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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''Choline-phosphate cytidylyltransferase A''' is an [[enzyme]] that in humans is encoded by the ''PCYT1A'' [[gene]].<ref name="pmid7918629">{{cite journal | vauthors = Kalmar GB, Kay RJ, LaChance AC, Cornell RB | title = Primary structure and expression of a human CTP:phosphocholine cytidylyltransferase | journal = Biochim Biophys Acta | volume = 1219 | issue = 2 | pages = 328–34 |date=Nov 1994 | pmid = 7918629 | pmc =  | doi =  10.1016/0167-4781(94)90056-6}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PCYT1A phosphate cytidylyltransferase 1, choline, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5130| accessdate = }}</ref>
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| image = PBB_Protein_PCYT1A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1peh.
| PDB = {{PDB2|1peh}}
| Name = Phosphate cytidylyltransferase 1, choline, alpha
| HGNCid = 8754
| Symbol = PCYT1A
| AltSymbols =; CT; CTPCT; PCYT1
| OMIM = 123695
| ECnumber = 
| Homologene = 3680
| MGIid = 88557
| GeneAtlas_image1 = PBB_GE_PCYT1A_204209_at_tn.png
| GeneAtlas_image2 = PBB_GE_PCYT1A_204210_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004105 |text = choline-phosphate cytidylyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0042587 |text = glycogen granule}}
  | Process = {{GNF_GO|id=GO:0006656 |text = phosphatidylcholine biosynthetic process}} {{GNF_GO|id=GO:0008654 |text = phospholipid biosynthetic process}} {{GNF_GO|id=GO:0009058 |text = biosynthetic process}} {{GNF_GO|id=GO:0009628 |text = response to abiotic stimulus}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5130
    | Hs_Ensembl = ENSG00000161217
    | Hs_RefseqProtein = NP_005008
    | Hs_RefseqmRNA = NM_005017
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 197449652
    | Hs_GenLoc_end = 197498981
    | Hs_Uniprot = P49585
    | Mm_EntrezGene = 13026
    | Mm_Ensembl = ENSMUSG00000005615
    | Mm_RefseqmRNA = NM_009981
    | Mm_RefseqProtein = NP_034111
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 32350743
    | Mm_GenLoc_end = 32391762
    | Mm_Uniprot = P49586
  }}
}}
'''Phosphate cytidylyltransferase 1, choline, alpha''', also known as '''PCYT1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PCYT1A phosphate cytidylyltransferase 1, choline, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5130| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Hunt AN, Normand CS, Postle AD |title=CTP:cholinephosphate cytidylyltransferase in human and rat lung: association in vitro with cytoskeletal actin. |journal=Biochim. Biophys. Acta |volume=1043 |issue= 1 |pages= 19-26 |year= 1990 |pmid= 2155660 |doi=  }}
*{{cite journal  | vauthors=Hunt AN, Normand CS, Postle AD |title=CTP:cholinephosphate cytidylyltransferase in human and rat lung: association in vitro with cytoskeletal actin. |journal=Biochim. Biophys. Acta |volume=1043 |issue= 1 |pages= 19–26 |year= 1990 |pmid= 2155660 |doi=  10.1016/0005-2760(90)90105-7}}
*{{cite journal  | author=Vance JE, Vance DE |title=Does rat liver Golgi have the capacity to synthesize phospholipids for lipoprotein secretion? |journal=J. Biol. Chem. |volume=263 |issue= 12 |pages= 5898-909 |year= 1988 |pmid= 2833521 |doi=  }}
*{{cite journal  | vauthors=Vance JE, Vance DE |title=Does rat liver Golgi have the capacity to synthesize phospholipids for lipoprotein secretion? |journal=J. Biol. Chem. |volume=263 |issue= 12 |pages= 5898–909 |year= 1988 |pmid= 2833521 |doi=  }}
*{{cite journal  | author=Weinhold PA, Feldman DA |title=Fatty acids promote the formation of complexes between choline-phosphate cytidylyltransferase and cytidylyltransferase binding protein. |journal=Arch. Biochem. Biophys. |volume=318 |issue= 1 |pages= 147-56 |year= 1995 |pmid= 7726555 |doi= 10.1006/abbi.1995.1215 }}
*{{cite journal  | vauthors=Weinhold PA, Feldman DA |title=Fatty acids promote the formation of complexes between choline-phosphate cytidylyltransferase and cytidylyltransferase binding protein. |journal=Arch. Biochem. Biophys. |volume=318 |issue= 1 |pages= 147–56 |year= 1995 |pmid= 7726555 |doi= 10.1006/abbi.1995.1215 }}
*{{cite journal  | author=Kalmar GB, Kay RJ, LaChance AC, Cornell RB |title=Primary structure and expression of a human CTP:phosphocholine cytidylyltransferase. |journal=Biochim. Biophys. Acta |volume=1219 |issue= 2 |pages= 328-34 |year= 1994 |pmid= 7918629 |doi=  }}
*{{cite journal  | vauthors=Johnson JE, Cornell RB |title=Membrane-binding amphipathic alpha-helical peptide derived from CTP:phosphocholine cytidylyltransferase. |journal=Biochemistry |volume=33 |issue= 14 |pages= 4327–35 |year= 1994 |pmid= 8155650 |doi=10.1021/bi00180a029 }}
*{{cite journal  | author=Johnson JE, Cornell RB |title=Membrane-binding amphipathic alpha-helical peptide derived from CTP:phosphocholine cytidylyltransferase. |journal=Biochemistry |volume=33 |issue= 14 |pages= 4327-35 |year= 1994 |pmid= 8155650 |doi=  }}
