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{{Infobox_gene}}
{{PBB_Controls
'''Guanylate cyclase soluble subunit beta-1''' is an [[enzyme]] that in humans is encoded by the ''GUCY1B3'' [[gene]].<ref name="pmid1352257">{{cite journal |vauthors=Giuili G, Scholl U, Bulle F, Guellaën G | title = Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain | journal = FEBS Lett | volume = 304 | issue = 1 | pages = 83–8 | date = Jul 1992 | pmid = 1352257 | pmc =  | doi = 10.1016/0014-5793(92)80594-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2983| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Guanylate cyclase 1, soluble, beta 3
| HGNCid = 4687
| Symbol = GUCY1B3
| AltSymbols =; GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3
| OMIM = 139397
| ECnumber = 
| Homologene = 664
| MGIid = 1860604
| GeneAtlas_image1 = PBB_GE_GUCY1B3_211555_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004383 |text = guanylate cyclase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0008074 |text = guanylate cyclase complex, soluble}}
| Process = {{GNF_GO|id=GO:0006182 |text = cGMP biosynthetic process}} {{GNF_GO|id=GO:0007263 |text = nitric oxide mediated signal transduction}} {{GNF_GO|id=GO:0008015 |text = circulation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2983
    | Hs_Ensembl = ENSG00000061918
    | Hs_RefseqProtein = NP_000848
    | Hs_RefseqmRNA = NM_000857
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 156899661
    | Hs_GenLoc_end = 156951636
    | Hs_Uniprot = Q02153
    | Mm_EntrezGene = 54195
    | Mm_Ensembl = ENSMUSG00000028005
    | Mm_RefseqmRNA = NM_017469
    | Mm_RefseqProtein = NP_059497
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 82119182
    | Mm_GenLoc_end = 82159998
    | Mm_Uniprot = Q3UTI4
  }}
}}
'''Guanylate cyclase 1, soluble, beta 3''', also known as '''GUCY1B3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2983| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Soluble guanylate cyclase]] (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of [[guanosine triphosphate|GTP]] to the second messenger [[cyclic guanosine monophosphate|cGMP]] and functions as the main receptor for [[nitric oxide]] and [[nitrovasodilator]] drugs.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs (Zabel et al., 1998).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2983| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
GUCY1B3 has been shown to [[Protein-protein interaction|interact]] with [[Heat shock protein 90kDa alpha (cytosolic), member A1]]<ref name=pmid12676772>{{cite journal |vauthors=Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD | title = Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase  | journal = Am. J. Physiol. Heart Circ. Physiol. | volume = 285 | issue = 2 | pages = H669–78 | date = Aug 2003 | pmid = 12676772 | doi = 10.1152/ajpheart.01025.2002 }}</ref> and [[Endothelial NOS]].<ref name=pmid12676772/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal |vauthors=Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA | title = Guanylyl cyclases and signaling by cyclic GMP | journal = Pharmacol. Rev. | volume = 52 | issue = 3 | pages = 375–414 | year = 2000 | pmid = 10977868 | doi =  }}
| citations =
*{{cite journal |vauthors=Chhajlani V, Frändberg PA, Ahlner J, Axelsson KL, Wikberg JE | title = Heterogeneity in human soluble guanylate cyclase due to alternative splicing | journal = FEBS Lett. | volume = 290 | issue = 1–2 | pages = 157–8 | year = 1991 | pmid = 1680753 | doi = 10.1016/0014-5793(91)81248-7 }}
*{{cite journal | author=Lucas KA, Pitari GM, Kazerounian S, ''et al.'' |title=Guanylyl cyclases and signaling by cyclic GMP. |journal=Pharmacol. Rev. |volume=52 |issue= 3 |pages= 375-414 |year= 2000 |pmid= 10977868 |doi=  }}
*{{cite journal |vauthors=Giuili G, Roechel N, Scholl U, Mattei MG, Guellaen G | title = Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33 | journal = Hum. Genet. | volume = 91 | issue = 3 | pages = 257–60 | year = 1993 | pmid = 8097486 | doi = 10.1007/BF00218267 }}
*{{cite journal | author=Giuili G, Scholl U, Bulle F, Guellaën G |title=Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. |journal=FEBS Lett. |volume=304 |issue= 1 |pages= 83-8 |year= 1992 |pmid= 1352257 |doi=  }}
*{{cite journal |vauthors=Papapetropoulos A, Cziraki A, Rubin JW, Stone CD, Catravas JD | title = cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue | journal = J. Cell. Physiol. | volume = 167 | issue = 2 | pages = 213–21 | year = 1996 | pmid = 8613461 | doi = 10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S }}
*{{cite journal  | author=Chhajlani V, Frändberg PA, Ahlner J, ''et al.'' |title=Heterogeneity in human soluble guanylate cyclase due to alternative splicing. |journal=FEBS Lett. |volume=290 |issue= 1-2 |pages= 157-8 |year= 1991 |pmid= 1680753 |doi= }}
*{{cite journal |vauthors=Zabel U, Weeger M, La M, Schmidt HH | title = Human soluble guanylate cyclase: functional expression and revised isoenzyme family | journal = Biochem. J. | volume = 335 | issue = 1 | pages = 51–7 | year = 1998 | pmid = 9742212 | pmc = 1219751 | doi =  }}
*{{cite journal | author=Giuili G, Roechel N, Scholl U, ''et al.'' |title=Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33. |journal=Hum. Genet. |volume=91 |issue= 3 |pages= 257-60 |year= 1993 |pmid= 8097486 |doi= }}
*{{cite journal |vauthors=Russwurm M, Wittau N, Koesling D | title = Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes | journal = J. Biol. Chem. | volume = 276 | issue = 48 | pages = 44647–52 | year = 2002 | pmid = 11572861 | doi = 10.1074/jbc.M105587200 }}
*{{cite journal | author=Papapetropoulos A, Cziraki A, Rubin JW, ''et al.'' |title=cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue. |journal=J. Cell. Physiol. |volume=167 |issue= 2 |pages= 213-21 |year= 1996 |pmid= 8613461 |doi= 10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S }}
*{{cite journal |vauthors=Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD | title = Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase | journal = Am. J. Physiol. Heart Circ. Physiol. | volume = 285 | issue = 2 | pages = H669–78 | year = 2003 | pmid = 12676772 | doi = 10.1152/ajpheart.01025.2002 }}
*{{cite journal | author=Zabel U, Weeger M, La M, Schmidt HH |title=Human soluble guanylate cyclase: functional expression and revised isoenzyme family. |journal=Biochem. J. |volume=335 ( Pt 1) |issue= |pages= 51-7 |year= 1998 |pmid= 9742212 |doi=  }}
*{{cite journal |vauthors=Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S | title = AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase | journal = J. Biol. Chem. | volume = 279 | issue = 47 | pages = 49346–54 | year = 2005 | pmid = 15381706 | doi = 10.1074/jbc.M410565200 }}
*{{cite journal | author=Russwurm M, Wittau N, Koesling D |title=Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 44647-52 |year= 2002 |pmid= 11572861 |doi= 10.1074/jbc.M105587200 }}
*{{cite journal |vauthors=Mateos-Cáceres PJ, Garcia-Cardoso J, Lapuente L, Zamorano-León JJ, Sacristán D, de Prada TP, Calahorra J, Macaya C, Vela-Navarrete R, López-Farré AJ | title = Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction | journal = Int. J. Impot. Res. | volume = 18 | issue = 5 | pages = 432–7 | year = 2006 | pmid = 16528291 | doi = 10.1038/sj.ijir.3901461 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Venema RC, Venema VJ, Ju H, ''et al.'' |title=Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=285 |issue= 2 |pages= H669-78 |year= 2003 |pmid= 12676772 |doi= 10.1152/ajpheart.01025.2002 }}
*{{cite journal | author=Meurer S, Pioch S, Wagner K, ''et al.'' |title=AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase. |journal=J. Biol. Chem. |volume=279 |issue= 47 |pages= 49346-54 |year= 2005 |pmid= 15381706 |doi= 10.1074/jbc.M410565200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Mateos-Cáceres PJ, Garcia-Cardoso J, Lapuente L, ''et al.'' |title=Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction. |journal=Int. J. Impot. Res. |volume=18 |issue= 5 |pages= 432-7 |year= 2006 |pmid= 16528291 |doi= 10.1038/sj.ijir.3901461 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 09:10, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.[1][2]

