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{{Infobox_gene}}
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'''TRAF-interacting protein''' is a [[protein]] that in humans is encoded by the ''TRAIP'' [[gene]].<ref name="pmid9104814">{{cite journal |vauthors=Lee SY, Lee SY, Choi Y | title = TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation | journal = J Exp Med | volume = 185 | issue = 7 | pages = 1275–85 |date=May 1997 | pmid = 9104814 | pmc = 2196258 | doi =10.1084/jem.185.7.1275 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRAIP TRAF interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10293| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = TRAF interacting protein
| HGNCid = 30764
| Symbol = TRAIP
| AltSymbols =; TRIP; RNF206
| OMIM = 605958
| ECnumber = 
| Homologene = 31343
| MGIid = 1096377
| GeneAtlas_image1 = PBB_GE_TRAIP_205598_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}{{GNF_GO|id=GO:0008270 |text = zinc ion binding}}{{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10293
    | Hs_Ensembl = ENSG00000183763
    | Hs_RefseqProtein = NP_005870
    | Hs_RefseqmRNA = NM_005879
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 49841032
    | Hs_GenLoc_end = 49868996
    | Hs_Uniprot = Q9BWF2
    | Mm_EntrezGene = 22036
    | Mm_Ensembl = ENSMUSG00000032586
    | Mm_RefseqmRNA = XM_976945
    | Mm_RefseqProtein = XP_982039
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 107808237
    | Mm_GenLoc_end = 107830369
    | Mm_Uniprot = Q8VIG6
  }}
}}
'''TRAF interacting protein''', also known as '''TRAIP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TRAIP TRAF interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10293| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.<ref name="entrez">{{cite web | title = Entrez Gene: TRAIP TRAF interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10293| accessdate = }}</ref>
| summary_text = This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.<ref name="entrez">{{cite web | title = Entrez Gene: TRAIP TRAF interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10293| accessdate = }}</ref>
}}
}}
==Interactions==
TRAF interacting protein has been shown to [[Protein-protein interaction|interact]] with [[FLII]],<ref name=pmid9671805>{{cite journal |last=Wilson |first=S A |authorlink= |author2=Brown E C |author3=Kingsman A J |author4=Kingsman S M  |date=Aug 1998 |title=TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I |journal=Nucleic Acids Res. |volume=26 |issue=15 |pages=3460–7 |publisher= |location = ENGLAND| issn = 0305-1048| pmid = 9671805 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/nar/26.15.3460 |pmc=147727 }}</ref> [[TRAF1]]<ref name=pmid9104814 /> and [[TRAF2]].<ref name=pmid9104814/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Beckly JB, Hancock L, Geremia A, ''et al.'' |title=Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease. |journal=Inflamm. Bowel Dis. |volume=14 |issue= 4 |pages= 500-7 |year=  |pmid= 18200509 |doi= 10.1002/ibd.20365 }}
*{{cite journal   |vauthors=Beckly JB, Hancock L, Geremia A, etal |title=Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease. |journal=Inflamm. Bowel Dis. |volume=14 |issue= 4 |pages= 500–7 |year=  2008|pmid= 18200509 |doi= 10.1002/ibd.20365 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Regamey A, Hohl D, Liu JW, ''et al.'' |title=The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor. |journal=J. Exp. Med. |volume=198 |issue= 12 |pages= 1959-64 |year= 2004 |pmid= 14676304 |doi= 10.1084/jem.20031187 }}
*{{cite journal   |vauthors=Regamey A, Hohl D, Liu JW, etal |title=The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor. |journal=J. Exp. Med. |volume=198 |issue= 12 |pages= 1959–64 |year= 2004 |pmid= 14676304 |doi= 10.1084/jem.20031187 | pmc=2194148 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Wilson SA, Brown EC, Kingsman AJ, Kingsman SM |title=TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I. |journal=Nucleic Acids Res. |volume=26 |issue= 15 |pages= 3460-7 |year= 1998 |pmid= 9671805 |doi=  }}
*{{cite journal  |vauthors=Wilson SA, Brown EC, Kingsman AJ, Kingsman SM |title=TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I. |journal=Nucleic Acids Res. |volume=26 |issue= 15 |pages= 3460–7 |year= 1998 |pmid= 9671805 |doi=10.1093/nar/26.15.3460  | pmc=147727 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Lee SY, Lee SY, Choi Y |title=TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. |journal=J. Exp. Med. |volume=185 |issue= 7 |pages= 1275-85 |year= 1997 |pmid= 9104814 |doi= }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|TRAIP}}
* {{UCSC gene details|TRAIP}}
 
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Revision as of 12:13, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

TRAF-interacting protein is a protein that in humans is encoded by the TRAIP gene.[1][2]

This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.[2]

Interactions

TRAF interacting protein has been shown to interact with FLII,[3] TRAF1[1] and TRAF2.[1]

References

  1. ↑ 1.0 1.1 1.2 Lee SY, Lee SY, Choi Y (May 1997). "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation". J Exp Med. 185 (7): 1275–85. doi:10.1084/jem.185.7.1275. PMC 2196258. PMID 9104814.
  2. ↑ 2.0 2.1 "Entrez Gene: TRAIP TRAF interacting protein".
  3. ↑ Wilson, S A; Brown E C; Kingsman A J; Kingsman S M (Aug 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. ENGLAND. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. ISSN 0305-1048. PMC 147727. PMID 9671805.

Further reading

External links



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