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{{ | '''CUGBP, Elav-like family member 2''', also known as '''Etr-3''' is a [[protein]] that in humans is encoded by the ''CELF2'' [[gene]].<ref name="pmid7869393">{{cite journal | vauthors = Hwang DM, Hwang WS, Liew CC | title = Single pass sequencing of a unidirectional human fetal heart cDNA library to discover novel genes of the cardiovascular system | journal = J Mol Cell Cardiol | volume = 26 | issue = 10 | pages = 1329–33 |date=Mar 1995 | pmid = 7869393 | pmc = | doi = 10.1006/jmcc.1994.1151 }}</ref><ref name="pmid9887331">{{cite journal | vauthors = Lu X, Timchenko NA, Timchenko LT | title = Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy | journal = Hum Mol Genet | volume = 8 | issue = 1 | pages = 53–60 |date=Mar 1999 | pmid = 9887331 | pmc = | doi =10.1093/hmg/8.1.53 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CELF2 CUGBP, Elav-like family member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10659| accessdate = }}</ref> | ||
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| summary_text = Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez" | | summary_text = Members of the CELF/BRUNOL protein family are [[RNA-binding protein]]s and contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA [[alternative splicing]] and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different [[protein isoforms|isoforms]].<ref name="entrez" /> | ||
}} | }} | ||
==Interactions== | |||
CUGBP2 has been shown to [[Protein-protein interaction|interact]] with [[A1CF]].<ref name=pmid11577082>{{cite journal |last=Anant |first=S |author2=Henderson J O |author3=Mukhopadhyay D |author4=Navaratnam N |author5=Kennedy S |author6=Min J |author7=Davidson N O |date=Dec 2001 |title=Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor |journal=J. Biol. Chem. |volume=276 |issue=50 |pages=47338–51 |publisher= |location = United States| issn = 0021-9258| pmid = 11577082 |doi = 10.1074/jbc.M104911200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | |||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|CELF2}} | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Choi DK, Ito T, Tsukahara F |title=Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein |journal=Gene |volume=237 |issue= 1 |pages= 135–42 |year= 1999 |pmid= 10524244 |doi=10.1016/S0378-1119(99)00312-1 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Good PJ, Chen Q, Warner SJ, Herring DC |title=A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28583–92 |year= 2000 |pmid= 10893231 |doi= 10.1074/jbc.M003083200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Ladd AN, Charlet N, Cooper TA |title=The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative Splicing |journal=Mol. Cell. Biol. |volume=21 |issue= 4 |pages= 1285–96 |year= 2001 |pmid= 11158314 |doi= 10.1128/MCB.21.4.1285-1296.2001 | pmc=99581 }} | ||
*{{cite journal | vauthors=Li D, Bachinski LL, Roberts R |title=Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia |journal=Genomics |volume=74 |issue= 3 |pages= 396–401 |year= 2001 |pmid= 11414768 |doi= 10.1006/geno.2001.6558 }} | |||
*{{cite journal | | *{{cite journal | vauthors=Anant S, Henderson JO, Mukhopadhyay D |title=Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 47338–51 |year= 2002 |pmid= 11577082 |doi=10.1074/jbc.M104911200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Lichtner P, Attié-Bitach T, Schuffenhauer S |title=Expression and mutation analysis of BRUNOL3, a candidate gene for heart and thymus developmental defects associated with partial monosomy 10p |journal=J. Mol. Med. |volume=80 |issue= 7 |pages= 431–42 |year= 2003 |pmid= 12110949 |doi= 10.1007/s00109-002-0331-9 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Mukhopadhyay D, Houchen CW, Kennedy S |title=Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2 |journal=Mol. Cell |volume=11 |issue= 1 |pages= 113–26 |year= 2003 |pmid= 12535526 |doi=10.1016/S1097-2765(03)00012-1 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Singh G, Charlet-B N, Han J, Cooper TA |title=ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo |journal=Nucleic Acids Res. |volume=32 |issue= 3 |pages= 1232–41 |year= 2004 |pmid= 14973222 |doi= 10.1093/nar/gkh275 | pmc=373409 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Mukhopadhyay D, Jung J, Murmu N |title=CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury |journal=Ann. N. Y. Acad. Sci. |volume=1010 |issue= |pages= 504–9 |year= 2004 |pmid= 15033780 |doi=10.1196/annals.1299.093 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Brandenberger R, Wei H, Zhang S |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Suzuki Y, Yamashita R, Shirota M |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Murmu N, Jung J, Mukhopadhyay D |title=Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 38 |pages= 13873–8 |year= 2004 |pmid= 15358864 |doi= 10.1073/pnas.0406066101 | pmc=518846 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Han J, Cooper TA |title=Identification of CELF splicing activation and repression domains in vivo |journal=Nucleic Acids Res. |volume=33 |issue= 9 |pages= 2769–80 |year= 2005 |pmid= 15894795 |doi= 10.1093/nar/gki561 | pmc=1126903 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}} | ||
*{{cite journal | vauthors=Chen Z, Eggerman TL, Patterson AP |title=ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=292 |issue= 1 |pages= G53–65 |year= 2007 |pmid= 16920700 |doi= 10.1152/ajpgi.00118.2006 }} | |||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=10659}} | |||
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Revision as of 10:11, 30 August 2017
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| Location (UCSC) | n/a | n/a | |||||
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CUGBP, Elav-like family member 2, also known as Etr-3 is a protein that in humans is encoded by the CELF2 gene.[1][2][3]
Members of the CELF/BRUNOL protein family are RNA-binding proteins and contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]
Interactions
CUGBP2 has been shown to interact with A1CF.[4]
References
- ↑ Hwang DM, Hwang WS, Liew CC (Mar 1995). "Single pass sequencing of a unidirectional human fetal heart cDNA library to discover novel genes of the cardiovascular system". J Mol Cell Cardiol. 26 (10): 1329–33. doi:10.1006/jmcc.1994.1151. PMID 7869393.
