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{{Infobox_gene}}
'''Uroplakin 1B''', also known as '''UPK1B''', is a [[protein]] which in humans is encoded by the ''UPK1B'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UPK1B uroplakin 1B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7348| accessdate = }}</ref><ref name="pmid9846985">{{cite journal | vauthors = Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J | title = Uroplakin gene expression by normal and neoplastic human urothelium | journal = Am. J. Pathol. | volume = 153 | issue = 6 | pages = 1957–67 |date=December 1998 | pmid = 9846985 | pmc = 1866332 | doi = 10.1016/S0002-9440(10)65709-4| url = http://ajp.amjpathol.org/cgi/content/abstract/153/6/1957 | issn = }}</ref><ref name="pmid9935153">{{cite journal | vauthors = Finch JL, Miller J, Aspinall JO, Cowled PA | title = Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue | journal = Int. J. Cancer | volume = 80 | issue = 4 | pages = 533–8 |date=February 1999 | pmid = 9935153 | doi = 10.1002/(SICI)1097-0215(19990209)80:4<533::AID-IJC9>3.0.CO;2-5 | url =  }}</ref>
== Function ==
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the [[tetraspanin]] family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic [[protein domain|domain]]s. These proteins mediate [[signal transduction]] events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating [[Cell membrane#Permeability|membrane permeability]] of superficial umbrella cells or in stabilizing the apical membrane through AUM/[[cytoskeleton|cytoskeletal]] interactions. The AUM is believed to be involved in strengthening the cells that line the [[bladder]], and in enhancing the inner bladder membrane's ability to stretch, thus preventing these cells from rupturing during bladder distension. The use of alternate [[polyadenylation]] sites has been found for this gene.<ref name="entrez"/>
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye |journal=J. Cell Sci. |volume=114 |issue= Pt 23 |pages= 4143–51 |year= 2002 |pmid= 11739647 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | vauthors=Wu XR, Medina JJ, Sun TT |title=Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells |journal=J. Biol. Chem. |volume=270 |issue= 50 |pages= 29752–9 |year= 1996 |pmid= 8530366 |doi=10.1074/jbc.270.50.29752  }}
*{{cite journal  | vauthors=Finch JL, Webb GC, Evdokiou A, Cowled PA |title=Chromosomal localization of the human urothelial "tetraspan" gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism |journal=Genomics |volume=40 |issue= 3 |pages= 501–3 |year= 1997 |pmid= 9073521 |doi= 10.1006/geno.1996.4589 }}
*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal  |vauthors=Yuasa T, Yoshiki T, Tanaka T, etal |title=Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma |journal=Jpn. J. Cancer Res. |volume=89 |issue= 9 |pages= 879–82 |year= 1998 |pmid= 9818021 |doi=  10.1111/j.1349-7006.1998.tb00643.x}}
*{{cite journal  |vauthors=Lobban ED, Smith BA, Hall GD, etal |title=Uroplakin gene expression by normal and neoplastic human urothelium |journal=Am. J. Pathol. |volume=153 |issue= 6 |pages= 1957–67 |year= 1998 |pmid= 9846985 |doi=  10.1016/S0002-9440(10)65709-4| pmc=1866332  }}
*{{cite journal  | vauthors=Finch JL, Miller J, Aspinall JO, Cowled PA |title=Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue |journal=Int. J. Cancer |volume=80 |issue= 4 |pages= 533–8 |year= 1999 |pmid= 9935153 |doi=10.1002/(SICI)1097-0215(19990209)80:4<533::AID-IJC9>3.0.CO;2-5  }}
*{{cite journal  | vauthors=Ogawa K, Johansson SL, Cohen SM |title=Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract |journal=Am. J. Pathol. |volume=155 |issue= 4 |pages= 1047–50 |year= 1999 |pmid= 10514386 |doi=  10.1016/S0002-9440(10)65206-6| pmc=1867018  }}
*{{cite journal  | vauthors=Olsburgh J, Weeks R, Selby P, Southgate J |title=Human uroplakin lb gene structure and promoter analysis |journal=Biochim. Biophys. Acta |volume=1576 |issue= 1–2 |pages= 163–70 |year= 2002 |pmid= 12031497 |doi=  10.1016/s0167-4781(02)00304-4}}
*{{cite journal  |vauthors=Deng FM, Liang FX, Tu L, etal |title=Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly |journal=J. Cell Biol. |volume=159 |issue= 4 |pages= 685–94 |year= 2003 |pmid= 12446744 |doi= 10.1083/jcb.200204102  | pmc=2173100 }}
*{{cite journal  | vauthors=Tu L, Sun TT, Kreibich G |title=Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4221–30 |year= 2003 |pmid= 12475947 |doi= 10.1091/mbc.E02-04-0211  | pmc=138628 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Varga AE, Leonardos L, Jackson P, etal |title=Methylation of a CpG island within the uroplakin Ib promoter: a possible mechanism for loss of uroplakin Ib expression in bladder carcinoma |journal=Neoplasia |volume=6 |issue= 2 |pages= 128–35 |year= 2004 |pmid= 15140401 |doi= 10.1593/neo.03337  | pmc=1502093 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
}}
{{refend}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Category:Uroplakins]]
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Uroplakin 1B
