RCHY1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''RING finger and CHY zinc finger domain-containing protein 1''' is a [[protein]] that in humans is encoded by the ''RCHY1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RCHY1 ring finger and CHY zinc finger domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25898| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ring finger and CHY zinc finger domain containing 1
| HGNCid = 17479
| Symbol = RCHY1
| AltSymbols =; ARNIP; CHIMP; DKFZp586C1620; PIRH2; PRO1996; RNF199; ZNF363; hARNIP
| OMIM = 607680
| ECnumber = 
| Homologene = 22894
| MGIid = 1915348
| GeneAtlas_image1 = PBB_GE_RCHY1_212743_at_tn.png
| GeneAtlas_image2 = PBB_GE_RCHY1_212749_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RCHY1_214281_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 25898
    | Hs_Ensembl = ENSG00000163743
    | Hs_RefseqProtein = NP_001008925
    | Hs_RefseqmRNA = NM_001008925
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 76623381
    | Hs_GenLoc_end = 76658652
    | Hs_Uniprot = Q96PM5
    | Mm_EntrezGene = 68098
    | Mm_Ensembl = ENSMUSG00000029397
    | Mm_RefseqmRNA = NM_026557
    | Mm_RefseqProtein = NP_080833
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 93024102
    | Mm_GenLoc_end = 93038268
    | Mm_Uniprot = Q8R593
  }}
}}
'''Ring finger and CHY zinc finger domain containing 1''', also known as '''RCHY1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RCHY1 ring finger and CHY zinc finger domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25898| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: RCHY1 ring finger and CHY zinc finger domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25898| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
RCHY1 has been shown to [[Protein-protein interaction|interact]] with [[P53]]<ref name=pmid12654245>{{cite journal | vauthors = Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S | title = Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation | journal = Cell | volume = 112 | issue = 6 | pages = 779–91 | date = Mar 2003 | pmid = 12654245 | doi = 10.1016/S0092-8674(03)00193-4 }}</ref><ref name=pmid19043414>{{cite journal | vauthors = Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, Lukin J, Sunnerhagen M, Srisailam S, Karra M, Benchimol S, Arrowsmith CH | title = Molecular basis of Pirh2-mediated p53 ubiquitylation | journal = Nature Structural & Molecular Biology | volume = 15 | issue = 12 | pages = 1334–42 | date = Dec 2008 | pmid = 19043414 | doi = 10.1038/nsmb.1521 }}</ref> and [[Androgen receptor]].<ref name=pmid12200228>{{cite journal | vauthors = Beitel LK, Elhaji YA, Lumbroso R, Wing SS, Panet-Raymond V, Gottlieb B, Pinsky L, Trifiro MA | title = Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity | journal = Journal of Molecular Endocrinology | volume = 29 | issue = 1 | pages = 41–60 | date = Aug 2002 | pmid = 12200228 | doi = 10.1677/jme.0.0290041 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
| citations =
* {{cite journal | vauthors = Beitel LK, Elhaji YA, Lumbroso R, Wing SS, Panet-Raymond V, Gottlieb B, Pinsky L, Trifiro MA | title = Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity | journal = Journal of Molecular Endocrinology | volume = 29 | issue = 1 | pages = 41–60 | date = Aug 2002 | pmid = 12200228 | doi = 10.1677/jme.0.0290041 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S | title = Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation | journal = Cell | volume = 112 | issue = 6 | pages = 779–91 | date = Mar 2003 | pmid = 12654245 | doi = 10.1016/S0092-8674(03)00193-4 }}
*{{cite journal | author=Beitel LK, Elhaji YA, Lumbroso R, ''et al.'' |title=Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity. |journal=J. Mol. Endocrinol. |volume=29 |issue= 1 |pages= 41-60 |year= 2002 |pmid= 12200228 |doi=  }}
* {{cite journal | vauthors = Logan IR, Sapountzi V, Gaughan L, Neal DE, Robson CN | title = Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome | journal = The Journal of Biological Chemistry | volume = 279 | issue = 12 | pages = 11696–704 | date = Mar 2004 | pmid = 14701804 | doi = 10.1074/jbc.M312712200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Corcoran CA, Huang Y, Sheikh MS | title = The p53 paddy wagon: COP1, Pirh2 and MDM2 are found resisting apoptosis and growth arrest | journal = Cancer Biology & Therapy | volume = 3 | issue = 8 | pages = 721–5 | date = Aug 2004 | pmid = 15280670 | doi = 10.4161/cbt.3.8.1068 }}
*{{cite journal | author=Leng RP, Lin Y, Ma W, ''et al.'' |title=Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. |journal=Cell |volume=112 |issue= 6 |pages= 779-91 |year= 2003 |pmid= 12654245 |doi= }}
* {{cite journal | vauthors = Duan W, Gao L, Druhan LJ, Zhu WG, Morrison C, Otterson GA, Villalona-Calero MA | title = Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer | journal = Journal of the National Cancer Institute | volume = 96 | issue = 22 | pages = 1718–21 | date = Nov 2004 | pmid = 15547185 | doi = 10.1093/jnci/djh292 }}
*{{cite journal | author=Logan IR, Sapountzi V, Gaughan L, ''et al.'' |title=Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11696-704 |year= 2004 |pmid= 14701804 |doi= 10.1074/jbc.M312712200 }}
* {{cite journal | vauthors = Zhang L, Li J, Wang C, Ma Y, Huo K | title = A new human gene hNTKL-BP1 interacts with hPirh2 | journal = Biochemical and Biophysical Research Communications | volume = 330 | issue = 1 | pages = 293–7 | date = Apr 2005 | pmid = 15781263 | doi = 10.1016/j.bbrc.2005.02.156 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Logan IR, Gaughan L, McCracken SR, Sapountzi V, Leung HY, Robson CN | title = Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer | journal = Molecular and Cellular Biology | volume = 26 | issue = 17 | pages = 6502–10 | date = Sep 2006 | pmid = 16914734 | pmc = 1592843 | doi = 10.1128/MCB.00147-06 }}
*{{cite journal  | author=Corcoran CA, Huang Y, Sheikh MS |title=The p53 paddy wagon: COP1, Pirh2 and MDM2 are found resisting apoptosis and growth arrest. |journal=Cancer Biol. Ther. |volume=3 |issue= 8 |pages= 721-5 |year= 2005 |pmid= 15280670 |doi= }}
* {{cite journal | vauthors = Duan W, Gao L, Wu X, Zhang Y, Otterson GA, Villalona-Calero MA | title = Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells | journal = Experimental Cell Research | volume = 312 | issue = 17 | pages = 3370–8 | date = Oct 2006 | pmid = 16934800 | doi = 10.1016/j.yexcr.2006.07.005 }}
*{{cite journal | author=Duan W, Gao L, Druhan LJ, ''et al.'' |title=Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer. |journal=J. Natl. Cancer Inst. |volume=96 |issue= 22 |pages= 1718-21 |year= 2004 |pmid= 15547185 |doi= 10.1093/jnci/djh292 }}
* {{cite journal | vauthors = Duan S, Yao Z, Hou D, Wu Z, Zhu WG, Wu M | title = Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53 | journal = The EMBO Journal | volume = 26 | issue = 13 | pages = 3062–74 | date = Jul 2007 | pmid = 17568776 | pmc = 1914097 | doi = 10.1038/sj.emboj.7601749 }}
*{{cite journal | author=Zhang L, Li J, Wang C, ''et al.'' |title=A new human gene hNTKL-BP1 interacts with hPirh2. |journal=Biochem. Biophys. Res. Commun. |volume=330 |issue= 1 |pages= 293-7 |year= 2005 |pmid= 15781263 |doi= 10.1016/j.bbrc.2005.02.156 }}
* {{cite journal | vauthors = Hattori T, Isobe T, Abe K, Kikuchi H, Kitagawa K, Oda T, Uchida C, Kitagawa M | title = Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1 | journal = Cancer Research | volume = 67 | issue = 22 | pages = 10789–95 | date = Nov 2007 | pmid = 18006823 | doi = 10.1158/0008-5472.CAN-07-2033 }}
*{{cite journal | author=Logan IR, Gaughan L, McCracken SR, ''et al.'' |title=Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer. |journal=Mol. Cell. Biol. |volume=26 |issue= 17 |pages= 6502-10 |year= 2006 |pmid= 16914734 |doi= 10.1128/MCB.00147-06 }}
*{{cite journal | author=Duan W, Gao L, Wu X, ''et al.'' |title=Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells. |journal=Exp. Cell Res. |volume=312 |issue= 17 |pages= 3370-8 |year= 2006 |pmid= 16934800 |doi= 10.1016/j.yexcr.2006.07.005 }}
*{{cite journal | author=Duan S, Yao Z, Hou D, ''et al.'' |title=Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. |journal=EMBO J. |volume=26 |issue= 13 |pages= 3062-74 |year= 2007 |pmid= 17568776 |doi= 10.1038/sj.emboj.7601749 }}
*{{cite journal | author=Hattori T, Isobe T, Abe K, ''et al.'' |title=Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1. |journal=Cancer Res. |volume=67 |issue= 22 |pages= 10789-95 |year= 2007 |pmid= 18006823 |doi= 10.1158/0008-5472.CAN-07-2033 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}

