SMARCC1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +)
 
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''SWI/SNF complex subunit SMARCC1''' is a [[protein]] that in humans is encoded by the ''SMARCC1'' [[gene]].<ref name="pmid8804307">{{cite journal | vauthors = Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR | title = Diversity and specialization of mammalian SWI/SNF complexes | journal = Genes Dev | volume = 10 | issue = 17 | pages = 2117–30 | date = November 1996 | pmid = 8804307 | pmc =  | doi = 10.1101/gad.10.17.2117 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6599| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
| HGNCid = 11104
| Symbol = SMARCC1
| AltSymbols =; BAF155; CRACC1; Rsc8; SRG3; SWI3
| OMIM = 601732
| ECnumber = 
| Homologene = 68296
| MGIid = 1203524
| GeneAtlas_image1 = PBB_GE_SMARCC1_201075_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMARCC1_201072_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SMARCC1_201073_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0016514 |text = SWI/SNF complex}}
| Process = {{GNF_GO|id=GO:0006333 |text = chromatin assembly or disassembly}} {{GNF_GO|id=GO:0006338 |text = chromatin remodeling}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6599
    | Hs_Ensembl = ENSG00000173473
    | Hs_RefseqProtein = NP_003065
    | Hs_RefseqmRNA = NM_003074
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 47602391
    | Hs_GenLoc_end = 47798410
    | Hs_Uniprot = Q92922
    | Mm_EntrezGene = 20588
    | Mm_Ensembl = ENSMUSG00000032481
    | Mm_RefseqmRNA = NM_009211
    | Mm_RefseqProtein = NP_033237
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 109977231
    | Mm_GenLoc_end = 110084487
    | Mm_Uniprot = Q3UMX0
  }}
}}
'''SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1''', also known as '''SMARCC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6599| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the [[SWI/SNF]] family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors.<ref name="entrez">{{cite web | title = Entrez Gene: SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6599| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Wang W, Xue Y, Zhou S, ''et al.'' |title=Diversity and specialization of mammalian SWI/SNF complexes. |journal=Genes Dev. |volume=10 |issue= 17 |pages= 2117-30 |year= 1996 |pmid= 8804307 |doi=  }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | author=Wang W, Côté J, Xue Y, ''et al.'' |title=Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. |journal=EMBO J. |volume=15 |issue= 19 |pages= 5370-82 |year= 1996 |pmid= 8895581 |doi=  }}
*{{cite journal  | author=Fryer CJ, Archer TK |title=Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex. |journal=Nature |volume=393 |issue= 6680 |pages= 88-91 |year= 1998 |pmid= 9590696 |doi= 10.1038/30032 }}
*{{cite journal  | author=Ring HZ, Vameghi-Meyers V, Wang W, ''et al.'' |title=Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome. |journal=Genomics |volume=51 |issue= 1 |pages= 140-3 |year= 1998 |pmid= 9693044 |doi= 10.1006/geno.1998.5343 }}
*{{cite journal  | author=Cho H, Orphanides G, Sun X, ''et al.'' |title=A human RNA polymerase II complex containing factors that modify chromatin structure. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5355-63 |year= 1998 |pmid= 9710619 |doi=  }}
*{{cite journal  | author=Sif S, Stukenberg PT, Kirschner MW, Kingston RE |title=Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. |journal=Genes Dev. |volume=12 |issue= 18 |pages= 2842-51 |year= 1998 |pmid= 9744861 |doi=  }}
*{{cite journal  | author=Shanahan F, Seghezzi W, Parry D, ''et al.'' |title=Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest. |journal=Mol. Cell. Biol. |volume=19 |issue= 2 |pages= 1460-9 |year= 1999 |pmid= 9891079 |doi=  }}
*{{cite journal  | author=Phelan ML, Sif S, Narlikar GJ, Kingston RE |title=Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. |journal=Mol. Cell |volume=3 |issue= 2 |pages= 247-53 |year= 1999 |pmid= 10078207 |doi=  }}
*{{cite journal  | author=Kowenz-Leutz E, Leutz A |title=A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes. |journal=Mol. Cell |volume=4 |issue= 5 |pages= 735-43 |year= 2000 |pmid= 10619021 |doi=  }}
*{{cite journal  | author=Bochar DA, Wang L, Beniya H, ''et al.'' |title=BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. |journal=Cell |volume=102 |issue= 2 |pages= 257-65 |year= 2000 |pmid= 10943845 |doi=  }}
*{{cite journal  | author=Kadam S, McAlpine GS, Phelan ML, ''et al.'' |title=Functional selectivity of recombinant mammalian SWI/SNF subunits. |journal=Genes Dev. |volume=14 |issue= 19 |pages= 2441-51 |year= 2000 |pmid= 11018012 |doi=  }}
*{{cite journal  | author=Xue Y, Canman JC, Lee CS, ''et al.'' |title=The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 24 |pages= 13015-20 |year= 2001 |pmid= 11078522 |doi= 10.1073/pnas.240208597 }}
*{{cite journal  | author=Sif S, Saurin AJ, Imbalzano AN, Kingston RE |title=Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes. |journal=Genes Dev. |volume=15 |issue= 5 |pages= 603-18 |year= 2001 |pmid= 11238380 |doi= 10.1101/gad.872801 }}
*{{cite journal  | author=Otsuki T, Furukawa Y, Ikeda K, ''et al.'' |title=Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex. |journal=Hum. Mol. Genet. |volume=10 |issue= 23 |pages= 2651-60 |year= 2002 |pmid= 11726552 |doi=  }}
*{{cite journal  | author=Kato H, Tjernberg A, Zhang W, ''et al.'' |title=SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5498-505 |year= 2002 |pmid= 11734557 |doi= 10.1074/jbc.M108702200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Nie Z, Yan Z, Chen EH, ''et al.'' |title=Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. |journal=Mol. Cell. Biol. |volume=23 |issue= 8 |pages= 2942-52 |year= 2003 |pmid= 12665591 |doi=  }}
*{{cite journal  | author=Kitagawa H, Fujiki R, Yoshimura K, ''et al.'' |title=The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. |journal=Cell |volume=113 |issue= 7 |pages= 905-17 |year= 2003 |pmid= 12837248 |doi=  }}
*{{cite journal  | author=Hsiao PW, Fryer CJ, Trotter KW, ''et al.'' |title=BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. |journal=Mol. Cell. Biol. |volume=23 |issue= 17 |pages= 6210-20 |year= 2003 |pmid= 12917342 |doi=  }}
}}
{{refend}}


