PPP2R2C: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform''' is an [[enzyme]] that in humans is encoded by the ''PPP2R2C'' [[gene]].<ref name="pmid10574460">{{cite journal | vauthors = Torres R, Ide SE, Dehejia A, Baras A, Polymeropoulos MH | title = Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit | journal = DNA Research | volume = 6 | issue = 5 | pages = 323–7 | date = Oct 1999 | pmid = 10574460 | pmc =  | doi = 10.1093/dnares/6.5.323 }}</ref><ref name="pmid10945473">{{cite journal | vauthors = Hu P, Yu L, Zhang M, Zheng L, Zhao Y, Fu Q, Zhao S | title = Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16 | journal = Genomics | volume = 67 | issue = 1 | pages = 83–6 | date = Jul 2000 | pmid = 10945473 | pmc = | doi = 10.1006/geno.2000.6219 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5522| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform
| HGNCid = 9306
| Symbol = PPP2R2C
| AltSymbols =; IMYPNO; IMYPNO1; MGC33570; PR52; PR55G
| OMIM = 605997
| ECnumber = 
| Homologene = 36386
| MGIid = 2442660
| Function = {{GNF_GO|id=GO:0008601 |text = protein phosphatase type 2A regulator activity}}
| Component = {{GNF_GO|id=GO:0000159 |text = protein phosphatase type 2A complex}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5522
    | Hs_Ensembl = ENSG00000074211
    | Hs_RefseqProtein = NP_065149
    | Hs_RefseqmRNA = NM_020416
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 6373209
    | Hs_GenLoc_end = 6525074
    | Hs_Uniprot = Q9Y2T4
    | Mm_EntrezGene = 269643
    | Mm_Ensembl = ENSMUSG00000029120
    | Mm_RefseqmRNA = XM_988885
    | Mm_RefseqProtein = XP_993979
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 37156819
    | Mm_GenLoc_end = 37243329
    | Mm_Uniprot = Q8BG02
  }}
}}
'''Protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform''', also known as '''PPP2R2C''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5522| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5522| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Zolnierowicz S | title = Type 2A protein phosphatase, the complex regulator of numerous signaling pathways | journal = Biochemical Pharmacology | volume = 60 | issue = 8 | pages = 1225–35 | date = Oct 2000 | pmid = 11007961 | doi = 10.1016/S0006-2952(00)00424-X }}
| citations =
* {{cite journal | vauthors = Andersen JL, Planelles V | title = The role of Vpr in HIV-1 pathogenesis | journal = Current HIV Research | volume = 3 | issue = 1 | pages = 43–51 | date = Jan 2005 | pmid = 15638722 | doi = 10.2174/1570162052772988 }}
*{{cite journal | author=Zolnierowicz S |title=Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. |journal=Biochem. Pharmacol. |volume=60 |issue= 8 |pages= 1225-35 |year= 2000 |pmid= 11007961 |doi= }}
* {{cite journal | vauthors = Le Rouzic E, Benichou S | title = The Vpr protein from HIV-1: distinct roles along the viral life cycle | journal = Retrovirology | volume = 2 | issue =  | pages = 11 | year = 2006 | pmid = 15725353 | pmc = 554975 | doi = 10.1186/1742-4690-2-11 }}
*{{cite journal | author=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 43-51 |year= 2005 |pmid= 15638722 |doi= }}
* {{cite journal | vauthors = Zhao RY, Elder RT | title = Viral infections and cell cycle G2/M regulation | journal = Cell Research | volume = 15 | issue = 3 | pages = 143–9 | date = Mar 2005 | pmid = 15780175 | doi = 10.1038/sj.cr.7290279 }}
*{{cite journal | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue=  |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 }}
* {{cite journal | vauthors = Zhao RY, Bukrinsky M, Elder RT | title = HIV-1 viral protein R (Vpr) & host cellular responses | journal = The Indian Journal of Medical Research | volume = 121 | issue = 4 | pages = 270–86 | date = Apr 2005 | pmid = 15817944 | doi =  }}
*{{cite journal | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143-9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
* {{cite journal | vauthors = Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R | title = Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr | journal = FEBS Letters | volume = 401 | issue = 2-3 | pages = 197–201 | date = Jan 1997 | pmid = 9013886 | doi = 10.1016/S0014-5793(96)01470-6 }}
*{{cite journal | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270-86 |year= 2005 |pmid= 15817944 |doi=  }}
* {{cite journal | vauthors = Ruediger R, Brewis N, Ohst K, Walter G | title = Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production | journal = Virology | volume = 238 | issue = 2 | pages = 432–43 | date = Nov 1997 | pmid = 9400615 | doi = 10.1006/viro.1997.8873 }}
*{{cite journal | author=Tung HY, De Rocquigny H, Zhao LJ, ''et al.'' |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue= 2-3 |pages= 197-201 |year= 1997 |pmid= 9013886 |doi= }}
