 8206971.
Scholich K, Barbier AJ, Mullenix JB, Patel TB (1997). "Characterization of soluble forms of nonchimeric type V adenylyl cyclases". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2915–20. doi:10.1073/pnas.94.7.2915. PMC 20297. PMID 9096321.
Sunahara RK, Dessauer CW, Whisnant RE, Kleuss C, Gilman AG (1997). "Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase". J. Biol. Chem. 272 (35): 22265–71. doi:10.1074/jbc.272.35.22265. PMID 9268375.
Scholich K, Wittpoth C, Barbier AJ, Mullenix JB, Patel TB (1997). "Identification of an intramolecular interaction between small regions in type V adenylyl cyclase that influences stimulation of enzyme activity by Gsα". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9602–7. doi:10.1073/pnas.94.18.9602. PMC 23231. PMID 9275169.
Dessauer CW, Tesmer JJ, Sprang SR, Gilman AG (1998). "Identification of a Gialpha binding site on type V adenylyl cyclase". J. Biol. Chem. 273 (40): 25831–9. doi:10.1074/jbc.273.40.25831. PMID 9748257.
Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflugers Arch. 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566.
Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185.
Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
Côté M, Guillon G, Payet MD, Gallo-Payet N (2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". J. Clin. Endocrinol. Metab. 86 (9): 4495–503. doi:10.1210/jc.86.9.4495. PMID 11549699.
Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP (2002). "Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons". J. Virol. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542.
Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609.
Salim S, Sinnarajah S, Kehrl JH, Dessauer CW (2003). "Identification of RGS2 and type V adenylyl cyclase interaction sites". J. Biol. Chem. 278 (18): 15842–9. doi:10.1074/jbc.M210663200. PMID 12604604.
Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD (2006). "Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes". Mol. Cell. 23 (6): 925–31. doi:10.1016/j.molcel.2006.07.025. PMID 16973443.
Wang SC, Lai HL, Chiu YT, Ou R, Huang CL, Chern Y (2007). "Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor". Biochem J. 406 (3): 383–8. doi:10.1042/BJ20070512. PMC 2049038. PMID 17593019.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[pmid10481931-1] Raimundo S, Giray J, Volff JN, Schwab M, Altenbuchner J, Ratge D, Wisser H (October 1999). "Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues". Clin Chim Acta. 285 (1–2): 155–61. doi:10.1016/S0009-8981(99)00067-4. PMID 10481931.

[entrez-2] "Entrez Gene: ADCY5 adenylate cyclase 5".