| HGNCid = 12578
| Symbol = UPK1B
| AltSymbols =; TSPAN20; UPIB; UPK1
| OMIM = 602380
| ECnumber = 
| Homologene = 5065
| MGIid = 98912
| GeneAtlas_image1 = PBB_GE_UPK1B_210064_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_UPK1B_210065_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0030855 |text = epithelial cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7348
    | Hs_Ensembl = ENSG00000114638
    | Hs_RefseqProtein = NP_008883
    | Hs_RefseqmRNA = NM_006952
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 120375115
    | Hs_GenLoc_end = 120406690
    | Hs_Uniprot = O75841
    | Mm_EntrezGene = 22268
    | Mm_Ensembl = ENSMUSG00000049436
    | Mm_RefseqmRNA = NM_178924
    | Mm_RefseqProtein = NP_849255
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 38692522
    | Mm_GenLoc_end = 38719533
    | Mm_Uniprot = Q9Z2C6
  }}
}}
'''Uroplakin 1B''', also known as '''UPK1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UPK1B uroplakin 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7348| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: UPK1B uroplakin 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7348| accessdate = }}</ref>
}}
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143-51 |year= 2002 |pmid= 11739647 |doi=  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Wu XR, Medina JJ, Sun TT |title=Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells. |journal=J. Biol. Chem. |volume=270 |issue= 50 |pages= 29752-9 |year= 1996 |pmid= 8530366 |doi=  }}
*{{cite journal  | author=Finch JL, Webb GC, Evdokiou A, Cowled PA |title=Chromosomal localization of the human urothelial "tetraspan" gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism. |journal=Genomics |volume=40 |issue= 3 |pages= 501-3 |year= 1997 |pmid= 9073521 |doi= 10.1006/geno.1996.4589 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Yuasa T, Yoshiki T, Tanaka T, ''et al.'' |title=Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma. |journal=Jpn. J. Cancer Res. |volume=89 |issue= 9 |pages= 879-82 |year= 1998 |pmid= 9818021 |doi=  }}
*{{cite journal  | author=Lobban ED, Smith BA, Hall GD, ''et al.'' |title=Uroplakin gene expression by normal and neoplastic human urothelium. |journal=Am. J. Pathol. |volume=153 |issue= 6 |pages= 1957-67 |year= 1998 |pmid= 9846985 |doi=  }}
*{{cite journal  | author=Finch JL, Miller J, Aspinall JO, Cowled PA |title=Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue. |journal=Int. J. Cancer |volume=80 |issue= 4 |pages= 533-8 |year= 1999 |pmid= 9935153 |doi=  }}
*{{cite journal  | author=Ogawa K, Johansson SL, Cohen SM |title=Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. |journal=Am. J. Pathol. |volume=155 |issue= 4 |pages= 1047-50 |year= 1999 |pmid= 10514386 |doi=  }}
*{{cite journal  | author=Olsburgh J, Weeks R, Selby P, Southgate J |title=Human uroplakin lb gene structure and promoter analysis. |journal=Biochim. Biophys. Acta |volume=1576 |issue= 1-2 |pages= 163-70 |year= 2002 |pmid= 12031497 |doi=  }}
*{{cite journal  | author=Deng FM, Liang FX, Tu L, ''et al.'' |title=Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly. |journal=J. Cell Biol. |volume=159 |issue= 4 |pages= 685-94 |year= 2003 |pmid= 12446744 |doi= 10.1083/jcb.200204102 }}
*{{cite journal  | author=Tu L, Sun TT, Kreibich G |title=Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum. |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4221-30 |year= 2003 |pmid= 12475947 |doi= 10.1091/mbc.E02-04-0211 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Varga AE, Leonardos L, Jackson P, ''et al.'' |title=Methylation of a CpG island within the uroplakin Ib promoter: a possible mechanism for loss of uroplakin Ib expression in bladder carcinoma. |journal=Neoplasia |volume=6 |issue= 2 |pages= 128-35 |year= 2004 |pmid= 15140401 |doi= 10.1593/neo.03337 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}


{{protein-stub}}
{{gene-3-stub}}
{{WikiDoc Sources}}

Latest revision as of 22:34, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Uroplakin 1B, also known as UPK1B, is a protein which in humans is encoded by the UPK1B gene.[1][2][3]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The AUM is believed to be involved in strengthening the cells that line the bladder, and in enhancing the inner bladder membrane's ability to stretch, thus preventing these cells from rupturing during bladder distension. The use of alternate polyadenylation sites has been found for this gene.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: UPK1B uroplakin 1B".
  2. ↑ Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J (December 1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am. J. Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985.
  3. ↑ Finch JL, Miller J, Aspinall JO, Cowled PA (February 1999). "Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue". Int. J. Cancer. 80 (4): 533–8. doi:10.1002/(SICI)1097-0215(19990209)80:4<533::AID-IJC9>3.0.CO;2-5. PMID 9935153.

Further reading


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