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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''DNA polymerase theta''' is an [[enzyme]] that in humans is encoded by the ''POLQ'' [[gene]].<ref name="pmid10395804">{{cite journal | vauthors = Sharief FS, Vojta PJ, Ropp PA, Copeland WC | title = Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase | journal = Genomics | volume = 59 | issue = 1 | pages = 90–6 |date=Aug 1999 | pmid = 10395804 | pmc =  | doi = 10.1006/geno.1999.5843 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: POLQ polymerase (DNA directed), theta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10721| accessdate = }}</ref>
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| image = 
| image_source = 
| PDB =
| Name = Polymerase (DNA directed), theta
| HGNCid = 9186
| Symbol = POLQ
| AltSymbols =; POLH; DKFZp781A0112; PRO0327
| OMIM = 604419
| ECnumber = 
| Homologene = 32727
| MGIid = 2155399
| GeneAtlas_image1 = PBB_GE_POLQ_219510_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0003887 |text = DNA-directed DNA polymerase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008026 |text = ATP-dependent helicase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005654 |text = nucleoplasm}}
  | Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10721
    | Hs_Ensembl = ENSG00000051341
    | Hs_RefseqProtein = NP_955452
    | Hs_RefseqmRNA = NM_199420
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 122632968
    | Hs_GenLoc_end = 122747543
    | Hs_Uniprot = O75417
    | Mm_EntrezGene = 77782
    | Mm_Ensembl = ENSMUSG00000034206
    | Mm_RefseqmRNA = NM_029977
    | Mm_RefseqProtein = NP_084253
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 36931025
    | Mm_GenLoc_end = 37014636
    | Mm_Uniprot = 
  }}
}}
'''Polymerase (DNA directed), theta''', also known as '''POLQ''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: POLQ polymerase (DNA directed), theta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10721| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, ''et al.'' |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42-50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 }}
*{{cite journal   |vauthors=Hogg M, ((Sauer-Eriksson AE)), Johansson E |title=Promiscuous DNA synthesis by human DNA polymerase θ. |journal=Nucleic Acids Research |volume=40 |issue= 6 |pages= 2611–2622. |year= 2012 |doi= 10.1093/nar/gkr1102 |pmid=22135286 |pmc=3315306}}
*{{cite journal | author=Sharief FS, Vojta PJ, Ropp PA, Copeland WC |title=Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase. |journal=Genomics |volume=59 |issue= 1 |pages= 90-6 |year= 1999 |pmid= 10395804 |doi= 10.1006/geno.1999.5843 }}
*{{cite journal   |vauthors=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, etal |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 }}
*{{cite journal | author=Maga G, Shevelev I, Ramadan K, ''et al.'' |title=DNA polymerase theta purified from human cells is a high-fidelity enzyme. |journal=J. Mol. Biol. |volume=319 |issue= 2 |pages= 359-69 |year= 2002 |pmid= 12051913 |doi= 10.1016/S0022-2836(02)00325-X }}
*{{cite journal   |vauthors=Maga G, Shevelev I, Ramadan K, etal |title=DNA polymerase theta purified from human cells is a high-fidelity enzyme. |journal=J. Mol. Biol. |volume=319 |issue= 2 |pages= 359–69 |year= 2002 |pmid= 12051913 |doi= 10.1016/S0022-2836(02)00325-X }}
*{{cite journal  | author=Seki M, Marini F, Wood RD |title=POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells. |journal=Nucleic Acids Res. |volume=31 |issue= 21 |pages= 6117-26 |year= 2003 |pmid= 14576298 |doi=  }}
*{{cite journal  | vauthors=Seki M, Marini F, Wood RD |title=POLQ (Pol θ), a DNA polymerase and DNA-dependent ATPase in human cells |journal=Nucleic Acids Res. |volume=31 |issue= 21 |pages= 6117–26 |year= 2003 |pmid= 14576298 |doi=10.1093/nar/gkg814  | pmc=275456 }}
*{{cite journal | author=Kawamura K, Bahar R, Seimiya M, ''et al.'' |title=DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers. |journal=Int. J. Cancer |volume=109 |issue= 1 |pages= 9-16 |year= 2004 |pmid= 14735462 |doi= 10.1002/ijc.11666 }}
*{{cite journal   |vauthors=Kawamura K, Bahar R, Seimiya M, etal |title=DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers |journal=Int. J. Cancer |volume=109 |issue= 1 |pages= 9–16 |year= 2004 |pmid= 14735462 |doi= 10.1002/ijc.11666 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal   |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