[pmid12604604-3] Salim S, Sinnarajah S, Kehrl JH, Dessauer CW (May 2003). "Identification of RGS2 and type V adenylyl cyclase interaction sites". J. Biol. Chem. 278 (18): 15842–9. doi:10.1074/jbc.M210663200. PMID 12604604.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Adenylyl cyclase type 5''' is an [[enzyme]] that in humans is encoded by the ''ADCY5'' [[gene]].<ref name="pmid10481931">{{cite journal | vauthors = Raimundo S, Giray J, Volff JN, Schwab M, Altenbuchner J, Ratge D, Wisser H | title = Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues | journal = Clin Chim Acta | volume = 285 | issue = 1–2 | pages = 155–61 | date = October 1999 | pmid = 10481931 | pmc =  | doi = 10.1016/S0009-8981(99)00067-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ADCY5 adenylate cyclase 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=111| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Interactions ==
-{{GNF_Protein_box
- | image = PBB_Protein_ADCY5_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1azs.
- | PDB = {{PDB2|1azs}}, {{PDB2|1cjk}}, {{PDB2|1cjt}}, {{PDB2|1cju}}, {{PDB2|1cjv}}, {{PDB2|1cs4}}, {{PDB2|1cul}}, {{PDB2|1tl7}}, {{PDB2|1u0h}}, {{PDB2|2gvd}}, {{PDB2|2gvz}}
- | Name = Adenylate cyclase 5
- | HGNCid = 236
- | Symbol = ADCY5
- | AltSymbols =;
- | OMIM = 600293
- | ECnumber =
- | Homologene = 11213
- | MGIid = 99673
- | GeneAtlas_image1 = PBB_GE_ADCY5_gnf1h01583_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_ADCY5_gnf1h01584_x_at_tn.png
- | Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004016 |text = adenylate cyclase activity}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0001973 |text = adenosine receptor signaling pathway}} {{GNF_GO|id=GO:0006171 |text = cAMP biosynthetic process}} {{GNF_GO|id=GO:0007191 |text = dopamine receptor, adenylate cyclase activating pathway}} {{GNF_GO|id=GO:0007195 |text = dopamine receptor, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0050885 |text = regulation of balance}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 111
-    | Hs_Ensembl = ENSG00000173175
-    | Hs_RefseqProtein = NP_899200
-    | Hs_RefseqmRNA = NM_183357
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 3
-    | Hs_GenLoc_start = 124486089
-    | Hs_GenLoc_end = 124650082
-    | Hs_Uniprot = O95622
-    | Mm_EntrezGene = 224129
-    | Mm_Ensembl = ENSMUSG00000022840
-    | Mm_RefseqmRNA = XM_916755
-    | Mm_RefseqProtein = XP_921848
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 16
-    | Mm_GenLoc_start = 35074624
-    | Mm_GenLoc_end = 35224118
-    | Mm_Uniprot = P84309
-  }}
-}}
-'''Adenylate cyclase 5''', also known as '''ADCY5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ADCY5 adenylate cyclase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=111| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+ADCY5 has been shown to [[Protein-protein interaction|interact]] with [[RGS2]].<ref name="pmid12604604">{{cite journal | vauthors = Salim S, Sinnarajah S, Kehrl JH, Dessauer CW | title = Identification of RGS2 and type V adenylyl cyclase interaction sites | journal = J. Biol. Chem. | volume = 278 | issue = 18 | pages = 15842–9 | date = May 2003 | pmid = 12604604 | doi = 10.1074/jbc.M210663200 }}</ref>
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+==External links==
+* {{UCSC gene info|ADCY5}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Yoshimura M, Cooper DM | title = Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 15 | pages = 6716–20 | year = 1992 | pmid = 1379717 | pmc = 49574 | doi = 10.1073/pnas.89.15.6716 }}
-| citations =
+* {{cite journal | vauthors = Iwami G, Kawabe J, Ebina T, Cannon PJ, Homcy CJ, Ishikawa Y | title = Regulation of adenylyl cyclase by protein kinase A | journal = J. Biol. Chem. | volume = 270 | issue = 21 | pages = 12481–4 | year = 1995 | pmid = 7759492 | doi = 10.1074/jbc.270.21.12481 }}
-*{{cite journal  | author=Yoshimura M, Cooper DM |title=Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 15 |pages= 6716-20 |year= 1992 |pmid= 1379717 |doi=  }}
+* {{cite journal | vauthors = Haber N, Stengel D, Defer N, Roeckel N, Mattei MG, Hanoune J | title = Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI | journal = Hum. Genet. | volume = 94 | issue = 1 | pages = 69–73 | year = 1994 | pmid = 8034296 | doi = 10.1007/BF02272844 }}
-*{{cite journal  | author=Iwami G, Kawabe J, Ebina T, ''et al.'' |title=Regulation of adenylyl cyclase by protein kinase A. |journal=J. Biol. Chem. |volume=270 |issue= 21 |pages= 12481-4 |year= 1995 |pmid= 7759492 |doi=  }}
