PCBP4: Difference between revisions

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{{Infobox_gene}}
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'''Poly(rC)-binding protein 4''' is a [[protein]] that in humans is encoded by the ''PCBP4'' [[gene]].<ref name="pmid10936052">{{cite journal | vauthors = Makeyev AV, Liebhaber SA | title = Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins | journal = Genomics | volume = 67 | issue = 3 | pages = 301–16 |date=Sep 2000 | pmid = 10936052 | pmc =  | doi = 10.1006/geno.2000.6244 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PCBP4 poly(rC) binding protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57060| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Poly(rC) binding protein 4
| HGNCid = 8652
| Symbol = PCBP4
| AltSymbols =; LIP4; MCG10
| OMIM = 608503
| ECnumber = 
| Homologene = 56926
| MGIid = 1890471
| GeneAtlas_image1 = PBB_GE_PCBP4_209361_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006977 |text = DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008630 |text = DNA damage response, signal transduction resulting in induction of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 57060
    | Hs_Ensembl = ENSG00000090097
    | Hs_RefseqProtein = NP_065151
    | Hs_RefseqmRNA = NM_020418
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 51966515
    | Hs_GenLoc_end = 51976509
    | Hs_Uniprot = P57723
    | Mm_EntrezGene = 59092
    | Mm_Ensembl = ENSMUSG00000023495
    | Mm_RefseqmRNA = XM_975004
    | Mm_RefseqProtein = XP_980098
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 106311991
    | Mm_GenLoc_end = 106322110
    | Mm_Uniprot = Q8BP63
  }}
}}
'''Poly(rC) binding protein 4''', also known as '''PCBP4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PCBP4 poly(rC) binding protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57060| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.<ref name="entrez">{{cite web | title = Entrez Gene: PCBP4 poly(rC) binding protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57060| accessdate = }}</ref>
| summary_text = This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Taylor WR, Stark GR |title=Regulation of the G2/M transition by p53. |journal=Oncogene |volume=20 |issue= 15 |pages= 1803-15 |year= 2001 |pmid= 11313928 |doi= 10.1038/sj.onc.1204252 }}
*{{cite journal  | vauthors=Taylor WR, Stark GR |title=Regulation of the G2/M transition by p53 |journal=Oncogene |volume=20 |issue= 15 |pages= 1803–15 |year= 2001 |pmid= 11313928 |doi= 10.1038/sj.onc.1204252 }}
*{{cite journal  | author=Makeyev AV, Liebhaber SA |title=The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms. |journal=RNA |volume=8 |issue= 3 |pages= 265-78 |year= 2002 |pmid= 12003487 |doi=  }}
*{{cite journal  | vauthors=Makeyev AV, Liebhaber SA |title=The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms |journal=RNA |volume=8 |issue= 3 |pages= 265–78 |year= 2002 |pmid= 12003487 |doi=10.1017/S1355838202024627  | pmc=1370249 }}
*{{cite journal  | author=Kiledjian M, Wang X, Liebhaber SA |title=Identification of two KH domain proteins in the alpha-globin mRNP stability complex. |journal=EMBO J. |volume=14 |issue= 17 |pages= 4357-64 |year= 1995 |pmid= 7556077 |doi=  }}
*{{cite journal  | vauthors=Kiledjian M, Wang X, Liebhaber SA |title=Identification of two KH domain proteins in the alpha-globin mRNP stability complex |journal=EMBO J. |volume=14 |issue= 17 |pages= 4357–64 |year= 1995 |pmid= 7556077 |doi= | pmc=394520 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Zhu J, Chen X |title=MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M. |journal=Mol. Cell. Biol. |volume=20 |issue= 15 |pages= 5602-18 |year= 2000 |pmid= 10891498 |doi= }}
*{{cite journal  | vauthors=Zhu J, Chen X |title=MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M |journal=Mol. Cell. Biol. |volume=20 |issue= 15 |pages= 5602–18 |year= 2000 |pmid= 10891498 |doi=10.1128/MCB.20.15.5602-5618.2000 | pmc=86022  }}
*{{cite journal  | author=Makeyev AV, Liebhaber SA |title=Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins. |journal=Genomics |volume=67 |issue= 3 |pages= 301-16 |year= 2000 |pmid= 10936052 |doi= 10.1006/geno.2000.6244 }}
*{{cite journal   |vauthors=Tchernev VT, Mansfield TA, Giot L, etal |title=The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins |journal=Mol. Med. |volume=8 |issue= 1 |pages= 56–64 |year= 2002 |pmid= 11984006 |doi= | pmc=2039936 }}
*{{cite journal | author=Tchernev VT, Mansfield TA, Giot L, ''et al.'' |title=The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. |journal=Mol. Med. |volume=8 |issue= 1 |pages= 56-64 |year= 2002 |pmid= 11984006 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Chkheidze AN, Liebhaber SA |title=A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins |journal=Mol. Cell. Biol. |volume=23 |issue= 23 |pages= 8405–15 |year= 2003 |pmid= 14612387 |doi=10.1128/MCB.23.23.8405-8415.2003  | pmc=262676 }}
*{{cite journal  | author=Chkheidze AN, Liebhaber SA |title=A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 23 |pages= 8405-15 |year= 2003 |pmid= 14612387 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 17:40, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Poly(rC)-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene.[1][2]

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.[2]

References

  1. ↑ Makeyev AV, Liebhaber SA (Sep 2000). "Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins". Genomics. 67 (3): 301–16. doi:10.1006/geno.2000.6244. PMID 10936052.
  2. ↑ 2.0 2.1 "Entrez Gene: PCBP4 poly(rC) binding protein 4".

Further reading



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