{{protein-stub}}
SMARCC1 has been shown to [[Protein-protein interaction|interact]] with:
{{WikiDoc Sources}}
* [[BAZ1B]],<ref name = pmid12837248>{{cite journal | vauthors = Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S | title = The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome | journal = Cell | volume = 113 | issue = 7 | pages = 905–17 | date = June 2003 | pmid = 12837248 | doi =  10.1016/s0092-8674(03)00436-7}}</ref>
* [[ING1]],<ref name = pmid11784859/>
* [[SIN3A]],<ref name = pmid11784859>{{cite journal | vauthors = Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D | title = Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) | journal = Mol. Cell. Biol. | volume = 22 | issue = 3 | pages = 835–48 | date = February 2002 | pmid = 11784859 | pmc = 133546 | doi =  10.1128/mcb.22.3.835-848.2002}}</ref><ref name = pmid11238380>{{cite journal | vauthors = Sif S, Saurin AJ, Imbalzano AN, Kingston RE | title = Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes | journal = Genes Dev. | volume = 15 | issue = 5 | pages = 603–18 | date = March 2001 | pmid = 11238380 | pmc = 312641 | doi = 10.1101/gad.872801 }}</ref>
* [[SMARCA2]],<ref name = pmid11238380/><ref name = pmid8895581>{{cite journal | vauthors = Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR | title = Purification and biochemical heterogeneity of the mammalian SWI-SNF complex | journal = EMBO J. | volume = 15 | issue = 19 | pages = 5370–82 | date = October 1996 | pmid = 8895581 | pmc = 452280 | doi =  }}</ref>
* [[SMARCA4]],<ref name = pmid11238380/><ref name = pmid8895581/><ref name = pmid11726552>{{cite journal | vauthors = Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM | title = Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex | journal = Hum. Mol. Genet. | volume = 10 | issue = 23 | pages = 2651–60 | date = November 2001 | pmid = 11726552 | doi =  10.1093/hmg/10.23.2651}}</ref><ref name = pmid9845365>{{cite journal | vauthors = Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR | title = Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling | journal = Cell | volume = 95 | issue = 5 | pages = 625–36 | date = November 1998 | pmid = 9845365 | doi =  10.1016/s0092-8674(00)81633-5}}</ref> and
* [[SMARCB1]].<ref name = pmid11238380/><ref name = pmid8895581/>
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
* {{cite journal | vauthors = Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR | title = Purification and biochemical heterogeneity of the mammalian SWI-SNF complex | journal = EMBO J. | volume = 15 | issue = 19 | pages = 5370–82 | year = 1996 | pmid = 8895581 | pmc = 452280 | doi =  }}
* {{cite journal | vauthors = Fryer CJ, Archer TK | title = Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex | journal = Nature | volume = 393 | issue = 6680 | pages = 88–91 | year = 1998 | pmid = 9590696 | doi = 10.1038/30032 }}
* {{cite journal | vauthors = Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U | title = Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome | journal = Genomics | volume = 51 | issue = 1 | pages = 140–3 | year = 1998 | pmid = 9693044 | doi = 10.1006/geno.1998.5343 }}
* {{cite journal | vauthors = Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D | title = A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure | journal = Mol. Cell. Biol. | volume = 18 | issue = 9 | pages = 5355–63 | year = 1998 | pmid = 9710619 | pmc = 109120 | doi =  }}
* {{cite journal | vauthors = Sif S, Stukenberg PT, Kirschner MW, Kingston RE | title = Mitotic inactivation of a human SWI/SNF chromatin remodeling complex | journal = Genes Dev. | volume = 12 | issue = 18 | pages = 2842–51 | year = 1998 | pmid = 9744861 | pmc = 317164 | doi = 10.1101/gad.12.18.2842 }}