+* {{cite journal | vauthors = Kawabe J, Iwami G, Ebina T, Ohno S, Katada T, Ueda Y, Homcy CJ, Ishikawa Y | title = Differential activation of adenylyl cyclase by protein kinase C isoenzymes | journal = J. Biol. Chem. | volume = 269 | issue = 24 | pages = 16554–8 | year = 1994 | pmid = 8206971 | doi =  }}
-*{{cite journal  | author=Haber N, Stengel D, Defer N, ''et al.'' |title=Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI. |journal=Hum. Genet. |volume=94 |issue= 1 |pages= 69-73 |year= 1994 |pmid= 8034296 |doi=  }}
+* {{cite journal | vauthors = Scholich K, Barbier AJ, Mullenix JB, Patel TB | title = Characterization of soluble forms of nonchimeric type V adenylyl cyclases | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 7 | pages = 2915–20 | year = 1997 | pmid = 9096321 | pmc = 20297 | doi = 10.1073/pnas.94.7.2915 }}
-*{{cite journal  | author=Kawabe J, Iwami G, Ebina T, ''et al.'' |title=Differential activation of adenylyl cyclase by protein kinase C isoenzymes. |journal=J. Biol. Chem. |volume=269 |issue= 24 |pages= 16554-8 |year= 1994 |pmid= 8206971 |doi=  }}
+* {{cite journal | vauthors = Sunahara RK, Dessauer CW, Whisnant RE, Kleuss C, Gilman AG | title = Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase | journal = J. Biol. Chem. | volume = 272 | issue = 35 | pages = 22265–71 | year = 1997 | pmid = 9268375 | doi = 10.1074/jbc.272.35.22265 }}
-*{{cite journal  | author=Scholich K, Barbier AJ, Mullenix JB, Patel TB |title=Characterization of soluble forms of nonchimeric type V adenylyl cyclases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 7 |pages= 2915-20 |year= 1997 |pmid= 9096321 |doi=  }}
+* {{cite journal | vauthors = Scholich K, Wittpoth C, Barbier AJ, Mullenix JB, Patel TB | title = Identification of an intramolecular interaction between small regions in type V adenylyl cyclase that influences stimulation of enzyme activity by Gsα | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 18 | pages = 9602–7 | year = 1997 | pmid = 9275169 | pmc = 23231 | doi = 10.1073/pnas.94.18.9602 }}
-*{{cite journal  | author=Sunahara RK, Dessauer CW, Whisnant RE, ''et al.'' |title=Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22265-71 |year= 1997 |pmid= 9268375 |doi=  }}
+* {{cite journal | vauthors = Dessauer CW, Tesmer JJ, Sprang SR, Gilman AG | title = Identification of a Gialpha binding site on type V adenylyl cyclase | journal = J. Biol. Chem. | volume = 273 | issue = 40 | pages = 25831–9 | year = 1998 | pmid = 9748257 | doi = 10.1074/jbc.273.40.25831 }}
-*{{cite journal  | author=Scholich K, Wittpoth C, Barbier AJ, ''et al.'' |title=Identification of an intramolecular interaction between small regions in type V adenylyl cyclase that influences stimulation of enzyme activity by Gsalpha. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 18 |pages= 9602-7 |year= 1997 |pmid= 9275169 |doi=  }}
+* {{cite journal | vauthors = Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP | title = Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1 | journal = Pflugers Arch. | volume = 437 | issue = 4 | pages = 538–46 | year = 1999 | pmid = 10089566 | doi = 10.1007/s004240050815 }}
-*{{cite journal  | author=Dessauer CW, Tesmer JJ, Sprang SR, Gilman AG |title=Identification of a Gialpha binding site on type V adenylyl cyclase. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25831-9 |year= 1998 |pmid= 9748257 |doi=  }}
+* {{cite journal | vauthors = Speth C, Joebstl B, Barcova M, Dierich MP | title = HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones | journal = AIDS | volume = 14 | issue = 6 | pages = 629–36 | year = 2000 | pmid = 10807185 | doi = 10.1097/00002030-200004140-00001 }}
-*{{cite journal  | author=Barcova M, Speth C, Kacani L, ''et al.'' |title=Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. |journal=Pflugers Arch. |volume=437 |issue= 4 |pages= 538-46 |year= 1999 |pmid= 10089566 |doi=  }}
+* {{cite journal | vauthors = Patke CL, Shearer WT | title = gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression | journal = J. Allergy Clin. Immunol. | volume = 105 | issue = 5 | pages = 975–82 | year = 2000 | pmid = 10808179 | doi = 10.1067/mai.2000.105315 }}
-*{{cite journal  | author=Raimundo S, Giray J, Volff JN, ''et al.'' |title=Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues. |journal=Clin. Chim. Acta |volume=285 |issue= 1-2 |pages= 155-61 |year= 1999 |pmid= 10481931 |doi=  }}
