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{{Infobox_gene}}
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'''Rap1 GTPase-GDP dissociation stimulator 1''' is an [[enzyme]] that in humans is encoded by the ''RAP1GDS1'' [[gene]].<ref name="pmid8262526">{{cite journal |vauthors=Riess O, Epplen C, Siedlaczck I, Epplen JT | title = Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25 | journal = Hum Genet | volume = 92 | issue = 6 | pages = 629–30 |date=Jan 1994 | pmid = 8262526 | pmc =  | doi =10.1007/BF00420952 }}</ref><ref name="pmid17951244">{{cite journal |vauthors=Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL | title = SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma | journal = J Biol Chem | volume = 283 | issue = 2 | pages = 963–76 |date=Jan 2008 | pmid = 17951244 | pmc =  | doi = 10.1074/jbc.M707526200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5910| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = RAP1, GTP-GDP dissociation stimulator 1
| HGNCid = 9859
| Symbol = RAP1GDS1
| AltSymbols =; GDS1; MGC118859; MGC118861
| OMIM = 179502
| ECnumber =
| Homologene = 41422
| MGIid = 2385189
  | GeneAtlas_image1 = PBB_GE_RAP1GDS1_209444_at_tn.png
  | GeneAtlas_image2 = PBB_GE_RAP1GDS1_217457_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005488 |text = binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5910
    | Hs_Ensembl = ENSG00000138698
    | Hs_RefseqProtein = NP_066982
    | Hs_RefseqmRNA = NM_021159
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 99401692
    | Hs_GenLoc_end = 99582508
    | Hs_Uniprot = P52306
    | Mm_EntrezGene = 229877
    | Mm_Ensembl = ENSMUSG00000028149
    | Mm_RefseqmRNA = NM_001040690
    | Mm_RefseqProtein = NP_001035780
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 138864972
    | Mm_GenLoc_end = 138987976
    | Mm_Uniprot = 
  }}
}}
'''RAP1, GTP-GDP dissociation stimulator 1''', also known as '''RAP1GDS1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5910| accessdate = }}</ref>