* {{cite journal | vauthors = Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E | title = Cyclin E Associates with BAF155 and BRG1, Components of the Mammalian SWI-SNF Complex, and Alters the Ability of BRG1 To Induce Growth Arrest | journal = Mol. Cell. Biol. | volume = 19 | issue = 2 | pages = 1460–9 | year = 1999 | pmid = 9891079 | pmc = 116074 | doi =  10.1128/mcb.19.2.1460}}
* {{cite journal | vauthors = Phelan ML, Sif S, Narlikar GJ, Kingston RE | title = Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits | journal = Mol. Cell | volume = 3 | issue = 2 | pages = 247–53 | year = 1999 | pmid = 10078207 | doi = 10.1016/S1097-2765(00)80315-9 }}
* {{cite journal | vauthors = Kowenz-Leutz E, Leutz A | title = A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes | journal = Mol. Cell | volume = 4 | issue = 5 | pages = 735–43 | year = 2000 | pmid = 10619021 | doi = 10.1016/S1097-2765(00)80384-6 }}
* {{cite journal | vauthors = Bochar DA, Wang L, Beniya H, Kinev A, Xue Y, Lane WS, Wang W, Kashanchi F, Shiekhattar R | title = BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer | journal = Cell | volume = 102 | issue = 2 | pages = 257–65 | year = 2000 | pmid = 10943845 | doi = 10.1016/S0092-8674(00)00030-1 }}
* {{cite journal | vauthors = Kadam S, McAlpine GS, Phelan ML, Kingston RE, Jones KA, Emerson BM | title = Functional selectivity of recombinant mammalian SWI/SNF subunits | journal = Genes Dev. | volume = 14 | issue = 19 | pages = 2441–51 | year = 2000 | pmid = 11018012 | pmc = 316972 | doi = 10.1101/gad.828000 }}
* {{cite journal | vauthors = Xue Y, Canman JC, Lee CS, Nie Z, Yang D, Moreno GT, Young MK, Salmon ED, Wang W | title = The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 24 | pages = 13015–20 | year = 2001 | pmid = 11078522 | pmc = 27170 | doi = 10.1073/pnas.240208597 }}
* {{cite journal | vauthors = Sif S, Saurin AJ, Imbalzano AN, Kingston RE | title = Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes | journal = Genes Dev. | volume = 15 | issue = 5 | pages = 603–18 | year = 2001 | pmid = 11238380 | pmc = 312641 | doi = 10.1101/gad.872801 }}
* {{cite journal | vauthors = Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM | title = Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex | journal = Hum. Mol. Genet. | volume = 10 | issue = 23 | pages = 2651–60 | year = 2002 | pmid = 11726552 | doi = 10.1093/hmg/10.23.2651 }}
* {{cite journal | vauthors = Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG | title = SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones | journal = J. Biol. Chem. | volume = 277 | issue = 7 | pages = 5498–505 | year = 2002 | pmid = 11734557 | doi = 10.1074/jbc.M108702200 }}
* {{cite journal | vauthors = Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, Xue Y, Yang D, Murray D, Kanakubo E, Cleary ML, Wang W | title = Novel SWI/SNF Chromatin-Remodeling Complexes Contain a Mixed-Lineage Leukemia Chromosomal Translocation Partner | journal = Mol. Cell. Biol. | volume = 23 | issue = 8 | pages = 2942–52 | year = 2003 | pmid = 12665591 | pmc = 152562 | doi = 10.1128/MCB.23.8.2942-2952.2003 }}
* {{cite journal | vauthors = Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S | title = The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome | journal = Cell | volume = 113 | issue = 7 | pages = 905–17 | year = 2003 | pmid = 12837248 | doi = 10.1016/S0092-8674(03)00436-7 }}
* {{cite journal | vauthors = Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK | title = BAF60a Mediates Critical Interactions between Nuclear Receptors and the BRG1 Chromatin-Remodeling Complex for Transactivation | journal = Mol. Cell. Biol. | volume = 23 | issue = 17 | pages = 6210–20 | year = 2003 | pmid = 12917342 | pmc = 180928 | doi = 10.1128/MCB.23.17.6210-6220.2003 }}
{{Refend}}
 