+* {{cite journal | vauthors = Patrizio M, Colucci M, Levi G | title = Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures | journal = J. Neurochem. | volume = 77 | issue = 2 | pages = 399–407 | year = 2001 | pmid = 11299302 | doi = 10.1046/j.1471-4159.2001.00249.x }}
-*{{cite journal  | author=Speth C, Joebstl B, Barcova M, Dierich MP |title=HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. |journal=AIDS |volume=14 |issue= 6 |pages= 629-36 |year= 2000 |pmid= 10807185 |doi=  }}
+* {{cite journal | vauthors = Côté M, Guillon G, Payet MD, Gallo-Payet N | title = Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland | journal = J. Clin. Endocrinol. Metab. | volume = 86 | issue = 9 | pages = 4495–503 | year = 2001 | pmid = 11549699 | doi = 10.1210/jc.86.9.4495 }}
-*{{cite journal  | author=Patke CL, Shearer WT |title=gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 5 |pages= 975-82 |year= 2000 |pmid= 10808179 |doi= 10.1067/mai.2000.105315 }}
+* {{cite journal | vauthors = Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP | title = Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons | journal = J. Virol. | volume = 76 | issue = 7 | pages = 3179–88 | year = 2002 | pmid = 11884542 | pmc = 136041 | doi = 10.1128/JVI.76.7.3179-3188.2002 }}
-*{{cite journal  | author=Patrizio M, Colucci M, Levi G |title=Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. |journal=J. Neurochem. |volume=77 |issue= 2 |pages= 399-407 |year= 2001 |pmid= 11299302 |doi=  }}
+* {{cite journal | vauthors = Ludwig MG, Seuwen K | title = Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms | journal = J. Recept. Signal Transduct. Res. | volume = 22 | issue = 1–4 | pages = 79–110 | year = 2003 | pmid = 12503609 | doi = 10.1081/RRS-120014589 }}
-*{{cite journal  | author=Côté M, Guillon G, Payet MD, Gallo-Payet N |title=Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 9 |pages= 4495-503 |year= 2001 |pmid= 11549699 |doi=  }}
+* {{cite journal | vauthors = Salim S, Sinnarajah S, Kehrl JH, Dessauer CW | title = Identification of RGS2 and type V adenylyl cyclase interaction sites | journal = J. Biol. Chem. | volume = 278 | issue = 18 | pages = 15842–9 | year = 2003 | pmid = 12604604 | doi = 10.1074/jbc.M210663200 }}
-*{{cite journal  | author=Speth C, Schabetsberger T, Mohsenipour I, ''et al.'' |title=Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons. |journal=J. Virol. |volume=76 |issue= 7 |pages= 3179-88 |year= 2002 |pmid= 11884542 |doi=  }}
+* {{cite journal | vauthors = Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD | title = Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes | journal = Mol. Cell | volume = 23 | issue = 6 | pages = 925–31 | year = 2006 | pmid = 16973443 | doi = 10.1016/j.molcel.2006.07.025 }}
-*{{cite journal  | author=Ludwig MG, Seuwen K |title=Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. |journal=J. Recept. Signal Transduct. Res. |volume=22 |issue= 1-4 |pages= 79-110 |year= 2003 |pmid= 12503609 |doi=  }}
+* {{cite journal | vauthors = Wang SC, Lai HL, Chiu YT, Ou R, Huang CL, Chern Y | title = Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor | journal = Biochem J | volume = 406 | issue = 3 | pages = 383–8 | year = 2007 | pmid = 17593019 | pmc = 2049038 | doi = 10.1042/BJ20070512 }}
-*{{cite journal  | author=Salim S, Sinnarajah S, Kehrl JH, Dessauer CW |title=Identification of RGS2 and type V adenylyl cyclase interaction sites. |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 15842-9 |year= 2003 |pmid= 12604604 |doi= 10.1074/jbc.M210663200 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Muzny DM, Scherer SE, Kaul R, ''et al.'' |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194-8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728 }}
-*{{cite journal  | author=Bauman AL, Soughayer J, Nguyen BT, ''et al.'' |title=Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. |journal=Mol. Cell |volume=23 |issue= 6 |pages= 925-31 |year= 2006 |pmid= 16973443 |doi= 10.1016/j.molcel.2006.07.025 }}
-}}
 {{refend}}
-{{protein-stub}}
+{{PDB Gallery|geneid=111}}
-{{WikiDoc Sources}}
+{{Phosphorus-oxygen lyases}}
+{{Enzymes}}
+{{Portal bar|Molecular and Cellular Biology|border=no}}
+[[Category:EC 4.6.1]]
+{{gene-3-stub}}

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

ADCY5: Difference between revisions

Revision as of 17:50, 29 August 2017

Contents

Interactions

References

External links

Further reading

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