Function

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.[2]

Interactions

GUCY1B3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1[3] and Endothelial NOS.[3]

References

  1. ↑ Giuili G, Scholl U, Bulle F, Guellaën G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257.
  2. ↑ 2.0 2.1 "Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3".
  3. ↑ 3.0 3.1 Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD (Aug 2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. PMID 12676772.

Further reading

  • Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA (2000). "Guanylyl cyclases and signaling by cyclic GMP". Pharmacol. Rev. 52 (3): 375–414. PMID 10977868.
  • Chhajlani V, Frändberg PA, Ahlner J, Axelsson KL, Wikberg JE (1991). "Heterogeneity in human soluble guanylate cyclase due to alternative splicing". FEBS Lett. 290 (1–2): 157–8. doi:10.1016/0014-5793(91)81248-7. PMID 1680753.
  • Giuili G, Roechel N, Scholl U, Mattei MG, Guellaen G (1993). "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33". Hum. Genet. 91 (3): 257–60. doi:10.1007/BF00218267. PMID 8097486.
  • Papapetropoulos A, Cziraki A, Rubin JW, Stone CD, Catravas JD (1996). "cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue". J. Cell. Physiol. 167 (2): 213–21. doi:10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S. PMID 8613461.
  • Zabel U, Weeger M, La M, Schmidt HH (1998). "Human soluble guanylate cyclase: functional expression and revised isoenzyme family". Biochem. J. 335 (1): 51–7. PMC 1219751. PMID 9742212.
  • Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861.
  • Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD (2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. PMID 12676772.
  • Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–54. doi:10.1074/jbc.M410565200. PMID 15381706.
  • Mateos-Cáceres PJ, Garcia-Cardoso J, Lapuente L, Zamorano-León JJ, Sacristán D, de Prada TP, Calahorra J, Macaya C, Vela-Navarrete R, López-Farré AJ (2006). "Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction". Int. J. Impot. Res. 18 (5): 432–7. doi:10.1038/sj.ijir.3901461. PMID 16528291.


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