* {{cite journal | vauthors = Strack S, Zaucha JA, Ebner FF, Colbran RJ, Wadzinski BE | title = Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits | journal = The Journal of Comparative Neurology | volume = 392 | issue = 4 | pages = 515–27 | date = Mar 1998 | pmid = 9514514 | doi = 10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3 }}
*{{cite journal | author=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. |journal=Virology |volume=238 |issue= 2 |pages= 432-43 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873 }}
* {{cite journal | vauthors = | title = Toward a complete human genome sequence | journal = Genome Research | volume = 8 | issue = 11 | pages = 1097–108 | date = Nov 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 }}
*{{cite journal | author=Strack S, Zaucha JA, Ebner FF, ''et al.'' |title=Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits. |journal=J. Comp. Neurol. |volume=392 |issue= 4 |pages= 515-27 |year= 1998 |pmid= 9514514 |doi= }}
* {{cite journal | vauthors = Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y | title = HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25 | journal = Virology | volume = 287 | issue = 2 | pages = 359–70 | date = Sep 2001 | pmid = 11531413 | doi = 10.1006/viro.2001.1007 }}
*{{cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
* {{cite journal | vauthors = Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, Wahlestedt C, Zabarovsky ER | title = NotI flanking sequences: a tool for gene discovery and verification of the human genome | journal = Nucleic Acids Research | volume = 30 | issue = 14 | pages = 3163–70 | date = Jul 2002 | pmid = 12136098 | pmc = 135748 | doi = 10.1093/nar/gkf428 | last15 = Wasserman | last14 = Kisselev | last17 = Zabarovsky | last16 = Wahlestedt | last13 = Kashuba | last12 = Protopopov | first12 = AI | first13 = VI | first16 = C | first17 = ER | first14 = LL | first15 = W }}
*{{cite journal  | author=Torres R, Ide SE, Dehejia A, ''et al.'' |title=Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit. |journal=DNA Res. |volume=6 |issue= 5 |pages= 323-7 |year= 2000 |pmid= 10574460 |doi=  }}
* {{cite journal | vauthors = Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA | title = Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A | journal = The Journal of Biological Chemistry | volume = 278 | issue = 42 | pages = 40829–36 | date = Oct 2003 | pmid = 12912990 | doi = 10.1074/jbc.M308678200 }}
*{{cite journal  | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3956-67 |year= 2000 |pmid= 10921877 |doi= 10.1093/emboj/19.15.3956 }}
* {{cite journal | vauthors = Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, Hahn WC | title = Identification of specific PP2A complexes involved in human cell transformation | journal = Cancer Cell | volume = 5 | issue = 2 | pages = 127–36 | date = Feb 2004 | pmid = 14998489 | doi = 10.1016/S1535-6108(04)00026-1 }}
*{{cite journal  | author=Hu P, Yu L, Zhang M, ''et al.'' |title=Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16. |journal=Genomics |volume=67 |issue= 1 |pages= 83-6 |year= 2001 |pmid= 10945473 |doi= 10.1006/geno.2000.6219 }}
*{{cite journal | author=Elder RT, Yu M, Chen M, ''et al.'' |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359-70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007 }}
*{{cite journal | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=21 |issue= 14 |pages= 3918 |year= 2002 |pmid= 12110603 |doi= 10.1093/emboj/cdf420 }}
*{{cite journal  | author=Kutsenko AS, Gizatullin RZ, Al-Amin AN, ''et al.'' |title=NotI flanking sequences: a tool for gene discovery and verification of the human genome. |journal=Nucleic Acids Res. |volume=30 |issue= 14 |pages= 3163-70 |year= 2002 |pmid= 12136098 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Shern JF, Sharer JD, Pallas DC, ''et al.'' |title=Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A. |journal=J. Biol. Chem. |volume=278 |issue= 42 |pages= 40829-36 |year= 2003 |pmid= 12912990 |doi= 10.1074/jbc.M308678200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Chen W, Possemato R, Campbell KT, ''et al.'' |title=Identification of specific PP2A complexes involved in human cell transformation. |journal=Cancer Cell |volume=5 |issue= 2 |pages= 127-36 |year= 2004 |pmid= 14998489 |doi= }}
}}
{{refend}}
{{refend}}
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Latest revision as of 18:35, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.[1][2][3]

Function

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

References

  1. ↑ Torres R, Ide SE, Dehejia A, Baras A, Polymeropoulos MH (Oct 1999). "Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit". DNA Research. 6 (5): 323–7. doi:10.1093/dnares/6.5.323. PMID 10574460.
  2. ↑ Hu P, Yu L, Zhang M, Zheng L, Zhao Y, Fu Q, Zhao S (Jul 2000). "Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16". Genomics. 67 (1): 83–6. doi:10.1006/geno.2000.6219. PMID 10945473.
  3. ↑ 3.0 3.1 "Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform".

Further reading

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