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| summary_text =  
}}
}}
==Interactions==
RAP1GDS1 has been shown to [[Protein-protein interaction|interact]] with [[KIFAP3]],<ref name=pmid8900189>{{cite journal |doi=10.1074/jbc.271.43.27013 |last=Shimizu |first=K |authorlink= |author2=Kawabe H |author3=Minami S |author4=Honda T |author5=Takaishi K |author6=Shirataki H |author7=Takai Y  |date=Oct 1996 |title=SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase |journal=J. Biol. Chem. |volume=271 |issue=43 |pages=27013–7 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8900189 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[HRAS]]<ref name=pmid11948427>{{cite journal |last=Vikis |first=Haris G |authorlink= |author2=Stewart Scott |author3=Guan Kun-Liang  |date=Apr 2002 |title=SmgGDS displays differential binding and exchange activity towards different Ras isoforms |journal=Oncogene |volume=21 |issue=15 |pages=2425–32 |publisher= |location = England| issn = 0950-9232| pmid = 11948427 |doi = 10.1038/sj.onc.1205306 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[RHOA]].<ref name=pmid11948427/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Kikuchi A, Kaibuchi K, Hori Y, ''et al.'' |title=Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21. |journal=Oncogene |volume=7 |issue= 2 |pages= 289-93 |year= 1992 |pmid= 1549351 |doi=  }}
*{{cite journal   |vauthors=Kikuchi A, Kaibuchi K, Hori Y, etal |title=Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21. |journal=Oncogene |volume=7 |issue= 2 |pages= 289–93 |year= 1992 |pmid= 1549351 |doi=  }}
*{{cite journal | author=Riess O, Epplen C, Siedlaczck I, Epplen JT |title=Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25. |journal=Hum. Genet. |volume=92 |issue= 6 |pages= 629-30 |year= 1994 |pmid= 8262526 |doi=  }}
*{{cite journal   |vauthors=Shimizu K, Kawabe H, Minami S, etal |title=SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase. |journal=J. Biol. Chem. |volume=271 |issue= 43 |pages= 27013–7 |year= 1996 |pmid= 8900189 |doi=10.1074/jbc.271.43.27013 }}
*{{cite journal  | author=Shimizu K, Kawabe H, Minami S, ''et al.'' |title=SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase. |journal=J. Biol. Chem. |volume=271 |issue= 43 |pages= 27013-7 |year= 1996 |pmid= 8900189 |doi=  }}
*{{cite journal  |vauthors=Vikis HG, Stewart S, Guan KL |title=SmgGDS displays differential binding and exchange activity towards different Ras isoforms. |journal=Oncogene |volume=21 |issue= 15 |pages= 2425–32 |year= 2002 |pmid= 11948427 |doi= 10.1038/sj.onc.1205306 }}
*{{cite journal  | author=Vikis HG, Stewart S, Guan KL |title=SmgGDS displays differential binding and exchange activity towards different Ras isoforms. |journal=Oncogene |volume=21 |issue= 15 |pages= 2425-32 |year= 2002 |pmid= 11948427 |doi= 10.1038/sj.onc.1205306 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=de Bruyn KM, Zwartkruis FJ, de Rooij J, etal |title=The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22412–7 |year= 2003 |pmid= 12690117 |doi= 10.1074/jbc.M212036200 }}
*{{cite journal | author=de Bruyn KM, Zwartkruis FJ, de Rooij J, ''et al.'' |title=The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22412-7 |year= 2003 |pmid= 12690117 |doi= 10.1074/jbc.M212036200 }}
*{{cite journal   |vauthors=Tiwari S, Felekkis K, Moon EY, etal |title=Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis. |journal=Blood |volume=103 |issue= 7 |pages= 2661–7 |year= 2004 |pmid= 14615375 |doi= 10.1182/blood-2003-06-2154 }}
*{{cite journal | author=Tiwari S, Felekkis K, Moon EY, ''et al.'' |title=Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis. |journal=Blood |volume=103 |issue= 7 |pages= 2661-7 |year= 2004 |pmid= 14615375 |doi= 10.1182/blood-2003-06-2154 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}


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[[Category:Armadillo-repeat-containing proteins]]

Revision as of 08:54, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.[1][2][3]


Interactions

RAP1GDS1 has been shown to interact with KIFAP3,[4] HRAS[5] and RHOA.[5]

References

  1. ↑ Riess O, Epplen C, Siedlaczck I, Epplen JT (Jan 1994). "Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25". Hum Genet. 92 (6): 629–30. doi:10.1007/BF00420952. PMID 8262526.
  2. ↑ Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL (Jan 2008). "SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma". J Biol Chem. 283 (2): 963–76. doi:10.1074/jbc.M707526200. PMID 17951244.
  3. ↑ "Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1".
  4. ↑ Shimizu, K; Kawabe H; Minami S; Honda T; Takaishi K; Shirataki H; Takai Y (Oct 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. UNITED STATES. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. ISSN 0021-9258. PMID 8900189.
  5. ↑ 5.0 5.1 Vikis, Haris G; Stewart Scott; Guan Kun-Liang (Apr 2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. England. 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. ISSN 0950-9232. PMID 11948427.

Further reading

  • Kikuchi A, Kaibuchi K, Hori Y, et al. (1992). "Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21". Oncogene. 7 (2): 289–93. PMID 1549351.
  • Shimizu K, Kawabe H, Minami S, et al. (1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. PMID 8900189.
  • Vikis HG, Stewart S, Guan KL (2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. PMID 11948427.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • de Bruyn KM, Zwartkruis FJ, de Rooij J, et al. (2003). "The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes". J. Biol. Chem. 278 (25): 22412–7. doi:10.1074/jbc.M212036200. PMID 12690117.
  • Tiwari S, Felekkis K, Moon EY, et al. (2004). "Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis". Blood. 103 (7): 2661–7. doi:10.1182/blood-2003-06-2154. PMID 14615375.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.



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