*{{cite journal | author=Seki M, Masutani C, Yang LW, ''et al.'' |title=High-efficiency bypass of DNA damage by human DNA polymerase Q. |journal=EMBO J. |volume=23 |issue= 22 |pages= 4484-94 |year= 2005 |pmid= 15496986 |doi= 10.1038/sj.emboj.7600424 }}
*{{cite journal   |vauthors=Seki M, Masutani C, Yang LW, etal |title=High-efficiency bypass of DNA damage by human DNA polymerase Q |journal=EMBO J. |volume=23 |issue= 22 |pages= 4484–94 |year= 2005 |pmid= 15496986 |doi= 10.1038/sj.emboj.7600424 | pmc=526458 }}
*{{cite journal | author=Chiapperino D, Cai M, Sayer JM, ''et al.'' |title=Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. |journal=J. Biol. Chem. |volume=280 |issue= 48 |pages= 39684-92 |year= 2006 |pmid= 16188888 |doi= 10.1074/jbc.M508008200 }}
*{{cite journal   |vauthors=Chiapperino D, Cai M, Sayer JM, etal |title=Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene |journal=J. Biol. Chem. |volume=280 |issue= 48 |pages= 39684–92 |year= 2006 |pmid= 16188888 |doi= 10.1074/jbc.M508008200 }}
*{{cite journal | author=Zan H, Shima N, Xu Z, ''et al.'' |title=The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation. |journal=EMBO J. |volume=24 |issue= 21 |pages= 3757-69 |year= 2005 |pmid= 16222339 |doi= 10.1038/sj.emboj.7600833 }}
*{{cite journal   |vauthors=Zan H, Shima N, Xu Z, etal |title=The translesion DNA polymerase θ plays a dominant role in immunoglobulin gene somatic hypermutation |journal=EMBO J. |volume=24 |issue= 21 |pages= 3757–69 |year= 2005 |pmid= 16222339 |doi= 10.1038/sj.emboj.7600833 | pmc=1276717 }}
*{{cite journal | author=Cruet-Hennequart S, Coyne S, Glynn MT, ''et al.'' |title=UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK. |journal=DNA Repair (Amst.) |volume=5 |issue= 4 |pages= 491-504 |year= 2006 |pmid= 16520097 |doi= 10.1016/j.dnarep.2006.01.008 }}
*{{cite journal   |vauthors=Cruet-Hennequart S, Coyne S, Glynn MT, etal |title=UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK |journal=DNA Repair (Amst.) |volume=5 |issue= 4 |pages= 491–504 |year= 2006 |pmid= 16520097 |doi= 10.1016/j.dnarep.2006.01.008 }}
*{{cite journal | author=Chen YW, Cleaver JE, Hanaoka F, ''et al.'' |title=A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents. |journal=Mol. Cancer Res. |volume=4 |issue= 4 |pages= 257-65 |year= 2006 |pmid= 16603639 |doi= 10.1158/1541-7786.MCR-05-0118 }}
*{{cite journal   |vauthors=Chen YW, Cleaver JE, Hanaoka F, etal |title=A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents |journal=Mol. Cancer Res. |volume=4 |issue= 4 |pages= 257–65 |year= 2006 |pmid= 16603639 |doi= 10.1158/1541-7786.MCR-05-0118 }}
*{{cite journal | author=Yuasa MS, Masutani C, Hirano A, ''et al.'' |title=A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest. |journal=Genes Cells |volume=11 |issue= 7 |pages= 731-44 |year= 2006 |pmid= 16824193 |doi= 10.1111/j.1365-2443.2006.00974.x }}
*{{cite journal   |vauthors=Yuasa MS, Masutani C, Hirano A, etal |title=A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest |journal=Genes Cells |volume=11 |issue= 7 |pages= 731–44 |year= 2006 |pmid= 16824193 |doi= 10.1111/j.1365-2443.2006.00974.x }}
*{{cite journal | author=Choi JY, Stover JS, Angel KC, ''et al.'' |title=Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site. |journal=J. Biol. Chem. |volume=281 |issue= 35 |pages= 25297-306 |year= 2006 |pmid= 16835218 |doi= 10.1074/jbc.M605699200 }}
*{{cite journal   |vauthors=Choi JY, Stover JS, Angel KC, etal |title=Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site |journal=J. Biol. Chem. |volume=281 |issue= 35 |pages= 25297–306 |year= 2006 |pmid= 16835218 |doi= 10.1074/jbc.M605699200 }}
*{{cite journal | author=Kino K, Ito N, Sugasawa K, ''et al.'' |title=Translesion synthesis by human DNA polymerase eta across oxidative products of guanine. |journal=Nucleic Acids Symp Ser (Oxf) |volume= |issue= 48 |pages= 171-2 |year= 2007 |pmid= 17150533 |doi= 10.1093/nass/48.1.171 }}
*{{cite journal   |vauthors=Kino K, Ito N, Sugasawa K, etal |title=Translesion synthesis by human DNA polymerase eta across oxidative products of guanine |journal=Nucleic Acids Symp Ser (Oxf) |volume= 48|issue= 1 |pages= 171–2 |year= 2007 |pmid= 17150533 |doi= 10.1093/nass/48.1.171 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 18:24, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA polymerase theta is an enzyme that in humans is encoded by the POLQ gene.[1][2]


References

  1. ↑ Sharief FS, Vojta PJ, Ropp PA, Copeland WC (Aug 1999). "Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase". Genomics. 59 (1): 90–6. doi:10.1006/geno.1999.5843. PMID 10395804.
  2. ↑ "Entrez Gene: POLQ polymerase (DNA directed), theta".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=POLQ&oldid=1413195"