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{{Infobox_gene}}
{{PBB_Controls
'''Cysteine-rich with EGF-like domain protein 1''' is a [[protein]] that in humans is encoded by the ''CRELD1'' [[gene]].<ref name="pmid10922384">{{cite journal | vauthors = Green EK, Priestley MD, Waters J, Maliszewska C, Latif F, Maher ER | title = Detailed mapping of a congenital heart disease gene in chromosome 3p25 | journal = J Med Genet | volume = 37 | issue = 8 | pages = 581–7 |date=Sep 2000 | pmid = 10922384 | pmc = 1734659 | doi =10.1136/jmg.37.8.581  }}</ref><ref name="pmid12137942">{{cite journal | vauthors = Rupp PA, Fouad GT, Egelston CA, Reifsteck CA, Olson SB, Knosp WM, Glanville RW, Thornburg KL, Robinson SW, Maslen CL | title = Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of [[matricellular protein]]s | journal = Gene | volume = 293 | issue = 1–2 | pages = 47–57 |date=Jul 2002 | pmid = 12137942 | pmc = | doi =10.1016/S0378-1119(02)00696-0  }}</ref><ref name="entrez"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cysteine-rich with EGF-like domains 1
| HGNCid = 14630
| Symbol = CRELD1
| AltSymbols =; AVSD2; CIRRIN; DKFZP566D213
| OMIM = 607170
| ECnumber = 
| Homologene = 32265
| MGIid = 2152539
| GeneAtlas_image1 = PBB_GE_CRELD1_203368_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 78987
    | Hs_Ensembl = ENSG00000163703
    | Hs_RefseqProtein = NP_001026887
    | Hs_RefseqmRNA = NM_001031717
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 9950524
    | Hs_GenLoc_end = 9962097
    | Hs_Uniprot = Q96HD1
    | Mm_EntrezGene = 171508
    | Mm_Ensembl = ENSMUSG00000030284
    | Mm_RefseqmRNA = NM_133930
    | Mm_RefseqProtein = NP_598691
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 113449203
    | Mm_GenLoc_end = 113459115
    | Mm_Uniprot = Q91XD7
  }}
}}
'''Cysteine-rich with EGF-like domains 1''', also known as '''CRELD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CRELD1 cysteine-rich with EGF-like domains 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=78987| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Epidermal growth factor]] (EGF)-like repeats are a class of [[cysteine]]-rich domains that mediate interactions between proteins of diverse function. [[EGF domain]]s are found in proteins that are either completely secreted or have transmembrane regions that tether the protein to the cell surface. CRELD1 is the founding member of a family of [[matricellular protein]]s.<ref name="entrez">{{cite web | title = Entrez Gene: CRELD1 cysteine-rich with EGF-like domains 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=78987| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = Epidermal growth factor (EGF; MIM 131530)-like repeats are a class of cysteine-rich domains that mediate interactions between proteins of diverse function. EGF domains are found in proteins that are either completely secreted or have transmembrane regions that tether the protein to the cell surface. CRELD1 is the founding member of a family of matricellular proteins.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CRELD1 cysteine-rich with EGF-like domains 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=78987| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CRELD1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
| citations =
*{{cite journal  | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |display-authors=etal}}
*{{cite journal  | author=Green EK, Priestley MD, Waters J, ''et al.'' |title=Detailed mapping of a congenital heart disease gene in chromosome 3p25. |journal=J. Med. Genet. |volume=37 |issue= 8 |pages= 581-7 |year= 2000 |pmid= 10922384 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | vauthors=Robinson SW, Morris CD, Goldmuntz E |title=Missense Mutations in CRELD1 Are Associated with Cardiac Atrioventricular Septal Defects |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 1047–52 |year= 2003 |pmid= 12632326 |doi=10.1086/374319  | pmc=1180336 |display-authors=etal}}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
*{{cite journal | author=Rupp PA, Fouad GT, Egelston CA, ''et al.'' |title=Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins. |journal=Gene |volume=293 |issue= 1-2 |pages= 47-57 |year= 2002 |pmid= 12137942 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Wiemann S, Arlt D, Huber W |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |display-authors=etal}}
*{{cite journal  | author=Robinson SW, Morris CD, Goldmuntz E, ''et al.'' |title=Missense mutations in CRELD1 are associated with cardiac atrioventricular septal defects. |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 1047-52 |year= 2003 |pmid= 12632326 |doi=  }}
*{{cite journal  | vauthors=Zatyka M, Priestley M, Ladusans EJ |title=Analysis of CRELD1 as a candidate 3p25 atrioventicular septal defect locus (AVSD2) |journal=Clin. Genet. |volume=67 |issue= 6 |pages= 526–8 |year= 2005 |pmid= 15857420 |doi= 10.1111/j.1399-0004.2005.00435.x |display-authors=etal}}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | vauthors=Stelzl U, Worm U, Lalowski M |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | vauthors=Mehrle A, Rosenfelder H, Schupp I |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |display-authors=etal}}
*{{cite journal  | author=Zatyka M, Priestley M, Ladusans EJ, ''et al.'' |title=Analysis of CRELD1 as a candidate 3p25 atrioventicular septal defect locus (AVSD2). |journal=Clin. Genet. |volume=67 |issue= 6 |pages= 526-8 |year= 2005 |pmid= 15857420 |doi= 10.1111/j.1399-0004.2005.00435.x }}
*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
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Latest revision as of 10:02, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cysteine-rich with EGF-like domain protein 1 is a protein that in humans is encoded by the CRELD1 gene.[1][2][3]

Function

Epidermal growth factor (EGF)-like repeats are a class of cysteine-rich domains that mediate interactions between proteins of diverse function. EGF domains are found in proteins that are either completely secreted or have transmembrane regions that tether the protein to the cell surface. CRELD1 is the founding member of a family of matricellular proteins.[3]

References

  1. ↑ Green EK, Priestley MD, Waters J, Maliszewska C, Latif F, Maher ER (Sep 2000). "Detailed mapping of a congenital heart disease gene in chromosome 3p25". J Med Genet. 37 (8): 581–7. doi:10.1136/jmg.37.8.581. PMC 1734659. PMID 10922384.
  2. ↑ Rupp PA, Fouad GT, Egelston CA, Reifsteck CA, Olson SB, Knosp WM, Glanville RW, Thornburg KL, Robinson SW, Maslen CL (Jul 2002). "Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins". Gene. 293 (1–2): 47–57. doi:10.1016/S0378-1119(02)00696-0. PMID 12137942.
  3. ↑ 3.0 3.1 "Entrez Gene: CRELD1 cysteine-rich with EGF-like domains 1".

External links

Further reading


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