HGFAC: Difference between revisions

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{{Infobox_gene}}
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'''Hepatocyte growth factor activator''' is a [[protein]] that in humans is encoded by the ''HGFAC'' [[gene]].<ref name="pmid7683665">{{cite journal |vauthors=Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N | title = Molecular Cloning and Sequence Analysis of the cDNA for a Human Serine Protease Responsible for Activation of Hepatocyte Growth Factor. Structural similarity of the protease precursor to blood coagulation factor XII | journal = J Biol Chem | volume = 268 | issue = 14 | pages = 10024–8 |date=Jun 1993 | pmid = 7683665 | pmc =  | doi =  }}</ref><ref name="pmid8226803">{{cite journal |vauthors=Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N | title = Activation of the zymogen of hepatocyte growth factor activator by thrombin | journal = J Biol Chem | volume = 268 | issue = 30 | pages = 22927–32 |date=Dec 1993 | pmid = 8226803 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HGFAC HGF activator| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3083| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_HGFAC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ybw.
| PDB = {{PDB2|1ybw}}, {{PDB2|1yc0}}
| Name = HGF activator
| HGNCid = 4894
| Symbol = HGFAC
| AltSymbols =; HGFA; MGC138395; MGC138397
| OMIM = 604552
| ECnumber =
| Homologene = 1170
| MGIid = 1859281
  | GeneAtlas_image1 = PBB_GE_HGFAC_207027_at_tn.png
  | Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006928 |text = cell motility}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3083
    | Hs_Ensembl = ENSG00000109758
    | Hs_RefseqProtein = NP_001519
    | Hs_RefseqmRNA = NM_001528
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 3413412
    | Hs_GenLoc_end = 3421011
    | Hs_Uniprot = Q04756
    | Mm_EntrezGene = 54426
    | Mm_Ensembl = ENSMUSG00000029102
    | Mm_RefseqmRNA = NM_019447
    | Mm_RefseqProtein = NP_062320
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 35358417
    | Mm_GenLoc_end = 35365269
    | Mm_Uniprot = Q3TDU8
  }}
}}
'''HGF activator''', also known as '''HGFAC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HGFAC HGF activator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3083| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.<ref name="entrez">{{cite web | title = Entrez Gene: HGFAC HGF activator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3083| accessdate = }}</ref>
| summary_text = The protein encoded by this gene belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.<ref name="entrez">{{cite web | title = Entrez Gene: HGFAC HGF activator| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3083| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nakamura T |title=Structure and function of hepatocyte growth factor. |journal=Prog. Growth Factor Res. |volume=3 |issue= 1 |pages= 67-85 |year= 1992 |pmid= 1838014 |doi=  }}
*{{cite journal  | author=Nakamura T |title=Structure and function of hepatocyte growth factor. |journal=Prog. Growth Factor Res. |volume=3 |issue= 1 |pages= 67–85 |year= 1992 |pmid= 1838014 |doi=10.1016/0955-2235(91)90014-U }}
*{{cite journal  | author=Shimomura T, Ochiai M, Kondo J, Morimoto Y |title=A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture. |journal=Cytotechnology |volume=8 |issue= 3 |pages= 219-29 |year= 1992 |pmid= 1368819 |doi= }}
*{{cite journal  |vauthors=Shimomura T, Ochiai M, Kondo J, Morimoto Y |title=A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture. |journal=Cytotechnology |volume=8 |issue= 3 |pages= 219–29 |year= 1992 |pmid= 1368819 |doi=10.1007/BF02522039 }}
*{{cite journal  | author=Miyazawa K, Shimomura T, Kitamura A, ''et al.'' |title=Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII. |journal=J. Biol. Chem. |volume=268 |issue= 14 |pages= 10024-8 |year= 1993 |pmid= 7683665 |doi=  }}
*{{cite journal  |vauthors=Miyazawa K, Shimomura T, Kitamura N |title=Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator. |journal=J. Biol. Chem. |volume=271 |issue= 7 |pages= 3615–8 |year= 1996 |pmid= 8631970 |doi=10.1074/jbc.271.7.3615 }}
*{{cite journal  | author=Shimomura T, Kondo J, Ochiai M, ''et al.'' |title=Activation of the zymogen of hepatocyte growth factor activator by thrombin. |journal=J. Biol. Chem. |volume=268 |issue= 30 |pages= 22927-32 |year= 1993 |pmid= 8226803 |doi= }}
*{{cite journal   |vauthors=Shimomura T, Denda K, Kitamura A, etal |title=Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6370–6 |year= 1997 |pmid= 9045658 |doi=10.1074/jbc.272.10.6370 }}
*{{cite journal  | author=Miyazawa K, Shimomura T, Kitamura N |title=Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator. |journal=J. Biol. Chem. |volume=271 |issue= 7 |pages= 3615-8 |year= 1996 |pmid= 8631970 |doi=  }}
*{{cite journal   |vauthors=Kawaguchi T, Qin L, Shimomura T, etal |title=Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 27558–64 |year= 1997 |pmid= 9346890 |doi=10.1074/jbc.272.44.27558 }}