- ↑ Lu X, Timchenko NA, Timchenko LT (Mar 1999). "Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy". Hum Mol Genet. 8 (1): 53–60. doi:10.1093/hmg/8.1.53. PMID 9887331.
- ↑ 3.0 3.1 "Entrez Gene: CELF2 CUGBP, Elav-like family member 2".
- ↑ Anant, S; Henderson J O; Mukhopadhyay D; Navaratnam N; Kennedy S; Min J; Davidson N O (Dec 2001). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor". J. Biol. Chem. United States. 276 (50): 47338–51. doi:10.1074/jbc.M104911200. ISSN 0021-9258. PMID 11577082.
External links
- Human CELF2 genome location and CELF2 gene details page in the UCSC Genome Browser.
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Choi DK, Ito T, Tsukahara F, et al. (1999). "Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein". Gene. 237 (1): 135–42. doi:10.1016/S0378-1119(99)00312-1. PMID 10524244.
- Good PJ, Chen Q, Warner SJ, Herring DC (2000). "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator". J. Biol. Chem. 275 (37): 28583–92. doi:10.1074/jbc.M003083200. PMID 10893231.
- Ladd AN, Charlet N, Cooper TA (2001). "The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative Splicing". Mol. Cell. Biol. 21 (4): 1285–96. doi:10.1128/MCB.21.4.1285-1296.2001. PMC 99581. PMID 11158314.
- Li D, Bachinski LL, Roberts R (2001). "Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia". Genomics. 74 (3): 396–401. doi:10.1006/geno.2001.6558. PMID 11414768.
- Anant S, Henderson JO, Mukhopadhyay D, et al. (2002). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor". J. Biol. Chem. 276 (50): 47338–51. doi:10.1074/jbc.M104911200. PMID 11577082.
- Lichtner P, Attié-Bitach T, Schuffenhauer S, et al. (2003). "Expression and mutation analysis of BRUNOL3, a candidate gene for heart and thymus developmental defects associated with partial monosomy 10p". J. Mol. Med. 80 (7): 431–42. doi:10.1007/s00109-002-0331-9. PMID 12110949.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mukhopadhyay D, Houchen CW, Kennedy S, et al. (2003). "Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2". Mol. Cell. 11 (1): 113–26. doi:10.1016/S1097-2765(03)00012-1. PMID 12535526.
- Singh G, Charlet-B N, Han J, Cooper TA (2004). "ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo". Nucleic Acids Res. 32 (3): 1232–41. doi:10.1093/nar/gkh275. PMC 373409. PMID 14973222.
- Mukhopadhyay D, Jung J, Murmu N, et al. (2004). "CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury". Ann. N. Y. Acad. Sci. 1010: 504–9. doi:10.1196/annals.1299.093. PMID 15033780.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Murmu N, Jung J, Mukhopadhyay D, et al. (2004). "Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13873–8. doi:10.1073/pnas.0406066101. PMC 518846. PMID 15358864.
- Han J, Cooper TA (2005). "Identification of CELF splicing activation and repression domains in vivo". Nucleic Acids Res. 33 (9): 2769–80. doi:10.1093/nar/gki561. PMC 1126903. PMID 15894795.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Chen Z, Eggerman TL, Patterson AP (2007). "ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (1): G53–65. doi:10.1152/ajpgi.00118.2006. PMID 16920700.
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