CLASP2: Difference between revisions

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{{Underlinked|date=October 2013}}
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{{Infobox_gene}}
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'''Cytoplasmic linker associated protein 2''', also known as '''CLASP2''', is a [[protein]] which in humans is encoded by the ''CLASP2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLASP2 cytoplasmic linker associated protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23122| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Cytoplasmic linker associated protein 2
| HGNCid = 17078
| Symbol = CLASP2
| AltSymbols =;
| OMIM = 605853
| ECnumber = 
| Homologene = 24944
| MGIid = 1923749
| GeneAtlas_image1 = PBB_GE_CLASP2_212306_at_tn.png
| GeneAtlas_image2 = PBB_GE_CLASP2_212308_at_tn.png
| GeneAtlas_image3 = PBB_GE_CLASP2_212309_at_tn.png
| Function = {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008107 |text = galactoside 2-alpha-L-fucosyltransferase activity}} {{GNF_GO|id=GO:0051010 |text = microtubule plus-end binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005828 |text = kinetochore microtubule}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005881 |text = cytoplasmic microtubule}}  
| Process = {{GNF_GO|id=GO:0007026 |text = negative regulation of microtubule depolymerization}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007163 |text = establishment and/or maintenance of cell polarity}} {{GNF_GO|id=GO:0031110 |text = regulation of microtubule polymerization or depolymerization}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23122
    | Hs_Ensembl = ENSG00000163539
    | Hs_RefseqProtein = NP_055912
    | Hs_RefseqmRNA = NM_015097
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 33512745
    | Hs_GenLoc_end = 33734852
    | Hs_Uniprot = O75122
    | Mm_EntrezGene = 76499
    | Mm_Ensembl = ENSMUSG00000033392
    | Mm_RefseqmRNA = NM_001081960
    | Mm_RefseqProtein = NP_001075429
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 113590210
    | Mm_GenLoc_end = 113767152
    | Mm_Uniprot = Q08EB5
  }}
}}
'''Cytoplasmic linker associated protein 2''', also known as '''CLASP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLASP2 cytoplasmic linker associated protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23122| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CLASP2}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Galjart N |title=CLIPs and CLASPs and cellular dynamics. |journal=Nat. Rev. Mol. Cell Biol. |volume=6 |issue= 6 |pages= 487-98 |year= 2005 |pmid= 15928712 |doi= 10.1038/nrm1664 }}
*{{cite journal  | author=Galjart N |title=CLIPs and CLASPs and cellular dynamics. |journal=Nat. Rev. Mol. Cell Biol. |volume=6 |issue= 6 |pages= 487–98 |year= 2005 |pmid= 15928712 |doi= 10.1038/nrm1664 }}
*{{cite journal  | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169-76 |year= 1998 |pmid= 9734811 |doi=  }}
*{{cite journal  | vauthors=Ishikawa K, Nagase T, Suyama M |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi=10.1093/dnares/5.3.169 |display-authors=etal}}
*{{cite journal  | author=Lemos CL, Sampaio P, Maiato H, ''et al.'' |title=Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization. |journal=EMBO J. |volume=19 |issue= 14 |pages= 3668-82 |year= 2000 |pmid= 10899121 |doi= 10.1093/emboj/19.14.3668 }}
*{{cite journal  | vauthors=Lemos CL, Sampaio P, Maiato H |title=Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization. |journal=EMBO J. |volume=19 |issue= 14 |pages= 3668–82 |year= 2000 |pmid= 10899121 |doi= 10.1093/emboj/19.14.3668 | pmc=313969 |display-authors=etal}}
*{{cite journal  | author=Akhmanova A, Hoogenraad CC, Drabek K, ''et al.'' |title=Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. |journal=Cell |volume=104 |issue= 6 |pages= 923-35 |year= 2001 |pmid= 11290329 |doi=  }}
*{{cite journal  | vauthors=Akhmanova A, Hoogenraad CC, Drabek K |title=Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. |journal=Cell |volume=104 |issue= 6 |pages= 923–35 |year= 2001 |pmid= 11290329 |doi=10.1016/S0092-8674(01)00288-4 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Maiato H, Fairley EA, Rieder CL, ''et al.'' |title=Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics. |journal=Cell |volume=113 |issue= 7 |pages= 891-904 |year= 2003 |pmid= 12837247 |doi=  }}