Revision as of 02:14, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

RING finger and CHY zinc finger domain-containing protein 1 is a protein that in humans is encoded by the RCHY1 gene.[1]

Function

The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53. Alternative splicing results in multiple transcript variants encoding different isoforms.[1]

Interactions

RCHY1 has been shown to interact with P53[2][3] and Androgen receptor.[4]

References

  1. ↑ 1.0 1.1 "Entrez Gene: RCHY1 ring finger and CHY zinc finger domain containing 1".
  2. ↑ Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S (Mar 2003). "Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation". Cell. 112 (6): 779–91. doi:10.1016/S0092-8674(03)00193-4. PMID 12654245.
  3. ↑ Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, Lukin J, Sunnerhagen M, Srisailam S, Karra M, Benchimol S, Arrowsmith CH (Dec 2008). "Molecular basis of Pirh2-mediated p53 ubiquitylation". Nature Structural & Molecular Biology. 15 (12): 1334–42. doi:10.1038/nsmb.1521. PMID 19043414.
  4. ↑ Beitel LK, Elhaji YA, Lumbroso R, Wing SS, Panet-Raymond V, Gottlieb B, Pinsky L, Trifiro MA (Aug 2002). "Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity". Journal of Molecular Endocrinology. 29 (1): 41–60. doi:10.1677/jme.0.0290041. PMID 12200228.

Further reading

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