*{{cite journal   |vauthors=Dunne SJ, Cornell RB, Johnson JE, etal |title=Structure of the membrane binding domain of CTP:phosphocholine cytidylyltransferase. |journal=Biochemistry |volume=35 |issue= 37 |pages= 11975–84 |year= 1996 |pmid= 8810902 |doi= 10.1021/bi960821+}}
*{{cite journal | author=Dunne SJ, Cornell RB, Johnson JE, ''et al.'' |title=Structure of the membrane binding domain of CTP:phosphocholine cytidylyltransferase. |journal=Biochemistry |volume=35 |issue= 37 |pages= 11975-84 |year= 1996 |pmid= 8810902 |doi= 10.1021/bi960821+ }}
*{{cite journal  | vauthors=Arnold RS, DePaoli-Roach AA, Cornell RB |title=Binding of CTP:phosphocholine cytidylyltransferase to lipid vesicles: diacylglycerol and enzyme dephosphorylation increase the affinity for negatively charged membranes. |journal=Biochemistry |volume=36 |issue= 20 |pages= 6149–56 |year= 1997 |pmid= 9166786 |doi= 10.1021/bi970023z }}
*{{cite journal  | author=Arnold RS, DePaoli-Roach AA, Cornell RB |title=Binding of CTP:phosphocholine cytidylyltransferase to lipid vesicles: diacylglycerol and enzyme dephosphorylation increase the affinity for negatively charged membranes. |journal=Biochemistry |volume=36 |issue= 20 |pages= 6149-56 |year= 1997 |pmid= 9166786 |doi= 10.1021/bi970023z }}
*{{cite journal   |vauthors=Yang J, Wang J, Tseu I, etal |title=Identification of an 11-residue portion of CTP-phosphocholine cytidylyltransferase that is required for enzyme-membrane interactions. | series=325 |journal=Biochem. J. |volume=( Pt 1) |issue=  |pages= 29–38 |year= 1997 |pmid= 9224626 |doi= | pmc=1218525 }}
*{{cite journal | author=Yang J, Wang J, Tseu I, ''et al.'' |title=Identification of an 11-residue portion of CTP-phosphocholine cytidylyltransferase that is required for enzyme-membrane interactions. |journal=Biochem. J. |volume=325 ( Pt 1) |issue=  |pages= 29-38 |year= 1997 |pmid= 9224626 |doi=  }}
*{{cite journal  | vauthors=Lykidis A, Baburina I, Jackowski S |title=Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant. |journal=J. Biol. Chem. |volume=274 |issue= 38 |pages= 26992–7001 |year= 1999 |pmid= 10480912 |doi=10.1074/jbc.274.38.26992 }}
*{{cite journal  | author=Lykidis A, Baburina I, Jackowski S |title=Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant. |journal=J. Biol. Chem. |volume=274 |issue= 38 |pages= 26992-7001 |year= 1999 |pmid= 10480912 |doi=  }}
*{{cite journal  | vauthors=Lagace TA, Miller JR, Ridgway ND |title=Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4851–62 |year= 2002 |pmid= 12052891 |doi=10.1128/MCB.22.13.4851-4862.2002  | pmc=133913 }}
*{{cite journal  | author=Lagace TA, Miller JR, Ridgway ND |title=Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4851-62 |year= 2002 |pmid= 12052891 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Guenther MG, Yu J, Kao GD, etal |title=Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. |journal=Genes Dev. |volume=16 |issue= 24 |pages= 3130–5 |year= 2003 |pmid= 12502735 |doi= 10.1101/gad.1037502 | pmc=187500 }}
*{{cite journal | author=Guenther MG, Yu J, Kao GD, ''et al.'' |title=Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. |journal=Genes Dev. |volume=16 |issue= 24 |pages= 3130-5 |year= 2003 |pmid= 12502735 |doi= 10.1101/gad.1037502 }}
*{{cite journal   |vauthors=Xie M, Smith JL, Ding Z, etal |title=Membrane binding modulates the quaternary structure of CTP:phosphocholine cytidylyltransferase. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28817–25 |year= 2004 |pmid= 15069071 |doi= 10.1074/jbc.M403311200 }}
*{{cite journal | author=Xie M, Smith JL, Ding Z, ''et al.'' |title=Membrane binding modulates the quaternary structure of CTP:phosphocholine cytidylyltransferase. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28817-25 |year= 2004 |pmid= 15069071 |doi= 10.1074/jbc.M403311200 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Enaw JO, Zhu H, Yang W, etal |title=CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population. |journal=BMC Medicine |volume=4|pages= 36 |year= 2007 |pmid= 17184542 |doi= 10.1186/1741-7015-4-36 | pmc=1770928 }}
*{{cite journal | author=Enaw JO, Zhu H, Yang W, ''et al.'' |title=CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population. |journal=BMC medicine |volume=4 |issue=  |pages= 36 |year= 2007 |pmid= 17184542 |doi= 10.1186/1741-7015-4-36 }}
}} {{open access}}
{{refend}}
{{PDB Gallery|geneid=5130}}
 
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Revision as of 17:47, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Choline-phosphate cytidylyltransferase A is an enzyme that in humans is encoded by the PCYT1A gene.[1][2]


References

  1. ↑ Kalmar GB, Kay RJ, LaChance AC, Cornell RB (Nov 1994). "Primary structure and expression of a human CTP:phosphocholine cytidylyltransferase". Biochim Biophys Acta. 1219 (2): 328–34. doi:10.1016/0167-4781(94)90056-6. PMID 7918629.
  2. ↑ "Entrez Gene: PCYT1A phosphate cytidylyltransferase 1, choline, alpha".

Further reading



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