SMC4: Difference between revisions

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'''Structural maintenance of chromosomes protein 4''' (SMC-4) also known as '''chromosome-associated polypeptide C''' (CAP-C) or '''XCAP-C homolog''' is a [[protein]] that in humans is encoded by the ''SMC4'' [[gene]].<ref name="pmid9789013">{{cite journal | vauthors = Schmiesing JA, ((Ball AR Jr)), Gregson HC, Alderton JM, Zhou S, Yokomori K | title = Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 22 | pages = 12906–11 |date=Nov 1998 | pmid = 9789013 | pmc = 23650 | doi =10.1073/pnas.95.22.12906  }}</ref><ref name="pmid10319587">{{cite journal | vauthors = Nishiwaki T, Daigo Y, Kawasoe T, Nagasawa Y, Ishiguro H, Fujita M, Furukawa Y, Nakamura Y | title = Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family | journal = J Hum Genet | volume = 44 | issue = 3 | pages = 197–202 |date=Jun 1999 | pmid = 10319587 | pmc = | doi = 10.1007/s100380050142 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SMC4 structural maintenance of chromosomes 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10051| accessdate = }}</ref> SMC-4 is a core subunit of [[condensin]] I and II, large protein complexes involved in chromosome condensation.
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==References==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Structural maintenance of chromosomes 4
| HGNCid = 14013
| Symbol = SMC4
| AltSymbols =; CAPC; SMC4L1; hCAP-C
| OMIM = 605575
| ECnumber = 
| Homologene = 4015
| MGIid = 1917349
| GeneAtlas_image1 = PBB_GE_SMC4_201664_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMC4_201663_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0000796 |text = condensin complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0006259 |text = DNA metabolic process}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007076 |text = mitotic chromosome condensation}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10051
    | Hs_Ensembl = ENSG00000113810
    | Hs_RefseqProtein = NP_001002799
    | Hs_RefseqmRNA = NM_001002799
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 161600124
    | Hs_GenLoc_end = 161635433
    | Hs_Uniprot = Q9NTJ3
    | Mm_EntrezGene = 70099
    | Mm_Ensembl =
    | Mm_RefseqmRNA = XM_974335
    | Mm_RefseqProtein = XP_979429
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Structural maintenance of chromosomes 4''', also known as '''SMC4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SMC4 structural maintenance of chromosomes 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10051| accessdate = }}</ref>