== External links ==
* {{FactorBook|BAF155}}
 
 
{{Gene-3-stub}}

Latest revision as of 06:39, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SWI/SNF complex subunit SMARCC1 is a protein that in humans is encoded by the SMARCC1 gene.[1][2]

Function

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors.[2]

Interactions

SMARCC1 has been shown to interact with:

References

  1. ↑ Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (November 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307.
  2. ↑ 2.0 2.1 "Entrez Gene: SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1".
  3. ↑ Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (June 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/s0092-8674(03)00436-7. PMID 12837248.
  4. ↑ 4.0 4.1 Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (February 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Mol. Cell. Biol. 22 (3): 835–48. doi:10.1128/mcb.22.3.835-848.2002. PMC 133546. PMID 11784859.
  5. ↑ 5.0 5.1 5.2 5.3 Sif S, Saurin AJ, Imbalzano AN, Kingston RE (March 2001). "Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes". Genes Dev. 15 (5): 603–18. doi:10.1101/gad.872801. PMC 312641. PMID 11238380.
  6. ↑ 6.0 6.1 6.2 Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR (October 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. PMC 452280. PMID 8895581.
  7. ↑ Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM (November 2001). "Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex". Hum. Mol. Genet. 10 (23): 2651–60. doi:10.1093/hmg/10.23.2651. PMID 11726552.
  8. ↑ Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR (November 1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling". Cell. 95 (5): 625–36. doi:10.1016/s0092-8674(00)81633-5. PMID 9845365.

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=SMARCC1&oldid=1413521"