*{{cite journal | author=Shimomura T, Denda K, Kitamura A, ''et al.'' |title=Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6370-6 |year= 1997 |pmid= 9045658 |doi=  }}
*{{cite journal   |vauthors=Miyazawa K, Wang Y, Minoshima S, etal |title=Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator. |journal=Eur. J. Biochem. |volume=258 |issue= 2 |pages= 355–61 |year= 1999 |pmid= 9874200 |doi=10.1046/j.1432-1327.1998.2580355.x }}
*{{cite journal | author=Kawaguchi T, Qin L, Shimomura T, ''et al.'' |title=Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 27558-64 |year= 1997 |pmid= 9346890 |doi=  }}
*{{cite journal   |vauthors=Kataoka H, Shimomura T, Kawaguchi T, etal |title=Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40453–62 |year= 2001 |pmid= 11013244 |doi= 10.1074/jbc.M006412200 }}
*{{cite journal | author=Miyazawa K, Wang Y, Minoshima S, ''et al.'' |title=Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator. |journal=Eur. J. Biochem. |volume=258 |issue= 2 |pages= 355-61 |year= 1999 |pmid= 9874200 |doi=  }}
*{{cite journal   |vauthors=Kataoka H, Meng JY, Itoh H, etal |title=Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta. |journal=Histochem. Cell Biol. |volume=114 |issue= 6 |pages= 469–75 |year= 2001 |pmid= 11201608 |doi= 10.1007/s004180000228 }}
*{{cite journal | author=Kataoka H, Shimomura T, Kawaguchi T, ''et al.'' |title=Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40453-62 |year= 2001 |pmid= 11013244 |doi= 10.1074/jbc.M006412200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Kataoka H, Meng JY, Itoh H, ''et al.'' |title=Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta. |journal=Histochem. Cell Biol. |volume=114 |issue= 6 |pages= 469-75 |year= 2001 |pmid= 11201608 |doi= }}
*{{cite journal   |vauthors=Anderson NL, Polanski M, Pieper R, etal |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell. Proteomics |volume=3 |issue= 4 |pages= 311–26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Tjin EP, Derksen PW, Kataoka H, etal |title=Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator. |journal=Blood |volume=104 |issue= 7 |pages= 2172–5 |year= 2004 |pmid= 15172968 |doi= 10.1182/blood-2003-12-4386 }}
*{{cite journal | author=Anderson NL, Polanski M, Pieper R, ''et al.'' |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell Proteomics |volume=3 |issue= 4 |pages= 311-26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200 }}
*{{cite journal  |vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
*{{cite journal | author=Tjin EP, Derksen PW, Kataoka H, ''et al.'' |title=Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator. |journal=Blood |volume=104 |issue= 7 |pages= 2172-5 |year= 2004 |pmid= 15172968 |doi= 10.1182/blood-2003-12-4386 }}
*{{cite journal   |vauthors=Shia S, Stamos J, Kirchhofer D, etal |title=Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B. |journal=J. Mol. Biol. |volume=346 |issue= 5 |pages= 1335–49 |year= 2005 |pmid= 15713485 |doi= 10.1016/j.jmb.2004.12.048 }}
*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal   |vauthors=Tjin EP, Groen RW, Vogelzang I, etal |title=Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma. |journal=Blood |volume=107 |issue= 2 |pages= 760–8 |year= 2006 |pmid= 16189274 |doi= 10.1182/blood-2005-05-1929 }}
*{{cite journal | author=Shia S, Stamos J, Kirchhofer D, ''et al.'' |title=Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B. |journal=J. Mol. Biol. |volume=346 |issue= 5 |pages= 1335-49 |year= 2005 |pmid= 15713485 |doi= 10.1016/j.jmb.2004.12.048 }}
*{{cite journal   |vauthors=Liu T, Qian WJ, Gritsenko MA, etal |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 }}
*{{cite journal | author=Tjin EP, Groen RW, Vogelzang I, ''et al.'' |title=Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma. |journal=Blood |volume=107 |issue= 2 |pages= 760-8 |year= 2006 |pmid= 16189274 |doi= 10.1182/blood-2005-05-1929 }}
*{{cite journal | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=3083}}
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Revision as of 13:35, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene.[1][2][3]

The protein encoded by this gene belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.[3]

References

  1. ↑ Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N (Jun 1993). "Molecular Cloning and Sequence Analysis of the cDNA for a Human Serine Protease Responsible for Activation of Hepatocyte Growth Factor. Structural similarity of the protease precursor to blood coagulation factor XII". J Biol Chem. 268 (14): 10024–8. PMID 7683665.
  2. ↑ Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N (Dec 1993). "Activation of the zymogen of hepatocyte growth factor activator by thrombin". J Biol Chem. 268 (30): 22927–32. PMID 8226803.
  3. ↑ 3.0 3.1 "Entrez Gene: HGFAC HGF activator".

Further reading



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