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==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | author=Hirano T |title=The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair |journal=Genes Dev. |volume=16 |issue= 4 |pages= 399–414 |year= 2002 |pmid= 11850403 |doi= 10.1101/gad.955102 }}
| citations =
*{{cite journal  | vauthors=Ball Jr AR, Yokomori K |title=The structural maintenance of chromosomes (SMC) family of proteins in mammals |journal=Chromosome Res. |volume=9 |issue= 2 |pages= 85–96 |year= 2001 |pmid= 11321372 |doi=10.1023/A:1009287518015 }}
*{{cite journal  | author=Hirano T |title=The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair. |journal=Genes Dev. |volume=16 |issue= 4 |pages= 399-414 |year= 2002 |pmid= 11850403 |doi= 10.1101/gad.955102 }}
*{{cite journal   |vauthors=Ham MF, Takakuwa T, Rahadiani N, etal |title=Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma |journal=Cancer Sci. |volume=98 |issue= 7 |pages= 1041–7 |year= 2007 |pmid= 17488335 |doi= 10.1111/j.1349-7006.2007.00500.x }}
*{{cite journal  | author=Ball Jr AR, Yokomori K |title=The structural maintenance of chromosomes (SMC) family of proteins in mammals. |journal=Chromosome Res. |volume=9 |issue= 2 |pages= 85-96 |year= 2001 |pmid= 11321372 |doi=  }}
*{{cite journal   |vauthors=Nousiainen M, Silljé HH, Sauer G, etal |title=Phosphoproteome analysis of the human mitotic spindle |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 }}
*{{cite journal | author=Ham MF, Takakuwa T, Rahadiani N, ''et al.'' |title=Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma. |journal=Cancer Sci. |volume=98 |issue= 7 |pages= 1041-7 |year= 2007 |pmid= 17488335 |doi= 10.1111/j.1349-7006.2007.00500.x }}
*{{cite journal   |vauthors=Geiman TM, Sankpal UT, Robertson AK, etal |title=Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery |journal=Nucleic Acids Res. |volume=32 |issue= 9 |pages= 2716–29 |year= 2004 |pmid= 15148359 |doi= 10.1093/nar/gkh589 | pmc=419596 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Geiman TM, Sankpal UT, Robertson AK, ''et al.'' |title=Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. |journal=Nucleic Acids Res. |volume=32 |issue= 9 |pages= 2716-29 |year= 2004 |pmid= 15148359 |doi= 10.1093/nar/gkh589 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Kimura K, Cuvier O, Hirano T |title=Chromosome condensation by a human condensin complex in Xenopus egg extracts |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5417–20 |year= 2001 |pmid= 11136719 |doi= 10.1074/jbc.C000873200 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | vauthors=Schmiesing JA, Gregson HC, Zhou S, Yokomori K |title=A Human Condensin Complex Containing hCAP-C–hCAP-E and CNAP1, a Homolog of Xenopus XCAP-D2, Colocalizes with Phosphorylated Histone H3 during the Early Stage of Mitotic Chromosome Condensation |journal=Mol. Cell. Biol. |volume=20 |issue= 18 |pages= 6996–7006 |year= 2000 |pmid= 10958694 |doi=10.1128/MCB.20.18.6996-7006.2000 | pmc=88774 }}
*{{cite journal  | author=Kimura K, Cuvier O, Hirano T |title=Chromosome condensation by a human condensin complex in Xenopus egg extracts. |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5417-20 |year= 2001 |pmid= 11136719 |doi= 10.1074/jbc.C000873200 }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Schmiesing JA, Gregson HC, Zhou S, Yokomori K |title=A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. |journal=Mol. Cell. Biol. |volume=20 |issue= 18 |pages= 6996-7006 |year= 2000 |pmid= 10958694 |doi= }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Nishiwaki T, Daigo Y, Kawasoe T, ''et al.'' |title=Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family. |journal=J. Hum. Genet. |volume=44 |issue= 3 |pages= 197-202 |year= 1999 |pmid= 10319587 |doi= }}
*{{cite journal  | author=Schmiesing JA, Ball AR, Gregson HC, ''et al.'' |title=Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 22 |pages= 12906-11 |year= 1998 |pmid= 9789013 |doi=  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|SMC4}}
* {{UCSC gene details|SMC4}}
 
{{Nucleus}}
 
 
{{gene-3-stub}}

Latest revision as of 06:40, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Structural maintenance of chromosomes protein 4 (SMC-4) also known as chromosome-associated polypeptide C (CAP-C) or XCAP-C homolog is a protein that in humans is encoded by the SMC4 gene.[1][2][3] SMC-4 is a core subunit of condensin I and II, large protein complexes involved in chromosome condensation.

References

  1. ↑ Schmiesing JA, Ball AR Jr, Gregson HC, Alderton JM, Zhou S, Yokomori K (Nov 1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics". Proc Natl Acad Sci U S A. 95 (22): 12906–11. doi:10.1073/pnas.95.22.12906. PMC 23650. PMID 9789013.
  2. ↑ Nishiwaki T, Daigo Y, Kawasoe T, Nagasawa Y, Ishiguro H, Fujita M, Furukawa Y, Nakamura Y (Jun 1999). "Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family". J Hum Genet. 44 (3): 197–202. doi:10.1007/s100380050142. PMID 10319587.
  3. ↑ "Entrez Gene: SMC4 structural maintenance of chromosomes 4".

Further reading

External links


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