*{{cite journal  | vauthors=Maiato H, Fairley EA, Rieder CL |title=Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics. |journal=Cell |volume=113 |issue= 7 |pages= 891–904 |year= 2003 |pmid= 12837247 |doi=10.1016/S0092-8674(03)00465-3 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Lee H, Engel U, Rusch J, ''et al.'' |title=The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance. |journal=Neuron |volume=42 |issue= 6 |pages= 913-26 |year= 2004 |pmid= 15207236 |doi= 10.1016/j.neuron.2004.05.020 }}
*{{cite journal  | vauthors=Lee H, Engel U, Rusch J |title=The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance. |journal=Neuron |volume=42 |issue= 6 |pages= 913–26 |year= 2004 |pmid= 15207236 |doi= 10.1016/j.neuron.2004.05.020 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, ''et al.'' |title=CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. |journal=J. Cell Biol. |volume=168 |issue= 1 |pages= 141-53 |year= 2005 |pmid= 15631994 |doi= 10.1083/jcb.200405094 }}
*{{cite journal  | vauthors=Mimori-Kiyosue Y, Grigoriev I, Lansbergen G |title=CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. |journal=J. Cell Biol. |volume=168 |issue= 1 |pages= 141–53 |year= 2005 |pmid= 15631994 |doi= 10.1083/jcb.200405094 | pmc=2171674 |display-authors=etal}}
*{{cite journal  | author=Wittmann T, Waterman-Storer CM |title=Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells. |journal=J. Cell Biol. |volume=169 |issue= 6 |pages= 929-39 |year= 2005 |pmid= 15955847 |doi= 10.1083/jcb.200412114 }}
*{{cite journal  | vauthors=Wittmann T, Waterman-Storer CM |title=Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells. |journal=J. Cell Biol. |volume=169 |issue= 6 |pages= 929–39 |year= 2005 |pmid= 15955847 |doi= 10.1083/jcb.200412114 | pmc=2171640 }}
*{{cite journal  | author=Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, ''et al.'' |title=CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta. |journal=Dev. Cell |volume=11 |issue= 1 |pages= 21-32 |year= 2006 |pmid= 16824950 |doi= 10.1016/j.devcel.2006.05.012 }}
*{{cite journal  | vauthors=Lansbergen G, Grigoriev I, Mimori-Kiyosue Y |title=CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta. |journal=Dev. Cell |volume=11 |issue= 1 |pages= 21–32 |year= 2006 |pmid= 16824950 |doi= 10.1016/j.devcel.2006.05.012 |display-authors=etal}}
*{{cite journal  | author=Mimori-Kiyosue Y, Grigoriev I, Sasaki H, ''et al.'' |title=Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. |journal=Genes Cells |volume=11 |issue= 8 |pages= 845-57 |year= 2006 |pmid= 16866869 |doi= 10.1111/j.1365-2443.2006.00990.x }}
*{{cite journal  | vauthors=Mimori-Kiyosue Y, Grigoriev I, Sasaki H |title=Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. |journal=Genes Cells |volume=11 |issue= 8 |pages= 845–57 |year= 2006 |pmid= 16866869 |doi= 10.1111/j.1365-2443.2006.00990.x |display-authors=etal}}
*{{cite journal  | author=Pereira AL, Pereira AJ, Maia AR, ''et al.'' |title=Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. |journal=Mol. Biol. Cell |volume=17 |issue= 10 |pages= 4526-42 |year= 2007 |pmid= 16914514 |doi= 10.1091/mbc.E06-07-0579 }}
*{{cite journal  | vauthors=Pereira AL, Pereira AJ, Maia AR |title=Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. |journal=Mol. Biol. Cell |volume=17 |issue= 10 |pages= 4526–42 |year= 2007 |pmid= 16914514 |doi= 10.1091/mbc.E06-07-0579 | pmc=1635371 |display-authors=etal}}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
}}
}}
{{refend}}
{{refend}}


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Revision as of 09:44, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cytoplasmic linker associated protein 2, also known as CLASP2, is a protein which in humans is encoded by the CLASP2 gene.[1]


References

  1. ↑ "Entrez Gene: CLASP2 cytoplasmic linker associated protein 2".

External links

Further reading



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